{"title":"Albumin Binding Fluorescent Probes","description":"\u003cp\u003e\u003cstrong\u003eAlbumin Binding Fluorescent Probes\u003c\/strong\u003e — mencakup senyawa fluoresen (fluorescent) turunan dansil (dansyl) dan struktur serupa yang dirancang agar berikatan secara nonkovalen dengan protein albumin. Interaksi pengikatan ini mengubah intensitas atau pergeseran panjang gelombang emisi fluoresensi sehingga dapat diamati secara optis.\u003c\/p\u003e\u003cp\u003eProbe seperti Dansylsarcosine, Dansylglycine, Dansylamide, dan BD140 digunakan dalam uji pengikatan albumin (albumin binding assay) untuk mempelajari afinitas suatu molekul terhadap serum albumin, langkah penting dalam riset farmakokinetik dan formulasi obat. Laboratorium bioanalitik memanfaatkan perubahan sinyal fluoresensi saat probe berpindah dari lingkungan berair ke kantong hidrofobik albumin untuk mengukur kompetisi pengikatan berbagai ligan.\u003c\/p\u003e\u003cp\u003eContoh produk dalam koleksi ini: \u003ca href=\"\/en\/products\/tci2510d588326872\"\u003eTCI D5883 2733745-64-5 Dansylsarcosine Cyclohexylammonium Salt [for Albumin binding assay]\u003c\/a\u003e, \u003ca href=\"\/en\/products\/tci2510d489825648\"\u003eTCI D4898 1201643-08-4 BD140 [for Albumin binding assay]\u003c\/a\u003e, \u003ca href=\"\/en\/products\/tci2510d540626299\"\u003eTCI D5406 1091-85-6 Dansylglycine [for Albumin binding assay]\u003c\/a\u003e, \u003ca href=\"\/en\/products\/tci2510d540526297\"\u003eTCI D5405 1431-39-6 Dansylamide [for Albumin binding assay]\u003c\/a\u003e.\u003c\/p\u003e\u003cp\u003ePilih probe berdasarkan gugus fluorofor dan bentuk garam (seperti garam sikloheksilamonium) yang sesuai dengan sistem pelarut, serta panjang gelombang eksitasi-emisi yang cocok dengan instrumen fluorometer yang tersedia di laboratorium. Seluruh produk merupakan produk asli Tokyo Chemical Industry (TCI) Jepang, dengan kemurnian, kemasan, dan kondisi penyimpanan tercantum pada halaman masing-masing item.\u003c\/p\u003e\u003cp\u003eKategori lain yang sejajar di bawah Albumin Binding Agents, sering dipakai bersamaan dalam satu alur kerja laboratorium:\u003c\/p\u003e\u003cul\u003e\n\u003cli\u003e\u003ca href=\"\/en\/collections\/tci-l4-albumin-binding-modification-reagents\"\u003eAlbumin Binding Modification Reagents\u003c\/a\u003e\u003c\/li\u003e\n\u003cli\u003e\u003ca href=\"\/en\/collections\/tci-l4-albumin-binding-color-development-reagents\"\u003eAlbumin Binding Color Development Reagents\u003c\/a\u003e\u003c\/li\u003e\n\u003c\/ul\u003e\u003cp\u003eKembali ke \u003ca href=\"\/en\/collections\/tci-l3-albumin-binding-agents\"\u003eAlbumin Binding Agents\u003c\/a\u003e. Untuk pengadaan volume besar, kemasan khusus, atau grade tertentu, hubungi tim AMI Scientific — distributor resmi TCI Japan di Indonesia — untuk pengecekan ketersediaan dan lead time langsung ke Jepang.\u003c\/p\u003e","products":[{"product_id":"tci2510d489825648","title":"TCI D4898 1201643-08-4 BD140 [for Albumin binding assay]","description":"\u003ch3\u003eDescription\u003c\/h3\u003e\n\u003cp\u003eTCI D4898 1201643-08-4 BD140 is a chemical compound specifically designed for use in albumin binding assays. This reagent plays a crucial role in laboratory research by enabling scientists to study how various molecules interact with albumin, a key protein in blood plasma. Albumin serves as a major carrier for many drugs, and understanding its binding behavior is essential for drug development and pharmacological research. This compound is widely utilized in laboratories to assess the stability and bioavailability of pharmaceutical compounds under physiological conditions.\u003c\/p\u003e\n\u003cp\u003eThe compound is known for its chemical stability and high purity, making it a preferred choice for scientific research. Its resistance to degradation ensures consistent results across multiple experiments, which is vital for reproducibility in scientific studies. Additionally, the material is highly transparent and free from interfering contaminants, which enhances the accuracy of analytical results. These properties make it suitable for use in a variety of research settings where precision and reliability are paramount.\u003c\/p\u003e\n\u003cp\u003eIn Indonesian laboratories, this reagent is commonly used in pharmaceutical, biochemical, and drug discovery research. Researchers in Indonesia rely on this compound to investigate molecular interactions that are critical for the development of new therapeutic agents. Its versatility and reliability have made it a standard tool in both academic and industrial research environments.\u003c\/p\u003e\n\u003ch3\u003eLaboratory Applications\u003c\/h3\u003e\n\u003cul\u003e\n\u003cli\u003eAlbumin Binding Assays – This compound is ideal for assessing how drugs bind to albumin, which is crucial for understanding drug distribution and metabolism in the body.\u003c\/li\u003e\n\u003cli\u003ePharmaceutical Development – It supports the evaluation of drug stability and efficacy by simulating physiological conditions in vitro.\u003c\/li\u003e\n\u003cli\u003eDrug Discovery Research – It aids in identifying potential drug candidates by analyzing their interaction with albumin, a key transport protein.\u003c\/li\u003e\n\u003cli\u003eBiochemical Studies – It is used to investigate molecular interactions that influence drug behavior in biological systems.\u003c\/li\u003e\n\u003cli\u003eAnalytical Testing – Its high purity and stability make it suitable for use in analytical procedures requiring accurate and reproducible results.\u003c\/li\u003e\n\u003c\/ul\u003e\n\u003ch3\u003eSpecifications\u003c\/h3\u003e\n\u003cul\u003e\n\u003cli\u003eBrand: TCI\u003c\/li\u003e\n\u003cli\u003eCAS number: 1201643-08-4\u003c\/li\u003e\n\u003cli\u003eCategory: Chemistry \u0026gt; Pharmaceutical Development and Drug Discovery Research Reagents \u0026gt; Albumin Binding Agents\u003c\/li\u003e\n\u003cli\u003ePack sizes: Not specified\u003c\/li\u003e\n\u003cli\u003ePhysical form: Not specified\u003c\/li\u003e\n\u003cli\u003eStorage note: Store in a cool, dry place away from direct sunlight\u003c\/li\u003e\n\u003c\/ul\u003e\n\u003ch3\u003eHandling and Storage\u003c\/h3\u003e\n\u003cp\u003eThis compound should be stored in a cool, dry environment to maintain its chemical stability and prevent degradation. It is recommended to keep it in a sealed container to minimize exposure to moisture and air. Since it is used in laboratory settings, it should be handled with appropriate personal protective equipment, such as gloves and safety goggles, to ensure safe handling. The material should be stored away from incompatible substances to avoid any potential chemical reactions. Proper labeling of containers is essential for safe storage and easy identification. Regular monitoring of storage conditions is advised to ensure the integrity of the compound remains unaffected over time.\u003c\/p\u003e","brand":"TCI","offers":[{"title":"25mg","offer_id":48086732013786,"sku":"TCI2510D489825648","price":5060000.0,"currency_code":"IDR","in_stock":true},{"title":"100mg","offer_id":48086732046554,"sku":"TCI2510D489825649","price":13773000.0,"currency_code":"IDR","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0756\/7156\/8602\/files\/TCI2510D4898.jpg?v=1767108156"},{"product_id":"tci2510d540526297","title":"TCI D5405 1431-39-6 Dansylamide [for Albumin binding assay]","description":"\u003ch3\u003eDescription\u003c\/h3\u003e\n\u003cp\u003eDansylamide, with CAS number 1431-39-6, is a chemical compound widely used in scientific research, particularly in pharmacology and pharmaceutical chemistry. It serves as an essential reagent in albumin binding assays, which are critical for studying how drugs interact with plasma proteins. In the laboratory, this compound is used to evaluate the ability of a substance to bind to albumin, a key protein in blood plasma. Understanding this interaction is vital for assessing drug distribution and metabolism within the body.\u003c\/p\u003e\n\u003cp\u003eThe compound is valued for its chemical stability and reactivity, making it suitable for a variety of experimental conditions. Its molecular structure allows for specific binding to albumin, ensuring accurate and reliable results. This specificity is crucial in pharmaceutical research, where precise data is necessary for drug development and formulation. The consistency of results obtained with dansylamide makes it a preferred choice for researchers aiming to produce reproducible data.\u003c\/p\u003e\n\u003cp\u003eIn Indonesian laboratories, dansylamide is commonly used by researchers and research institutions to support studies on drug-protein interactions. It plays a significant role in the development of new pharmaceuticals and in the analysis of existing drugs. Its application is widespread in both academic and industrial research settings, contributing to the advancement of pharmacological studies in the region.\u003c\/p\u003e\n\u003ch3\u003eLaboratory Applications\u003c\/h3\u003e\n\u003cul\u003e\n\u003cli\u003eAlbumin Binding Assays: This item is ideal for assessing how drugs interact with albumin, a critical protein in plasma, allowing researchers to evaluate drug distribution and metabolism.\u003c\/li\u003e\n\u003cli\u003ePharmaceutical Development: It supports the development of new drugs by providing insights into their binding behavior with plasma proteins, which is essential for formulation and dosing.\u003c\/li\u003e\n\u003cli\u003eDrug Interaction Studies: Dansylamide enables the investigation of how different compounds interact with albumin, helping to predict potential drug interactions and side effects.\u003c\/li\u003e\n\u003cli\u003eBioavailability Analysis: It is used to study how drugs are absorbed and distributed in the body, offering valuable data for optimizing therapeutic outcomes.\u003c\/li\u003e\n\u003cli\u003eResearch and Development in Biopharmaceuticals: This compound is crucial for developing biopharmaceuticals, where understanding protein binding is essential for efficacy and safety.\u003c\/li\u003e\n\u003c\/ul\u003e\n\u003ch3\u003eSpecifications\u003c\/h3\u003e\n\u003cul\u003e\n\u003cli\u003eBrand: TCI\u003c\/li\u003e\n\u003cli\u003eCAS Number: 1431-39-6\u003c\/li\u003e\n\u003cli\u003eCategory: Chemistry \u0026gt; Pharmaceutical Development and Drug Discovery Research Reagents \u0026gt; Albumin Binding Agents\u003c\/li\u003e\n\u003cli\u003ePack Sizes: Available in various quantities as per standard laboratory supply\u003c\/li\u003e\n\u003cli\u003ePhysical Form: Solid powder\u003c\/li\u003e\n\u003cli\u003eStorage Note: Store in a cool, dry place away from light\u003c\/li\u003e\n\u003c\/ul\u003e\n\u003ch3\u003eHandling and Storage\u003c\/h3\u003e\n\u003cp\u003eDansylamide should be stored in a cool, dry place, away from direct light to maintain its chemical stability. It is recommended to keep the compound in a sealed container to prevent moisture absorption and contamination. Proper labeling of containers is essential for safe handling and identification. When handling, it is advisable to use appropriate personal protective equipment, such as gloves and safety goggles, to minimize exposure. The compound is generally non-hazardous under normal laboratory conditions, but care should be taken to avoid inhalation or contact with skin. Regular checks of storage conditions ensure the integrity of the material is preserved for reliable experimental results.\u003c\/p\u003e","brand":"TCI","offers":[{"title":"25mg","offer_id":48086757802202,"sku":"TCI2510D540526297","price":1378000.0,"currency_code":"IDR","in_stock":true},{"title":"100mg","offer_id":48086757834970,"sku":"TCI2510D540526298","price":4049000.0,"currency_code":"IDR","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0756\/7156\/8602\/files\/TCI2510D5405.jpg?v=1767108704"},{"product_id":"tci2510d540626299","title":"TCI D5406 1091-85-6 Dansylglycine [for Albumin binding assay]","description":"\u003ch3\u003eDescription\u003c\/h3\u003e\n\u003cp\u003eDansylglycine is a chemical compound widely used in scientific research, particularly in pharmacology and biochemistry. It plays a crucial role in laboratory settings by serving as an albumin-binding agent, enabling the analysis of albumin levels in plasma or other biological fluids. This compound is essential for studies related to drug development and understanding how drugs interact within the human body. Its application extends to various research fields where precise measurement of albumin is required.\u003c\/p\u003e\n\u003cp\u003eThe unique properties of Dansylglycine make it a preferred choice for analytical purposes. It exhibits strong fluorescent characteristics, which significantly enhance detection and measurement through spectroscopy techniques. This fluorescence allows for highly sensitive and accurate analysis, making it ideal for modern analytical methods. Additionally, its ability to bind specifically to albumin ensures reliable and reproducible results in laboratory experiments.\u003c\/p\u003e\n\u003cp\u003eIn Indonesian laboratories, Dansylglycine is extensively used in scientific research across universities, research centers, and pharmaceutical companies. It is particularly relevant in drug interaction studies, new drug development, and biochemical analyses requiring high precision. Its role in supporting scientific innovation and research is vital, especially in the context of advancing pharmaceutical and biochemical studies in Indonesia.\u003c\/p\u003e\n\u003ch3\u003eLaboratory Applications\u003c\/h3\u003e\n\u003cul\u003e\n\u003cli\u003eAlbumin Binding Assay: This item is ideal for measuring albumin levels in biological samples due to its specific binding properties.\u003c\/li\u003e\n\u003cli\u003eDrug Interaction Studies: Its fluorescent properties allow for accurate detection of drug-albumin interactions in pharmacological research.\u003c\/li\u003e\n\u003cli\u003eBiochemical Analysis: The compound supports precise and sensitive measurements in biochemical experiments requiring high accuracy.\u003c\/li\u003e\n\u003cli\u003ePharmaceutical Development: It is essential for assessing drug binding behavior during the development of new therapeutic agents.\u003c\/li\u003e\n\u003cli\u003eResearch and Development: Its reliability and sensitivity make it a key reagent in various R\u0026amp;D projects within academic and industrial laboratories.\u003c\/li\u003e\n\u003c\/ul\u003e\n\u003ch3\u003eSpecifications\u003c\/h3\u003e\n\u003cul\u003e\n\u003cli\u003eBrand: TCI\u003c\/li\u003e\n\u003cli\u003eCAS number: 1091-85-6\u003c\/li\u003e\n\u003cli\u003eCategory: Chemistry \u0026gt; Pharmaceutical Development and Drug Discovery Research Reagents \u0026gt; Albumin Binding Agents\u003c\/li\u003e\n\u003cli\u003ePack sizes: As per supplier specifications\u003c\/li\u003e\n\u003cli\u003ePhysical form: Solid (as per standard product description)\u003c\/li\u003e\n\u003cli\u003eStorage note: Store in a cool, dry place away from light\u003c\/li\u003e\n\u003c\/ul\u003e\n\u003ch3\u003eHandling and Storage\u003c\/h3\u003e\n\u003cp\u003eDansylglycine should be stored in a cool, dry place, away from direct light to maintain its stability and effectiveness. It is recommended to use airtight containers to prevent moisture absorption and contamination. Due to its fluorescent nature, it should be handled with care to avoid exposure to excessive light, which may degrade its properties. In laboratory settings, it is important to follow standard safety protocols, including the use of personal protective equipment. Proper labeling of containers is essential to ensure safe handling and prevent accidental use. The compound should be stored in a secure location to prevent unauthorized access and ensure compliance with laboratory safety standards.\u003c\/p\u003e","brand":"TCI","offers":[{"title":"25mg","offer_id":48086757867738,"sku":"TCI2510D540626299","price":1378000.0,"currency_code":"IDR","in_stock":true},{"title":"100mg","offer_id":48086757900506,"sku":"TCI2510D540626300","price":4049000.0,"currency_code":"IDR","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0756\/7156\/8602\/files\/TCI2510D5406.jpg?v=1767108708"},{"product_id":"tci2510d588326872","title":"TCI D5883 2733745-64-5 Dansylsarcosine Cyclohexylammonium Salt [for Albumin binding assay]","description":"\u003ch3\u003eDescription\u003c\/h3\u003e\n\u003cp\u003eTCI D5883 Dansylsarcosine Cyclohexylammonium Salt is a fluorescent reagent prepared specifically for albumin binding assays. The molecule combines a dansyl group — a naphthalene sulfonamide-derived fluorophore well known for its sensitivity to the surrounding environment — with a sarcosine unit, and is supplied as the cyclohexylammonium salt for easier handling. In routine laboratory practice, the compound serves as a marker probe that occupies one of the drug binding sites on serum albumin, so that the binding strength of a test compound can be estimated by measuring competitive displacement of the probe.\u003c\/p\u003e\n\u003cp\u003eThe characteristic that makes this reagent valuable is the fluorescence behaviour of the dansyl group, which depends strongly on the polarity of its environment. When free in aqueous solution the probe fluoresces relatively weakly, but once bound inside a hydrophobic pocket of the protein its intensity rises sharply and its emission maximum shifts. This clear change in signal is what allows measurements to be carried out without radioactive labelling and without physical separation of the bound and free fractions. The cyclohexylammonium salt form helps keep the material as a solid that is convenient to weigh and dispense.\u003c\/p\u003e\n\u003cp\u003eIn Indonesian laboratories, reagents of this type are used in pharmaceutical development and drug discovery research groups, in university and institutional research laboratories, and in analytical facilities equipped with fluorescence instrumentation. They are typically ordered in small quantities appropriate to assay-scale work, kept under controlled conditions between experiments, and handled as part of a documented reagent inventory so that the same probe material can be used consistently across a series of binding studies.\u003c\/p\u003e\n\u003ch3\u003eLaboratory Applications\u003c\/h3\u003e\n\u003cul\u003e\n\u003cli\u003eCompetitive albumin binding assays — the probe occupies a defined drug binding site on serum albumin, so displacement by a test compound gives a direct, quantifiable measure of relative binding affinity.\u003c\/li\u003e\n\u003cli\u003eFluorescence-based plasma protein binding screening — the strong intensity change on binding lets samples be read directly in a fluorimeter or plate reader, without separating bound and free fractions.\u003c\/li\u003e\n\u003cli\u003eDrug discovery lead characterisation — early estimates of albumin binding help research groups interpret how strongly candidate molecules associate with plasma protein during compound selection and prioritisation.\u003c\/li\u003e\n\u003cli\u003eBinding site mapping studies — because the dansylsarcosine probe reports on one particular site, it can be used to distinguish which region of albumin a test compound interacts with preferentially.\u003c\/li\u003e\n\u003cli\u003eFluorescence probe method development — the environment-sensitive dansyl group makes this reagent a useful reference material when establishing, validating, or troubleshooting protein binding assay protocols in the laboratory.\u003c\/li\u003e\n\u003c\/ul\u003e\n\u003ch3\u003eSpecifications\u003c\/h3\u003e\n\u003cul\u003e\n\u003cli\u003eBrand: TCI (Tokyo Chemical Industry)\u003c\/li\u003e\n\u003cli\u003eCAS number: 2733745-64-5\u003c\/li\u003e\n\u003cli\u003eProduct code: D5883\u003c\/li\u003e\n\u003cli\u003eCategory: Chemistry \u0026gt; Pharmaceutical Development and Drug Discovery Research Reagents \u0026gt; Albumin Binding Agents\u003c\/li\u003e\n\u003cli\u003ePhysical form: solid, supplied as the cyclohexylammonium salt\u003c\/li\u003e\n\u003cli\u003ePack sizes: research-scale packs; please confirm the currently available pack size when ordering\u003c\/li\u003e\n\u003cli\u003eStorage: keep in the closed original container under the conditions stated on the manufacturer's label\u003c\/li\u003e\n\u003c\/ul\u003e\n\u003ch3\u003eHandling and Storage\u003c\/h3\u003e\n\u003cp\u003eStore the reagent in its original tightly closed container, protected from light and moisture, and follow the storage conditions printed on the manufacturer's label and safety data sheet. Because the compound is a fluorescent probe, prolonged exposure to light should be avoided so that its optical performance is not affected. Prepare solutions in clean amber glass or other light-protecting vessels, and label all working dilutions with contents and preparation date. Weigh and transfer the solid in a well-ventilated area or fume hood, wearing gloves, a laboratory coat, and eye protection. Avoid generating dust, avoid contact with skin and eyes, and wash hands after handling. Dispose of residues and contaminated consumables through the laboratory's chemical waste procedure rather than the general drain or bin.\u003c\/p\u003e","brand":"TCI","offers":[{"title":"25mg","offer_id":48086782214362,"sku":"TCI2510D588326872","price":1941000.0,"currency_code":"IDR","in_stock":true},{"title":"100mg","offer_id":48086782247130,"sku":"TCI2510D588326873","price":5623000.0,"currency_code":"IDR","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0756\/7156\/8602\/files\/TCI2510D5883.jpg?v=1767109387"}],"url":"https:\/\/amiscientific.com\/en\/collections\/tci-l4-albumin-binding-fluorescent-probes.oembed","provider":"AMI Scientific","version":"1.0","type":"link"}