{"title":"Apoptosis inhibitors","description":"\u003cp\u003e\u003cstrong\u003eApoptosis inhibitors\u003c\/strong\u003e — berisi senyawa kecil (small molecule) yang menghambat jalur sinyal pemicu kematian sel terprogram (apoptosis) pada berbagai target seperti protein Bcl-2, kinase, atau enzim mitokondria. Senyawa dalam kategori ini digunakan untuk mengintervensi tahapan spesifik kaskade apoptosis dalam sistem seluler.\u003c\/p\u003e\u003cp\u003eSenyawa seperti Mdivi-1 (penghambat fisi mitokondria), SB 203580 (penghambat jalur p38 MAPK), Teprenone, dan Alisol B 23-Acetate dipakai dalam riset biologi sel untuk mempelajari mekanisme regulasi apoptosis pada model kultur sel. Peneliti kanker dan neurobiologi memanfaatkan penghambat ini untuk membedah peran jalur mitokondria maupun jalur kinase dalam kelangsungan hidup sel.\u003c\/p\u003e\u003cp\u003eContoh produk dalam koleksi ini: \u003ca href=\"\/en\/products\/tci2510t270154124\"\u003eTCI T2701 6809-52-5 Teprenone [mixture of (5E,9E,13E)- and (5Z,9E,13E)- isomers]\u003c\/a\u003e, \u003ca href=\"\/en\/products\/tci2510f086430864\"\u003eTCI F0864 152121-47-6 SB 203580\u003c\/a\u003e, \u003ca href=\"\/en\/products\/tci2510a36064439\"\u003eTCI A3606 26575-95-1 Alisol B 23-Acetate\u003c\/a\u003e, \u003ca href=\"\/en\/products\/tci2510m310841614\"\u003eTCI M3108 338967-87-6 Mdivi-1\u003c\/a\u003e.\u003c\/p\u003e\u003cp\u003ePerhatikan target molekuler spesifik (Bcl-2, kinase, atau komponen mitokondria) dan konfigurasi isomer geometri senyawa (seperti campuran isomer E\/Z pada Teprenone) agar sesuai dengan desain eksperimen. Seluruh produk merupakan produk asli Tokyo Chemical Industry (TCI) Jepang, dengan kemurnian, kemasan, dan kondisi penyimpanan tercantum pada halaman masing-masing item.\u003c\/p\u003e\u003cp\u003eKategori lain yang sejajar di bawah Apoptosis, sering dipakai bersamaan dalam satu alur kerja laboratorium:\u003c\/p\u003e\u003cul\u003e\n\u003cli\u003e\u003ca href=\"\/en\/collections\/tci-l4-apoptosis-inducers\"\u003eApoptosis Inducers\u003c\/a\u003e\u003c\/li\u003e\n\u003cli\u003e\u003ca href=\"\/en\/collections\/tci-l3-nutrition-research\"\u003eNutrition Research\u003c\/a\u003e\u003c\/li\u003e\n\u003cli\u003e\u003ca href=\"\/en\/collections\/tci-l3-cell-signaling-and-neuroscience\"\u003eCell Signaling and Neuroscience\u003c\/a\u003e\u003c\/li\u003e\n\u003cli\u003e\u003ca href=\"\/en\/collections\/tci-l3-cancer-research\"\u003eCancer Research\u003c\/a\u003e\u003c\/li\u003e\n\u003cli\u003e\u003ca href=\"\/en\/collections\/tci-l3-immune-system-inflammation-allergy-research\"\u003eImmune System, Inflammation, Allergy Research\u003c\/a\u003e\u003c\/li\u003e\n\u003cli\u003e\u003ca href=\"\/en\/collections\/tci-l3-bioactive-small-molecules\"\u003eBioactive Small Molecules\u003c\/a\u003e\u003c\/li\u003e\n\u003c\/ul\u003e\u003cp\u003eKembali ke \u003ca href=\"\/en\/collections\/tci-l3-apoptosis\"\u003eApoptosis\u003c\/a\u003e. Untuk pengadaan volume besar, kemasan khusus, atau grade tertentu, hubungi tim AMI Scientific — distributor resmi TCI Japan di Indonesia — untuk pengecekan ketersediaan dan lead time langsung ke Jepang.\u003c\/p\u003e","products":[{"product_id":"tci2510m310841614","title":"TCI M3108 338967-87-6 Mdivi-1","description":"\u003ch3\u003eDescription\u003c\/h3\u003e\n\u003cp\u003eTCI M3108 Mdivi-1 is a bioactive small molecule widely recognised as an inhibitor of mitochondrial division, and it is used extensively in research on apoptosis and organelle dynamics. The compound acts by interfering with the DRP1-mediated mitochondrial fission process, so that mitochondrial networks inside the cell tend to remain elongated rather than fragmented. Its role in the laboratory is that of a chemical tool used to test how much mitochondrial fragmentation contributes to cell death pathways, cytochrome c release, and cellular responses to oxidative stress or ischaemia-reperfusion injury.\u003c\/p\u003e\n\u003cp\u003eThe principal reason researchers select Mdivi-1 is its ability to produce a rapid effect that can be observed directly through fluorescence microscopy, because a change in mitochondrial morphology is a clear visual readout that requires no complex downstream processing. The compound is supplied as a solid that is stable under dry storage conditions and dissolves readily in DMSO, allowing high-concentration stock solutions to be prepared conveniently. This combination of a straightforward readout, storage stability, and easy solubilisation makes it a practical choice for laboratories that need a dependable pharmacological probe for mitochondrial dynamics.\u003c\/p\u003e\n\u003cp\u003eThe 10 mg and 50 mg pack sizes are designed for laboratory-scale research needs, where the working concentrations employed generally fall within the micromolar range, so that a single small pack can support many experimental runs. This suits the typical pattern of work in Indonesian laboratories, including university cell biology groups and research institutes, where a compact pack covers repeated cell culture experiments without leaving large quantities of unused material in storage.\u003c\/p\u003e\n\u003ch3\u003eLaboratory Applications\u003c\/h3\u003e\n\u003cul\u003e\n\u003cli\u003eApoptosis pathway research: the compound blocks DRP1-mediated fission, allowing investigators to determine how strongly mitochondrial fragmentation contributes to the execution of programmed cell death.\u003c\/li\u003e\n\u003cli\u003eCytochrome c release studies: by keeping mitochondrial networks elongated, Mdivi-1 lets researchers separate the contribution of fission events from downstream cytochrome c release during cell death signalling.\u003c\/li\u003e\n\u003cli\u003eOxidative stress experiments: researchers apply it to cultured cells to examine whether the mitochondrial fragmentation seen under oxidative challenge is a cause or a consequence of injury.\u003c\/li\u003e\n\u003cli\u003eIschaemia-reperfusion injury models: the inhibitor is used to test how much mitochondrial division contributes to cellular damage arising during reperfusion, a central question in this field.\u003c\/li\u003e\n\u003cli\u003eFluorescence microscopy of organelle dynamics: mitochondrial morphology changes quickly and visibly after treatment, giving a clear and directly observable imaging readout for live-cell work.\u003c\/li\u003e\n\u003c\/ul\u003e\n\u003ch3\u003eSpecifications\u003c\/h3\u003e\n\u003cul\u003e\n\u003cli\u003eBrand: TCI\u003c\/li\u003e\n\u003cli\u003eCAS number: 338967-87-6\u003c\/li\u003e\n\u003cli\u003eCategory: Life Science \u0026gt; Cell Biology \u0026gt; Apoptosis\u003c\/li\u003e\n\u003cli\u003ePack sizes: 10 mg and 50 mg\u003c\/li\u003e\n\u003cli\u003ePhysical form: solid\u003c\/li\u003e\n\u003cli\u003eStorage: stable under dry storage conditions; soluble in DMSO for preparation of high-concentration stock solutions\u003c\/li\u003e\n\u003c\/ul\u003e\n\u003ch3\u003eHandling and Storage\u003c\/h3\u003e\n\u003cp\u003eStore the material in a dry condition, since the compound is stable when kept dry and protected from moisture. Keep it in its original tightly closed container, or transfer it to a clean, well-sealed vial that is clearly labelled with the compound name and CAS number. Stock solutions prepared in DMSO should be held in sealed, chemically compatible vials and dispensed in small aliquots to limit repeated opening. Handle the solid in a fume hood or a suitable ventilated enclosure, wear gloves, a laboratory coat, and eye protection, and avoid generating dust when weighing. As with any bioactive research chemical, restrict use to trained laboratory personnel, keep it away from food and drink, and follow institutional procedures for chemical waste disposal.\u003c\/p\u003e","brand":"TCI","offers":[{"title":"10mg","offer_id":48087735206106,"sku":"TCI2510M310841614","price":3207000.0,"currency_code":"IDR","in_stock":true},{"title":"50mg","offer_id":48087735238874,"sku":"TCI2510M310841615","price":11156000.0,"currency_code":"IDR","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0756\/7156\/8602\/files\/TCI2510M3108.jpg?v=1767127766"},{"product_id":"tci2510a36064439","title":"TCI A3606 26575-95-1 Alisol B 23-Acetate","description":"\u003cp\u003e\u003cstrong\u003eAlisol B 23-Acetate\u003c\/strong\u003e (CAS 26575-95-1) is a high-quality chemical from TCI, supplied as \u003cstrong\u003eHPLC Grade\u003c\/strong\u003e.\u003c\/p\u003e\u003cp\u003e\u003cstrong\u003eApplication:\u003c\/strong\u003e Synthesis reagent for a wide range of organic chemistry transformations in laboratory and industrial settings.\u003c\/p\u003e\u003cp\u003e\u003cstrong\u003eSpecifications:\u003c\/strong\u003e\u003c\/p\u003e\u003cul\u003e\n\u003cli\u003eMolecular formula: C32H50O5\u003c\/li\u003e\n\u003cli\u003eCAS number: 26575-95-1\u003c\/li\u003e\n\u003cli\u003ePurity: \u0026gt;98.0%(HPLC)\u003c\/li\u003e\n\u003cli\u003eTCI product code: A3606\u003c\/li\u003e\n\u003c\/ul\u003e\u003cp\u003e\u003cstrong\u003eSynonyms:\u003c\/strong\u003e 23-Acetylalismol B; (23s,24r)-11beta-Hydroxy-3-oxo-8alpha,9beta,14beta-24,25-epoxydammar-13(17)-en-23-yl Acetate; (8alpha,9beta,11beta,14beta,23S,24R)-23-(Acetyloxy)-24,25-epoxy-11-hydroxydammar-13(17)-en-3-one\u003c\/p\u003e\u003cp\u003eAvailable from \u003cstrong\u003eAMI Scientific\u003c\/strong\u003e, the authorised TCI distributor in Indonesia. \u003cstrong\u003eContact us for pricing and stock availability\u003c\/strong\u003e — we ship throughout Indonesia.\u003c\/p\u003e","brand":"TCI","offers":[{"title":"50mg","offer_id":48085476147418,"sku":"TCI2510A36064439","price":7926000.0,"currency_code":"IDR","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0756\/7156\/8602\/files\/TCI2510A3606.jpg?v=1767084578"},{"product_id":"tci2510t270154124","title":"TCI T2701 6809-52-5 Teprenone [mixture of (5E,9E,13E)- and (5Z,9E,13E)- isomers]","description":"\u003cp\u003e\u003cstrong\u003eTeprenone [mixture of (5E,9E,13E)- and (5Z,9E,13E)- isomers]\u003c\/strong\u003e (CAS 6809-52-5) is a high-quality chemical from TCI, supplied as \u003cstrong\u003eGC Grade \/ for Synthesis\u003c\/strong\u003e.\u003c\/p\u003e\u003cp\u003e\u003cstrong\u003eApplication:\u003c\/strong\u003e Synthesis reagent for a wide range of organic chemistry transformations in laboratory and industrial settings.\u003c\/p\u003e\u003cp\u003e\u003cstrong\u003eSpecifications:\u003c\/strong\u003e\u003c\/p\u003e\u003cul\u003e\n\u003cli\u003eMolecular formula: C23H38O\u003c\/li\u003e\n\u003cli\u003eCAS number: 6809-52-5\u003c\/li\u003e\n\u003cli\u003ePurity: \u0026gt;95.0%(GC)\u003c\/li\u003e\n\u003cli\u003eTCI product code: T2701\u003c\/li\u003e\n\u003c\/ul\u003e\u003cp\u003e\u003cstrong\u003eSynonyms:\u003c\/strong\u003e Geranylgeranylacetone [mixture of (5E,9E,13E)- and (5Z,9E,13E)- isomers]; 6,10,14,18-Tetramethyl-5,9,13,17-nonadecatetraen-2-one [mixture of (5E,9E,13E)- and (5Z,9E,13E)- isomers]\u003c\/p\u003e\u003cp\u003eAvailable from \u003cstrong\u003eAMI Scientific\u003c\/strong\u003e, the authorised TCI distributor in Indonesia. \u003cstrong\u003eContact us for pricing and stock availability\u003c\/strong\u003e — we ship throughout Indonesia.\u003c\/p\u003e","brand":"TCI","offers":[{"title":"1g","offer_id":48088498766042,"sku":"TCI2510T270154124","price":2045000.0,"currency_code":"IDR","in_stock":true},{"title":"5g","offer_id":48088498798810,"sku":"TCI2510T270154125","price":6940000.0,"currency_code":"IDR","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0756\/7156\/8602\/files\/TCI2510T2701.jpg?v=1767143256"}],"url":"https:\/\/amiscientific.com\/en\/collections\/tci-l4-apoptosis-inhibitors.oembed","provider":"AMI Scientific","version":"1.0","type":"link"}