{"title":"Azidation, Diazo Transfer [Synthetic Reagents]","description":"\u003cp\u003e\u003cstrong\u003eAzidation, Diazo Transfer [Synthetic Reagents]\u003c\/strong\u003e — covers azide- and diazo-carrying reagents such as sulfonyl azides, sodium azide, trimethylsilyl azide, and azido-imidazolinium salts that transfer the N3 group to various organic substrates. These reagents are the primary means of forming non-halogen carbon–nitrogen bonds in modern organic synthesis.\u003c\/p\u003e\u003cp\u003eThese azidation and diazo transfer reagents are used in the synthesis of azido compounds as precursors for click reactions (azide-alkyne cycloaddition), in the synthesis of modified peptides, and in the formation of diazo compounds from primary amines in synthetic chemistry. Organic chemists use reagents such as trimethylsilyl azide or tetrabutylammonium azide for nucleophilic substitution that forms azides on a variety of molecular frameworks.\u003c\/p\u003e\u003cp\u003eExample products in this collection: \u003ca href=\"\/en\/products\/tci2510t343455059\"\u003eTCI T3434 36982-84-0 2,4,6-Triisopropylbenzenesulfonyl Azide (wetted with ca. 10% Water) (unit weight on dry weight basis)\u003c\/a\u003e, \u003ca href=\"\/en\/products\/tci2510d167221524\"\u003eTCI D1672 26386-88-9 Diphenylphosphoryl Azide\u003c\/a\u003e, \u003ca href=\"\/en\/products\/tci2510a24573111\"\u003eTCI A2457 1266134-54-6 2-Azido-1,3-dimethylimidazolinium Hexafluorophosphate\u003c\/a\u003e, \u003ca href=\"\/en\/products\/tci2510d258022850\"\u003eTCI D2580 79791-38-1 Dodecylbenzenesulfonyl Azide (soft type) (mixture)\u003c\/a\u003e, \u003ca href=\"\/en\/products\/tci2510a17862324\"\u003eTCI A1786 2158-14-7 4-Acetamidobenzenesulfonyl Azide\u003c\/a\u003e, \u003ca href=\"\/en\/products\/tci2510s048950316\"\u003eTCI S0489 26628-22-8 Sodium Azide\u003c\/a\u003e, \u003ca href=\"\/en\/products\/tci2510t092051873\"\u003eTCI T0920 993-22-6 Tetrabutylammonium Azide\u003c\/a\u003e, \u003ca href=\"\/en\/products\/tci2510t080151712\"\u003eTCI T0801 4648-54-8 Trimethylsilyl Azide\u003c\/a\u003e.\u003c\/p\u003e\u003cp\u003ePay attention to the physical form of the reagent (solid, solution, or wetted with a solvent) as well as the stated purity and water content, since these affect the stoichiometry of the azide or diazo transfer reaction. All products are genuine Tokyo Chemical Industry (TCI) Japan products, with purity, packaging, and storage conditions listed on each item's page.\u003c\/p\u003e\u003cp\u003eOther categories at the same level under C-X(Non-Halogen) Bond Formation [Synthetic Reagents], often used together in a single laboratory workflow:\u003c\/p\u003e\u003cul\u003e\n\u003cli\u003e\u003ca href=\"\/en\/collections\/tci-l4-c-h-bond-activation-reaction-synthetic-reagents\"\u003eC-H Bond Activation Reaction [Synthetic Reagents]\u003c\/a\u003e\u003c\/li\u003e\n\u003cli\u003e\u003ca href=\"\/en\/collections\/tci-l4-formylation-synthetic-reagents\"\u003eFormylation [Synthetic Reagents]\u003c\/a\u003e\u003c\/li\u003e\n\u003cli\u003e\u003ca href=\"\/en\/collections\/tci-l4-phosphorylation-synthetic-reagents\"\u003ePhosphorylation [Synthetic Reagents]\u003c\/a\u003e\u003c\/li\u003e\n\u003cli\u003e\u003ca href=\"\/en\/collections\/tci-l4-mitsunobu-reaction-synthetic-reagents\"\u003eMitsunobu Reaction [Synthetic Reagents]\u003c\/a\u003e\u003c\/li\u003e\n\u003cli\u003e\u003ca href=\"\/en\/collections\/tci-l4-vinylation-synthetic-reagents\"\u003eVinylation [Synthetic Reagents]\u003c\/a\u003e\u003c\/li\u003e\n\u003cli\u003e\u003ca href=\"\/en\/collections\/tci-l4-amination-synthetic-reagents\"\u003eAmination [Synthetic Reagents]\u003c\/a\u003e\u003c\/li\u003e\n\u003c\/ul\u003e\u003cp\u003eBack to \u003ca href=\"\/en\/collections\/tci-l3-c-x-non-halogen-bond-formation-synthetic-reagents\"\u003eC-X(Non-Halogen) Bond Formation [Synthetic Reagents]\u003c\/a\u003e. For large-volume procurement, special packaging, or specific grades, contact the AMI Scientific team — the official TCI Japan distributor in Indonesia — to check availability and lead time directly from Japan.\u003c\/p\u003e","products":[{"product_id":"tci2510d258022850","title":"TCI D2580 79791-38-1 Dodecylbenzenesulfonyl Azide (soft type) (mixture)","description":"\u003ch3\u003eDescription\u003c\/h3\u003e\n\u003cp\u003eTCI D2580 Dodecylbenzenesulfonyl Azide (soft type) (mixture) is a synthetic reagent belonging to the group of reagents used for carbon–heteroatom (non-halogen) bond formation. Its primary laboratory function is as a diazo transfer reagent, meaning it delivers a diazo group to compounds bearing an active hydrogen — such as 1,3-dicarbonyl compounds, beta-ketoesters, and malonates — to form alpha-diazocarbonyl compounds. The diazo compounds produced in this reaction are highly useful intermediates, because they can be decomposed into carbenes or metal carbenoids for cyclopropanation, C–H insertion, and rearrangement reactions.\u003c\/p\u003e\n\u003cp\u003eThe characteristic that makes this reagent a preferred choice is its handling profile. Short-chain aryl sulfonyl azides such as tosyl azide are known to be sensitive to impact and heat, whereas this \"soft type\" product is supplied as a mixture formulation with a long dodecyl chain that appreciably reduces that sensitivity and makes the reagent far more convenient to use in a research laboratory setting. The long alkyl chain on the benzene ring also improves solubility in non-polar organic solvents and simplifies separation of the sulfonamide by-product during work-up, which together support smoother, more reproducible synthetic procedures.\u003c\/p\u003e\n\u003cp\u003eIn Indonesian laboratories, this reagent is typically used in organic synthesis and methodology research groups at universities, research institutes, and industrial R\u0026amp;D units that prepare alpha-diazocarbonyl intermediates in-house. It suits work programmes in which diazo transfer is performed on a bench scale for further carbene-based transformations, and where a less impact- and heat-sensitive alternative to short-chain sulfonyl azides is preferred so that routine synthetic work can proceed with more comfortable handling requirements.\u003c\/p\u003e\n\u003ch3\u003eLaboratory Applications\u003c\/h3\u003e\n\u003cul\u003e\n\u003cli\u003eDiazo transfer to 1,3-dicarbonyl compounds — the reagent delivers the diazo group to active-hydrogen substrates directly, giving access to alpha-diazocarbonyl products without resorting to more impact-sensitive short-chain sulfonyl azides.\u003c\/li\u003e\n\u003cli\u003ePreparation of alpha-diazo beta-ketoesters — beta-ketoesters are classic active-methylene substrates for this reagent, and the resulting diazo esters serve as stable-handling intermediates for downstream carbene chemistry.\u003c\/li\u003e\n\u003cli\u003eDiazo functionalisation of malonate derivatives — malonates possess the activated hydrogens required for diazo transfer, and the reagent's good solubility in non-polar solvents helps keep such reaction mixtures homogeneous.\u003c\/li\u003e\n\u003cli\u003ePrecursor synthesis for cyclopropanation studies — diazocarbonyl compounds made with this reagent decompose to carbenes or metal carbenoids, which are the working species used to build cyclopropane rings.\u003c\/li\u003e\n\u003cli\u003eSubstrate preparation for C–H insertion and rearrangement work — the same metal carbenoid intermediates generated from these diazo compounds are used in C–H insertion and rearrangement reactions in methodology research.\u003c\/li\u003e\n\u003c\/ul\u003e\n\u003ch3\u003eSpecifications\u003c\/h3\u003e\n\u003cul\u003e\n\u003cli\u003eBrand: TCI (Tokyo Chemical Industry)\u003c\/li\u003e\n\u003cli\u003eCAS number: 79791-38-1\u003c\/li\u003e\n\u003cli\u003eCategory: Chemistry \u0026gt; Synthetic Reagents \u0026gt; C-X(Non-Halogen) Bond Formation [Synthetic Reagents]\u003c\/li\u003e\n\u003cli\u003eProduct code: D2580\u003c\/li\u003e\n\u003cli\u003ePhysical form: supplied as a \"soft type\" mixture formulation containing the long-chain dodecylbenzenesulfonyl azide\u003c\/li\u003e\n\u003cli\u003eStorage note: store according to the manufacturer's stated conditions on the product label and Safety Data Sheet\u003c\/li\u003e\n\u003c\/ul\u003e\n\u003ch3\u003eHandling and Storage\u003c\/h3\u003e\n\u003cp\u003eStore the reagent in its original tightly closed container, kept in a cool, dry, well-ventilated area away from heat sources, direct sunlight, ignition sources, and incompatible materials, and follow the storage conditions stated by the manufacturer on the label and Safety Data Sheet. Although the soft type mixture formulation is markedly less sensitive to impact and heat than short-chain aryl sulfonyl azides, sulfonyl azides as a class still warrant careful handling: avoid friction, shock, and unnecessary heating or concentration to dryness. Handle in a fume hood using appropriate gloves, safety glasses, and a laboratory coat, keep containers closed when not in use, and review the Safety Data Sheet before work.\u003c\/p\u003e","brand":"TCI","offers":[{"title":"25g","offer_id":48086566469850,"sku":"TCI2510D258022850","price":1263000.0,"currency_code":"IDR","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0756\/7156\/8602\/files\/tci2510d258022850-struktur-1000.png?v=1792638123"},{"product_id":"tci2510s048950316","title":"TCI S0489 26628-22-8 Sodium Azide","description":"\u003ch3\u003eDescription\u003c\/h3\u003e\n\u003cp\u003eSodium Azide (NaN₃) is a chemical compound widely used in various chemical reactions and laboratory applications. It plays a crucial role in synthetic chemistry, particularly in the preparation of nitrogen-containing compounds. This compound is valued for its ability to provide a stable source of nitrogen, making it essential in substitution and coupling reactions. Due to its reactivity and utility, sodium azide is a common reagent in both organic and inorganic chemistry. Its versatility allows it to be used in a wide range of experimental setups, from basic research to advanced chemical synthesis.\u003c\/p\u003e\n\u003cp\u003eSodium Azide is preferred for its chemical properties, including its ability to release nitrogen gas under specific conditions. It is chemically stable in certain environments, which makes it suitable for controlled laboratory use. However, it is also highly toxic and can be hazardous if not handled properly. Its reactivity and effectiveness in nitrogen-related reactions make it a valuable tool in chemical research. Despite its risks, sodium azide remains a popular choice in laboratories that require nitrogen sources for various chemical processes.\u003c\/p\u003e\n\u003cp\u003eIn Indonesian laboratories, sodium azide is commonly used in chemical research, including organic synthesis, catalytic testing, and nitrogen-based reaction experiments. It is frequently found in chemistry and pharmaceutical laboratories, where it supports the development of new compounds and the testing of chemical processes. Its role in providing a reliable nitrogen source makes it an essential component in many experimental protocols across different scientific disciplines.\u003c\/p\u003e\n\u003ch3\u003eLaboratory Applications\u003c\/h3\u003e\n\u003cul\u003e\n\u003cli\u003eOrganic synthesis where nitrogen-containing compounds are required for reaction mechanisms.\u003c\/li\u003e\n\u003cli\u003eCatalytic testing to evaluate the performance of catalysts in nitrogen-based reactions.\u003c\/li\u003e\n\u003cli\u003ePreparation of nitrogen compounds in inorganic chemistry experiments for structural analysis.\u003c\/li\u003e\n\u003cli\u003eNitrogen release applications in gas generation setups for controlled chemical environments.\u003c\/li\u003e\n\u003cli\u003eResearch in pharmaceutical chemistry for the development of nitrogen-containing drug molecules.\u003c\/li\u003e\n\u003c\/ul\u003e\n\u003ch3\u003eSpecifications\u003c\/h3\u003e\n\u003cul\u003e\n\u003cli\u003eBrand: TCI\u003c\/li\u003e\n\u003cli\u003eCAS number: 26628-22-8\u003c\/li\u003e\n\u003cli\u003eCategory: Chemistry \u0026gt; Catalysis and Inorganic Chemistry \u0026gt; Main-group Elements\u003c\/li\u003e\n\u003cli\u003ePack sizes: Available in various quantities as per supplier specifications\u003c\/li\u003e\n\u003cli\u003ePhysical form: Solid powder\u003c\/li\u003e\n\u003cli\u003eStorage note: Store in a cool, dry place away from incompatible materials\u003c\/li\u003e\n\u003c\/ul\u003e\n\u003ch3\u003eHandling and Storage\u003c\/h3\u003e\n\u003cp\u003eSodium Azide should be stored in a cool, dry, and well-ventilated area, away from heat sources and incompatible substances such as strong acids or oxidizing agents. It is recommended to use sealed containers made of materials like glass or polyethylene to prevent contamination and exposure. Due to its toxicity, proper personal protective equipment, including gloves and safety goggles, should always be worn when handling this compound. Laboratory personnel must be trained in safe handling procedures to minimize the risk of exposure. Regular inspection of storage conditions is essential to ensure the compound remains stable and safe for use.\u003c\/p\u003e","brand":"TCI","offers":[{"title":"100g","offer_id":48088254152922,"sku":"TCI2510S048950316","price":834000.0,"currency_code":"IDR","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0756\/7156\/8602\/files\/TCI2510S0489_f0844637-cfa9-4327-aa94-4fd69956f5c0.jpg?v=1792654953"},{"product_id":"tci2510t092051873","title":"TCI T0920 993-22-6 Tetrabutylammonium Azide","description":"\u003ch3\u003eDescription\u003c\/h3\u003e\n\u003cp\u003eTetrabutylammonium Azide (TCI T0920), with CAS number 993-22-6, is a chemical compound widely used in organic synthesis reactions. It serves as an effective source of azide ions, playing a crucial role in the formation of C-N bonds. This reagent is particularly valuable in azidation reactions and the synthesis of heterocyclic compounds. Its utility in the laboratory is extensive, as it enables the creation of complex molecules that require azide functionality. Due to its chemical stability under controlled conditions, it is a reliable choice for various synthetic processes.\u003c\/p\u003e\n\u003cp\u003eOne of the key properties that make Tetrabutylammonium Azide a preferred choice is its solubility in organic solvents. This characteristic simplifies mixing and reaction procedures, making it highly convenient for laboratory use. Additionally, its chemical stability ensures that it remains effective throughout the reaction process, minimizing the risk of unwanted side reactions. The compound’s reactivity is well-controlled, allowing chemists to manipulate its behavior in a predictable manner. These properties collectively contribute to its widespread adoption in synthetic chemistry.\u003c\/p\u003e\n\u003cp\u003eIn Indonesian laboratories, Tetrabutylammonium Azide is commonly used in organic chemistry research, especially in academic and research institutions. It is essential for the development of new compounds, drug synthesis, and the study of chemical reactivity. Its role in these contexts underscores its importance as a fundamental reagent in modern chemical research. Its availability and reliability make it a staple in both teaching and research settings.\u003c\/p\u003e\n\u003ch3\u003eLaboratory Applications\u003c\/h3\u003e\n\u003cul\u003e\n\u003cli\u003eOrganic synthesis reactions benefit from Tetrabutylammonium Azide as it provides a stable and efficient source of azide ions for C-N bond formation.\u003c\/li\u003e\n\u003cli\u003eHeterocyclic compound synthesis relies on this reagent for its ability to facilitate the introduction of azide groups into complex molecular structures.\u003c\/li\u003e\n\u003cli\u003eAzidation reactions utilize this compound as a versatile reagent that enhances the efficiency and selectivity of nitrogen incorporation.\u003c\/li\u003e\n\u003cli\u003eDrug development processes incorporate this material to create novel compounds with potential pharmaceutical applications.\u003c\/li\u003e\n\u003cli\u003eChemical reactivity studies use Tetrabutylammonium Azide to investigate the behavior of azide groups in various synthetic environments.\u003c\/li\u003e\n\u003c\/ul\u003e\n\u003ch3\u003eSpecifications\u003c\/h3\u003e\n\u003cul\u003e\n\u003cli\u003eBrand: TCI\u003c\/li\u003e\n\u003cli\u003eCAS number: 993-22-6\u003c\/li\u003e\n\u003cli\u003eCategory: Chemistry \u0026gt; Synthetic Reagents \u0026gt; C-X(Non-Halogen) Bond Formation\u003c\/li\u003e\n\u003cli\u003ePack sizes: Available in various sizes as per standard laboratory reagent packaging\u003c\/li\u003e\n\u003cli\u003ePhysical form: Solid or crystalline powder\u003c\/li\u003e\n\u003cli\u003eStorage note: Store in a cool, dry place away from moisture and heat\u003c\/li\u003e\n\u003c\/ul\u003e\n\u003ch3\u003eHandling and Storage\u003c\/h3\u003e\n\u003cp\u003eTetrabutylammonium Azide should be stored in a cool, dry environment to maintain its chemical stability. It is recommended to keep it in airtight containers to prevent exposure to moisture, which can lead to decomposition. Due to its reactivity towards high temperatures, it should be stored away from heat sources. In laboratory settings, it is essential to handle this compound with care, using appropriate personal protective equipment. Proper labeling and storage conditions are necessary to ensure safety and maintain the integrity of the reagent. Always follow standard laboratory protocols when handling reactive chemicals to minimize risks.\u003c\/p\u003e","brand":"TCI","offers":[{"title":"5g","offer_id":48088358617306,"sku":"TCI2510T092051873","price":2399000.0,"currency_code":"IDR","in_stock":true},{"title":"25g","offer_id":48088358650074,"sku":"TCI2510T092051874","price":8127000.0,"currency_code":"IDR","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0756\/7156\/8602\/files\/TCI2510T0920_428094e7-7052-449f-a66f-719c56ce0236.jpg?v=1792655924"}],"url":"https:\/\/amiscientific.com\/en\/collections\/tci-l4-azidation-diazo-transfer-synthetic-reagents.oembed","provider":"AMI Scientific","version":"1.0","type":"link"}