{"title":"Bicyclo[1.1.1]pentane Building Blocks","description":"\u003cp\u003e\u003cstrong\u003eBicyclo[1.1.1]pentane Building Blocks\u003c\/strong\u003e — mencakup turunan bisiklo[1.1.1]pentana tersubstitusi amina, ester, asam karboksilat, dan trifluoroborat yang menjadi kerangka tiga dimensi kaku sebagai pengganti bioisosterik cincin fenil atau tert-butil. Struktur sangkar (cage) khasnya memberikan sudut ikatan dan jarak spasial unik yang sulit dicapai gugus aromatik konvensional.\u003c\/p\u003e\u003cp\u003eSenyawa seperti Bicyclo[1.1.1]pentan-1-amine Hydrochloride dan Methyl 3-Aminobicyclo[1.1.1]pentane-1-carboxylate Hydrochloride digunakan peneliti kimia medisinal sebagai building block untuk menggantikan cincin aromatik pada perancangan molekul dengan sifat fisikokimia dan metabolik yang berbeda. Turunan asam seperti 3-Fluorobicyclo[1.1.1]pentane-1-carboxylic Acid dan garam trifluoroborat kalium juga dipakai dalam reaksi kopling untuk memperluas pustaka senyawa pada tahap penemuan awal.\u003c\/p\u003e\u003cp\u003eContoh produk dalam koleksi ini: \u003ca href=\"\/en\/products\/tci2510b547912128\"\u003eTCI B5479 22287-35-0 Bicyclo[1.1.1]pentan-1-amine Hydrochloride\u003c\/a\u003e, \u003ca href=\"\/en\/products\/tci2510b652213434\"\u003eTCI B6522 56842-95-6 Bicyclo[1.1.1]pentane-1,3-dicarboxylic Acid\u003c\/a\u003e, \u003ca href=\"\/en\/products\/tci2510a36554491\"\u003eTCI A3655 676371-65-6 Methyl 3-Aminobicyclo[1.1.1]pentane-1-carboxylate Hydrochloride\u003c\/a\u003e, \u003ca href=\"\/en\/products\/tci2510b652313435\"\u003eTCI B6523 1638767-25-5 tert-Butyl (3-Aminobicyclo[1.1.1]pentan-1-yl)carbamate\u003c\/a\u003e, \u003ca href=\"\/en\/products\/tci2510p312749069\"\u003eTCI P3127 2410559-74-7 Potassium Trifluoro[3-(methoxycarbonyl)bicyclo[1.1.1]pentan-1-yl]borate\u003c\/a\u003e, \u003ca href=\"\/en\/products\/tci2510b661913574\"\u003eTCI B6619 22287-28-1 Bicyclo[1.1.1]pentane-1-carboxylic Acid\u003c\/a\u003e, \u003ca href=\"\/en\/products\/tci2510m371042356\"\u003eTCI M3710 65862-01-3 3-Methylbicyclo[1.1.1]pentane-1-carboxylic Acid\u003c\/a\u003e, \u003ca href=\"\/en\/products\/tci2510d618427235\"\u003eTCI D6184 303752-38-7 3-[(tert-Butoxycarbonyl)amino]bicyclo[1.1.1]pentane-1-carboxylic Acid\u003c\/a\u003e.\u003c\/p\u003e\u003cp\u003ePerhatikan gugus fungsi terminal (amina, ester, asam karboksilat, atau trifluoroborat) yang menentukan jalur sintesis lanjutan, serta bentuk garam (hidroklorida atau kalium trifluoroborat) yang memengaruhi kelarutan dan stabilitas penyimpanan. Seluruh produk merupakan produk asli Tokyo Chemical Industry (TCI) Jepang, dengan kemurnian, kemasan, dan kondisi penyimpanan tercantum pada halaman masing-masing item.\u003c\/p\u003e\u003cp\u003eKategori lain yang sejajar di bawah Specialized Building Blocks for Drug Discovery, sering dipakai bersamaan dalam satu alur kerja laboratorium:\u003c\/p\u003e\u003cul\u003e\n\u003cli\u003e\u003ca href=\"\/en\/collections\/tci-l4-cubane-building-blocks\"\u003eCubane Building Blocks\u003c\/a\u003e\u003c\/li\u003e\n\u003cli\u003e\u003ca href=\"\/en\/collections\/tci-l4-bicyclo-2-1-1-hexane-building-blocks\"\u003eBicyclo[2.1.1]hexane Building Blocks\u003c\/a\u003e\u003c\/li\u003e\n\u003cli\u003e\u003ca href=\"\/en\/collections\/tci-l4-bicyclo-3-1-1-heptane-building-blocks\"\u003eBicyclo[3.1.1]heptane Building Blocks\u003c\/a\u003e\u003c\/li\u003e\n\u003c\/ul\u003e\u003cp\u003eKembali ke \u003ca href=\"\/en\/collections\/tci-l3-specialized-building-blocks-for-drug-discovery\"\u003eSpecialized Building Blocks for Drug Discovery\u003c\/a\u003e. Untuk pengadaan volume besar, kemasan khusus, atau grade tertentu, hubungi tim AMI Scientific — distributor resmi TCI Japan di Indonesia — untuk pengecekan ketersediaan dan lead time langsung ke Jepang.\u003c\/p\u003e","products":[{"product_id":"tci2510b652213434","title":"TCI B6522 56842-95-6 Bicyclo[1.1.1]pentane-1,3-dicarboxylic Acid","description":"\u003ch3\u003eDescription\u003c\/h3\u003e\n\u003cp\u003eTCI B6522 Bicyclo[1.1.1]pentane-1,3-dicarboxylic Acid (CAS 56842-95-6) is a rigid, three-dimensional building block widely used in modern medicinal chemistry. The bicyclo[1.1.1]pentane core is frequently explored as a bioisostere for para-substituted benzene rings, offering a fixed linear vector between substituents. Its two bridgehead carboxylic acids can be converted into esters, amides, and rigid linkers for further elaboration. Supplied in a 1 g research pack, it should be weighed in a well-ventilated area and stored cool, dry, and tightly sealed.\u003c\/p\u003e","brand":"TCI","offers":[{"title":"1g","offer_id":48085944697050,"sku":"TCI2510B652213434","price":5088000.0,"currency_code":"IDR","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0756\/7156\/8602\/files\/TCI2510B6522.jpg?v=1767093799"},{"product_id":"tci2510b652313435","title":"TCI B6523 1638767-25-5 tert-Butyl (3-Aminobicyclo[1.1.1]pentan-1-yl)carbamate","description":"\u003ch3\u003eDescription\u003c\/h3\u003e\n\u003cp\u003eTCI B6523, tert-Butyl (3-Aminobicyclo[1.1.1]pentan-1-yl)carbamate (CAS 1638767-25-5), is a mono-Boc-protected bicyclo[1.1.1]pentane diamine widely used as a rigid, three-dimensional building block in medicinal chemistry. The BCP core serves as a well-known bioisostere of the benzene ring, allowing researchers to explore saturated alternatives to aromatic scaffolds. Its free amine can be selectively functionalised while the Boc-protected nitrogen remains masked until acidic deprotection is required. AMI Scientific supplies this reagent in original TCI packaging in 100 mg and 500 mg sizes for discovery-scale research.\u003c\/p\u003e\n\u003ch3\u003eScientific References\u003c\/h3\u003e\n\u003cul\u003e\n\u003cli\u003eChmovzh et al. (2021). tert-Butyl Bis(4′-(Hexyloxy)-[1,1′-biphenyl]-4-yl)carbamate. \u003cem\u003eMolbank\u003c\/em\u003e \u003ca href=\"https:\/\/doi.org\/10.3390\/m1247\" target=\"_blank\" rel=\"nofollow noopener\"\u003edoi:10.3390\/m1247\u003c\/a\u003e\n\u003c\/li\u003e\n\u003cli\u003e(2009). MILD AND EFFICIENT ONE-POT CURTIUS REARRANGEMENT: PREPARATION OF N-tert-BUTYL ADAMANTANYL-1-YL-CARBAMATE. \u003cem\u003eOrganic Syntheses\u003c\/em\u003e \u003ca href=\"https:\/\/doi.org\/10.15227\/orgsyn.086.0113\" target=\"_blank\" rel=\"nofollow noopener\"\u003edoi:10.15227\/orgsyn.086.0113\u003c\/a\u003e\n\u003c\/li\u003e\n\u003cli\u003e(2022). Diasterocontrol Synthesis of Tamiflu Intermediate of Tert- butyl(5-hydroxy-6-(1-ethylpropoxy)-1,2-epoxycyclohex- 3-en-1-yl)carbamate. \u003cem\u003eMALAYSIAN JOURNAL OF CHEMISTRY\u003c\/em\u003e \u003ca href=\"https:\/\/doi.org\/10.55373\/mjchem.v24i2.258\" target=\"_blank\" rel=\"nofollow noopener\"\u003edoi:10.55373\/mjchem.v24i2.258\u003c\/a\u003e\n\u003c\/li\u003e\n\u003c\/ul\u003e\n\u003cp\u003e\u003csmall\u003eReferences were compiled automatically from Crossref and every DOI was verified to exist. AMI Scientific is not affiliated with the authors or the publishers.\u003c\/small\u003e\u003c\/p\u003e","brand":"TCI","offers":[{"title":"100mg","offer_id":48085944729818,"sku":"TCI2510B652313435","price":1969000.0,"currency_code":"IDR","in_stock":true},{"title":"500mg","offer_id":48085944762586,"sku":"TCI2510B652313436","price":6662000.0,"currency_code":"IDR","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0756\/7156\/8602\/files\/TCI2510B6523.jpg?v=1767093803"},{"product_id":"tci2510b661913574","title":"TCI B6619 22287-28-1 Bicyclo[1.1.1]pentane-1-carboxylic Acid","description":"\u003ch3\u003eDescription\u003c\/h3\u003e\n\u003cp\u003eTCI B6619 is bicyclo[1.1.1]pentane-1-carboxylic acid, a monofunctional derivative of the widely studied BCP cage. The bridgehead-to-bridgehead axis of bicyclo[1.1.1]pentane closely mimics the linear geometry of para-substituted benzene rings, making it a favoured aromatic bioisostere. Replacing arenes with BCP units is frequently associated with improved aqueous solubility, reduced lipophilicity, and enhanced metabolic stability. AMI Scientific supplies this TCI building block in a 100 mg pack size for drug discovery and organic synthesis laboratories.\u003c\/p\u003e\n\u003cp\u003e---\u003c\/p\u003e","brand":"TCI","offers":[{"title":"100mg","offer_id":48085950464218,"sku":"TCI2510B661913574","price":9670000.0,"currency_code":"IDR","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0756\/7156\/8602\/files\/TCI2510B6619.jpg?v=1767094032"},{"product_id":"tci2510d618427235","title":"TCI D6184 303752-38-7 3-[(tert-Butoxycarbonyl)amino]bicyclo[1.1.1]pentane-1-carboxylic Acid","description":"\u003ch3\u003eDescription\u003c\/h3\u003e\n\u003cp\u003e3-[(tert-Butoxycarbonyl)amino]bicyclo[1.1.1]pentane-1-carboxylic Acid is a complex organic compound widely used in synthetic chemistry applications. This compound serves as a building block in the synthesis of various organic molecules, particularly those requiring controlled chemical transformations. Its unique molecular structure, featuring a bicyclo framework and a protected amino group, makes it a versatile reagent in laboratory settings. It is especially valuable in the development of new compounds with complex structures, supporting research in pharmaceutical and organic chemistry fields.\u003c\/p\u003e\n\u003cp\u003eThe compound's stability and reactivity make it a preferred choice for synthetic chemists. The tert-butoxycarbonyl (Boc) group provides chemical stability, allowing for controlled reactions under various conditions. This feature is crucial for maintaining the integrity of the molecule during synthesis. Additionally, its reactivity enables participation in substitution, hydrolysis, and organic solvent reactions, making it suitable for a wide range of synthetic processes. These properties ensure its reliability in both academic and industrial research environments.\u003c\/p\u003e\n\u003cp\u003eIn Indonesian laboratories, this compound is commonly used in organic chemistry research, particularly in the development of new compounds with complex structures. Its role in pharmaceutical research is significant, as it supports the synthesis of compounds with potential therapeutic applications. The compound's ability to participate in multiple chemical reactions makes it an essential tool for researchers aiming to achieve high precision and control in their experiments.\u003c\/p\u003e\n\u003ch3\u003eLaboratory Applications\u003c\/h3\u003e\n\u003cul\u003e\n\u003cli\u003eOrganic synthesis of heterocyclic compounds due to its bicyclo framework and protected amino group.\u003c\/li\u003e\n\u003cli\u003eDevelopment of pharmaceutical compounds where controlled chemical transformations are required.\u003c\/li\u003e\n\u003cli\u003eResearch in synthetic chemistry requiring reactivity and stability in various reaction conditions.\u003c\/li\u003e\n\u003cli\u003ePreparation of complex molecules in academic and industrial research settings.\u003c\/li\u003e\n\u003cli\u003eUse in chemical processes involving substitution, hydrolysis, and organic solvent reactions.\u003c\/li\u003e\n\u003c\/ul\u003e\n\u003ch3\u003eSpecifications\u003c\/h3\u003e\n\u003cul\u003e\n\u003cli\u003eBrand: TCI\u003c\/li\u003e\n\u003cli\u003eCAS number: 303752-38-7\u003c\/li\u003e\n\u003cli\u003eCategory: Chemistry \u0026gt; Building Blocks \u0026gt; Non-Heterocyclic Building Blocks\u003c\/li\u003e\n\u003cli\u003ePack sizes: Available in standard laboratory quantities\u003c\/li\u003e\n\u003cli\u003ePhysical form: Solid powder\u003c\/li\u003e\n\u003cli\u003eStorage note: Store in a cool, dry place away from moisture and direct sunlight\u003c\/li\u003e\n\u003c\/ul\u003e\n\u003ch3\u003eHandling and Storage\u003c\/h3\u003e\n\u003cp\u003eThis compound should be stored in a cool, dry environment to maintain its chemical stability. It is recommended to keep it in a tightly sealed container to prevent exposure to moisture and air. Due to its reactivity, it should be handled in a well-ventilated laboratory setting. Avoid contact with strong acids or bases to prevent unwanted chemical reactions. Proper personal protective equipment, such as gloves and safety goggles, should be worn during handling. The compound is best stored in airtight containers made of materials that are chemically inert to ensure long-term stability and safety.\u003c\/p\u003e","brand":"TCI","offers":[{"title":"200mg","offer_id":48086795026650,"sku":"TCI2510D618427235","price":2306000.0,"currency_code":"IDR","in_stock":true},{"title":"1g","offer_id":48086795059418,"sku":"TCI2510D618427236","price":7280000.0,"currency_code":"IDR","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0756\/7156\/8602\/files\/TCI2510D6184.jpg?v=1767109862"},{"product_id":"tci2510d635127392","title":"TCI D6351 115913-32-1 Dimethyl Bicyclo[1.1.1]pentane-1,3-dicarboxylate","description":"\u003ch3\u003eDescription\u003c\/h3\u003e\n\u003cp\u003eDimethyl Bicyclo[1.1.1]pentane-1,3-dicarboxylate is a chemical compound widely used in laboratory settings for the synthesis of complex molecules. As a building block in organic chemistry, it plays a crucial role in the development of both heterocyclic and non-heterocyclic compounds. Its unique molecular structure allows for versatile reactivity, making it an essential reagent in various synthetic pathways. This compound is particularly valuable for its ability to participate in esterification and substitution reactions, contributing to the creation of a wide range of organic products.\u003c\/p\u003e\n\u003cp\u003eThe compound is known for its chemical stability and moderate reactivity, which make it a preferred choice for laboratory applications. Its ability to form stable intermediates and interact with a variety of functional groups enhances its utility in synthetic chemistry. This reactivity, combined with its structural versatility, allows chemists to design and synthesize complex molecules with high precision. These properties make it a reliable and effective tool in both academic and industrial research environments.\u003c\/p\u003e\n\u003cp\u003eIn Indonesian laboratories, Dimethyl Bicyclo[1.1.1]pentane-1,3-dicarboxylate is commonly used in research and development projects, especially in the fields of pharmaceuticals and organic chemistry. It is frequently employed in the synthesis of new compounds and is a key component in experimental studies aimed at discovering novel chemical structures. Its availability and reliability make it a preferred choice for researchers and institutions seeking to advance their chemical research initiatives.\u003c\/p\u003e\n\u003ch3\u003eLaboratory Applications\u003c\/h3\u003e\n\u003cul\u003e\n\u003cli\u003eUsed in the synthesis of heterocyclic compounds due to its ability to form stable intermediates and participate in esterification reactions.\u003c\/li\u003e\n\u003cli\u003eApplied in organic synthesis to create complex molecules through substitution and functional group modification.\u003c\/li\u003e\n\u003cli\u003eUtilized in pharmaceutical research for the development of new drug compounds and molecular structures.\u003c\/li\u003e\n\u003cli\u003eEmployed in academic research to explore chemical reactivity and molecular interactions in laboratory settings.\u003c\/li\u003e\n\u003cli\u003eValuable in industrial applications for the production of specialty chemicals and advanced materials.\u003c\/li\u003e\n\u003c\/ul\u003e\n\u003ch3\u003eSpecifications\u003c\/h3\u003e\n\u003cul\u003e\n\u003cli\u003eBrand: TCI\u003c\/li\u003e\n\u003cli\u003eCAS number: 115913-32-1\u003c\/li\u003e\n\u003cli\u003eCategory: Chemistry \u0026gt; Building Blocks \u0026gt; Non-Heterocyclic Building Blocks\u003c\/li\u003e\n\u003cli\u003ePack sizes: Available in various quantities as per supplier specifications\u003c\/li\u003e\n\u003cli\u003ePhysical form: Solid or liquid, depending on the specific product variant\u003c\/li\u003e\n\u003cli\u003eStorage note: Store in a cool, dry place away from direct sunlight and moisture\u003c\/li\u003e\n\u003c\/ul\u003e\n\u003ch3\u003eHandling and Storage\u003c\/h3\u003e\n\u003cp\u003eThis compound should be stored in a cool, dry environment to maintain its chemical stability. It is recommended to keep it in a sealed container to prevent exposure to moisture and air. Proper ventilation is essential when handling the material to minimize inhalation risks. Avoid contact with skin and eyes, and use appropriate personal protective equipment such as gloves and safety goggles. Ensure that storage areas are free from incompatible substances to prevent any potential chemical reactions. Regular monitoring of storage conditions is advised to ensure the compound remains in optimal condition for use in laboratory applications.\u003c\/p\u003e","brand":"TCI","offers":[{"title":"500mg","offer_id":48086803349722,"sku":"TCI2510D635127392","price":3458000.0,"currency_code":"IDR","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0756\/7156\/8602\/files\/TCI2510D6351.jpg?v=1767110078"},{"product_id":"tci2510f139831550","title":"TCI F1398 146038-53-1 3-Fluorobicyclo[111]pentane-1-carboxylic Acid","description":"\u003ch3\u003eDescription\u003c\/h3\u003e\n\u003cp\u003e3-Fluorobicyclo[111]pentane-1-carboxylic Acid is a specialized chemical compound used as a building block in the synthesis of complex molecules. This compound features a cyclic structure with a fluorine atom and a carboxylic acid group, making it highly relevant in organic chemistry. Its unique structure provides a versatile platform for chemical modifications, allowing researchers to tailor molecular properties for specific applications. In the laboratory, it serves as a key reagent for creating compounds with desired biological or physical characteristics.\u003c\/p\u003e\n\u003cp\u003eThe compound’s cyclic framework and fluorinated group contribute to its stability and reactivity, making it a preferred choice for synthetic chemists. The presence of the fluorine atom enhances the molecule’s functional versatility, enabling it to participate in a wide range of chemical reactions. Its predictable behavior under various reaction conditions ensures reliable results, which is crucial in research settings. Additionally, its compatibility with multiple functional groups allows for greater flexibility in synthetic pathways.\u003c\/p\u003e\n\u003cp\u003eIn Indonesian laboratories, this compound is widely used in organic chemistry research, particularly in pharmaceutical and materials science applications. It is a valuable tool for developing new drugs or materials with specific properties. Its availability in the local market supports ongoing research efforts, enabling scientists to conduct experiments efficiently. The compound’s role in advancing chemical innovation is well recognized in academic and industrial settings.\u003c\/p\u003e\n\u003ch3\u003eLaboratory Applications\u003c\/h3\u003e\n\u003cul\u003e\n\u003cli\u003eOrganic synthesis of pharmaceutical compounds due to its versatile functional groups and cyclic structure.\u003c\/li\u003e\n\u003cli\u003eDevelopment of novel materials with tailored physical and chemical properties through functional group modification.\u003c\/li\u003e\n\u003cli\u003eResearch in medicinal chemistry for the design of bioactive molecules with improved pharmacological profiles.\u003c\/li\u003e\n\u003cli\u003eInvestigation of fluorinated compounds for their unique reactivity and stability in synthetic pathways.\u003c\/li\u003e\n\u003cli\u003eExploration of chemical reactivity in reaction mechanisms involving cyclic and fluorinated building blocks.\u003c\/li\u003e\n\u003c\/ul\u003e\n\u003ch3\u003eSpecifications\u003c\/h3\u003e\n\u003cul\u003e\n\u003cli\u003eBrand: TCI\u003c\/li\u003e\n\u003cli\u003eCAS number: 146038-53-1\u003c\/li\u003e\n\u003cli\u003eCategory: Chemistry \u0026gt; Building Blocks \u0026gt; Fluorinated Building Blocks\u003c\/li\u003e\n\u003cli\u003ePack sizes: Available in various quantities as per standard chemical supply practices\u003c\/li\u003e\n\u003cli\u003ePhysical form: Solid (as per typical fluorinated building block compounds)\u003c\/li\u003e\n\u003cli\u003eStorage note: Store in a cool, dry place away from light and moisture\u003c\/li\u003e\n\u003c\/ul\u003e\n\u003ch3\u003eHandling and Storage\u003c\/h3\u003e\n\u003cp\u003eThis compound should be stored in a cool, dry environment, away from direct sunlight and moisture. It is recommended to use airtight containers to prevent exposure to air and humidity, which could affect its stability. Proper labeling of containers is essential for safe handling and identification. Laboratory personnel should wear appropriate personal protective equipment, such as gloves and safety goggles, when handling the compound. It should be kept in a well-ventilated area to minimize inhalation risks. 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