{"title":"Bicyclo[2.1.1]hexane Building Blocks","description":"\u003cp\u003e\u003cstrong\u003eBicyclo[2.1.1]hexane Building Blocks\u003c\/strong\u003e — mencakup building block bisiklik terstruktur bicyclo[2.1.1]hexane dengan gugus amina, karboksilat, atau boronat terlindungi, berfungsi sebagai pengganti cincin aromatik dalam desain molekul obat berbasis sp3-rich scaffold pada tahap eksplorasi hubungan struktur-aktivitas.\u003c\/p\u003e\u003cp\u003eBuilding block bicyclo[2.1.1]hexane seperti metil 4-aminobisiklo[2.1.1]heksana-1-karboksilat digunakan kimiawan medisinal untuk menggantikan cincin fenil atau piperidin dalam optimasi senyawa timbal (lead optimization), meningkatkan sifat fisikokimia dan metabolisme senyawa. Turunan asam karboksilat dan boc-amina pada kerangka ini memudahkan konjugasi lanjutan dalam sintesis paralel obat kandidat.\u003c\/p\u003e\u003cp\u003eContoh produk dalam koleksi ini: \u003ca href=\"\/en\/products\/tci2510p312849070\"\u003eTCI P3128 Potassium Trifluoro[4-(methoxycarbonyl)bicyclo[2.1.1]hexan-1-yl]borate\u003c\/a\u003e, \u003ca href=\"\/en\/products\/tci2510b660913565\"\u003eTCI B6609 1050886-56-0 4-[(tert-Butoxycarbonyl)amino]bicyclo[2.1.1]hexane-1-carboxylic Acid\u003c\/a\u003e, \u003ca href=\"\/en\/products\/tci2510m370542352\"\u003eTCI M3705 1638772-04-9 Methyl 4-Aminobicyclo[2.1.1]hexane-1-carboxylate Hydrochloride\u003c\/a\u003e, \u003ca href=\"\/en\/products\/tci2510b661013566\"\u003eTCI B6610 1050890-47-5 tert-Butyl (4-Aminobicyclo[2.1.1]hexan-1-yl)carbamate\u003c\/a\u003e, \u003ca href=\"\/en\/products\/tci2510m370342350\"\u003eTCI M3703 141046-52-8 4-(Methoxycarbonyl)bicyclo[2.1.1]hexane-1-carboxylic Acid\u003c\/a\u003e.\u003c\/p\u003e\u003cp\u003ePerhatikan gugus pelindung (Boc, ester metil, trifluoroborat) dan bentuk garam (hidroklorida atau bebas) yang menentukan kompatibilitas dengan langkah sintesis dan jalur derivatisasi berikutnya dalam rute sintesis. Seluruh produk merupakan produk asli Tokyo Chemical Industry (TCI) Jepang, dengan kemurnian, kemasan, dan kondisi penyimpanan tercantum pada halaman masing-masing item.\u003c\/p\u003e\u003cp\u003eKategori lain yang sejajar di bawah Specialized Building Blocks for Drug Discovery, sering dipakai bersamaan dalam satu alur kerja laboratorium:\u003c\/p\u003e\u003cul\u003e\n\u003cli\u003e\u003ca href=\"\/en\/collections\/tci-l4-bicyclo-1-1-1-pentane-building-blocks\"\u003eBicyclo[1.1.1]pentane Building Blocks\u003c\/a\u003e\u003c\/li\u003e\n\u003cli\u003e\u003ca href=\"\/en\/collections\/tci-l4-cubane-building-blocks\"\u003eCubane Building Blocks\u003c\/a\u003e\u003c\/li\u003e\n\u003cli\u003e\u003ca href=\"\/en\/collections\/tci-l4-bicyclo-3-1-1-heptane-building-blocks\"\u003eBicyclo[3.1.1]heptane Building Blocks\u003c\/a\u003e\u003c\/li\u003e\n\u003c\/ul\u003e\u003cp\u003eKembali ke \u003ca href=\"\/en\/collections\/tci-l3-specialized-building-blocks-for-drug-discovery\"\u003eSpecialized Building Blocks for Drug Discovery\u003c\/a\u003e. Untuk pengadaan volume besar, kemasan khusus, atau grade tertentu, hubungi tim AMI Scientific — distributor resmi TCI Japan di Indonesia — untuk pengecekan ketersediaan dan lead time langsung ke Jepang.\u003c\/p\u003e","products":[{"product_id":"tci2510b660913565","title":"TCI B6609 1050886-56-0 4-[(tert-Butoxycarbonyl)amino]bicyclo[2.1.1]hexane-1-carboxylic Acid","description":"\u003ch3\u003eDescription\u003c\/h3\u003e\n\u003cp\u003eTCI B6609 is 4-[(tert-butoxycarbonyl)amino]bicyclo[2.1.1]hexane-1-carboxylic acid, a compact and rigid saturated building block. It carries orthogonal carboxylic acid and Boc-protected amine handles on opposite bridgehead positions, allowing stepwise elaboration. The bicyclo[2.1.1]hexane core is actively studied as a three-dimensional bioisostere for ortho- and meta-substituted benzene rings in drug discovery. AMI Scientific supplies this TCI building block in a 100 mg pack size for medicinal chemistry and advanced synthesis laboratories.\u003c\/p\u003e\n\u003ch3\u003eScientific References\u003c\/h3\u003e\n\u003cul\u003e\n\u003cli\u003eWang et al. (2013). A scalable synthesis of (1R,3S,5R)-2-(tert-butoxycarbonyl)-2-azabicyclo[3.1.0]hexane-3-carboxylic acid. \u003cem\u003eTetrahedron Letters\u003c\/em\u003e \u003ca href=\"https:\/\/doi.org\/10.1016\/j.tetlet.2013.09.114\" target=\"_blank\" rel=\"nofollow noopener\"\u003edoi:10.1016\/j.tetlet.2013.09.114\u003c\/a\u003e\n\u003c\/li\u003e\n\u003cli\u003eBakonyi et al. (2013). Synthesis of All Four Stereoisomers of 3-(tert-Butoxycarbonyl)-3-azabicyclo[3.1.0]hexane-2-carboxylic Acid. \u003cem\u003eThe Journal of Organic Chemistry\u003c\/em\u003e \u003ca href=\"https:\/\/doi.org\/10.1021\/jo4013282\" target=\"_blank\" rel=\"nofollow noopener\"\u003edoi:10.1021\/jo4013282\u003c\/a\u003e\n\u003c\/li\u003e\n\u003cli\u003eKadyrov et al. (2021). Convenient Synthesis of (R)-3-[(tert-Butoxycarbonyl)amino]piperidine and (R)-3-[(tert-Butoxycarbonyl)amino]azepane. \u003cem\u003eSynthesis\u003c\/em\u003e \u003ca href=\"https:\/\/doi.org\/10.1055\/a-1526-7657\" target=\"_blank\" rel=\"nofollow noopener\"\u003edoi:10.1055\/a-1526-7657\u003c\/a\u003e\n\u003c\/li\u003e\n\u003c\/ul\u003e\n\u003cp\u003e\u003csmall\u003eReferences were compiled automatically from Crossref and every DOI was verified to exist. AMI Scientific is not affiliated with the authors or the publishers.\u003c\/small\u003e\u003c\/p\u003e","brand":"TCI","offers":[{"title":"100mg","offer_id":48085950136538,"sku":"TCI2510B660913565","price":5312000.0,"currency_code":"IDR","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0756\/7156\/8602\/files\/TCI2510B6609.jpg?v=1767094020"},{"product_id":"tci2510b661013566","title":"TCI B6610 1050890-47-5 tert-Butyl (4-Aminobicyclo[2.1.1]hexan-1-yl)carbamate","description":"\u003ch3\u003eDescription\u003c\/h3\u003e\n\u003cp\u003eTCI B6610, tert-butyl (4-aminobicyclo[2.1.1]hexan-1-yl)carbamate, is a mono-Boc-protected bridged diamine building block. The free primary amine allows selective acylation, urea formation, or reductive alkylation before the second nitrogen is unmasked under acidic conditions. Its rigid bicyclo[2.1.1]hexane framework fixes the distance and orientation between the two nitrogen handles. AMI Scientific offers this TCI reagent in a 100 mg pack size for medicinal chemistry and synthetic research laboratories.\u003c\/p\u003e\n\u003ch3\u003eScientific References\u003c\/h3\u003e\n\u003cul\u003e\n\u003cli\u003eChmovzh et al. (2021). tert-Butyl Bis(4′-(Hexyloxy)-[1,1′-biphenyl]-4-yl)carbamate. \u003cem\u003eMolbank\u003c\/em\u003e \u003ca href=\"https:\/\/doi.org\/10.3390\/m1247\" target=\"_blank\" rel=\"nofollow noopener\"\u003edoi:10.3390\/m1247\u003c\/a\u003e\n\u003c\/li\u003e\n\u003cli\u003e(2009). MILD AND EFFICIENT ONE-POT CURTIUS REARRANGEMENT: PREPARATION OF N-tert-BUTYL ADAMANTANYL-1-YL-CARBAMATE. \u003cem\u003eOrganic Syntheses\u003c\/em\u003e \u003ca href=\"https:\/\/doi.org\/10.15227\/orgsyn.086.0113\" target=\"_blank\" rel=\"nofollow noopener\"\u003edoi:10.15227\/orgsyn.086.0113\u003c\/a\u003e\n\u003c\/li\u003e\n\u003cli\u003e(2022). Diasterocontrol Synthesis of Tamiflu Intermediate of Tert- butyl(5-hydroxy-6-(1-ethylpropoxy)-1,2-epoxycyclohex- 3-en-1-yl)carbamate. \u003cem\u003eMALAYSIAN JOURNAL OF CHEMISTRY\u003c\/em\u003e \u003ca href=\"https:\/\/doi.org\/10.55373\/mjchem.v24i2.258\" target=\"_blank\" rel=\"nofollow noopener\"\u003edoi:10.55373\/mjchem.v24i2.258\u003c\/a\u003e\n\u003c\/li\u003e\n\u003c\/ul\u003e\n\u003cp\u003e\u003csmall\u003eReferences were compiled automatically from Crossref and every DOI was verified to exist. AMI Scientific is not affiliated with the authors or the publishers.\u003c\/small\u003e\u003c\/p\u003e","brand":"TCI","offers":[{"title":"100mg","offer_id":48085950169306,"sku":"TCI2510B661013566","price":17005000.0,"currency_code":"IDR","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0756\/7156\/8602\/files\/TCI2510B6610.jpg?v=1767094023"},{"product_id":"tci2510m370342350","title":"TCI M3703 141046-52-8 4-(Methoxycarbonyl)bicyclo[2.1.1]hexane-1-carboxylic Acid","description":"\u003cp\u003e\u003cstrong\u003e4-(Methoxycarbonyl)bicyclo[2.1.1]hexane-1-carboxylic Acid\u003c\/strong\u003e (CAS 141046-52-8) is a high-quality chemical from TCI, supplied as \u003cstrong\u003eGC Grade \/ for Synthesis\u003c\/strong\u003e.\u003c\/p\u003e\u003cp\u003e\u003cstrong\u003eApplication:\u003c\/strong\u003e Synthesis reagent for a wide range of organic chemistry transformations in laboratory and industrial settings.\u003c\/p\u003e\u003cp\u003e\u003cstrong\u003eSpecifications:\u003c\/strong\u003e\u003c\/p\u003e\u003cul\u003e\n\u003cli\u003eMolecular formula: C9H12O4\u003c\/li\u003e\n\u003cli\u003eCAS number: 141046-52-8\u003c\/li\u003e\n\u003cli\u003ePurity: \u0026gt;98.0%(GC)(qNMR)\u003c\/li\u003e\n\u003cli\u003eTCI product code: M3703\u003c\/li\u003e\n\u003c\/ul\u003e\u003cp\u003e\u003cstrong\u003eSynonyms:\u003c\/strong\u003e Bicyclo[2.1.1]hexane-1,4-dicarboxylic Acid 1-Methyl Ester; Bicyclo[2.1.1]hexane-1,4-dicarboxylic Acid Monomethyl Ester\u003c\/p\u003e\u003cp\u003eAvailable from \u003cstrong\u003eAMI Scientific\u003c\/strong\u003e, the authorised TCI distributor in Indonesia. \u003cstrong\u003eContact us for pricing and stock availability\u003c\/strong\u003e — we ship throughout Indonesia.\u003c\/p\u003e","brand":"TCI","offers":[{"title":"200mg","offer_id":48087770661082,"sku":"TCI2510M370342350","price":5679000.0,"currency_code":"IDR","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0756\/7156\/8602\/files\/TCI2510M3703.jpg?v=1767128696"},{"product_id":"tci2510m370542352","title":"TCI M3705 1638772-04-9 Methyl 4-Aminobicyclo[2.1.1]hexane-1-carboxylate Hydrochloride","description":"\u003cp\u003e\u003cstrong\u003eMethyl 4-Aminobicyclo[2.1.1]hexane-1-carboxylate Hydrochloride\u003c\/strong\u003e (CAS 1638772-04-9) is a high-quality chemical from TCI, supplied as \u003cstrong\u003eGC Grade \/ for Synthesis\u003c\/strong\u003e.\u003c\/p\u003e\u003cp\u003e\u003cstrong\u003eApplication:\u003c\/strong\u003e Synthesis reagent for a wide range of organic chemistry transformations in laboratory and industrial settings.\u003c\/p\u003e\u003cp\u003e\u003cstrong\u003eSpecifications:\u003c\/strong\u003e\u003c\/p\u003e\u003cul\u003e\n\u003cli\u003eMolecular formula: C8H13NO2.HCl\u003c\/li\u003e\n\u003cli\u003eCAS number: 1638772-04-9\u003c\/li\u003e\n\u003cli\u003ePurity: \u0026gt;95.0%(GC)(qNMR)\u003c\/li\u003e\n\u003cli\u003eTCI product code: M3705\u003c\/li\u003e\n\u003c\/ul\u003e\u003cp\u003eAvailable from \u003cstrong\u003eAMI Scientific\u003c\/strong\u003e, the authorised TCI distributor in Indonesia. \u003cstrong\u003eContact us for pricing and stock availability\u003c\/strong\u003e — we ship throughout Indonesia.\u003c\/p\u003e","brand":"TCI","offers":[{"title":"100mg","offer_id":48087770726618,"sku":"TCI2510M370542352","price":9106000.0,"currency_code":"IDR","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0756\/7156\/8602\/files\/TCI2510M3705.jpg?v=1767128704"}],"url":"https:\/\/amiscientific.com\/en\/collections\/tci-l4-bicyclo-2-1-1-hexane-building-blocks.oembed","provider":"AMI Scientific","version":"1.0","type":"link"}