{"title":"Bicyclo[3.1.1]heptane Building Blocks","description":"\u003cp\u003e\u003cstrong\u003eBicyclo[3.1.1]heptane Building Blocks\u003c\/strong\u003e — mencakup building block bisiklik bicyclo[3.1.1]heptane dengan gugus amina, karboksilat, atau boronat terlindungi, berfungsi sebagai pengganti cincin aromatik atau sikloheksana dalam desain molekul obat berbasis sp3-rich scaffold guna meningkatkan keragaman geometri tiga dimensi senyawa.\u003c\/p\u003e\u003cp\u003eBuilding block bicyclo[3.1.1]heptane seperti metil 5-aminobisiklo[3.1.1]heptana-1-karboksilat dipakai kimiawan medisinal sebagai bioisoster sikloheksana atau piperidin dalam pengembangan senyawa kandidat obat, membantu meningkatkan kelarutan dan menurunkan lipofilisitas berlebih. Turunan Boc-amina dan asam karboksilat pada rangka ini memfasilitasi elaborasi struktur lanjutan dalam program penemuan obat berbasis fragmen.\u003c\/p\u003e\u003cp\u003eContoh produk dalam koleksi ini: \u003ca href=\"\/en\/products\/tci2510p312949071\"\u003eTCI P3129 Potassium Trifluoro[5-(methoxycarbonyl)bicyclo[3.1.1]heptan-1-yl]borate\u003c\/a\u003e, \u003ca href=\"\/en\/products\/tci2510b660713563\"\u003eTCI B6607 1035325-28-0 5-[(tert-Butoxycarbonyl)amino]bicyclo[3.1.1]heptane-1-carboxylic Acid\u003c\/a\u003e, \u003ca href=\"\/en\/products\/tci2510m375142395\"\u003eTCI M3751 1824132-78-6 Methyl 5-Aminobicyclo[3.1.1]heptane-1-carboxylate\u003c\/a\u003e, \u003ca href=\"\/en\/products\/tci2510b660813564\"\u003eTCI B6608 1049607-15-9 tert-Butyl (5-Aminobicyclo[3.1.1]heptan-1-yl)carbamate\u003c\/a\u003e, \u003ca href=\"\/en\/products\/tci2510m370142349\"\u003eTCI M3701 110371-28-3 5-(Methoxycarbonyl)bicyclo[3.1.1]heptane-1-carboxylic Acid\u003c\/a\u003e.\u003c\/p\u003e\u003cp\u003ePerhatikan gugus pelindung dan bentuk turunan (ester, asam bebas, garam kalium trifluoroborat) yang sesuai dengan tahap sintesis, serta kemurnian enansiomer bila diperlukan stereokimia spesifik pada target molekul. Seluruh produk merupakan produk asli Tokyo Chemical Industry (TCI) Jepang, dengan kemurnian, kemasan, dan kondisi penyimpanan tercantum pada halaman masing-masing item.\u003c\/p\u003e\u003cp\u003eKategori lain yang sejajar di bawah Specialized Building Blocks for Drug Discovery, sering dipakai bersamaan dalam satu alur kerja laboratorium:\u003c\/p\u003e\u003cul\u003e\n\u003cli\u003e\u003ca href=\"\/en\/collections\/tci-l4-bicyclo-1-1-1-pentane-building-blocks\"\u003eBicyclo[1.1.1]pentane Building Blocks\u003c\/a\u003e\u003c\/li\u003e\n\u003cli\u003e\u003ca href=\"\/en\/collections\/tci-l4-cubane-building-blocks\"\u003eCubane Building Blocks\u003c\/a\u003e\u003c\/li\u003e\n\u003cli\u003e\u003ca href=\"\/en\/collections\/tci-l4-bicyclo-2-1-1-hexane-building-blocks\"\u003eBicyclo[2.1.1]hexane Building Blocks\u003c\/a\u003e\u003c\/li\u003e\n\u003c\/ul\u003e\u003cp\u003eKembali ke \u003ca href=\"\/en\/collections\/tci-l3-specialized-building-blocks-for-drug-discovery\"\u003eSpecialized Building Blocks for Drug Discovery\u003c\/a\u003e. Untuk pengadaan volume besar, kemasan khusus, atau grade tertentu, hubungi tim AMI Scientific — distributor resmi TCI Japan di Indonesia — untuk pengecekan ketersediaan dan lead time langsung ke Jepang.\u003c\/p\u003e","products":[{"product_id":"tci2510b660713563","title":"TCI B6607 1035325-28-0 5-[(tert-Butoxycarbonyl)amino]bicyclo[3.1.1]heptane-1-carboxylic Acid","description":"\u003ch3\u003eDescription\u003c\/h3\u003e\n\u003cp\u003eTCI B6607 is 5-[(tert-butoxycarbonyl)amino]bicyclo[3.1.1]heptane-1-carboxylic acid, a rigid saturated building block with orthogonal carboxylic acid and Boc-protected amine handles. The bicyclo[3.1.1]heptane core is widely investigated as a three-dimensional bioisostere for meta-substituted benzene rings. Replacing flat aromatic rings with such saturated cages can improve solubility and reduce metabolic liability in lead optimisation programmes. AMI Scientific supplies this TCI building block in a 100 mg pack size for synthetic and medicinal chemistry laboratories.\u003c\/p\u003e\n\u003ch3\u003eScientific References\u003c\/h3\u003e\n\u003cul\u003e\n\u003cli\u003eBaenziger et al. (2015). ChemInform Abstract: Development Approaches Towards a 4‐Spiro Cyclopropane Proline Scaffold (S)‐5‐(tert‐Butoxycarbonyl)‐5‐azaspiro[2.4]heptane‐6‐carboxylic Acid. \u003cem\u003eChemInform\u003c\/em\u003e \u003ca href=\"https:\/\/doi.org\/10.1002\/chin.201536288\" target=\"_blank\" rel=\"nofollow noopener\"\u003edoi:10.1002\/chin.201536288\u003c\/a\u003e\n\u003c\/li\u003e\n\u003cli\u003eKadyrov et al. (2021). Convenient Synthesis of (R)-3-[(tert-Butoxycarbonyl)amino]piperidine and (R)-3-[(tert-Butoxycarbonyl)amino]azepane. \u003cem\u003eSynthesis\u003c\/em\u003e \u003ca href=\"https:\/\/doi.org\/10.1055\/a-1526-7657\" target=\"_blank\" rel=\"nofollow noopener\"\u003edoi:10.1055\/a-1526-7657\u003c\/a\u003e\n\u003c\/li\u003e\n\u003cli\u003eMatković (2024). 4-(2-(5-(2-(tert-Butoxycarbonyl)hydrazinecarbonyl)-2-methylthiophen-3-yl)cyclopent-1-enyl)-5-methylthiophene-2-carboxylic Acid. \u003cem\u003eMolbank\u003c\/em\u003e \u003ca href=\"https:\/\/doi.org\/10.3390\/m1760\" target=\"_blank\" rel=\"nofollow noopener\"\u003edoi:10.3390\/m1760\u003c\/a\u003e\n\u003c\/li\u003e\n\u003c\/ul\u003e\n\u003cp\u003e\u003csmall\u003eReferences were compiled automatically from Crossref and every DOI was verified to exist. AMI Scientific is not affiliated with the authors or the publishers.\u003c\/small\u003e\u003c\/p\u003e","brand":"TCI","offers":[{"title":"100mg","offer_id":48085950071002,"sku":"TCI2510B660713563","price":7280000.0,"currency_code":"IDR","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0756\/7156\/8602\/files\/TCI2510B6607.jpg?v=1767094012"},{"product_id":"tci2510b660813564","title":"TCI B6608 1049607-15-9 tert-Butyl (5-Aminobicyclo[3.1.1]heptan-1-yl)carbamate","description":"\u003ch3\u003eDescription\u003c\/h3\u003e\n\u003cp\u003eTCI B6608, tert-butyl (5-aminobicyclo[3.1.1]heptan-1-yl)carbamate, is a mono-Boc-protected bicyclic diamine building block. The free primary amine can be acylated, sulfonylated, or reductively alkylated while the second nitrogen remains masked until acidic deprotection. Its rigid bicyclo[3.1.1]heptane core provides a fixed spatial relationship between the two nitrogen handles, useful in three-dimensional scaffold design. AMI Scientific offers this TCI reagent in a 100 mg pack size for medicinal chemistry and organic synthesis laboratories.\u003c\/p\u003e\n\u003ch3\u003eScientific References\u003c\/h3\u003e\n\u003cul\u003e\n\u003cli\u003eChmovzh et al. (2021). tert-Butyl Bis(4′-(Hexyloxy)-[1,1′-biphenyl]-4-yl)carbamate. \u003cem\u003eMolbank\u003c\/em\u003e \u003ca href=\"https:\/\/doi.org\/10.3390\/m1247\" target=\"_blank\" rel=\"nofollow noopener\"\u003edoi:10.3390\/m1247\u003c\/a\u003e\n\u003c\/li\u003e\n\u003cli\u003e(2009). MILD AND EFFICIENT ONE-POT CURTIUS REARRANGEMENT: PREPARATION OF N-tert-BUTYL ADAMANTANYL-1-YL-CARBAMATE. \u003cem\u003eOrganic Syntheses\u003c\/em\u003e \u003ca href=\"https:\/\/doi.org\/10.15227\/orgsyn.086.0113\" target=\"_blank\" rel=\"nofollow noopener\"\u003edoi:10.15227\/orgsyn.086.0113\u003c\/a\u003e\n\u003c\/li\u003e\n\u003cli\u003e(2022). Diasterocontrol Synthesis of Tamiflu Intermediate of Tert- butyl(5-hydroxy-6-(1-ethylpropoxy)-1,2-epoxycyclohex- 3-en-1-yl)carbamate. \u003cem\u003eMALAYSIAN JOURNAL OF CHEMISTRY\u003c\/em\u003e \u003ca href=\"https:\/\/doi.org\/10.55373\/mjchem.v24i2.258\" target=\"_blank\" rel=\"nofollow noopener\"\u003edoi:10.55373\/mjchem.v24i2.258\u003c\/a\u003e\n\u003c\/li\u003e\n\u003c\/ul\u003e\n\u003cp\u003e\u003csmall\u003eReferences were compiled automatically from Crossref and every DOI was verified to exist. AMI Scientific is not affiliated with the authors or the publishers.\u003c\/small\u003e\u003c\/p\u003e","brand":"TCI","offers":[{"title":"100mg","offer_id":48085950103770,"sku":"TCI2510B660813564","price":14390000.0,"currency_code":"IDR","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0756\/7156\/8602\/files\/TCI2510B6608.jpg?v=1767094016"},{"product_id":"tci2510m370142349","title":"TCI M3701 110371-28-3 5-(Methoxycarbonyl)bicyclo[3.1.1]heptane-1-carboxylic Acid","description":"\u003cp\u003e\u003cstrong\u003e5-(Methoxycarbonyl)bicyclo[3.1.1]heptane-1-carboxylic Acid\u003c\/strong\u003e (CAS 110371-28-3) is a high-quality chemical from TCI, supplied as \u003cstrong\u003eReagent Grade \/ for Synthesis\u003c\/strong\u003e.\u003c\/p\u003e\u003cp\u003e\u003cstrong\u003eApplication:\u003c\/strong\u003e Synthesis reagent for a wide range of organic chemistry transformations in laboratory and industrial settings.\u003c\/p\u003e\u003cp\u003e\u003cstrong\u003eSpecifications:\u003c\/strong\u003e\u003c\/p\u003e\u003cul\u003e\n\u003cli\u003eMolecular formula: C10H14O4\u003c\/li\u003e\n\u003cli\u003eCAS number: 110371-28-3\u003c\/li\u003e\n\u003cli\u003ePurity: \u0026gt;98.0%(qNMR)\u003c\/li\u003e\n\u003cli\u003eTCI product code: M3701\u003c\/li\u003e\n\u003c\/ul\u003e\u003cp\u003e\u003cstrong\u003eSynonyms:\u003c\/strong\u003e 5-Methoxycarbonylnorpinane-1-carboxylic Acid; Monomethyl Bicyclo[3.1.1]heptane-1,5-dicarboxylate\u003c\/p\u003e\u003cp\u003eAvailable from \u003cstrong\u003eAMI Scientific\u003c\/strong\u003e, the authorised TCI distributor in Indonesia. \u003cstrong\u003eContact us for pricing and stock availability\u003c\/strong\u003e — we ship throughout Indonesia.\u003c\/p\u003e","brand":"TCI","offers":[{"title":"200mg","offer_id":48087770595546,"sku":"TCI2510M370142349","price":5567000.0,"currency_code":"IDR","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0756\/7156\/8602\/files\/TCI2510M3701.jpg?v=1767128692"},{"product_id":"tci2510m375142395","title":"TCI M3751 1824132-78-6 Methyl 5-Aminobicyclo[3.1.1]heptane-1-carboxylate","description":"\u003cp\u003e\u003cstrong\u003eMethyl 5-Aminobicyclo[3.1.1]heptane-1-carboxylate\u003c\/strong\u003e (CAS 1824132-78-6) is a high-quality chemical from TCI, supplied as \u003cstrong\u003eGC Grade \/ for Synthesis\u003c\/strong\u003e.\u003c\/p\u003e\u003cp\u003e\u003cstrong\u003eApplication:\u003c\/strong\u003e Synthesis reagent for a wide range of organic chemistry transformations in laboratory and industrial settings.\u003c\/p\u003e\u003cp\u003e\u003cstrong\u003eSpecifications:\u003c\/strong\u003e\u003c\/p\u003e\u003cul\u003e\n\u003cli\u003eMolecular formula: C9H15NO2\u003c\/li\u003e\n\u003cli\u003eCAS number: 1824132-78-6\u003c\/li\u003e\n\u003cli\u003ePurity: \u0026gt;98.0%(GC)(qNMR)\u003c\/li\u003e\n\u003cli\u003eTCI product code: M3751\u003c\/li\u003e\n\u003c\/ul\u003e\u003cp\u003eAvailable from \u003cstrong\u003eAMI Scientific\u003c\/strong\u003e, the authorised TCI distributor in Indonesia. \u003cstrong\u003eContact us for pricing and stock availability\u003c\/strong\u003e — we ship throughout Indonesia.\u003c\/p\u003e","brand":"TCI","offers":[{"title":"100mg","offer_id":48087773118682,"sku":"TCI2510M375142395","price":5623000.0,"currency_code":"IDR","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0756\/7156\/8602\/files\/TCI2510M3751.jpg?v=1767128757"}],"url":"https:\/\/amiscientific.com\/en\/collections\/tci-l4-bicyclo-3-1-1-heptane-building-blocks.oembed","provider":"AMI Scientific","version":"1.0","type":"link"}