{"title":"Buchwald Ligands and Complexes [Catalysis]","description":"\u003cp\u003e\u003cstrong\u003eBuchwald Ligands and Complexes [Catalysis]\u003c\/strong\u003e — berisi fosfin biarilik dengan substituen alkil besar seperti dialkil, di-tert-butil, atau disikloheksil, beserta kompleks logam transisi terkaitnya, dirancang sebagai ligan pendukung dalam katalisis paladium dan nikel. Struktur biarilnya yang kaya elektron dan bervolume besar menstabilkan spesies logam berkoordinasi rendah selama siklus katalitik.\u003c\/p\u003e\u003cp\u003eLigan Buchwald dan kompleksnya banyak dipakai kimiawan sintesis dalam reaksi kopling silang seperti Suzuki-Miyaura, Buchwald-Hartwig amination, dan pembentukan ikatan C-N\/C-O pada substrat aril klorida atau bromida yang kurang reaktif. Kombinasi kebasaan dan kerimbunan sterik ligan ini memungkinkan katalisis pada suhu lebih rendah dan loading paladium yang lebih kecil, sehingga sering dipakai dalam pengembangan proses sintesis bahan aktif dan material fungsional di skala laboratorium.\u003c\/p\u003e\u003cp\u003eContoh produk dalam koleksi ini: \u003ca href=\"\/en\/products\/tci2510r030249814\"\u003eTCI R0302 564483-18-7 Xphos (HPMC encapsulated)\u003c\/a\u003e, \u003ca href=\"\/en\/products\/tci2510b622113049\"\u003eTCI B6221 894086-00-1 5-(Di-tert-butylphosphino)-1',3',5'-triphenyl-1'H-1,4'-bipyrazole\u003c\/a\u003e, \u003ca href=\"\/en\/products\/tci2510d566426636\"\u003eTCI D5664 1070663-78-3 Dicyclohexyl(2',4',6'-triisopropyl-3,6-dimethoxy-[1,1'-biphenyl]-2-yl)phosphine\u003c\/a\u003e, \u003ca href=\"\/en\/products\/tci2510d338723653\"\u003eTCI D3387 224311-51-7 2-(Di-tert-butylphosphino)biphenyl\u003c\/a\u003e, \u003ca href=\"\/en\/products\/tci2510d566326635\"\u003eTCI D5663 1160861-53-9 Di-tert-butyl(2',4',6'-triisopropyl-3,6-dimethoxy-[1,1'-biphenyl]-2-yl)phosphine\u003c\/a\u003e, \u003ca href=\"\/en\/products\/tci2510d338823655\"\u003eTCI D3388 247940-06-3 2-(Dicyclohexylphosphino)biphenyl\u003c\/a\u003e, \u003ca href=\"\/en\/products\/tci2510d503925857\"\u003eTCI D5039 564483-19-8 2-Di-tert-butylphosphino-2',4',6'-triisopropylbiphenyl\u003c\/a\u003e, \u003ca href=\"\/en\/products\/tci2510d338923657\"\u003eTCI D3389 213697-53-1 2-(Dicyclohexylphosphino)-2'-(dimethylamino)biphenyl\u003c\/a\u003e.\u003c\/p\u003e\u003cp\u003ePerhatikan apakah produk berupa ligan bebas atau kompleks pra-katalis siap pakai (precatalyst), serta bentuk fisik seperti serbuk terenkapsulasi HPMC yang memudahkan penanganan dan penimbangan di udara terbuka. Seluruh produk merupakan produk asli Tokyo Chemical Industry (TCI) Jepang, dengan kemurnian, kemasan, dan kondisi penyimpanan tercantum pada halaman masing-masing item.\u003c\/p\u003e\u003cp\u003eKategori lain yang sejajar di bawah Cross-Coupling [Catalysis], sering dipakai bersamaan dalam satu alur kerja laboratorium:\u003c\/p\u003e\u003cul\u003e\n\u003cli\u003e\u003ca href=\"\/en\/collections\/tci-l4-phosphine-ligands-for-cross-coupling-catalysis\"\u003ePhosphine Ligands (for Cross-Coupling) [Catalysis]\u003c\/a\u003e\u003c\/li\u003e\n\u003cli\u003e\u003ca href=\"\/en\/collections\/tci-l4-buchwald-ligands-catalysis\"\u003eBuchwald Ligands [Catalysis]\u003c\/a\u003e\u003c\/li\u003e\n\u003c\/ul\u003e\u003cp\u003eKembali ke \u003ca href=\"\/en\/collections\/tci-l3-cross-coupling-catalysis\"\u003eCross-Coupling [Catalysis]\u003c\/a\u003e. Untuk pengadaan volume besar, kemasan khusus, atau grade tertentu, hubungi tim AMI Scientific — distributor resmi TCI Japan di Indonesia — untuk pengecekan ketersediaan dan lead time langsung ke Jepang.\u003c\/p\u003e","products":[{"product_id":"tci2510b622113049","title":"TCI B6221 894086-00-1 5-(Di-tert-butylphosphino)-1',3',5'-triphenyl-1'H-1,4'-bipyrazole","description":"\u003ch3\u003eDescription\u003c\/h3\u003e\n\u003cp\u003eTCI B6221, 5-(Di-tert-butylphosphino)-1',3',5'-triphenyl-1'H-1,4'-bipyrazole (CAS 894086-00-1), is a bipyrazole-based phosphine ligand designed for transition metal-catalyzed cross-coupling reactions. This electron-rich ligand significantly enhances catalyst performance in challenging bond-forming processes, including Suzuki-Miyaura and Buchwald-Hartwig couplings. Supplied in a 200 mg packaging, it is suitable for both research-scale and method development applications requiring high ligand efficiency.\u003c\/p\u003e","brand":"TCI","offers":[{"title":"200mg","offer_id":48276766884058,"sku":"TCI2510B622113049","price":1857000.0,"currency_code":"IDR","in_stock":false}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0756\/7156\/8602\/files\/TCI2510B6221_18556267-cf39-4841-9c7c-22c39c29b89e.jpg?v=1767864936"},{"product_id":"tci2510d383424226","title":"TCI D3834 628333-86-8 1-[2-(Di-tert-butylphosphino)phenyl]-3,5-diphenyl-1H-pyrazole","description":"\u003ch3\u003eDescription\u003c\/h3\u003e\n\u003cp\u003e1-[2-(Di-tert-butylphosphino)phenyl]-3,5-diphenyl-1H-pyrazole from TCI, listed under CAS number 628333-86-8, is a phosphine ligand built on a pyrazole framework and designed for the catalysis of cross-coupling reactions. The molecule combines an electron-rich phosphorus atom bearing di-tert-butyl groups with a diphenyl-substituted pyrazole ring, the two connected through a phenylene bridge. In the laboratory, this compound acts as a supporting ligand for transition metals, particularly palladium, where its task is to form the active catalytic complex and to direct the course of the catalytic cycle in reactions that build carbon–carbon and carbon–heteroatom bonds.\u003c\/p\u003e\n\u003cp\u003eThe properties that make this ligand a preferred choice are the combination of high basicity and substantial steric bulk contributed by the di-tert-butylphosphino group. High basicity accelerates the oxidative addition step on less reactive substrates, while the steric bulk promotes the reductive elimination step so that the catalytic cycle turns over more rapidly. The pyrazole ring supplies an additional donor nitrogen atom together with a rigid aromatic framework, giving a directed coordination environment around the metal centre. A structure of this kind generally allows low catalyst loadings and a broad substrate scope.\u003c\/p\u003e\n\u003cp\u003eIn Indonesian laboratories, a ligand of this type is typically used in synthetic and methodology work where a palladium-catalysed coupling has to be assembled from the metal precursor and the ligand in situ, or pre-formed as a defined complex before use. It suits organic synthesis groups in universities and research institutes, as well as process and formulation development laboratories that prepare intermediates on a small scale and need a coupling system that performs reliably on demanding substrates.\u003c\/p\u003e\n\u003ch3\u003eLaboratory Applications\u003c\/h3\u003e\n\u003cul\u003e\n\u003cli\u003eSuzuki–Miyaura coupling: the high basicity of the di-tert-butylphosphino group assists oxidative addition on less reactive aryl substrates, while the steric bulk speeds reductive elimination and turnover.\u003c\/li\u003e\n\u003cli\u003eBuchwald–Hartwig type carbon–nitrogen bond formation: the electron-rich phosphorus centre and rigid pyrazole framework give the directed coordination environment needed for reliable amination of aryl partners.\u003c\/li\u003e\n\u003cli\u003eGeneral carbon–carbon bond construction: the ligand forms active catalytic complexes with palladium and steers the catalytic cycle, supporting couplings that would otherwise stall on hindered substrates.\u003c\/li\u003e\n\u003cli\u003eCarbon–heteroatom coupling methodology studies: the additional donor nitrogen atom of the pyrazole ring offers a defined coordination geometry that researchers can exploit when screening reaction conditions.\u003c\/li\u003e\n\u003cli\u003eLow-loading catalysis work: because the structure generally permits reduced catalyst charges and broad substrate scope, it suits laboratories optimising ligand-to-metal ratios and catalyst economy.\u003c\/li\u003e\n\u003c\/ul\u003e\n\u003ch3\u003eSpecifications\u003c\/h3\u003e\n\u003cul\u003e\n\u003cli\u003eBrand: TCI\u003c\/li\u003e\n\u003cli\u003eCAS number: 628333-86-8\u003c\/li\u003e\n\u003cli\u003eCategory: Chemistry \u0026gt; Catalysis and Inorganic Chemistry \u0026gt; Cross-Coupling [Catalysis]\u003c\/li\u003e\n\u003cli\u003eChemical name: 1-[2-(Di-tert-butylphosphino)phenyl]-3,5-diphenyl-1H-pyrazole\u003c\/li\u003e\n\u003cli\u003ePack sizes: available in the standard research-scale pack sizes offered by the manufacturer; please confirm the packaging option required when ordering.\u003c\/li\u003e\n\u003cli\u003eStorage: keep in the closed original container under the conditions stated on the manufacturer's label and safety data sheet.\u003c\/li\u003e\n\u003c\/ul\u003e\n\u003ch3\u003eHandling and Storage\u003c\/h3\u003e\n\u003cp\u003eStore the product in its original tightly closed container, kept in a cool, dry and well-ventilated place away from heat, ignition sources and incompatible materials, and follow the specific storage conditions printed on the manufacturer's label and safety data sheet. As with other trialkylphosphine ligands, minimise exposure to air and moisture during handling; use tightly sealed glass or the supplied original containers rather than transferring to open vessels. Weigh and dispense in a fume hood using an inert atmosphere where the protocol calls for it, and wear a laboratory coat, safety glasses and suitable chemical-resistant gloves. Keep the container closed when not in use, label all secondary containers clearly, and dispose of residues and contaminated consumables through the laboratory's chemical waste procedure. Consult the manufacturer's safety data sheet before first use.\u003c\/p\u003e","brand":"TCI","offers":[{"title":"1g","offer_id":48086640558298,"sku":"TCI2510D383424226","price":1546000.0,"currency_code":"IDR","in_stock":true},{"title":"5g","offer_id":48086640591066,"sku":"TCI2510D383424227","price":4470000.0,"currency_code":"IDR","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0756\/7156\/8602\/files\/TCI2510D3834.jpg?v=1767106644"}],"url":"https:\/\/amiscientific.com\/en\/collections\/tci-l4-buchwald-ligands-and-complexes-catalysis.oembed","provider":"AMI Scientific","version":"1.0","type":"link"}