{"title":"Carbodiimides [Coupling Reagents]","description":"\u003cp\u003e\u003cstrong\u003eCarbodiimides [Coupling Reagents]\u003c\/strong\u003e — menghimpun reagen karbodiimida seperti DCC, EDC, dan turunan garamnya (hidroklorida, metiodida) yang mengandung gugus fungsi N=C=N sebagai pusat reaktif untuk aktivasi asam karboksilat. Reagen ini menjadi kelompok inti dalam pembentukan ikatan amida dan ester melalui reaksi kopling.\u003c\/p\u003e\u003cp\u003eKarbodiimida digunakan secara luas sebagai reagen kopling dalam sintesis peptida, pembentukan ikatan amida dan ester, serta konjugasi biomolekul seperti protein dan asam nukleat di laboratorium kimia organik dan bioorganik. EDC dan turunan hidrokloridanya umum dipakai peneliti bioconjugation karena kelarutannya dalam air, sedangkan DCC lebih sering digunakan pada sintesis fase organik konvensional.\u003c\/p\u003e\u003cp\u003eContoh produk dalam koleksi ini: \u003ca href=\"\/en\/products\/tci2510d534726230\"\u003eTCI D5347 691-24-7 N,N'-Di-tert-butylcarbodiimide\u003c\/a\u003e, \u003ca href=\"\/en\/products\/tci2510c079315057\"\u003eTCI C0793 2491-17-0 1-Cyclohexyl-3-(2-morpholinoethyl)carbodiimide Metho-p-toluenesulfonate [for Peptide Synthesis]\u003c\/a\u003e, \u003ca href=\"\/en\/products\/tci2510d533426216\"\u003eTCI D5334 22572-40-3 1-[3-(Dimethylamino)propyl]-3-ethylcarbodiimide Methiodide\u003c\/a\u003e, \u003ca href=\"\/en\/products\/tci2510d025419609\"\u003eTCI D0254 693-13-0 N,N'-Diisopropylcarbodiimide\u003c\/a\u003e, \u003ca href=\"\/en\/products\/tci2510d402924497\"\u003eTCI D4029 1892-57-5 1-(3-Dimethylaminopropyl)-3-ethylcarbodiimide\u003c\/a\u003e, \u003ca href=\"\/en\/products\/tci2510d043619870\"\u003eTCI D0436 538-75-0 N,N'-Dicyclohexylcarbodiimide\u003c\/a\u003e, \u003ca href=\"\/en\/products\/tci2510d160121410\"\u003eTCI D1601 25952-53-8 1-(3-Dimethylaminopropyl)-3-ethylcarbodiimide Hydrochloride [Coupling Agent for Peptides Synthesis]\u003c\/a\u003e, \u003ca href=\"\/en\/products\/tci2510d043719872\"\u003eTCI D0437 538-75-0 N,N'-Dicyclohexylcarbodiimide (25% in Pyridine, ca. 1.2mol\/L)\u003c\/a\u003e.\u003c\/p\u003e\u003cp\u003ePerhatikan kelarutan reagen (larut air seperti EDC versus DCC yang larut pelarut organik), bentuk garam, serta konsentrasi larutan yang tersedia, karena hal ini menentukan kompatibilitas dengan pelarut reaksi. Seluruh produk merupakan produk asli Tokyo Chemical Industry (TCI) Jepang, dengan kemurnian, kemasan, dan kondisi penyimpanan tercantum pada halaman masing-masing item.\u003c\/p\u003e\u003cp\u003eKategori lain yang sejajar di bawah Coupling [Synthetic Reagents], sering dipakai bersamaan dalam satu alur kerja laboratorium:\u003c\/p\u003e\u003cul\u003e\n\u003cli\u003e\u003ca href=\"\/en\/collections\/tci-l4-peptide-coupling-agents\"\u003ePeptide Coupling Agents\u003c\/a\u003e\u003c\/li\u003e\n\u003cli\u003e\u003ca href=\"\/en\/collections\/tci-l4-active-esters-additives-coupling-reagents\"\u003eActive Esters, Additives [Coupling Reagents]\u003c\/a\u003e\u003c\/li\u003e\n\u003cli\u003e\u003ca href=\"\/en\/collections\/tci-l4-phosphonium-salts-uronium-salts-formamidinium-salts-coupling-reagents\"\u003ePhosphonium Salts, Uronium Salts, Formamidinium Salts [Coupling Reagents]\u003c\/a\u003e\u003c\/li\u003e\n\u003cli\u003e\u003ca href=\"\/en\/collections\/tci-l4-coupling-reagents-other\"\u003eCoupling Reagents (Other)\u003c\/a\u003e\u003c\/li\u003e\n\u003cli\u003e\u003ca href=\"\/en\/collections\/tci-l4-triflate-formation-coupling-reagents\"\u003eTriflate Formation [Coupling Reagents]\u003c\/a\u003e\u003c\/li\u003e\n\u003cli\u003e\u003ca href=\"\/en\/collections\/tci-l4-phosgene-derivatives-coupling-reagents\"\u003ePhosgene Derivatives [Coupling Reagents]\u003c\/a\u003e\u003c\/li\u003e\n\u003c\/ul\u003e\u003cp\u003eKembali ke \u003ca href=\"\/en\/collections\/tci-l3-coupling-synthetic-reagents\"\u003eCoupling [Synthetic Reagents]\u003c\/a\u003e. Untuk pengadaan volume besar, kemasan khusus, atau grade tertentu, hubungi tim AMI Scientific — distributor resmi TCI Japan di Indonesia — untuk pengecekan ketersediaan dan lead time langsung ke Jepang.\u003c\/p\u003e","products":[{"product_id":"tci2510c079315057","title":"TCI C0793 2491-17-0 1-Cyclohexyl-3-(2-morpholinoethyl)carbodiimide Metho-p-toluenesulfonate [for Peptide Synthesis]","description":"\u003ch3\u003eDescription\u003c\/h3\u003e\n\u003cp\u003eTCI C0793 CMC (CAS 2491-17-0) is a water-soluble carbodiimide reagent developed for peptide synthesis and bioconjugation. Its quaternary ammonium moiety allows carboxyl activation and amide bond formation to proceed in aqueous media, which is valuable when working with sensitive biomolecules. Typical uses include peptide coupling, enzyme and biomolecule immobilisation, hydrogel crosslinking, and carbodiimide-based chemical probing of nucleic acids. Supplied by TCI in 5 g and 25 g packs, the salt is hygroscopic and should be kept cold, dry, and tightly closed.\u003c\/p\u003e","brand":"TCI","offers":[{"title":"5g","offer_id":48086029172954,"sku":"TCI2510C079315057","price":6606000.0,"currency_code":"IDR","in_stock":true},{"title":"25g","offer_id":48086029205722,"sku":"TCI2510C079315058","price":24818000.0,"currency_code":"IDR","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0756\/7156\/8602\/files\/TCI2510C0793.jpg?v=1767095766"},{"product_id":"tci2510d025419609","title":"TCI D0254 693-13-0 N,N'-Diisopropylcarbodiimide","description":"\u003ch3\u003eDescription\u003c\/h3\u003e\n\u003cp\u003eN,N’-Diisopropylcarbodiimide (DIC), also known as TCI D0254, is a widely used chemical compound in organic synthesis, particularly in the activation of carboxylic acid groups. This reagent plays a crucial role in the formation of amide and ester bonds, making it an essential tool in peptide chemistry and complex molecule synthesis. Its ability to efficiently activate carboxylic acid groups enables researchers to achieve high yields and purity in their reactions, which is vital in both academic and industrial laboratory settings.\u003c\/p\u003e\n\u003cp\u003eDIC is favored for its high reactivity and effectiveness in catalytic reactions. It is known for its ability to form highly efficient carbodiimide activators, which significantly enhance the rate of amide bond formation. Its stability under controlled conditions makes it a reliable choice for synthetic processes. However, it is highly sensitive to moisture and air, requiring careful handling and storage. These properties make it a preferred reagent in applications where precision and efficiency are paramount.\u003c\/p\u003e\n\u003cp\u003eIn Indonesian laboratories, N,N’-Diisopropylcarbodiimide is commonly used in organic chemistry research, especially in the synthesis of bioactive compounds and peptides. It is a key reagent in pharmaceutical and biochemical research, supporting the development of new drugs and materials. Its versatility and effectiveness make it a valuable tool for scientists working in various fields of chemical research.\u003c\/p\u003e\n\u003ch3\u003eLaboratory Applications\u003c\/h3\u003e\n\u003cul\u003e\n\u003cli\u003ePeptide Synthesis for Pharmacological Research: DIC is ideal for peptide synthesis due to its ability to efficiently activate carboxylic acid groups, enabling the formation of stable amide bonds necessary for drug development.\u003c\/li\u003e\n\u003cli\u003eOrganic Chemistry Research: It is widely used in the synthesis of bioactive compounds, where high reactivity and selectivity are required for complex molecule formation.\u003c\/li\u003e\n\u003cli\u003eBiochemical Studies: DIC supports the creation of complex molecules used in biochemical experiments, enhancing the accuracy and efficiency of reaction processes.\u003c\/li\u003e\n\u003cli\u003eMaterial Science Applications: Its role in activating functional groups makes it useful in the development of advanced materials with specific chemical properties.\u003c\/li\u003e\n\u003cli\u003eAnalytical Chemistry: DIC is employed in reactions requiring precise control over bond formation, ensuring high purity and reproducibility in analytical processes.\u003c\/li\u003e\n\u003c\/ul\u003e\n\u003ch3\u003eSpecifications\u003c\/h3\u003e\n\u003cul\u003e\n\u003cli\u003eBrand: TCI\u003c\/li\u003e\n\u003cli\u003eCAS number: 693-13-0\u003c\/li\u003e\n\u003cli\u003eCategory: Chemistry \u0026gt; Chemical Biology \u0026gt; Peptide Chemistry\u003c\/li\u003e\n\u003cli\u003ePack sizes: Not specified\u003c\/li\u003e\n\u003cli\u003ePhysical form: Not specified\u003c\/li\u003e\n\u003cli\u003eStorage note: Requires dry, cool, and well-ventilated conditions\u003c\/li\u003e\n\u003c\/ul\u003e\n\u003ch3\u003eHandling and Storage\u003c\/h3\u003e\n\u003cp\u003eN,N’-Diisopropylcarbodiimide should be stored in a dry, cool, and well-ventilated area away from moisture and air. It is typically kept in a sealed container to prevent exposure to humidity, which can degrade its effectiveness. Due to its reactivity, it should be handled in a fume hood to minimize inhalation risk. Appropriate personal protective equipment, such as gloves and safety goggles, should be worn during handling. The compound is sensitive to moisture, so it is important to ensure that all containers are tightly sealed and stored in a controlled environment to maintain its stability and efficacy.\u003c\/p\u003e","brand":"TCI","offers":[{"title":"25g","offer_id":48086362390746,"sku":"TCI2510D025419609","price":1462000.0,"currency_code":"IDR","in_stock":true},{"title":"250g","offer_id":48086362423514,"sku":"TCI2510D025419610","price":8376000.0,"currency_code":"IDR","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0756\/7156\/8602\/files\/TCI2510D0254.jpg?v=1767101058"},{"product_id":"tci2510d043619870","title":"TCI D0436 538-75-0 N,N'-Dicyclohexylcarbodiimide","description":"\u003ch3\u003eDescription\u003c\/h3\u003e\n\u003cp\u003eN,N’-Dicyclohexylcarbodiimide (DCC) is a chemical compound widely used in peptide synthesis and organic molecule coupling reactions. It functions as a catalyst in the activation of carboxylic acids, enabling the efficient formation of amide bonds. This compound is essential in laboratory settings where complex molecules such as peptides, proteins, or pharmacological agents are being synthesized. Its stability and reactivity make it a reliable choice for various organic chemistry applications. DCC is particularly favored for its ability to facilitate high-yield reactions without requiring additional reagents, thus streamlining the synthesis process.\u003c\/p\u003e\n\u003cp\u003eThe unique molecular structure of DCC, featuring two cyclohexyl groups surrounding the carbodiimide core, contributes to its stability and reactivity. This structure enhances the efficiency of chemical reactions by providing a robust platform for bond formation. Additionally, DCC is not prone to unwanted side reactions in laboratory environments, minimizing the risk of degradation or contamination. Its inertness in the presence of other compounds ensures that it remains a safe and effective reagent for a wide range of chemical processes.\u003c\/p\u003e\n\u003cp\u003eIn Indonesian laboratories, DCC is commonly used in research across chemistry, pharmacy, and biotechnology fields. It plays a crucial role in the synthesis of peptides and the modification of organic molecules, supporting both academic and industrial research. Its availability in the local market ensures that researchers have access to this essential compound for their experimental needs.\u003c\/p\u003e\n\u003ch3\u003eLaboratory Applications\u003c\/h3\u003e\n\u003cul\u003e\n\u003cli\u003ePeptide Synthesis: DCC is ideal for peptide synthesis due to its ability to activate carboxylic acid groups, enabling the formation of stable amide bonds with amino acids.\u003c\/li\u003e\n\u003cli\u003eOrganic Molecule Coupling: It facilitates efficient coupling reactions between organic molecules, making it a preferred choice for chemical modifications.\u003c\/li\u003e\n\u003cli\u003eProtein Modification: DCC is used in the chemical modification of proteins, allowing for the introduction of specific functional groups without disrupting the protein structure.\u003c\/li\u003e\n\u003cli\u003ePharmacological Research: It supports the synthesis of pharmacological compounds, aiding in the development of new drugs and therapeutic agents.\u003c\/li\u003e\n\u003cli\u003eBiotransformation Studies: DCC is useful in studies involving the transformation of organic compounds, providing a reliable method for bond formation in complex molecules.\u003c\/li\u003e\n\u003c\/ul\u003e\n\u003ch3\u003eSpecifications\u003c\/h3\u003e\n\u003cul\u003e\n\u003cli\u003eBrand: TCI\u003c\/li\u003e\n\u003cli\u003eCAS Number: 538-75-0\u003c\/li\u003e\n\u003cli\u003eCategory: Chemistry \u0026gt; Chemical Biology \u0026gt; Peptide Chemistry\u003c\/li\u003e\n\u003cli\u003ePack Sizes: Available in various quantities as per supplier specifications\u003c\/li\u003e\n\u003cli\u003ePhysical Form: Solid\u003c\/li\u003e\n\u003cli\u003eStorage Note: Store in a cool, dry place away from moisture and direct sunlight\u003c\/li\u003e\n\u003c\/ul\u003e\n\u003ch3\u003eHandling and Storage\u003c\/h3\u003e\n\u003cp\u003eDCC should be stored in a cool, dry environment to maintain its stability and reactivity. It is recommended to keep it in a sealed container to prevent exposure to moisture, which can affect its performance. Due to its chemical nature, it should be handled in a well-ventilated area, and appropriate personal protective equipment should be worn. While it is generally inert, it is advisable to avoid contact with incompatible substances to ensure safety. Proper storage conditions help preserve its effectiveness for use in laboratory applications.\u003c\/p\u003e","brand":"TCI","offers":[{"title":"25g","offer_id":48086384410842,"sku":"TCI2510D043619870","price":536000.0,"currency_code":"IDR","in_stock":true},{"title":"400g","offer_id":48086384443610,"sku":"TCI2510D043619871","price":3598000.0,"currency_code":"IDR","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0756\/7156\/8602\/files\/TCI2510D0436.jpg?v=1767101296"},{"product_id":"tci2510d043719872","title":"TCI D0437 538-75-0 N,N'-Dicyclohexylcarbodiimide (25% in Pyridine, ca. 1.2mol\/L)","description":"\u003ch3\u003eDescription\u003c\/h3\u003e\n\u003cp\u003eN,N’-Dicyclohexylcarbodiimide (DCC) is a widely used chemical compound in peptide synthesis and molecular coupling reactions. It is a liquid solution dissolved in pyridine with a concentration of approximately 1.2 mol\/L. This reagent plays a crucial role in activating carboxyl groups, enabling the formation of peptide bonds between two molecules. Its effectiveness and stability make it a key component in various synthetic processes. DCC is particularly valuable in laboratories where the production of complex molecules with specific structures is required.\u003c\/p\u003e\n\u003cp\u003eThe unique properties of N,N’-Dicyclohexylcarbodiimide make it a preferred choice for chemical synthesis. It is chemically stable under certain reaction conditions and exhibits high reactivity, allowing reactions to proceed efficiently. Its resistance to moisture and moderate temperatures enhances its usability in diverse laboratory settings. Additionally, its ability to function as a reliable activating agent ensures consistent results in peptide chemistry applications. These characteristics contribute to its popularity among researchers and scientists.\u003c\/p\u003e\n\u003cp\u003eIn Indonesian laboratories, N,N’-Dicyclohexylcarbodiimide is commonly used in organic and biochemical research. It is particularly relevant for academic institutions and research organizations focused on the synthesis of bioactive compounds. Its reliability and effectiveness make it a go-to reagent for those working on complex molecular structures and peptide-based experiments. Its consistent performance supports a wide range of scientific investigations.\u003c\/p\u003e\n\u003ch3\u003eLaboratory Applications\u003c\/h3\u003e\n\u003cul\u003e\n\u003cli\u003ePeptide Synthesis: DCC is ideal for peptide synthesis due to its ability to activate carboxyl groups, enabling efficient coupling reactions.\u003c\/li\u003e\n\u003cli\u003eMolecular Coupling Reactions: Its chemical stability and reactivity make it suitable for various molecular coupling processes in organic chemistry.\u003c\/li\u003e\n\u003cli\u003eBiochemical Research: DCC supports the synthesis of bioactive compounds, making it a valuable tool in biochemical studies.\u003c\/li\u003e\n\u003cli\u003eOrganic Chemistry Experiments: Its high efficiency and reliability make it a preferred reagent in synthetic organic chemistry applications.\u003c\/li\u003e\n\u003cli\u003eStructural Chemistry Studies: DCC is used to produce complex molecules with specific structural requirements, aiding in structural chemistry research.\u003c\/li\u003e\n\u003c\/ul\u003e\n\u003ch3\u003eSpecifications\u003c\/h3\u003e\n\u003cul\u003e\n\u003cli\u003eBrand: TCI\u003c\/li\u003e\n\u003cli\u003eCAS Number: 538-75-0\u003c\/li\u003e\n\u003cli\u003eCategory: Chemistry \u0026gt; Chemical Biology \u0026gt; Peptide Chemistry\u003c\/li\u003e\n\u003cli\u003ePack Sizes: 250 mL, 500 mL\u003c\/li\u003e\n\u003cli\u003ePhysical Form: Liquid\u003c\/li\u003e\n\u003cli\u003eStorage Note: Store in a cool, dry place away from direct sunlight\u003c\/li\u003e\n\u003c\/ul\u003e\n\u003ch3\u003eHandling and Storage\u003c\/h3\u003e\n\u003cp\u003eN,N’-Dicyclohexylcarbodiimide should be stored in a cool, dry place, away from direct sunlight and sources of heat. It is recommended to use airtight containers to prevent exposure to moisture, which can affect its stability. Due to its chemical reactivity, it should be handled in a well-ventilated area, preferably under a fume hood. Avoid contact with skin and eyes, and use appropriate personal protective equipment when handling. Ensure that the storage area is secure and inaccessible to unauthorized personnel. Regular monitoring of storage conditions is advised to maintain the integrity and effectiveness of the reagent.\u003c\/p\u003e","brand":"TCI","offers":[{"title":"100mL","offer_id":48086384476378,"sku":"TCI2510D043719872","price":3149000.0,"currency_code":"IDR","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0756\/7156\/8602\/files\/TCI2510D0437.jpg?v=1768204841"},{"product_id":"tci2510d160121410","title":"TCI D1601 25952-53-8 1-(3-Dimethylaminopropyl)-3-ethylcarbodiimide Hydrochloride [Coupling Agent for Peptides Synthesis]","description":"\u003ch3\u003eDescription\u003c\/h3\u003e\n\u003cp\u003e1-(3-Dimethylaminopropyl)-3-ethylcarbodiimide Hydrochloride (EDC.HCl) is a chemical compound widely used as a coupling agent in peptide synthesis. It plays a crucial role in activating carboxyl groups, enabling the formation of stable ester bonds between amino acid molecules. This compound is essential in laboratory settings where the synthesis of peptides is required, particularly in biochemical and pharmaceutical research. Its ability to facilitate efficient and reliable peptide bond formation makes it a fundamental reagent in modern synthetic chemistry.\u003c\/p\u003e\n\u003cp\u003eEDC.HCl is known for its high reactivity and effectiveness in promoting esterification reactions. Its chemical properties allow it to activate carboxylic acid groups, making them more susceptible to nucleophilic attack by amino groups. This makes it a preferred choice for researchers working on peptide synthesis, as it ensures consistent and reproducible results. The compound's stability under certain conditions further enhances its usability in various experimental setups, contributing to its widespread adoption in both academic and industrial laboratories.\u003c\/p\u003e\n\u003cp\u003eIn Indonesian laboratories, EDC.HCl is commonly used in biochemical and pharmacological research. It is a key reagent in the development of vaccines, drugs, and bioactive compounds. Its availability and reliability make it an essential tool for scientists engaged in peptide-based research. The compound’s role in enabling the synthesis of complex peptide structures supports its importance in both basic and applied research.\u003c\/p\u003e\n\u003ch3\u003eLaboratory Applications\u003c\/h3\u003e\n\u003cul\u003e\n\u003cli\u003ePeptide Synthesis: EDC.HCl is ideal for peptide synthesis due to its ability to activate carboxyl groups, enabling efficient coupling of amino acids.\u003c\/li\u003e\n\u003cli\u003eBiomedical Research: It supports the development of therapeutic peptides and bioactive compounds, making it essential for biomedical studies.\u003c\/li\u003e\n\u003cli\u003ePharmaceutical Development: EDC.HCl is used in drug discovery to create peptide-based therapeutics with specific biological activities.\u003c\/li\u003e\n\u003cli\u003eBiochemical Analysis: Its role in forming stable ester bonds makes it useful in biochemical assays requiring precise molecular interactions.\u003c\/li\u003e\n\u003cli\u003eDrug Target Validation: It aids in the synthesis of peptides used to study protein interactions and validate drug targets in pharmacological research.\u003c\/li\u003e\n\u003c\/ul\u003e\n\u003ch3\u003eSpecifications\u003c\/h3\u003e\n\u003cul\u003e\n\u003cli\u003eBrand: TCI\u003c\/li\u003e\n\u003cli\u003eCAS number: 25952-53-8\u003c\/li\u003e\n\u003cli\u003eCategory: Chemistry \u0026gt; Chemical Biology \u0026gt; Peptide Chemistry\u003c\/li\u003e\n\u003cli\u003ePack sizes: Available in various quantities as per standard laboratory supply\u003c\/li\u003e\n\u003cli\u003ePhysical form: Solid powder\u003c\/li\u003e\n\u003cli\u003eStorage note: Store in a cool, dry place away from moisture and light\u003c\/li\u003e\n\u003c\/ul\u003e\n\u003ch3\u003eHandling and Storage\u003c\/h3\u003e\n\u003cp\u003eEDC.HCl should be stored in a cool, dry environment, away from moisture and direct light to maintain its chemical integrity. It is recommended to keep the compound in a sealed container to prevent exposure to air and humidity. Due to its reactivity, it should be handled with care, using appropriate personal protective equipment such as gloves and safety goggles. It is important to ensure that the storage area is well-ventilated to avoid any potential fumes. Avoid contact with incompatible substances, and always follow standard laboratory safety protocols when working with this compound. Proper storage and handling will help preserve its effectiveness and ensure safe usage in laboratory settings.\u003c\/p\u003e","brand":"TCI","offers":[{"title":"5g","offer_id":48086449914074,"sku":"TCI2510D160121410","price":1518000.0,"currency_code":"IDR","in_stock":true},{"title":"25g","offer_id":48086449946842,"sku":"TCI2510D160121411","price":4386000.0,"currency_code":"IDR","in_stock":true},{"title":"100g","offer_id":48086449979610,"sku":"TCI2510D160121412","price":12592000.0,"currency_code":"IDR","in_stock":true},{"title":"250g","offer_id":48086450012378,"sku":"TCI2510D160121413","price":25239000.0,"currency_code":"IDR","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0756\/7156\/8602\/files\/TCI2510D1601.jpg?v=1767103323"},{"product_id":"tci2510d402924497","title":"TCI D4029 1892-57-5 1-(3-Dimethylaminopropyl)-3-ethylcarbodiimide","description":"\u003ch3\u003eDescription\u003c\/h3\u003e\n\u003cp\u003eTCI D4029, 1-(3-Dimethylaminopropyl)-3-ethylcarbodiimide, is known in most laboratories simply by the abbreviation EDC or EDAC. It is a carbodiimide-class coupling reagent that forms the backbone of modern peptide chemistry. Its primary function is to activate carboxylic acid groups, converting them into a highly reactive O-acylisourea intermediate that can then be attacked directly by an amine to form an amide bond or a peptide bond. Because it joins two molecular fragments together under mild conditions, this reagent is used widely across peptide synthesis, biomolecule conjugation, and the immobilization of proteins onto solid surfaces in biochemistry laboratories.\u003c\/p\u003e\n\u003cp\u003eThe property that has made EDC so popular is its water solubility, together with the fact that its by-product is a urea derivative that is also water soluble. The dimethylaminopropyl group in its structure is weakly basic and can be protonated, which means that both excess reagent and reaction by-products can be removed simply by washing with water or dilute acid, without the time-consuming chromatography required when working with dicyclohexylcarbodiimide. The reagent performs well over a weakly acidic to neutral pH range and is commonly paired with additives to improve coupling efficiency and suppress side reactions.\u003c\/p\u003e\n\u003cp\u003eIn Indonesian laboratories, TCI D4029 is a routine choice wherever amide bond formation is carried out under mild aqueous or mixed-solvent conditions. University research groups, biochemistry and biotechnology laboratories, and analytical development groups rely on it for peptide synthesis work, for preparing bioconjugates, and for attaching biomolecules to solid supports. Its straightforward aqueous work-up makes it particularly convenient for laboratories that prefer to avoid extended purification steps for every coupling reaction.\u003c\/p\u003e\n\u003ch3\u003eLaboratory Applications\u003c\/h3\u003e\n\u003cul\u003e\n\u003cli\u003ePeptide synthesis — EDC activates the carboxyl terminus of an amino acid or peptide fragment so that it couples cleanly with a free amine to form the peptide bond under mild conditions.\u003c\/li\u003e\n\u003cli\u003eAmide bond formation in organic synthesis — the reagent converts carboxylic acids into reactive O-acylisourea intermediates, allowing amines to be coupled without the harsh conditions normally needed for direct amidation.\u003c\/li\u003e\n\u003cli\u003eBiomolecule conjugation — because it works in weakly acidic to neutral aqueous media, EDC is well suited to joining proteins, peptides, and other sensitive biomolecules that would not survive aggressive coupling chemistry.\u003c\/li\u003e\n\u003cli\u003eProtein immobilization on solid surfaces — carboxyl-functionalized supports can be activated with EDC and then coupled to amine groups on proteins, a standard route for preparing functionalized surfaces in biochemistry work.\u003c\/li\u003e\n\u003cli\u003eCoupling reactions requiring simple work-up — the water-soluble urea by-product and protonatable dimethylaminopropyl group allow removal by water or dilute acid washing, making EDC ideal where chromatographic purification is impractical.\u003c\/li\u003e\n\u003c\/ul\u003e\n\u003ch3\u003eSpecifications\u003c\/h3\u003e\n\u003cul\u003e\n\u003cli\u003eBrand: TCI\u003c\/li\u003e\n\u003cli\u003eCAS Number: 1892-57-5\u003c\/li\u003e\n\u003cli\u003eChemical name: 1-(3-Dimethylaminopropyl)-3-ethylcarbodiimide (EDC \/ EDAC)\u003c\/li\u003e\n\u003cli\u003eCategory: Chemistry \u0026gt; Chemical Biology \u0026gt; Peptide Chemistry\u003c\/li\u003e\n\u003cli\u003ePack sizes: available in standard TCI catalogue pack sizes; please confirm the size required when ordering\u003c\/li\u003e\n\u003cli\u003eStorage: store according to the conditions stated on the manufacturer's label and Safety Data Sheet\u003c\/li\u003e\n\u003c\/ul\u003e\n\u003ch3\u003eHandling and Storage\u003c\/h3\u003e\n\u003cp\u003eStore this reagent in a cool, dry place in its original tightly closed container, following the storage conditions specified on the manufacturer's label and Safety Data Sheet. Carbodiimide reagents are moisture sensitive, so keep the container well sealed and allow it to reach room temperature before opening to limit condensation on the contents. Handle in a fume hood or a well-ventilated area, wearing gloves, safety glasses, and a laboratory coat, and avoid contact with skin and eyes as well as inhalation of any dust or vapour. Keep away from incompatible materials, weigh out only the quantity needed for the reaction, and dispose of residues and contaminated materials in accordance with your institution's chemical waste procedures. Always consult the Safety Data Sheet before first use.\u003c\/p\u003e","brand":"TCI","offers":[{"title":"5g","offer_id":48086651896026,"sku":"TCI2510D402924497","price":1462000.0,"currency_code":"IDR","in_stock":true},{"title":"25g","offer_id":48086651928794,"sku":"TCI2510D402924498","price":4695000.0,"currency_code":"IDR","in_stock":true},{"title":"100g","offer_id":48086651961562,"sku":"TCI2510D402924499","price":14025000.0,"currency_code":"IDR","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0756\/7156\/8602\/files\/TCI2510D4029.jpg?v=1767106964"},{"product_id":"tci2510d534726230","title":"TCI D5347 691-24-7 N,N'-Di-tert-butylcarbodiimide","description":"\u003ch3\u003eDescription\u003c\/h3\u003e\n\u003cp\u003eN,N'-Di-tert-butylcarbodiimide (DTB-CI), also known as TCI D5347, is a widely used chemical compound in laboratory settings for activating carboxyl groups during organic synthesis. It functions as a coupling agent that facilitates the formation of esters and amides from carboxylic acids through efficient activation mechanisms. This reagent is essential in chemical laboratories for its ability to enhance reaction rates without undergoing chemical changes itself, making it a reliable catalyst in various synthetic processes. Its role is critical in the development of complex organic molecules, particularly in the field of medicinal chemistry and polymer science.\u003c\/p\u003e\n\u003cp\u003eDTB-CI is valued for its chemical stability under controlled conditions, although it is highly sensitive to moisture and air. Its molecular structure, featuring two tert-butyl groups, contributes to its overall stability and reactivity. These properties make it a preferred choice for researchers needing a consistent and effective reagent for activating carboxylic acid groups. The compound’s versatility allows it to be used in a wide range of reaction conditions, making it a staple in both academic and industrial research environments.\u003c\/p\u003e\n\u003cp\u003eIn Indonesian laboratories, DTB-CI is commonly used in organic chemistry research, especially in the synthesis of compounds requiring carboxyl group activation. It is frequently found in academic and industrial research settings, particularly in fields such as pharmaceutical development and materials science. Its reliability and effectiveness make it a go-to reagent for chemists working on complex molecular structures.\u003c\/p\u003e\n\u003ch3\u003eLaboratory Applications\u003c\/h3\u003e\n\u003cul\u003e\n\u003cli\u003eOrganic synthesis for ester and amide formation due to its efficient carboxyl activation properties\u003c\/li\u003e\n\u003cli\u003eMedicinal chemistry research to develop pharmaceutical compounds requiring functional group modification\u003c\/li\u003e\n\u003cli\u003ePolymer science applications for cross-linking and modifying polymer chains through carboxyl group reactions\u003c\/li\u003e\n\u003cli\u003eIndustrial chemical production for large-scale synthesis of organic compounds with high purity\u003c\/li\u003e\n\u003cli\u003eAcademic research in chemistry departments for teaching and experimental studies on coupling reactions\u003c\/li\u003e\n\u003c\/ul\u003e\n\u003ch3\u003eSpecifications\u003c\/h3\u003e\n\u003cul\u003e\n\u003cli\u003eBrand: TCI\u003c\/li\u003e\n\u003cli\u003eCAS number: 691-24-7\u003c\/li\u003e\n\u003cli\u003eCategory: Chemistry \u0026gt; Building Blocks \u0026gt; Non-Heterocyclic Building Blocks\u003c\/li\u003e\n\u003cli\u003ePack sizes: Available in various quantities as per supplier specifications\u003c\/li\u003e\n\u003cli\u003ePhysical form: Solid powder\u003c\/li\u003e\n\u003cli\u003eStorage note: Store in a dry, cool, and well-ventilated area away from moisture and air\u003c\/li\u003e\n\u003c\/ul\u003e\n\u003ch3\u003eHandling and Storage\u003c\/h3\u003e\n\u003cp\u003eDTB-CI should be stored in a dry, cool, and well-ventilated area to prevent moisture absorption, which can degrade its effectiveness. It is recommended to use airtight containers made of glass or high-density polyethylene to minimize exposure to air and humidity. Due to its sensitivity, it should be handled in a fume hood to avoid inhalation of vapors. Always ensure proper personal protective equipment is worn when handling this compound. Avoid contact with water or moisture during storage and use to maintain its chemical integrity. Regular inspection of storage conditions is advised to ensure optimal performance in laboratory applications.\u003c\/p\u003e","brand":"TCI","offers":[{"title":"5mL","offer_id":48086755475674,"sku":"TCI2510D534726230","price":1266000.0,"currency_code":"IDR","in_stock":true},{"title":"25mL","offer_id":48086755508442,"sku":"TCI2510D534726231","price":4189000.0,"currency_code":"IDR","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0756\/7156\/8602\/files\/TCI2510D5347.jpg?v=1767108642"}],"url":"https:\/\/amiscientific.com\/en\/collections\/tci-l4-carbodiimides-coupling-reagents.oembed","provider":"AMI Scientific","version":"1.0","type":"link"}