{"title":"{Disable Category} Crosslinkers [Chemical Biology]","description":"\u003cp\u003e{Disable Category} Crosslinkers [Chemical Biology] — reagen TCI untuk riset dan industri. Tersedia di Indonesia melalui AMI Scientific.\u003c\/p\u003e","products":[{"product_id":"tci2510d389524316","title":"TCI D3895 68528-80-3 Di(N-succinimidyl) Suberate","description":"\u003ch3\u003eDescription\u003c\/h3\u003e\n\u003cp\u003eTCI D3895 Di(N-succinimidyl) Suberate, better known by the abbreviation DSS, is a homobifunctional crosslinking reagent that carries two N-hydroxysuccinimide (NHS) ester groups at both ends of an eight-carbon suberate chain. This reagent is one of the most established tools in chemical biology for covalently joining two amine groups that lie close to one another, particularly the lysine side-chain amines and the N-terminus of proteins. In routine laboratory practice, DSS is used to freeze transient protein–protein interactions so that the resulting complexes can be analysed by electrophoresis, western blot, or mass spectrometry.\u003c\/p\u003e\n\u003cp\u003eThe characteristic that makes DSS a first-choice reagent is the efficient reactivity of its NHS esters toward primary amines under slightly basic conditions, forming stable amide bonds that are irreversible. The suberate spacer arm provides a fixed and known reach, so the distance between the linked residues can be treated as a geometric distance constraint in protein structure modelling. DSS is also water-insoluble but dissolves in organic solvents such as DMSO or DMF, which allows it to cross cell membranes and makes intracellular crosslinking work possible. This combination of defined spacer length, predictable amine chemistry, and membrane permeability gives researchers reproducible results across repeated experiments.\u003c\/p\u003e\n\u003cp\u003eIn Indonesian laboratories, DSS from TCI is typically used in university research groups, biotechnology institutes, and protein chemistry facilities working on interaction mapping and structural studies. It supports work in which a protein complex must be stabilised before downstream separation or identification, and it fits laboratories that already run electrophoresis, western blotting, or mass spectrometry workflows. Because the reagent is supplied by TCI, it suits groups that require a consistent, catalogue-listed chemical biology reagent for repeated use across projects.\u003c\/p\u003e\n\u003ch3\u003eLaboratory Applications\u003c\/h3\u003e\n\u003cul\u003e\n\u003cli\u003eProtein–protein interaction capture: DSS covalently locks transient or weak binding partners together, so complexes that would otherwise dissociate during handling survive downstream separation and detection steps.\u003c\/li\u003e\n\u003cli\u003eCrosslinking mass spectrometry (XL-MS): the fixed suberate spacer length converts each identified crosslink into a measurable distance constraint, supporting structural modelling of proteins and protein assemblies.\u003c\/li\u003e\n\u003cli\u003eComplex stabilisation before electrophoresis: crosslinked assemblies remain intact under denaturing gel conditions, allowing subunit composition and stoichiometry to be assessed by band pattern analysis.\u003c\/li\u003e\n\u003cli\u003eWestern blot analysis of oligomeric states: irreversible amide bonds preserve the crosslinked species through transfer and immunodetection, so oligomers can be distinguished from monomeric forms.\u003c\/li\u003e\n\u003cli\u003eIntracellular crosslinking studies: solubility in DMSO or DMF combined with membrane permeability allows DSS to be introduced into living cells to capture interactions in their native cellular environment.\u003c\/li\u003e\n\u003c\/ul\u003e\n\u003ch3\u003eSpecifications\u003c\/h3\u003e\n\u003cul\u003e\n\u003cli\u003eBrand: TCI\u003c\/li\u003e\n\u003cli\u003eProduct code: D3895\u003c\/li\u003e\n\u003cli\u003eCAS number: 68528-80-3\u003c\/li\u003e\n\u003cli\u003eChemical name: Di(N-succinimidyl) Suberate (DSS), a homobifunctional NHS-ester crosslinker\u003c\/li\u003e\n\u003cli\u003eCategory: Chemistry \u0026gt; Chemical Biology \u0026gt; Linkers and Crosslinkers\u003c\/li\u003e\n\u003cli\u003ePack sizes: available in standard TCI catalogue pack sizes; please confirm the required size when ordering\u003c\/li\u003e\n\u003cli\u003eStorage note: store as indicated on the manufacturer label, protected from moisture\u003c\/li\u003e\n\u003c\/ul\u003e\n\u003ch3\u003eHandling and Storage\u003c\/h3\u003e\n\u003cp\u003eStore the container tightly closed in a dry place, following the storage conditions stated on the manufacturer's label, and keep the reagent protected from moisture because NHS esters are susceptible to hydrolysis. Use dry, sealed glass or compatible plastic containers, and allow the container to reach room temperature before opening to prevent condensation. Prepare stock solutions freshly in anhydrous DMSO or DMF immediately before use rather than storing aqueous dilutions. Handle in a fume hood with a laboratory coat, safety glasses, and chemically resistant gloves, avoid contact with skin and eyes, and dispose of residues in accordance with institutional chemical waste procedures. Consult the manufacturer's safety data sheet before first use.\u003c\/p\u003e","brand":"TCI","offers":[{"title":"1g","offer_id":48086643966170,"sku":"TCI2510D389524316","price":2626000.0,"currency_code":"IDR","in_stock":true},{"title":"5g","offer_id":48086643998938,"sku":"TCI2510D389524317","price":8909000.0,"currency_code":"IDR","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0756\/7156\/8602\/files\/TCI2510D3895.jpg?v=1767106746"},{"product_id":"tci2510d401924483","title":"TCI D4019 23024-29-5 Di(N-succinimidyl) Sebacate","description":"\u003ch3\u003eDescription\u003c\/h3\u003e\n\u003cp\u003eDi(N-succinimidyl) Sebacate is a homobifunctional crosslinking reagent carrying two N-hydroxysuccinimide (NHS) ester groups at either end of a ten-carbon sebacate chain. The NHS ester groups react with primary amines — principally the amino groups of lysine residues and the N-terminus of a protein chain — to form stable amide bonds. Because both ends of the molecule are reactive toward the same functional group, the reagent is used to join two protein-bearing molecules together, to immobilise biomolecules onto solid surfaces, or to lock protein–protein interactions in place so that they can be analysed further in the chemical biology laboratory.\u003c\/p\u003e\n\u003cp\u003eThe advantage that makes this reagent a preferred choice lies in the length of its spacer arm. The sebacate chain provides a more generous distance between the two points of attachment than short-arm crosslinkers do, which makes it well suited to bridging amine groups that are located far apart from one another, or to keeping an immobilised biomolecule free enough to move so that it does not lose its function. That long aliphatic chain is hydrophobic in character and dissolves well in organic solvents such as dimethyl sulfoxide or dimethylformamide, so stock solutions are normally prepared in one of those solvents before being added to the reaction.\u003c\/p\u003e\n\u003cp\u003eIn Indonesian laboratories, this type of reagent is typically handled in university research groups, biotechnology institutes, and protein chemistry facilities working on conjugation and bioimmobilisation. The usual working pattern is to prepare a concentrated stock in dimethyl sulfoxide or dimethylformamide first, then introduce a small volume of that stock into the aqueous protein solution being crosslinked. Because the reagent is supplied by TCI and is used in small quantities per experiment, it is normally kept as a shared stock item within the laboratory.\u003c\/p\u003e\n\u003ch3\u003eLaboratory Applications\u003c\/h3\u003e\n\u003cul\u003e\n\u003cli\u003eProtein–protein conjugation: the two NHS ester ends react with lysine and N-terminal amines on separate protein molecules, joining them through stable amide bonds.\u003c\/li\u003e\n\u003cli\u003eImmobilisation of biomolecules on solid supports: one NHS ester anchors to an amine-functionalised surface while the other captures the biomolecule to be tethered.\u003c\/li\u003e\n\u003cli\u003eCapture of protein–protein interaction partners: interacting proteins are locked together covalently so that the complex survives subsequent analytical steps in the laboratory.\u003c\/li\u003e\n\u003cli\u003eLong-spacer crosslinking studies: the ten-carbon sebacate chain bridges amine groups that lie too far apart for short-arm crosslinkers to reach effectively.\u003c\/li\u003e\n\u003cli\u003ePreparation of functionally active immobilised proteins: the generous arm length preserves conformational freedom, helping tethered biomolecules retain their biological function after attachment.\u003c\/li\u003e\n\u003c\/ul\u003e\n\u003ch3\u003eSpecifications\u003c\/h3\u003e\n\u003cul\u003e\n\u003cli\u003eBrand: TCI\u003c\/li\u003e\n\u003cli\u003eCAS number: 23024-29-5\u003c\/li\u003e\n\u003cli\u003eCatalogue reference: D4019\u003c\/li\u003e\n\u003cli\u003eCategory: Chemistry \u0026gt; Chemical Biology \u0026gt; Linkers and Crosslinkers\u003c\/li\u003e\n\u003cli\u003ePack sizes: available in standard TCI research-scale packaging; please confirm the size required when ordering\u003c\/li\u003e\n\u003cli\u003eStorage note: keep tightly closed and protected from moisture, since NHS esters are susceptible to hydrolysis\u003c\/li\u003e\n\u003c\/ul\u003e\n\u003ch3\u003eHandling and Storage\u003c\/h3\u003e\n\u003cp\u003eStore the container tightly sealed in a cool, dry place and protect it from moisture, because the NHS ester groups are hydrolysed by water and lose reactivity once that happens. Keep the reagent in its original tightly closed container, and allow it to reach ambient temperature before opening so that condensation does not form inside. Prepare stock solutions in dry dimethyl sulfoxide or dimethylformamide immediately before use rather than storing dilute aqueous solutions. Handle the material in a fume hood while wearing gloves, safety glasses, and a laboratory coat, avoid contact with skin and eyes, and consult the manufacturer's safety data sheet before beginning work.\u003c\/p\u003e","brand":"TCI","offers":[{"title":"1g","offer_id":48086651404506,"sku":"TCI2510D401924483","price":1541000.0,"currency_code":"IDR","in_stock":true},{"title":"5g","offer_id":48086651437274,"sku":"TCI2510D401924484","price":4871000.0,"currency_code":"IDR","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0756\/7156\/8602\/files\/TCI2510D4019.jpg?v=1767106956"},{"product_id":"tci2510m320641741","title":"TCI M3206 3815-86-9 Malonic Acid Dihydrazide","description":"\u003ch3\u003eDescription\u003c\/h3\u003e\n\u003cp\u003eTCI M3206 Malonic Acid Dihydrazide, bearing CAS number 3815-86-9, is a dihydrazide compound derived from malonic acid, a three-carbon dicarboxylic acid whose two carboxyl groups have both been converted into hydrazide functionalities. It belongs to the family of highly versatile non-heterocyclic building blocks used in synthetic chemistry. In the laboratory, the presence of a hydrazide group at each end of the molecule makes it a bifunctional reagent, meaning a single molecule is able to bind two other molecules simultaneously. This property makes it useful for constructing extended chains, molecular bridges, and new heterocyclic ring systems.\u003c\/p\u003e\n\u003cp\u003eThe characteristic that makes this compound a preferred choice is the high and dependable reactivity of the hydrazide group toward carbonyl functions. Hydrazides react rapidly with aldehydes and ketones to form stable hydrazones, and this reaction proceeds under mild conditions without requiring complicated catalysts. The hydrazide group is also a common precursor to a variety of nitrogen-containing heterocyclic rings such as pyrazolones, oxadiazoles, and triazoles through cyclisation with suitable reagents. In addition, its paired nitrogen and oxygen atoms are capable of coordinating metal ions, so the compound is frequently employed as a ligand framework in research work.\u003c\/p\u003e\n\u003cp\u003eIn Indonesian laboratories, this building block is typically found in university and institutional research settings where organic synthesis, heterocyclic chemistry, and coordination chemistry are studied. It serves researchers preparing hydrazone derivatives, building nitrogen heterocycle libraries, or assembling ligand scaffolds for metal complex investigations. As a TCI-branded reagent supplied by AMI Scientific, it suits synthesis groups that need a reliable bifunctional starting material for multi-step preparative work.\u003c\/p\u003e\n\u003ch3\u003eLaboratory Applications\u003c\/h3\u003e\n\u003cul\u003e\n\u003cli\u003eHydrazone synthesis: the two terminal hydrazide groups condense rapidly with aldehydes and ketones under mild conditions to give stable hydrazone products without complex catalysts.\u003c\/li\u003e\n\u003cli\u003eHeterocyclic ring construction: the hydrazide functionality serves as a common precursor for building nitrogen-containing rings such as pyrazolones, oxadiazoles, and triazoles through cyclisation with appropriate reagents.\u003c\/li\u003e\n\u003cli\u003eLigand framework preparation: the paired nitrogen and oxygen atoms coordinate metal ions, making this compound a frequently chosen scaffold for preparing ligands in coordination chemistry research.\u003c\/li\u003e\n\u003cli\u003eBifunctional linking and bridging: because one molecule can bind two partner molecules simultaneously, it is well suited to assembling extended chains and molecular bridges in preparative work.\u003c\/li\u003e\n\u003cli\u003eGeneral building block chemistry: as a versatile non-heterocyclic building block derived from a three-carbon dicarboxylic acid, it supports multi-step organic synthesis routes requiring a symmetrical difunctional core.\u003c\/li\u003e\n\u003c\/ul\u003e\n\u003ch3\u003eSpecifications\u003c\/h3\u003e\n\u003cul\u003e\n\u003cli\u003eBrand: TCI\u003c\/li\u003e\n\u003cli\u003eCAS number: 3815-86-9\u003c\/li\u003e\n\u003cli\u003eProduct code: M3206\u003c\/li\u003e\n\u003cli\u003eCategory: Chemistry \u0026gt; Building Blocks \u0026gt; Non-Heterocyclic Building Blocks\u003c\/li\u003e\n\u003cli\u003ePack sizes: available in standard laboratory research pack sizes; please confirm the currently offered packing when ordering\u003c\/li\u003e\n\u003cli\u003eStorage: store in a closed container under the conditions indicated on the manufacturer's label\u003c\/li\u003e\n\u003c\/ul\u003e\n\u003ch3\u003eHandling and Storage\u003c\/h3\u003e\n\u003cp\u003eStore this reagent in a tightly closed original container, kept in a cool, dry place away from direct sunlight, moisture, and sources of heat or ignition. Hydrazide compounds are reactive toward carbonyl-containing substances, so keep the container well sealed and separated from aldehydes, ketones, and strong oxidising agents. Handle the material in a well-ventilated area or inside a fume hood, and wear standard laboratory personal protective equipment including safety glasses, gloves, and a laboratory coat. Avoid generating dust, avoid inhalation and direct skin or eye contact, and wash hands thoroughly after handling. Always consult the manufacturer's Safety Data Sheet before use and follow institutional procedures for chemical waste disposal.\u003c\/p\u003e","brand":"TCI","offers":[{"title":"5g","offer_id":48087740317914,"sku":"TCI2510M320641741","price":834000.0,"currency_code":"IDR","in_stock":true},{"title":"25g","offer_id":48087740350682,"sku":"TCI2510M320641742","price":2853000.0,"currency_code":"IDR","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0756\/7156\/8602\/files\/TCI2510M3206.jpg?v=1767127913"},{"product_id":"tci2510p089246391","title":"TCI P0892 58537-94-3 Dimethyl Pimelimidate Dihydrochloride [Cross-linking Agent for Peptides Research]","description":"\u003ch3\u003eDescription\u003c\/h3\u003e\n\u003cp\u003eDimethyl Pimelimidate Dihydrochloride (DMPI) is a chemical compound widely used as a crosslinking agent in peptide research. It plays a crucial role in laboratories by enabling the specific linkage of two peptide or protein molecules. This functionality is essential for studying molecular interactions and structural biology. Its application extends to the development and modification of biological molecules, supporting advancements in biochemical and pharmacological research.\u003c\/p\u003e\n\u003cp\u003eDMPI is favored for its stable chemical properties and high reactivity, making it suitable for precise chemical reactions that require specific bonding. Its molecular structure allows it to react with amino or carboxyl groups, offering versatility in various experimental setups. These characteristics make it a preferred choice over other crosslinking agents, especially in applications requiring high precision and control.\u003c\/p\u003e\n\u003cp\u003eIn Indonesian laboratories, DMPI is commonly used in applied research such as vaccine development, molecular modification, and drug discovery. Its reliability and effectiveness in crosslinking make it an essential tool for researchers aiming to enhance the stability and activity of target molecules. Its consistent performance supports high-quality scientific outcomes in both academic and industrial settings.\u003c\/p\u003e\n\u003ch3\u003eLaboratory Applications\u003c\/h3\u003e\n\u003cul\u003e\n\u003cli\u003ePeptide Conjugation: DMPI is ideal for conjugating peptides to proteins or other molecules, enabling the study of molecular interactions and functional modifications.\u003c\/li\u003e\n\u003cli\u003eStructural Biology Research: It supports the analysis of molecular structures by allowing the crosslinking of specific amino acid residues, aiding in the understanding of protein folding and dynamics.\u003c\/li\u003e\n\u003cli\u003eDrug Discovery: DMPI facilitates the development of novel therapeutics by enabling the modification of peptide-based drugs to enhance their stability and bioavailability.\u003c\/li\u003e\n\u003cli\u003eBioconjugate Development: It is used to create bioconjugates for diagnostic and therapeutic applications, offering precise control over molecular linkages.\u003c\/li\u003e\n\u003cli\u003eMolecular Stability Studies: DMPI helps in assessing the stability of biomolecules under various conditions, contributing to the optimization of biopharmaceutical formulations.\u003c\/li\u003e\n\u003c\/ul\u003e\n\u003ch3\u003eSpecifications\u003c\/h3\u003e\n\u003cul\u003e\n\u003cli\u003eBrand: TCI\u003c\/li\u003e\n\u003cli\u003eCAS number: 58537-94-3\u003c\/li\u003e\n\u003cli\u003eCategory: Chemistry \u0026gt; Chemical Biology \u0026gt; Linkers and Crosslinkers\u003c\/li\u003e\n\u003cli\u003ePack sizes: Available in various quantities as per standard laboratory supply\u003c\/li\u003e\n\u003cli\u003ePhysical form: Solid powder\u003c\/li\u003e\n\u003cli\u003eStorage note: Store in a cool, dry place away from moisture and light\u003c\/li\u003e\n\u003c\/ul\u003e\n\u003ch3\u003eHandling and Storage\u003c\/h3\u003e\n\u003cp\u003eDMPI should be stored in a cool, dry place, away from moisture and direct light to maintain its chemical stability. It is recommended to use airtight containers to prevent exposure to humidity, which could affect its reactivity. In a laboratory setting, it should be handled with appropriate personal protective equipment, such as gloves and safety goggles, to ensure safety during use. Proper ventilation is also important when working with this compound to minimize inhalation risks. Due to its chemical nature, it should be stored separately from incompatible substances to prevent any potential reactions. Regular inspection of storage conditions is advised to ensure the integrity of the material remains unaffected.\u003c\/p\u003e","brand":"TCI","offers":[{"title":"5g","offer_id":48088003805402,"sku":"TCI2510P089246391","price":3131000.0,"currency_code":"IDR","in_stock":true},{"title":"25g","offer_id":48088003838170,"sku":"TCI2510P089246392","price":7976000.0,"currency_code":"IDR","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0756\/7156\/8602\/files\/TCI2510P0892.jpg?v=1767133915"},{"product_id":"tci2510s039850224","title":"TCI S0398 58626-38-3 N-Succinimidyl 3-Maleimidobenzoate [Cross-linking Reagent]","description":"\u003cp\u003e\u003cstrong\u003eN-Succinimidyl 3-Maleimidobenzoate [Cross-linking Reagent]\u003c\/strong\u003e (CAS 58626-38-3) is a high-quality chemical from TCI, supplied as \u003cstrong\u003eHPLC Grade\u003c\/strong\u003e.\u003c\/p\u003e\u003cp\u003e\u003cstrong\u003eApplication:\u003c\/strong\u003e Synthesis reagent for a wide range of organic 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Indonesia.\u003c\/p\u003e","brand":"TCI","offers":[{"title":"100mg","offer_id":48088248910042,"sku":"TCI2510S039850224","price":1237000.0,"currency_code":"IDR","in_stock":true},{"title":"1g","offer_id":48088248942810,"sku":"TCI2510S039850225","price":6008000.0,"currency_code":"IDR","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0756\/7156\/8602\/files\/TCI2510S0398.jpg?v=1767138733"},{"product_id":"tci2510s042750234","title":"TCI S0427 55750-62-4 N-Succinimidyl 3-Maleimidopropionate [Cross-linking Reagent]","description":"\u003cp\u003e\u003cstrong\u003eN-Succinimidyl 3-Maleimidopropionate [Cross-linking Reagent]\u003c\/strong\u003e (CAS 55750-62-4) is a high-quality chemical from TCI, supplied as \u003cstrong\u003eHPLC Grade\u003c\/strong\u003e.\u003c\/p\u003e\u003cp\u003e\u003cstrong\u003eApplication:\u003c\/strong\u003e Synthesis reagent for a wide range of organic chemistry transformations in laboratory and industrial settings.\u003c\/p\u003e\u003cp\u003e\u003cstrong\u003eSpecifications:\u003c\/strong\u003e\u003c\/p\u003e\u003cul\u003e\n\u003cli\u003eMolecular formula: C11H10N2O6\u003c\/li\u003e\n\u003cli\u003eCAS number: 55750-62-4\u003c\/li\u003e\n\u003cli\u003ePurity: \u0026gt;98.0%(HPLC)(N)\u003c\/li\u003e\n\u003cli\u003eTCI product code: S0427\u003c\/li\u003e\n\u003c\/ul\u003e\u003cp\u003e\u003cstrong\u003eSynonyms:\u003c\/strong\u003e 3-Maleimidopropionic Acid N-Succinimidyl Ester; N-(3-Maleimidopropionyloxy)succinimide; BMPS\u003c\/p\u003e\u003cp\u003eAvailable from \u003cstrong\u003eAMI Scientific\u003c\/strong\u003e, the authorised TCI distributor in Indonesia. \u003cstrong\u003eContact us for pricing and stock availability\u003c\/strong\u003e — we ship throughout Indonesia.\u003c\/p\u003e","brand":"TCI","offers":[{"title":"100mg","offer_id":48088249630938,"sku":"TCI2510S042750234","price":1389000.0,"currency_code":"IDR","in_stock":true},{"title":"1g","offer_id":48088249663706,"sku":"TCI2510S042750235","price":4140000.0,"currency_code":"IDR","in_stock":true},{"title":"5g","offer_id":48088249696474,"sku":"TCI2510S042750236","price":12367000.0,"currency_code":"IDR","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0756\/7156\/8602\/files\/TCI2510S0427.jpg?v=1767138756"},{"product_id":"tci2510s084450480","title":"TCI S0844 39028-27-8 N-Succinimidyl Iodoacetate","description":"\u003cp\u003e\u003cstrong\u003eN-Succinimidyl Iodoacetate\u003c\/strong\u003e (CAS 39028-27-8) is a high-quality chemical from TCI, supplied as \u003cstrong\u003eReagent Grade \/ for Synthesis\u003c\/strong\u003e.\u003c\/p\u003e\u003cp\u003e\u003cstrong\u003eApplication:\u003c\/strong\u003e Synthesis reagent for a wide range of organic chemistry 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