{"title":"DNA Alkylating Agents","description":"\u003cp\u003e\u003cstrong\u003eDNA Alkylating Agents\u003c\/strong\u003e — menghimpun senyawa pengalkilasi DNA seperti turunan oksazafosforin dan tiofosforamida yang berperan sebagai senyawa acuan untuk riset mekanisme alkilasi untai DNA serta interaksi genotoksik dalam model eksperimen biologi molekuler dan penelitian antitumor praklinis.\u003c\/p\u003e\u003cp\u003eDNA Alkylating Agents seperti tiotepa, siklofosfamid, dan ifosfamid dipakai peneliti sebagai model eksperimen untuk mempelajari mekanisme pembentukan ikatan silang (cross-link) pada untai DNA serta jalur respons kerusakan DNA sel. Senyawa ini juga menjadi acuan pembanding dalam penelitian farmakologi praklinis terkait pengembangan agen antitumor baru dan studi hubungan struktur-aktivitas.\u003c\/p\u003e\u003cp\u003eContoh produk dalam koleksi ini: \u003ca href=\"\/en\/products\/tci2510t418455931\"\u003eTCI T4184 52-24-4 Thiotepa\u003c\/a\u003e, \u003ca href=\"\/en\/products\/tci2510c223616934\"\u003eTCI C2236 6055-19-2 Cyclophosphamide Monohydrate\u003c\/a\u003e, \u003ca href=\"\/en\/products\/tci2510i071335946\"\u003eTCI I0713 3778-73-2 Ifosfamide\u003c\/a\u003e.\u003c\/p\u003e\u003cp\u003ePerhatikan kemurnian dan bentuk (anhidrat atau hidrat) senyawa karena memengaruhi kelarutan pada uji in vitro, serta kondisi penyimpanan yang menjaga stabilitas struktur alkilasi sebelum digunakan dalam eksperimen. Seluruh produk merupakan produk asli Tokyo Chemical Industry (TCI) Jepang, dengan kemurnian, kemasan, dan kondisi penyimpanan tercantum pada halaman masing-masing item.\u003c\/p\u003e\u003cp\u003eKategori lain yang sejajar di bawah Antitumor Research Reagents (for Experimental Use), sering dipakai bersamaan dalam satu alur kerja laboratorium:\u003c\/p\u003e\u003cul\u003e\n\u003cli\u003e\u003ca href=\"\/en\/collections\/tci-l4-pharmaceutical-research-reagents-others\"\u003ePharmaceutical Research Reagents (Others)\u003c\/a\u003e\u003c\/li\u003e\n\u003cli\u003e\u003ca href=\"\/en\/collections\/tci-l4-neurotransmitter-agent-ingredients-for-research-and-experimental-use\"\u003eNeurotransmitter Agent Ingredients (for Research and Experimental Use)\u003c\/a\u003e\u003c\/li\u003e\n\u003cli\u003e\u003ca href=\"\/en\/collections\/tci-l4-antihypertensive-ingredients-for-research-and-experimental-use\"\u003eAntihypertensive Ingredients (for Research and Experimental Use)\u003c\/a\u003e\u003c\/li\u003e\n\u003cli\u003e\u003ca href=\"\/en\/collections\/tci-l4-cosmetic-research-reagents-for-experimental-use\"\u003eCosmetic Research Reagents (for Experimental Use)\u003c\/a\u003e\u003c\/li\u003e\n\u003cli\u003e\u003ca href=\"\/en\/collections\/tci-l4-anti-osteoporosis-ingredients-for-research-and-experimental-use\"\u003eAnti-osteoporosis Ingredients (for Research and Experimental Use)\u003c\/a\u003e\u003c\/li\u003e\n\u003cli\u003e\u003ca href=\"\/en\/collections\/tci-l4-immunosuppressant-ingredients-for-research-and-experimental-use\"\u003eImmunosuppressant Ingredients (for Research and Experimental Use)\u003c\/a\u003e\u003c\/li\u003e\n\u003c\/ul\u003e\u003cp\u003eKembali ke \u003ca href=\"\/en\/collections\/tci-l4-antitumor-research-reagents-for-experimental-use\"\u003eAntitumor Research Reagents (for Experimental Use)\u003c\/a\u003e. Untuk pengadaan volume besar, kemasan khusus, atau grade tertentu, hubungi tim AMI Scientific — distributor resmi TCI Japan di Indonesia — untuk pengecekan ketersediaan dan lead time langsung ke Jepang.\u003c\/p\u003e","products":[{"product_id":"tci2510c223616934","title":"TCI C2236 6055-19-2 Cyclophosphamide Monohydrate","description":"\u003ch3\u003eDescription\u003c\/h3\u003e\n\u003cp\u003eTCI C2236 Cyclophosphamide Monohydrate is an oxazaphosphorine compound supplied in its monohydrate form, widely recognised as an alkylating agent and used as a research reagent in pharmaceutical development and in the study of drug delivery systems. The compound is a classic prodrug: the molecule only becomes active after undergoing metabolic transformation, and it is precisely this property that makes it such a valuable model in the laboratory. Researchers use it to study prodrug activation, the mechanisms of DNA damage caused by alkylating agents, and the behaviour of the active species once it has been formulated into a carrier system.\u003c\/p\u003e\n\u003cp\u003eThe properties that lead researchers to select this material begin with how thoroughly it has been documented in the scientific literature, which means experimental results can be compared against a large body of earlier references rather than interpreted in isolation. The monohydrate form yields a crystalline solid that is easier to handle and to weigh consistently than the more sensitive anhydrous form, an advantage in any workflow that depends on reproducible sample preparation. Its solubility in water simplifies the preparation of test solutions, while its prodrug character makes the compound a standard comparator in formulation research, particularly when investigators want to assess whether a given carrier system successfully alters the behaviour of the parent molecule.\u003c\/p\u003e\n\u003cp\u003eIn Indonesian laboratories this reagent is typically found in pharmaceutical faculties, in pharmacology and biomedical research groups, and in drug delivery laboratories developing carrier systems. It supports postgraduate research projects, method development work, and comparative formulation studies where a well characterised prodrug is required as a reference point. Because its behaviour is already established in the literature, it is frequently chosen for teaching-linked research and for laboratories building experimental protocols that need to be defensible against published data.\u003c\/p\u003e\n\u003ch3\u003eLaboratory Applications\u003c\/h3\u003e\n\u003cul\u003e\n\u003cli\u003eProdrug activation studies — the compound only becomes active after metabolic transformation, making it a reliable model for tracing how an inactive molecule is converted into its working form.\u003c\/li\u003e\n\u003cli\u003eAlkylating agent mechanism research — it is used to investigate how alkylating agents cause DNA damage, a mechanism that is extensively described in the existing scientific literature.\u003c\/li\u003e\n\u003cli\u003eDrug delivery system development — researchers formulate it into carrier systems to observe how the active species behaves once it has been incorporated into a delivery vehicle.\u003c\/li\u003e\n\u003cli\u003eFormulation comparison work — its prodrug character makes it a standard comparator for assessing whether a carrier system successfully changes the behaviour of the parent compound.\u003c\/li\u003e\n\u003cli\u003eAqueous test solution preparation — its solubility in water allows straightforward preparation of test solutions, supporting experimental designs that require consistent, easily reproduced sample handling.\u003c\/li\u003e\n\u003c\/ul\u003e\n\u003ch3\u003eSpecifications\u003c\/h3\u003e\n\u003cul\u003e\n\u003cli\u003eBrand: TCI\u003c\/li\u003e\n\u003cli\u003eCAS number: 6055-19-2\u003c\/li\u003e\n\u003cli\u003eCategory: Chemistry \u0026gt; Pharmaceutical Development and Drug Discovery Research Reagents \u0026gt; Drug Delivery Systems (DDS)\u003c\/li\u003e\n\u003cli\u003ePack sizes: available in standard laboratory pack sizes; please confirm the currently listed options when ordering\u003c\/li\u003e\n\u003cli\u003ePhysical form: crystalline solid, supplied as the monohydrate\u003c\/li\u003e\n\u003cli\u003eStorage: store according to the manufacturer's instructions on the product label and safety data sheet\u003c\/li\u003e\n\u003c\/ul\u003e\n\u003ch3\u003eHandling and Storage\u003c\/h3\u003e\n\u003cp\u003eStore the container closed in a cool, dry place away from direct sunlight, moisture, and incompatible materials, following the storage conditions stated by the manufacturer on the product label and safety data sheet. Keep the material in its original tightly sealed container, or in a clean, chemically compatible and clearly labelled vessel if it is subdivided. Handle the solid in a well ventilated area or fume hood, and wear appropriate personal protective equipment including gloves, safety goggles, and a laboratory coat. Because this is a cytotoxic research reagent, avoid inhalation of dust and any contact with skin or eyes, minimise the generation of airborne particles during weighing, and restrict handling to trained personnel. Consult the safety data sheet before use, and dispose of the material and any contaminated consumables through approved chemical waste channels in accordance with institutional and local regulations.\u003c\/p\u003e","brand":"TCI","offers":[{"title":"5g","offer_id":48086113452250,"sku":"TCI2510C223616934","price":3908000.0,"currency_code":"IDR","in_stock":true},{"title":"25g","offer_id":48086113485018,"sku":"TCI2510C223616935","price":13127000.0,"currency_code":"IDR","in_stock":true},{"title":"1g","offer_id":48086113517786,"sku":"TCI2604C2236100","price":1266000.0,"currency_code":"IDR","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0756\/7156\/8602\/files\/TCI2510C2236.jpg?v=1767097973"},{"product_id":"tci2510i071335946","title":"TCI I0713 3778-73-2 Ifosfamide","description":"\u003cp\u003e\u003cstrong\u003eIfosfamide\u003c\/strong\u003e (CAS 3778-73-2) is a high-quality chemical from TCI, supplied as \u003cstrong\u003eGC Grade \/ for Synthesis\u003c\/strong\u003e.\u003c\/p\u003e\u003cp\u003e\u003cstrong\u003eApplication:\u003c\/strong\u003e Synthesis reagent for a wide range of organic chemistry transformations in laboratory and industrial settings.\u003c\/p\u003e\u003cp\u003e\u003cstrong\u003eSpecifications:\u003c\/strong\u003e\u003c\/p\u003e\u003cul\u003e\n\u003cli\u003eMolecular formula: C7H15Cl2N2O2P\u003c\/li\u003e\n\u003cli\u003eCAS number: 3778-73-2\u003c\/li\u003e\n\u003cli\u003ePurity: \u0026gt;95.0%(GC)(T)\u003c\/li\u003e\n\u003cli\u003eTCI product code: I0713\u003c\/li\u003e\n\u003c\/ul\u003e\u003cp\u003e\u003cstrong\u003eSynonyms:\u003c\/strong\u003e N,3-Bis(2-chloroethyl)-1,3,2-oxazaphosphinan-2-amine 2-Oxide; 3-(2-Chloroethyl)-2-[(2-chloroethyl)amino]-1,3,2-oxazaphosphinane 2-Oxide; Isophosphamide\u003c\/p\u003e\u003cp\u003eAvailable from \u003cstrong\u003eAMI Scientific\u003c\/strong\u003e, the authorised TCI distributor in Indonesia. \u003cstrong\u003eContact us for pricing and stock availability\u003c\/strong\u003e — we ship throughout Indonesia.\u003c\/p\u003e","brand":"TCI","offers":[{"title":"1g","offer_id":48087407919322,"sku":"TCI2510I071335946","price":4807000.0,"currency_code":"IDR","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0756\/7156\/8602\/files\/TCI2510I0713.jpg?v=1768205615"}],"url":"https:\/\/amiscientific.com\/en\/collections\/tci-l4-dna-alkylating-agents.oembed","provider":"AMI Scientific","version":"1.0","type":"link"}