{"title":"Ferroptosis Activators","description":"\u003cp\u003e\u003cstrong\u003eFerroptosis Activators\u003c\/strong\u003e — menghimpun senyawa yang digunakan dalam riset biologi sel untuk memicu ferroptosis, yaitu bentuk kematian sel teregulasi yang bergantung pada akumulasi zat besi dan peroksidasi lipid, melalui berbagai jalur molekuler seperti penghambatan sistem antiporter sistin-glutamat.\u003c\/p\u003e\u003cp\u003eSenyawa pemicu ferroptosis ini dipakai peneliti kanker dan biologi molekuler untuk mempelajari mekanisme kematian sel non-apoptotik pada model sel maupun hewan. Erastin dan turunannya umum dipakai sebagai penginduksi ferroptosis rujukan dalam skrining, sementara senyawa lain seperti sulfasalazine bekerja melalui penghambatan transporter xCT sehingga menurunkan kadar glutation intraseluler dan meningkatkan kerentanan sel terhadap stres oksidatif.\u003c\/p\u003e\u003cp\u003eContoh produk dalam koleksi ini: \u003ca href=\"\/en\/products\/tci2510s058050396\"\u003eTCI S0580 599-79-1 Sulfasalazine\u003c\/a\u003e, \u003ca href=\"\/en\/products\/tci2510e152429572\"\u003eTCI E1524 571203-78-6 Erastin\u003c\/a\u003e, \u003ca href=\"\/en\/products\/tci2510s050950334\"\u003eTCI S0509 79902-63-9 Simvastatin\u003c\/a\u003e, \u003ca href=\"\/en\/products\/tci2510g005931643\"\u003eTCI G0059 56-86-0 L-Glutamic Acid\u003c\/a\u003e.\u003c\/p\u003e\u003cp\u003ePemilihan senyawa perlu disesuaikan dengan jalur ferroptosis yang ingin diteliti, baik melalui penghambatan xCT, penipisan glutation, atau jalur lain, serta memperhatikan kemurnian dan kelarutan senyawa dalam pelarut uji. Seluruh produk merupakan produk asli Tokyo Chemical Industry (TCI) Jepang, dengan kemurnian, kemasan, dan kondisi penyimpanan tercantum pada halaman masing-masing item.\u003c\/p\u003e\u003cp\u003eKategori lain yang sejajar di bawah Ferroptosis, sering dipakai bersamaan dalam satu alur kerja laboratorium:\u003c\/p\u003e\u003cul\u003e\n\u003cli\u003e\u003ca href=\"\/en\/collections\/tci-l4-ferroptosis-inhibitors\"\u003eFerroptosis Inhibitors\u003c\/a\u003e\u003c\/li\u003e\n\u003cli\u003e\u003ca href=\"\/en\/collections\/tci-l3-nutrition-research\"\u003eNutrition Research\u003c\/a\u003e\u003c\/li\u003e\n\u003cli\u003e\u003ca href=\"\/en\/collections\/tci-l3-cell-signaling-and-neuroscience\"\u003eCell Signaling and Neuroscience\u003c\/a\u003e\u003c\/li\u003e\n\u003cli\u003e\u003ca href=\"\/en\/collections\/tci-l3-cancer-research\"\u003eCancer Research\u003c\/a\u003e\u003c\/li\u003e\n\u003cli\u003e\u003ca href=\"\/en\/collections\/tci-l3-immune-system-inflammation-allergy-research\"\u003eImmune System, Inflammation, Allergy Research\u003c\/a\u003e\u003c\/li\u003e\n\u003cli\u003e\u003ca href=\"\/en\/collections\/tci-l3-bioactive-small-molecules\"\u003eBioactive Small Molecules\u003c\/a\u003e\u003c\/li\u003e\n\u003c\/ul\u003e\u003cp\u003eKembali ke \u003ca href=\"\/en\/collections\/tci-l3-ferroptosis\"\u003eFerroptosis\u003c\/a\u003e. Untuk pengadaan volume besar, kemasan khusus, atau grade tertentu, hubungi tim AMI Scientific — distributor resmi TCI Japan di Indonesia — untuk pengecekan ketersediaan dan lead time langsung ke Jepang.\u003c\/p\u003e","products":[{"product_id":"tci2510e152429572","title":"TCI E1524 571203-78-6 Erastin","description":"\u003ch3\u003eDescription\u003c\/h3\u003e\n\u003cp\u003eErastin is a small-molecule compound widely recognised as an inducer of ferroptosis, a form of programmed cell death that depends on iron and is characterised by the accumulation of lipid peroxides. The compound has become a classic reference tool in cell biology because it inhibits the cystine–glutamate transport system at the cell membrane. As cystine supply falls, glutathione synthesis is disrupted and the antioxidant defences of the cell collapse. In the laboratory, erastin is used as a pharmacological tool to trigger ferroptosis in a controlled manner in cell culture and to study the molecular pathways that accompany it.\u003c\/p\u003e\n\u003cp\u003eThe added value of erastin lies in its specific mechanism of action, which is already well documented in the scientific literature, so that experimental results can be compared easily between laboratories. The compound is active at low concentrations and is soluble in organic solvents such as dimethyl sulfoxide, which makes the preparation of stock solutions straightforward. Its effects can also be reversed by ferroptosis inhibitors. That last property is particularly useful, because it allows researchers to perform rescue experiments to confirm that the cell death observed genuinely proceeds through the ferroptosis pathway rather than through apoptosis or ordinary necrosis.\u003c\/p\u003e\n\u003cp\u003eIn Indonesian laboratories, erastin is typically used in cell biology and life science research groups working on cell death mechanisms, in university research units, and in institutional laboratories that maintain cell culture facilities. It is generally handled as a stock solution in dimethyl sulfoxide, prepared in small volumes and applied to cultured cells at low working concentrations. Because it is supplied in a 5 mg pack, it suits research groups that run a defined series of controlled ferroptosis experiments.\u003c\/p\u003e\n\u003ch3\u003eLaboratory Applications\u003c\/h3\u003e\n\u003cul\u003e\n\u003cli\u003eControlled induction of ferroptosis in cell culture, because erastin acts through a specific and well-documented mechanism that allows cell death to be triggered reproducibly in experimental systems.\u003c\/li\u003e\n\u003cli\u003eStudy of the cystine–glutamate transport system, since erastin inhibits this membrane transporter directly and therefore lets researchers observe the downstream consequences on cystine supply.\u003c\/li\u003e\n\u003cli\u003eInvestigation of glutathione metabolism and antioxidant defence, as the reduced cystine supply caused by erastin disrupts glutathione synthesis and exposes how cells depend on that pathway.\u003c\/li\u003e\n\u003cli\u003eRescue experiments using ferroptosis inhibitors, because the effects of erastin are reversible and can therefore be used to confirm that observed cell death truly follows the ferroptosis route.\u003c\/li\u003e\n\u003cli\u003eDiscrimination between cell death pathways in mechanistic research, since erastin provides a defined ferroptosis stimulus that can be compared against apoptosis or ordinary necrosis in the same experimental design.\u003c\/li\u003e\n\u003c\/ul\u003e\n\u003ch3\u003eSpecifications\u003c\/h3\u003e\n\u003cul\u003e\n\u003cli\u003eBrand: TCI\u003c\/li\u003e\n\u003cli\u003eCatalogue number: E1524\u003c\/li\u003e\n\u003cli\u003eCAS number: 571203-78-6\u003c\/li\u003e\n\u003cli\u003eCategory: Life Science \u0026gt; Cell Biology \u0026gt; Ferroptosis\u003c\/li\u003e\n\u003cli\u003ePack size: 5 mg\u003c\/li\u003e\n\u003cli\u003eSolubility note: soluble in organic solvents such as dimethyl sulfoxide, suitable for stock solution preparation\u003c\/li\u003e\n\u003c\/ul\u003e\n\u003ch3\u003eHandling and Storage\u003c\/h3\u003e\n\u003cp\u003eStore the compound according to the storage conditions stated on the manufacturer's label and product documentation, keeping the container tightly closed and protected from moisture. Stock solutions prepared in dimethyl sulfoxide should be kept in clean, well-sealed vials that are clearly labelled with the compound name, concentration, solvent and preparation date, and divided into small aliquots to limit repeated handling of the whole batch. Handle the material in a laboratory with adequate ventilation, using standard personal protective equipment such as a laboratory coat, gloves and eye protection. Because erastin is a biologically active compound intended for research use, preparation and weighing should be carried out by trained personnel following the internal laboratory procedures and the safety data sheet supplied with the product.\u003c\/p\u003e","brand":"TCI","offers":[{"title":"5mg","offer_id":48086966894810,"sku":"TCI2510E152429572","price":4610000.0,"currency_code":"IDR","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0756\/7156\/8602\/files\/TCI2510E1524.jpg?v=1768818845"},{"product_id":"tci2510g005931643","title":"TCI G0059 56-86-0 L-Glutamic Acid","description":"\u003ch3\u003eDescription\u003c\/h3\u003e\n\u003cp\u003eL-Glutamic Acid is a chemical compound widely used in various laboratory applications, particularly in organic synthesis and chemical analysis. This compound plays a crucial role in chiral resolution processes, where it is employed as a resolving agent to separate enantiomers. Its unique molecular structure, featuring both a carboxyl group and an amino group, enables complex chemical reactions and interactions. In the laboratory, it is a key reagent for achieving high precision in chiral separation techniques, making it essential for researchers working in asymmetric synthesis and related fields.\u003c\/p\u003e\n\u003cp\u003eThe properties of L-Glutamic Acid that make it a preferred choice include its chemical stability under controlled conditions and its ability to interact with a variety of reagents and catalysts. Its molecular structure allows it to form diastereomeric salts with chiral compounds, facilitating their separation through crystallization or chromatographic methods. Additionally, its solubility characteristics and compatibility with common laboratory solvents enhance its utility in diverse chemical processes. These features make it a reliable and versatile reagent for advanced chemical research.\u003c\/p\u003e\n\u003cp\u003eIn Indonesian laboratories, L-Glutamic Acid is commonly used in academic and industrial research settings. It is particularly favored in pharmaceutical and biochemical research for its role in chiral resolution. Its availability in solid form and ease of handling make it a popular choice among chemists and researchers. Its application in both teaching and research laboratories supports the development of new chemical methodologies and compounds.\u003c\/p\u003e\n\u003ch3\u003eLaboratory Applications\u003c\/h3\u003e\n\u003cul\u003e\n\u003cli\u003eChiral Resolution: L-Glutamic Acid is ideal for resolving enantiomers due to its ability to form diastereomeric salts with chiral compounds, enabling effective separation through crystallization or chromatography.\u003c\/li\u003e\n\u003cli\u003eOrganic Synthesis: Its unique molecular structure allows it to participate in various synthetic reactions, making it a valuable reagent for creating complex organic molecules with high stereochemical control.\u003c\/li\u003e\n\u003cli\u003eBiochemical Research: It is widely used in biochemical studies to analyze the behavior of chiral compounds and their biological activity, supporting research in drug development and metabolic processes.\u003c\/li\u003e\n\u003cli\u003eAnalytical Chemistry: Its chemical stability and reactivity make it suitable for use in analytical techniques that require precise separation and identification of chiral substances.\u003c\/li\u003e\n\u003cli\u003eTeaching and Training: L-Glutamic Acid is often used in educational settings to demonstrate chiral resolution techniques and to train students in advanced chemical methods.\u003c\/li\u003e\n\u003c\/ul\u003e\n\u003ch3\u003eSpecifications\u003c\/h3\u003e\n\u003cul\u003e\n\u003cli\u003eBrand: TCI\u003c\/li\u003e\n\u003cli\u003eCAS number: 56-86-0\u003c\/li\u003e\n\u003cli\u003eCategory: Chemistry \u0026gt; Asymmetric Synthesis \u0026gt; Chiral Resolution Reagents\u003c\/li\u003e\n\u003cli\u003ePack sizes: Available in various quantities as per supplier specifications\u003c\/li\u003e\n\u003cli\u003ePhysical form: Solid\u003c\/li\u003e\n\u003cli\u003eStorage note: Store in a cool, dry place away from moisture and direct sunlight\u003c\/li\u003e\n\u003c\/ul\u003e\n\u003ch3\u003eHandling and Storage\u003c\/h3\u003e\n\u003cp\u003eL-Glutamic Acid should be stored in a cool, dry environment to maintain its chemical stability. It is recommended to keep it in airtight containers to prevent exposure to moisture, which can affect its integrity. While it is generally stable under normal laboratory conditions, it should be protected from high temperatures and excessive humidity. Proper labeling of storage containers is essential to ensure safe handling and prevent cross-contamination. In laboratory settings, it is advisable to use gloves and appropriate safety equipment when handling this compound to minimize any potential risks. Regular monitoring of storage conditions will help maintain the quality and effectiveness of the material for research purposes.\u003c\/p\u003e","brand":"TCI","offers":[{"title":"25g","offer_id":48087087579354,"sku":"TCI2510G005931643","price":507000.0,"currency_code":"IDR","in_stock":true},{"title":"500g","offer_id":48087087612122,"sku":"TCI2510G005931644","price":1153000.0,"currency_code":"IDR","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0756\/7156\/8602\/files\/TCI2510G0059.jpg?v=1767114549"},{"product_id":"tci2510s058050396","title":"TCI S0580 599-79-1 Sulfasalazine","description":"\u003cp\u003e\u003cstrong\u003eSulfasalazine\u003c\/strong\u003e (CAS 599-79-1) is a high-quality chemical from TCI, supplied as \u003cstrong\u003eHPLC Grade\u003c\/strong\u003e.\u003c\/p\u003e\u003cp\u003e\u003cstrong\u003eApplication:\u003c\/strong\u003e Synthesis reagent for a wide range of organic chemistry transformations in laboratory and industrial settings.\u003c\/p\u003e\u003cp\u003e\u003cstrong\u003eSpecifications:\u003c\/strong\u003e\u003c\/p\u003e\u003cul\u003e\n\u003cli\u003eMolecular formula: C18H14N4O5S\u003c\/li\u003e\n\u003cli\u003eCAS number: 599-79-1\u003c\/li\u003e\n\u003cli\u003ePurity: \u0026gt;95.0%(HPLC)(T)\u003c\/li\u003e\n\u003cli\u003eTCI product code: S0580\u003c\/li\u003e\n\u003c\/ul\u003e\u003cp\u003e\u003cstrong\u003eSynonyms:\u003c\/strong\u003e 5-[4-(2-Pyridylsulfamoyl)phenylazo]salicylic Acid\u003c\/p\u003e\u003cp\u003eAvailable from \u003cstrong\u003eAMI Scientific\u003c\/strong\u003e, the authorised TCI distributor in Indonesia. \u003cstrong\u003eContact us for pricing and stock availability\u003c\/strong\u003e — we ship throughout Indonesia.\u003c\/p\u003e","brand":"TCI","offers":[{"title":"25g","offer_id":48088259264730,"sku":"TCI2510S058050396","price":3458000.0,"currency_code":"IDR","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0756\/7156\/8602\/files\/TCI2510S0580.jpg?v=1768206287"}],"url":"https:\/\/amiscientific.com\/en\/collections\/tci-l4-ferroptosis-activators.oembed","provider":"AMI Scientific","version":"1.0","type":"link"}