{"title":"Olefination [C-C Bond Formation]","description":"\u003cp\u003e\u003cstrong\u003eOlefination [C-C Bond Formation]\u003c\/strong\u003e — mencakup reagen fosfonium dan fosfonat yang digunakan untuk membentuk ikatan rangkap karbon-karbon melalui reaksi olefinasi seperti Wittig maupun Horner-Wadsworth-Emmons, termasuk garam fosfonium tersubstitusi beragam gugus fungsi dan pereaksi pendukung seperti titanium(IV) klorida.\u003c\/p\u003e\u003cp\u003eOlefination [C-C Bond Formation] dipakai dalam sintesis alkena tersubstitusi pada berbagai tahap total sintesis molekul organik kompleks, termasuk produk alam dan senyawa aktif farmasi. Ahli kimia sintetik memanfaatkan garam fosfonium seperti ylide Wittig untuk mengubah gugus aldehida atau keton menjadi ikatan rangkap dengan selektivitas geometri tertentu, sementara reagen fosfonat digunakan pada reaksi Horner-Wadsworth-Emmons untuk hasil yang lebih terkontrol.\u003c\/p\u003e\u003cp\u003eContoh produk dalam koleksi ini: \u003ca href=\"\/en\/products\/tci2510t431456067\"\u003eTCI T4314 24720-64-7 2-(Triphenylphosphoranylidene)propanal\u003c\/a\u003e, \u003ca href=\"\/en\/products\/tci2510b573012457\"\u003eTCI B5730 13371-17-0 Butyltriphenylphosphonium Chloride\u003c\/a\u003e, \u003ca href=\"\/en\/products\/tci2510t390455617\"\u003eTCI T3904 136455-49-7 Octaethyl [Benzene-1,2,4,5-tetrayltetrakis(methylene)]tetrakis(phosphonate)\u003c\/a\u003e, \u003ca href=\"\/en\/products\/tci2510c100915388\"\u003eTCI C1009 5293-84-5 (Chloromethyl)triphenylphosphonium Chloride\u003c\/a\u003e, \u003ca href=\"\/en\/products\/tci2510t323854803\"\u003eTCI T3238 7550-45-0 Titanium(IV) Chloride (ca 19% in Toluene, ca 10mol\/L)\u003c\/a\u003e, \u003ca href=\"\/en\/products\/tci2510c106115457\"\u003eTCI C1061 17814-85-6 4-(Carboxybutyl)triphenylphosphonium Bromide\u003c\/a\u003e, \u003ca href=\"\/en\/products\/tci2510t271854139\"\u003eTCI T2718 115754-62-6 Tributyl(1,3-dioxolan-2-ylmethyl)phosphonium Bromide\u003c\/a\u003e, \u003ca href=\"\/en\/products\/tci2510c128615772\"\u003eTCI C1286 7310-74-9 Cinnamyltriphenylphosphonium Bromide\u003c\/a\u003e.\u003c\/p\u003e\u003cp\u003ePemilihan reagen perlu mempertimbangkan gugus pelepas pada fosfonium, kestabilan terhadap kelembapan, serta bentuk fisik pereaksi seperti larutan dalam pelarut tertentu untuk memudahkan penanganan di laboratorium. Seluruh produk merupakan produk asli Tokyo Chemical Industry (TCI) Jepang, dengan kemurnian, kemasan, dan kondisi penyimpanan tercantum pada halaman masing-masing item.\u003c\/p\u003e\u003cp\u003eKategori lain yang sejajar di bawah C-C Bond Formation [Synthetic Reagents], sering dipakai bersamaan dalam satu alur kerja laboratorium:\u003c\/p\u003e\u003cul\u003e\n\u003cli\u003e\u003ca href=\"\/en\/collections\/tci-l4-cross-coupling-reaction-using-transition-metal-catalysts-c-c-bond-formation\"\u003eCross-coupling Reaction using Transition Metal Catalysts [C-C Bond Formation]\u003c\/a\u003e\u003c\/li\u003e\n\u003cli\u003e\u003ca href=\"\/en\/collections\/tci-l4-weinreb-amides-c-c-bond-formation\"\u003eWeinreb Amides [C-C Bond Formation]\u003c\/a\u003e\u003c\/li\u003e\n\u003cli\u003e\u003ca href=\"\/en\/collections\/tci-l4-c-c-bond-formation-other-synthetic-reagents\"\u003eC-C Bond Formation (Other) [Synthetic Reagents]\u003c\/a\u003e\u003c\/li\u003e\n\u003cli\u003e\u003ca href=\"\/en\/collections\/tci-l4-carbon-monoxide-surrogate-reagents-c-c-bond-formation\"\u003eCarbon Monoxide Surrogate Reagents [C-C Bond Formation]\u003c\/a\u003e\u003c\/li\u003e\n\u003c\/ul\u003e\u003cp\u003eKembali ke \u003ca href=\"\/en\/collections\/tci-l3-c-c-bond-formation-synthetic-reagents\"\u003eC-C Bond Formation [Synthetic Reagents]\u003c\/a\u003e. Untuk pengadaan volume besar, kemasan khusus, atau grade tertentu, hubungi tim AMI Scientific — distributor resmi TCI Japan di Indonesia — untuk pengecekan ketersediaan dan lead time langsung ke Jepang.\u003c\/p\u003e","products":[{"product_id":"tci2510d165521498","title":"TCI D1655 69891-92-5 2-(1,3-Dioxan-2-yl)ethyltriphenylphosphonium Bromide","description":"\u003ch3\u003eDescription\u003c\/h3\u003e\n\u003cp\u003e2-(1,3-Dioxan-2-yl)ethyltriphenylphosphonium Bromide is a synthetic reagent widely used in chemical laboratories for the formation of carbon-carbon bonds. It plays a crucial role in organic chemistry by facilitating substitution and coupling reactions under controlled conditions. This compound is particularly valuable for its ability to interact with various organic substrates, making it a versatile tool in synthetic chemistry. Its presence in laboratory workflows supports the development of complex organic molecules, contributing to advancements in chemical research and industrial applications.\u003c\/p\u003e\n\u003cp\u003eThe compound's chemical stability and controlled reactivity make it a preferred choice for researchers working in synthetic chemistry. Its complex molecular structure allows for precise reaction conditions, enabling high specificity in chemical transformations. The reagent's ability to participate in multiple reaction types, such as coupling and substitution, enhances its utility in diverse synthetic strategies. These properties ensure reliable performance across a range of experimental setups, making it a trusted component in both academic and industrial research environments.\u003c\/p\u003e\n\u003cp\u003eIn Indonesian laboratories, this reagent is commonly used in organic chemistry research, especially in the synthesis of complex compounds. It is a key material in laboratories focused on developing new chemical structures and improving synthetic methodologies. Its application is widespread in both academic and research settings, supporting the pursuit of innovative chemical solutions. The compound's reliability and effectiveness make it a standard choice for chemists working on advanced synthetic projects.\u003c\/p\u003e\n\u003ch3\u003eLaboratory Applications\u003c\/h3\u003e\n\u003cul\u003e\n\u003cli\u003eOrganic synthesis reactions where carbon-carbon bond formation is required due to its ability to facilitate coupling and substitution reactions.\u003c\/li\u003e\n\u003cli\u003eDevelopment of complex organic molecules in research settings where precise reactivity and selectivity are essential.\u003c\/li\u003e\n\u003cli\u003eCatalytic processes in chemical synthesis where controlled reactivity and stability are critical for successful outcomes.\u003c\/li\u003e\n\u003cli\u003eResearch in pharmaceutical and materials science where the formation of specific molecular structures is necessary.\u003c\/li\u003e\n\u003cli\u003eAnalytical applications in chemical testing where the compound's reactivity and stability support accurate and reproducible results.\u003c\/li\u003e\n\u003c\/ul\u003e\n\u003ch3\u003eSpecifications\u003c\/h3\u003e\n\u003cul\u003e\n\u003cli\u003eBrand: TCI\u003c\/li\u003e\n\u003cli\u003eCAS number: 69891-92-5\u003c\/li\u003e\n\u003cli\u003eCategory: Chemistry \u0026gt; Synthetic Reagents \u0026gt; C-C Bond Formation [Synthetic Reagents]\u003c\/li\u003e\n\u003cli\u003ePack sizes: Available in various quantities as per standard reagent packaging\u003c\/li\u003e\n\u003cli\u003ePhysical form: Solid or liquid, depending on the specific formulation\u003c\/li\u003e\n\u003cli\u003eStorage note: Store in a cool, dry place away from moisture and direct sunlight\u003c\/li\u003e\n\u003c\/ul\u003e\n\u003ch3\u003eHandling and Storage\u003c\/h3\u003e\n\u003cp\u003eThis reagent should be stored in a cool, dry environment to maintain its chemical stability and prevent degradation. It is recommended to keep it in a tightly sealed container to avoid exposure to moisture and air, which may affect its reactivity. Proper ventilation is essential when handling the compound to minimize inhalation risks. Avoid contact with skin and eyes, and use appropriate personal protective equipment such as gloves and safety goggles. The compound should be stored away from incompatible materials to ensure safety in the laboratory setting. Regular inspection of storage conditions is advised to ensure optimal preservation of the reagent's properties.\u003c\/p\u003e","brand":"TCI","offers":[{"title":"5g","offer_id":48086453911770,"sku":"TCI2510D165521498","price":2053000.0,"currency_code":"IDR","in_stock":true},{"title":"25g","offer_id":48086453944538,"sku":"TCI2510D165521499","price":8011000.0,"currency_code":"IDR","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0756\/7156\/8602\/files\/TCI2510D1655.jpg?v=1768204891"},{"product_id":"tci2510d205622095","title":"TCI D2056 86608-70-0 2-(1,3-Dioxolan-2-yl)ethyltriphenylphosphonium Bromide","description":"\u003ch3\u003eDescription\u003c\/h3\u003e\n\u003cp\u003eTCI D2056 2-(1,3-Dioxolan-2-yl)ethyltriphenylphosphonium Bromide is a phosphonium salt developed specifically as a reagent for carbon–carbon bond formation. The molecule consists of a central phosphorus atom bearing three phenyl groups together with an ethyl chain whose terminus carries a 1,3-dioxolane ring, that is, an aldehyde function already protected as a cyclic acetal. In the laboratory, this salt is converted into the corresponding phosphonium ylide with the aid of a base and then reacted with carbonyl compounds in the Wittig reaction, forming carbon–carbon double bonds in a directed and controlled manner.\u003c\/p\u003e\n\u003cp\u003eThe property that makes this reagent a preferred choice is the masked aldehyde group carried within the molecule. Once the Wittig olefination has taken place, the dioxolane ring can be reopened by acid hydrolysis to liberate a free aldehyde at the end of the newly formed chain. In other words, the reagent performs a chain extension while simultaneously leaving behind a reactive functional group for the next transformation, a strategy that is highly efficient in stepwise synthesis. As a solid phosphonium salt, the compound is also stable under ordinary storage, easy to weigh accurately, and does not demand handling as demanding as that required for organometallic reagents.\u003c\/p\u003e\n\u003cp\u003eIn Indonesian laboratories, this reagent is typically used in synthetic organic chemistry work at universities, research institutes, and industrial research units where multi-step synthesis routes are developed. It suits benchtop-scale Wittig olefination experiments, teaching and postgraduate research on carbonyl chemistry, and the preparation of intermediates that require a defined double bond followed by a recoverable aldehyde terminus. Its solid, easily weighed form fits routine laboratory practice without the elaborate infrastructure that more sensitive reagent classes would require.\u003c\/p\u003e\n\u003ch3\u003eLaboratory Applications\u003c\/h3\u003e\n\u003cul\u003e\n\u003cli\u003eWittig olefination of aldehydes and ketones: the salt is deprotonated to the ylide with a base and then delivers a controlled, directed carbon–carbon double bond at the former carbonyl position.\u003c\/li\u003e\n\u003cli\u003eHomologation and chain extension: the reagent lengthens a carbon skeleton in a single olefination step, giving synthetic chemists a predictable way to build up larger frameworks from simple carbonyl starting materials.\u003c\/li\u003e\n\u003cli\u003eProtected-aldehyde introduction: the 1,3-dioxolane ring carries the aldehyde in masked form through the olefination, so the sensitive function survives basic ylide conditions without competing side reactions.\u003c\/li\u003e\n\u003cli\u003eMulti-step synthesis of intermediates: after acid hydrolysis of the acetal, the liberated aldehyde terminus becomes the handle for further transformations, making the reagent valuable in stepwise route design.\u003c\/li\u003e\n\u003cli\u003eTeaching and research on carbonyl and ylide chemistry: as a stable, weighable solid phosphonium salt, it demonstrates ylide generation and Wittig methodology without the handling complexity of organometallic reagents.\u003c\/li\u003e\n\u003c\/ul\u003e\n\u003ch3\u003eSpecifications\u003c\/h3\u003e\n\u003cul\u003e\n\u003cli\u003eBrand: TCI\u003c\/li\u003e\n\u003cli\u003eCAS Number: 86608-70-0\u003c\/li\u003e\n\u003cli\u003eCategory: Chemistry \u0026gt; Synthetic Reagents \u0026gt; C-C Bond Formation [Synthetic Reagents]\u003c\/li\u003e\n\u003cli\u003eChemical name: 2-(1,3-Dioxolan-2-yl)ethyltriphenylphosphonium Bromide\u003c\/li\u003e\n\u003cli\u003ePhysical form: solid phosphonium salt\u003c\/li\u003e\n\u003cli\u003ePack sizes: available in the catalogue pack sizes offered for this product code\u003c\/li\u003e\n\u003cli\u003eStorage: stable under ordinary laboratory storage conditions\u003c\/li\u003e\n\u003c\/ul\u003e\n\u003ch3\u003eHandling and Storage\u003c\/h3\u003e\n\u003cp\u003eStore the reagent in a tightly closed original container, kept dry and protected from moisture, in a cool, well-ventilated chemical storage cabinet away from strong acids and sources of ignition. Because the acetal function is sensitive to acidic hydrolysis, avoid contact with acidic vapours during storage. Handle the solid in a fume hood, use a clean and dry spatula for weighing, and reseal the container promptly to limit moisture uptake. Wear a laboratory coat, chemical-resistant gloves, and safety goggles when weighing or transferring the material. Prepare ylide solutions only under the anhydrous conditions required by the reaction, and follow the safety data sheet supplied with the product for full handling, spillage, and disposal guidance.\u003c\/p\u003e","brand":"TCI","offers":[{"title":"5g","offer_id":48086490906842,"sku":"TCI2510D205622095","price":2390000.0,"currency_code":"IDR","in_stock":true},{"title":"25g","offer_id":48086490939610,"sku":"TCI2510D205622096","price":7562000.0,"currency_code":"IDR","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0756\/7156\/8602\/files\/TCI2510D2056.jpg?v=1768204910"},{"product_id":"tci2510d216422241","title":"TCI D2164 52509-14-5 (1,3-Dioxolan-2-yl)methyltriphenylphosphonium Bromide","description":"\u003ch3\u003eDescription\u003c\/h3\u003e\n\u003cp\u003eTCI D2164 (1,3-Dioxolan-2-yl)methyltriphenylphosphonium Bromide is a phosphonium salt that serves as a Wittig reagent precursor carrying an aldehyde group already protected as a cyclic 1,3-dioxolane acetal. In organic synthesis laboratories, this compound becomes a strategic choice whenever a chemist needs to extend a carbon skeleton while simultaneously installing an aldehyde group at the end of the newly formed chain. After deprotonation by a strong base, the salt forms a phosphorus ylide that reacts with aldehydes or ketones to build a carbon–carbon double bond, and the acetal it carries along can be hydrolysed in a subsequent step to unmask the carbonyl group.\u003c\/p\u003e\n\u003cp\u003eThe advantage that makes this reagent so widely used lies in the built-in protection of its aldehyde group. A free aldehyde is far too reactive to take part under Wittig conditions, because it would react with the ylide itself, so masking it as a dioxolane is an elegant and thoroughly proven solution. As a solid phosphonium salt, the material is stable under ordinary storage, is easy to weigh out accurately, and does not require the awkward handling associated with liquids. The dioxolane ring holds up well under the strongly basic conditions the Wittig reaction demands.\u003c\/p\u003e\n\u003cp\u003eIn Indonesian laboratories, this reagent fits naturally into synthetic organic chemistry work at universities, research institutes, and industrial R\u0026amp;D groups where multi-step syntheses are carried out. Its solid form and ordinary storage requirements suit local laboratory conditions, where accurate weighing on an analytical balance is more practical than transferring sensitive liquids. Chemists building extended carbon frameworks with a terminal carbonyl group rely on it as a dependable, well-documented route.\u003c\/p\u003e\n\u003ch3\u003eLaboratory Applications\u003c\/h3\u003e\n\u003cul\u003e\n\u003cli\u003eCarbon–carbon bond formation via the Wittig reaction: after deprotonation with a strong base, the salt generates a phosphorus ylide that couples with aldehydes or ketones to form an alkene.\u003c\/li\u003e\n\u003cli\u003eCarbon chain extension in multi-step synthesis: it lengthens an existing carbon skeleton while simultaneously delivering a protected aldehyde group to the end of the new chain.\u003c\/li\u003e\n\u003cli\u003eMasked aldehyde introduction: the dioxolane acetal carries the aldehyde functionality through the reaction unharmed, since a free aldehyde would be consumed by the ylide itself.\u003c\/li\u003e\n\u003cli\u003eProtecting-group strategy studies: the compound demonstrates how a cyclic acetal survives strongly basic Wittig conditions and is later removed by hydrolysis to unmask the carbonyl.\u003c\/li\u003e\n\u003cli\u003eTeaching and methodology development in organic synthesis: as a stable, accurately weighable solid reagent, it supports reproducible practical work on ylide chemistry and olefination.\u003c\/li\u003e\n\u003c\/ul\u003e\n\u003ch3\u003eSpecifications\u003c\/h3\u003e\n\u003cul\u003e\n\u003cli\u003eBrand: TCI (Tokyo Chemical Industry)\u003c\/li\u003e\n\u003cli\u003eCAS number: 52509-14-5\u003c\/li\u003e\n\u003cli\u003eCategory: Chemistry \u0026gt; Synthetic Reagents \u0026gt; C-C Bond Formation [Synthetic Reagents]\u003c\/li\u003e\n\u003cli\u003ePack sizes: available in standard TCI catalogue pack sizes; please confirm the current option when ordering\u003c\/li\u003e\n\u003cli\u003ePhysical form: solid phosphonium salt\u003c\/li\u003e\n\u003cli\u003eStorage note: stable under ordinary laboratory storage conditions in a closed container\u003c\/li\u003e\n\u003c\/ul\u003e\n\u003ch3\u003eHandling and Storage\u003c\/h3\u003e\n\u003cp\u003eStore the reagent in a tightly closed original container, kept dry and away from moisture, in a cool, well-ventilated chemical store away from strong bases and incompatible materials. As a solid phosphonium salt it is convenient to weigh out on an analytical balance; keep the container closed when not in use to prevent moisture uptake and caking. Handle it in a fume hood with safety glasses, gloves, and a laboratory coat, and use clean, dry spatulas and glassware. Deprotonation with strong base should be performed under controlled anhydrous conditions. Label all working solutions clearly and dispose of residues through the laboratory's chemical waste route.\u003c\/p\u003e","brand":"TCI","offers":[{"title":"5g","offer_id":48086501392602,"sku":"TCI2510D216422241","price":2138000.0,"currency_code":"IDR","in_stock":true},{"title":"25g","offer_id":48086501425370,"sku":"TCI2510D216422242","price":6128000.0,"currency_code":"IDR","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0756\/7156\/8602\/files\/TCI2510D2164.jpg?v=1771058332"},{"product_id":"tci2510d398124428","title":"TCI D3981 133113-76-5 Dimethyl 2-(1,3-Dithiole)phosphonate","description":"\u003ch3\u003eDescription\u003c\/h3\u003e\n\u003cp\u003eTCI D3981 Dimethyl 2-(1,3-Dithiole)phosphonate is a heterocyclic building block that combines a 1,3-dithiole ring with a dimethyl phosphonate group in a single molecule. The reagent is best known as a key precursor in synthetic routes toward tetrathiafulvalene (TTF) and its derivatives, a family of electron-donor molecules that form the backbone of organic conductor research. In the laboratory, the compound serves as a phosphonate-stabilised carbanion component that can be coupled with carbonyl compounds to form carbon-carbon double bonds in a controlled manner.\u003c\/p\u003e\n\u003cp\u003eThe property that makes this reagent valuable is its ability to undergo the Horner-Wadsworth-Emmons reaction. The phosphonate group stabilises the carbanion generated after deprotonation with a strong base, and the by-product is a water-soluble phosphate salt that is easily separated during the final work-up stage. This advantage makes the olefination reaction cleaner than some of the alternatives. At the same time, the sulfur-rich 1,3-dithiole ring contributes strong electron-donor character to the final product, while also supplying sulfur atoms that participate in intermolecular interactions in solid-state materials. The combination of these two features makes the reagent a targeted choice rather than a general-purpose one.\u003c\/p\u003e\n\u003cp\u003eIn Indonesian laboratories, this building block is typically used by university and institutional research groups working on organic synthesis and functional materials. It appears in projects where a specific dithiole-containing fragment must be introduced into a larger molecular framework, and where researchers require a defined, ready-to-use reagent instead of preparing the heterocyclic phosphonate in-house. Its role is usually that of a specialist intermediate within a multi-step synthetic sequence rather than a routine bench chemical.\u003c\/p\u003e\n\u003ch3\u003eLaboratory Applications\u003c\/h3\u003e\n\u003cul\u003e\n\u003cli\u003eTetrathiafulvalene (TTF) synthesis — the reagent is a recognised precursor in TTF routes, delivering the 1,3-dithiole unit that defines the electron-donor core of this molecular family.\u003c\/li\u003e\n\u003cli\u003eHorner-Wadsworth-Emmons olefination — the phosphonate group stabilises the carbanion after deprotonation with strong base, giving controlled carbon-carbon double bond formation with carbonyl partners.\u003c\/li\u003e\n\u003cli\u003eOrganic conductor materials research — TTF derivatives prepared from this building block underpin studies of electron-donor systems investigated as organic conducting materials.\u003c\/li\u003e\n\u003cli\u003eHeterocyclic building block coupling — laboratories use it to introduce an intact, sulfur-rich 1,3-dithiole ring into larger frameworks during multi-step synthetic sequences.\u003c\/li\u003e\n\u003cli\u003eSolid-state and supramolecular studies — the sulfur atoms of the dithiole ring contribute to intermolecular interactions that influence how the resulting materials pack and behave.\u003c\/li\u003e\n\u003c\/ul\u003e\n\u003ch3\u003eSpecifications\u003c\/h3\u003e\n\u003cul\u003e\n\u003cli\u003eBrand: TCI\u003c\/li\u003e\n\u003cli\u003eCAS number: 133113-76-5\u003c\/li\u003e\n\u003cli\u003eProduct code: D3981\u003c\/li\u003e\n\u003cli\u003eChemical name: Dimethyl 2-(1,3-Dithiole)phosphonate\u003c\/li\u003e\n\u003cli\u003eCategory: Chemistry \u0026gt; Building Blocks \u0026gt; Heterocyclic Building Blocks\u003c\/li\u003e\n\u003cli\u003ePack sizes and physical form: as listed on the current TCI catalogue entry for this product code; storage per the manufacturer's label and safety data sheet\u003c\/li\u003e\n\u003c\/ul\u003e\n\u003ch3\u003eHandling and Storage\u003c\/h3\u003e\n\u003cp\u003eStore the container tightly closed in a cool, dry, well-ventilated area, away from heat sources, direct sunlight, and incompatible materials, following the storage conditions stated on the manufacturer's label and safety data sheet. Keep the reagent in its original supplier container or in a comparable tightly sealed glass container with a chemically resistant closure, and reseal promptly after each use. Handle in a fume hood using standard personal protective equipment: safety goggles, chemically resistant gloves, and a laboratory coat. As with other organophosphorus reagents and sulfur-containing building blocks, avoid inhalation of vapour, avoid contact with skin and eyes, and label all working aliquots clearly. Consult the safety data sheet before use, and dispose of residues and contaminated materials through your institution's chemical waste procedures.\u003c\/p\u003e","brand":"TCI","offers":[{"title":"1g","offer_id":48086649241818,"sku":"TCI2510D398124428","price":6269000.0,"currency_code":"IDR","in_stock":true},{"title":"5g","offer_id":48086649274586,"sku":"TCI2510D398124429","price":21726000.0,"currency_code":"IDR","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0756\/7156\/8602\/files\/TCI2510D3981.jpg?v=1767106881"},{"product_id":"tci2510d399224443","title":"TCI D3992 62217-35-0 Dimethyl 1,3-Benzodithiol-2-ylphosphonate","description":"\u003ch3\u003eDescription\u003c\/h3\u003e\n\u003cp\u003eTCI D3992 Dimethyl 1,3-Benzodithiol-2-ylphosphonate (CAS 62217-35-0) is a phosphonate reagent that combines a dimethyl phosphonate group and a 1,3-benzodithiole ring on a single carbon atom. This combination makes it a characteristic Horner-Wadsworth-Emmons type carbon–carbon bond forming reagent: once deprotonated by a strong base, the resulting carbanion attacks an aldehyde or ketone group and delivers a cyclic ketene dithioacetal product. In synthetic organic laboratories this transformation is highly valuable, because the product serves both as a protected carbonyl group and as a precursor toward esters, thioesters, and carboxylic acids.\u003c\/p\u003e\n\u003cp\u003eThe property that makes this reagent a preferred choice is its layered carbanion stabilisation. The phosphorus atom stabilises the negative charge through the phosphonate group, while the two sulfur atoms of the benzodithiole ring add further stabilisation and at the same time direct the olefination reaction. As a result, the reagent can work on a diverse range of carbonyl substrates with relatively clean olefination outcomes and product groups that are easy to manipulate further, for example through hydrolysis or alcoholysis to reopen the carbonyl. The lipophilic character of the benzodithiole group also assists handling of the resulting products.\u003c\/p\u003e\n\u003cp\u003eIn Indonesian laboratories, a reagent of this type is normally used in university and research-institute organic synthesis groups, in natural product and medicinal chemistry work, and in method development where a carbonyl group must be converted into a protected, synthetically flexible functionality. It is typically ordered as a specialty synthetic reagent in small research quantities, drawn from the TCI catalogue of C-C bond formation reagents, and stored alongside other moisture-sensitive organophosphorus building blocks used for multi-step synthesis.\u003c\/p\u003e\n\u003ch3\u003eLaboratory Applications\u003c\/h3\u003e\n\u003cul\u003e\n\u003cli\u003eHorner-Wadsworth-Emmons olefination — after deprotonation with a strong base the stabilised carbanion attacks aldehydes and ketones to form the new carbon–carbon double bond directly.\u003c\/li\u003e\n\u003cli\u003eCyclic ketene dithioacetal synthesis — the benzodithiole ring is transferred intact to the carbonyl carbon, giving the ketene dithioacetal product in a single olefination step.\u003c\/li\u003e\n\u003cli\u003eCarbonyl group protection strategies — the ketene dithioacetal product acts as a masked carbonyl that can be reopened later by hydrolysis when the synthetic sequence allows it.\u003c\/li\u003e\n\u003cli\u003eEster and thioester precursor chemistry — the product group can be converted onward toward esters and thioesters, making the reagent useful for building acyl-level functionality.\u003c\/li\u003e\n\u003cli\u003eCarboxylic acid route development — alcoholysis or hydrolysis of the dithioacetal product provides access to carboxylic acid targets from simple aldehyde or ketone starting materials.\u003c\/li\u003e\n\u003c\/ul\u003e\n\u003ch3\u003eSpecifications\u003c\/h3\u003e\n\u003cul\u003e\n\u003cli\u003eBrand: TCI (Tokyo Chemical Industry)\u003c\/li\u003e\n\u003cli\u003eCAS number: 62217-35-0\u003c\/li\u003e\n\u003cli\u003eCategory: Chemistry \u0026gt; Synthetic Reagents \u0026gt; C-C Bond Formation [Synthetic Reagents]\u003c\/li\u003e\n\u003cli\u003eChemical name: Dimethyl 1,3-Benzodithiol-2-ylphosphonate\u003c\/li\u003e\n\u003cli\u003ePack sizes: available in research-scale catalogue pack sizes; please confirm the currently offered packaging when ordering\u003c\/li\u003e\n\u003cli\u003eStorage: keep in a cool, dry place in the tightly closed original container, away from moisture\u003c\/li\u003e\n\u003c\/ul\u003e\n\u003ch3\u003eHandling and Storage\u003c\/h3\u003e\n\u003cp\u003eStore the reagent in a cool, dry, well-ventilated place inside its tightly closed original container, protected from moisture and from direct sunlight or heat sources. Organophosphorus reagents of this class are best kept sealed and dry, since exposure to atmospheric humidity can degrade performance in base-mediated olefination reactions. Transfer only in a fume hood using clean, dry glassware and dry solvents, and handle with safety glasses, gloves, and a laboratory coat. Keep the reagent away from strong oxidising agents and from incompatible materials, and always consult the manufacturer's safety data sheet before use, weighing, or disposal.\u003c\/p\u003e","brand":"TCI","offers":[{"title":"1g","offer_id":48086649897178,"sku":"TCI2510D399224443","price":4217000.0,"currency_code":"IDR","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0756\/7156\/8602\/files\/TCI2510D3992.jpg?v=1769180633"},{"product_id":"tci2510d407424557","title":"TCI D4074 62999-73-9 Diethyl (1,3-Dithian-2-yl)phosphonate","description":"\u003ch3\u003eDescription\u003c\/h3\u003e\n\u003cp\u003eTCI D4074 Diethyl (1,3-Dithian-2-yl)phosphonate is a synthetic reagent that combines a 1,3-dithiane ring with a diethyl phosphonate group at the 2-position. This combination makes it a characteristic reagent for carbon–carbon bond formation through the Horner–Wadsworth–Emmons approach. In the laboratory, the compound is used to convert aldehydes and ketones into ketene dithioacetals, that is, alkene products carrying two sulfur atoms on a single carbon. That structure can subsequently be hydrolysed to give a carbonyl group that has been shifted by one carbon atom, so the reagent functions as an effective homologation strategy for chain extension work.\u003c\/p\u003e\n\u003cp\u003eThe characteristic that leads chemists to select this reagent is the umpolung behaviour it brings to a synthesis. The carbon at the 2-position of the dithiane ring, which is naturally electrophilic in its carbonyl form, here behaves as a nucleophile once it has been deprotonated by a strong base. The phosphonate anion that forms is sufficiently stable and reacts with carbonyl compounds to give alkenes, releasing a phosphate salt that is easily separated during the final work-up stage. The dithiane group also serves as a carbonyl protecting group that withstands many reaction conditions and can afterwards be reopened.\u003c\/p\u003e\n\u003cp\u003eIn Indonesian laboratories, a reagent of this type is normally handled within university research groups, institutional synthetic chemistry facilities, and industrial research units engaged in multi-step organic synthesis. It is typically used in small-scale reactions on the bench under anhydrous conditions, where a defined carbon–carbon bond-forming step or a carbonyl homologation sequence is required. Because it is supplied as a catalogue reagent under the TCI brand, it fits routine procurement for research programmes that rely on well-characterised building blocks.\u003c\/p\u003e\n\u003ch3\u003eLaboratory Applications\u003c\/h3\u003e\n\u003cul\u003e\n\u003cli\u003eHorner–Wadsworth–Emmons olefination: the diethyl phosphonate group forms a stabilised anion on deprotonation that reacts cleanly with carbonyl compounds to deliver the alkene product.\u003c\/li\u003e\n\u003cli\u003eKetene dithioacetal preparation: reaction with aldehydes and ketones installs an alkene bearing two sulfur atoms on one carbon, giving direct access to this structural motif.\u003c\/li\u003e\n\u003cli\u003eOne-carbon homologation of carbonyl compounds: the ketene dithioacetal formed can be hydrolysed to a carbonyl group shifted by one carbon along the chain.\u003c\/li\u003e\n\u003cli\u003eUmpolung-based carbon–carbon bond construction: the dithiane 2-position acts as a nucleophile rather than an electrophile, allowing disconnections that normal carbonyl reactivity does not permit.\u003c\/li\u003e\n\u003cli\u003eCarbonyl protection during multi-step synthesis: the dithiane ring tolerates many reaction conditions and can be reopened later, so it protects the masked carbonyl through intermediate steps.\u003c\/li\u003e\n\u003c\/ul\u003e\n\u003ch3\u003eSpecifications\u003c\/h3\u003e\n\u003cul\u003e\n\u003cli\u003eBrand: TCI\u003c\/li\u003e\n\u003cli\u003eCAS number: 62999-73-9\u003c\/li\u003e\n\u003cli\u003eChemical name: Diethyl (1,3-Dithian-2-yl)phosphonate\u003c\/li\u003e\n\u003cli\u003eCatalogue code: D4074\u003c\/li\u003e\n\u003cli\u003eCategory: Chemistry \u0026gt; Synthetic Reagents \u0026gt; C-C Bond Formation [Synthetic Reagents]\u003c\/li\u003e\n\u003cli\u003ePack sizes: available in standard TCI catalogue pack sizes; please confirm the required size when ordering\u003c\/li\u003e\n\u003cli\u003eStorage note: keep tightly closed in a cool, dry, well-ventilated place away from moisture\u003c\/li\u003e\n\u003c\/ul\u003e\n\u003ch3\u003eHandling and Storage\u003c\/h3\u003e\n\u003cp\u003eStore the reagent in its original tightly closed container in a cool, dry and well-ventilated area, away from moisture and from direct sunlight or other heat sources. Because the compound is used in reactions that require strong bases and anhydrous conditions, keep the container sealed between uses and avoid unnecessary exposure to atmospheric humidity. Handle it inside a fume hood, since organosulfur reagents commonly carry a persistent odour, and wear a laboratory coat, chemical-resistant gloves and safety goggles. Transfer with clean, dry glassware or syringes, keep it separated from strong oxidising agents, and follow the manufacturer's safety data sheet together with your institutional chemical waste procedures.\u003c\/p\u003e","brand":"TCI","offers":[{"title":"5g","offer_id":48086654353626,"sku":"TCI2510D407424557","price":4301000.0,"currency_code":"IDR","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0756\/7156\/8602\/files\/TCI2510D4074.jpg?v=1768205020"},{"product_id":"tci2510t151452708","title":"TCI T1514 13411-42-2 2-Trimethylsilyl-1,3-dithiane","description":"\u003cp\u003e\u003cstrong\u003e2-Trimethylsilyl-1,3-dithiane\u003c\/strong\u003e (CAS 13411-42-2) is a high-quality chemical from TCI, supplied as \u003cstrong\u003eGC Grade \/ for Synthesis\u003c\/strong\u003e.\u003c\/p\u003e\u003cp\u003e\u003cstrong\u003eApplication:\u003c\/strong\u003e Used as a silylating reagent for hydroxyl-group protection and GC derivatisation.\u003c\/p\u003e\u003cp\u003e\u003cstrong\u003eSpecifications:\u003c\/strong\u003e\u003c\/p\u003e\u003cul\u003e\n\u003cli\u003eMolecular formula: C7H16S2Si\u003c\/li\u003e\n\u003cli\u003eCAS number: 13411-42-2\u003c\/li\u003e\n\u003cli\u003ePurity: \u0026gt;96.0%(GC)\u003c\/li\u003e\n\u003cli\u003eTCI product code: T1514\u003c\/li\u003e\n\u003c\/ul\u003e\u003cp\u003e\u003cstrong\u003eSynonyms:\u003c\/strong\u003e 1,3-Dithian-2-yltrimethylsilane\u003c\/p\u003e\u003cp\u003eAvailable from \u003cstrong\u003eAMI Scientific\u003c\/strong\u003e, the authorised TCI distributor in Indonesia. \u003cstrong\u003eContact us for pricing and stock availability\u003c\/strong\u003e — we ship throughout Indonesia.\u003c\/p\u003e","brand":"TCI","offers":[{"title":"5g","offer_id":48088416354522,"sku":"TCI2510T151452708","price":4330000.0,"currency_code":"IDR","in_stock":true},{"title":"25g","offer_id":48088416387290,"sku":"TCI2510T151452709","price":15150000.0,"currency_code":"IDR","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0756\/7156\/8602\/files\/TCI2510T1514.jpg?v=1767141757"},{"product_id":"tci2510t271854139","title":"TCI T2718 115754-62-6 Tributyl(1,3-dioxolan-2-ylmethyl)phosphonium Bromide","description":"\u003cp\u003e\u003cstrong\u003eTributyl(1,3-dioxolan-2-ylmethyl)phosphonium Bromide\u003c\/strong\u003e (CAS 115754-62-6) is a high-quality chemical from TCI, supplied as \u003cstrong\u003eReagent Grade \/ for Synthesis\u003c\/strong\u003e.\u003c\/p\u003e\u003cp\u003e\u003cstrong\u003eApplication:\u003c\/strong\u003e Synthesis reagent for a wide range of organic chemistry transformations in laboratory and industrial settings.\u003c\/p\u003e\u003cp\u003e\u003cstrong\u003eSpecifications:\u003c\/strong\u003e\u003c\/p\u003e\u003cul\u003e\n\u003cli\u003eMolecular formula: C16H34BrO2P\u003c\/li\u003e\n\u003cli\u003eCAS number: 115754-62-6\u003c\/li\u003e\n\u003cli\u003ePurity: \u0026gt;98.0%(T)\u003c\/li\u003e\n\u003cli\u003eTCI product code: T2718\u003c\/li\u003e\n\u003c\/ul\u003e\u003cp\u003eAvailable from \u003cstrong\u003eAMI Scientific\u003c\/strong\u003e, the authorised TCI distributor in Indonesia. \u003cstrong\u003eContact us for pricing and stock availability\u003c\/strong\u003e — we ship throughout Indonesia.\u003c\/p\u003e","brand":"TCI","offers":[{"title":"5g","offer_id":48088499749082,"sku":"TCI2510T271854139","price":4330000.0,"currency_code":"IDR","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0756\/7156\/8602\/files\/TCI2510T2718.jpg?v=1768206498"}],"url":"https:\/\/amiscientific.com\/en\/collections\/tci-l4-olefination-c-c-bond-formation.oembed","provider":"AMI Scientific","version":"1.0","type":"link"}