{"title":"Payload (Drug) Candidates [ADC Preparation Research Reagents]","description":"\u003cp\u003e\u003cstrong\u003ePayload (Drug) Candidates [ADC Preparation Research Reagents]\u003c\/strong\u003e — menghimpun senyawa bahan alam dan turunannya seperti triptolid, rapamisin, paklitaksel, dan antrasiklin yang secara struktural menjadi kandidat payload dalam riset antibody-drug conjugate. Kelompok ini mewakili beragam kerangka kimia mulai dari diterpenoid, makrolida, hingga alkaloid kompleks.\u003c\/p\u003e\u003cp\u003eSenyawa dalam kategori ini dipelajari sebagai kandidat payload untuk riset konjugasi antibodi-obat (ADC), di mana struktur molekulnya dimodifikasi dengan linker sebelum digabungkan ke antibodi target dalam eksperimen laboratorium. Peneliti bioconjugation dan kimia medisinal menggunakan senyawa seperti paklitaksel atau daunorubisin hidroklorida sebagai model struktural untuk mempelajari strategi pelepasan payload dan kimia linker.\u003c\/p\u003e\u003cp\u003eContoh produk dalam koleksi ini: \u003ca href=\"\/en\/products\/tci2510t289954376\"\u003eTCI T2899 38748-32-2 Triptolide\u003c\/a\u003e, \u003ca href=\"\/en\/products\/tci2510c149516076\"\u003eTCI C1495 7689-03-4 (S)-(+)-Camptothecin\u003c\/a\u003e, \u003ca href=\"\/en\/products\/tci2510r009749555\"\u003eTCI R0097 53123-88-9 Rapamycin\u003c\/a\u003e, \u003ca href=\"\/en\/products\/tci2510c353718617\"\u003eTCI C3537 63283-36-3 Calcifediol Monohydrate\u003c\/a\u003e, \u003ca href=\"\/en\/products\/tci2510p163247292\"\u003eTCI P1632 33069-62-4 Paclitaxel\u003c\/a\u003e, \u003ca href=\"\/en\/products\/tci2510d419324714\"\u003eTCI D4193 25316-40-9 Doxorubicin Hydrochloride\u003c\/a\u003e, \u003ca href=\"\/en\/products\/tci2510m232040556\"\u003eTCI M2320 50-07-7 Ametycin\u003c\/a\u003e, \u003ca href=\"\/en\/products\/tci2510d453225150\"\u003eTCI D4532 23541-50-6 Daunorubicin Hydrochloride\u003c\/a\u003e.\u003c\/p\u003e\u003cp\u003ePerhatikan tingkat kemurnian, bentuk garam (misalnya hidroklorida), serta stabilitas senyawa terhadap cahaya dan kelembapan, mengingat kompleksitas struktur memengaruhi reaktivitas pada tahap konjugasi linker. Seluruh produk merupakan produk asli Tokyo Chemical Industry (TCI) Jepang, dengan kemurnian, kemasan, dan kondisi penyimpanan tercantum pada halaman masing-masing item.\u003c\/p\u003e\u003cp\u003eKategori lain yang sejajar di bawah Antibody-Drug Conjugates (ADC) Preparation Research Reagents, sering dipakai bersamaan dalam satu alur kerja laboratorium:\u003c\/p\u003e\u003cul\u003e\n\u003cli\u003e\u003ca href=\"\/en\/collections\/tci-l4-cross-linkers-regents-for-adc-preparation-research\"\u003eCross-Linkers [Regents for ADC Preparation Research]\u003c\/a\u003e\u003c\/li\u003e\n\u003cli\u003e\u003ca href=\"\/en\/collections\/tci-l4-enzyme-cleavable-linkers-cleave-motif-regents-for-adc-preparation-research\"\u003eEnzyme Cleavable Linkers (Cleave Motif) [Regents for ADC Preparation Research]\u003c\/a\u003e\u003c\/li\u003e\n\u003c\/ul\u003e\u003cp\u003eKembali ke \u003ca href=\"\/en\/collections\/tci-l3-antibody-drug-conjugates-adc-preparation-research-reagents\"\u003eAntibody-Drug Conjugates (ADC) Preparation Research Reagents\u003c\/a\u003e. Untuk pengadaan volume besar, kemasan khusus, atau grade tertentu, hubungi tim AMI Scientific — distributor resmi TCI Japan di Indonesia — untuk pengecekan ketersediaan dan lead time langsung ke Jepang.\u003c\/p\u003e","products":[{"product_id":"tci2510c149516076","title":"TCI C1495 7689-03-4 (S)-(+)-Camptothecin","description":"\u003ch3\u003eDescription\u003c\/h3\u003e\n\u003cp\u003eTCI C1495 (S)-(+)-Camptothecin (CAS 7689-03-4) is a pentacyclic quinoline alkaloid and a well-characterised topoisomerase I inhibitor. It is catalogued as a research reagent for pharmaceutical development, particularly for antibody-drug conjugate preparation, where its scaffold underpins an important class of payloads. Laboratories also use it as a positive control in cytotoxicity assays and as a starting material for analog synthesis. Supplied in 100 mg and 1 g packs; treat as a cytotoxic compound and follow the Safety Data Sheet and institutional handling procedures.\u003c\/p\u003e\n\u003ch3\u003eScientific References\u003c\/h3\u003e\n\u003cul\u003e\n\u003cli\u003eA et al. (2016). ANNUAL VARIATION IN CAMPTOTHECIN AND 9-METHOXY CAMPTOTHECIN ACCUMULATION AND ITS DETERMINATION IN DIFFERENT PARTS OF NOTHAPODYTES NIMMONIANA BY HPLC ANALYSIS. \u003cem\u003eBulletin of Pharmaceutical Research\u003c\/em\u003e \u003ca href=\"https:\/\/doi.org\/10.21276\/bpr.2016.6.1.3\" target=\"_blank\" rel=\"nofollow noopener\"\u003edoi:10.21276\/bpr.2016.6.1.3\u003c\/a\u003e\n\u003c\/li\u003e\n\u003cli\u003e(2002). Crystal Form of A Camptothecin Derivative. \u003cem\u003eJournal of Korean Pharmaceutical Sciences\u003c\/em\u003e \u003ca href=\"https:\/\/doi.org\/10.4333\/kps.2002.32.2.081\" target=\"_blank\" rel=\"nofollow noopener\"\u003edoi:10.4333\/kps.2002.32.2.081\u003c\/a\u003e\n\u003c\/li\u003e\n\u003cli\u003e(2018). Characterization of Camptothecin-induced Genomic Changes in the Camptothecin-resistant T-ALL-derived Cell Line CPT-K5. \u003cem\u003eCancer Genomics \u0026amp; Proteomics\u003c\/em\u003e \u003ca href=\"https:\/\/doi.org\/10.21873\/cgp.20068\" target=\"_blank\" rel=\"nofollow noopener\"\u003edoi:10.21873\/cgp.20068\u003c\/a\u003e\n\u003c\/li\u003e\n\u003c\/ul\u003e\n\u003cp\u003e\u003csmall\u003eReferences were compiled automatically from Crossref and every DOI was verified to exist. AMI Scientific is not affiliated with the authors or the publishers.\u003c\/small\u003e\u003c\/p\u003e","brand":"TCI","offers":[{"title":"100mg","offer_id":48086073573594,"sku":"TCI2510C149516076","price":760000.0,"currency_code":"IDR","in_stock":true},{"title":"1g","offer_id":48086073606362,"sku":"TCI2510C149516077","price":4414000.0,"currency_code":"IDR","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0756\/7156\/8602\/files\/TCI2510C1495.jpg?v=1767097022"},{"product_id":"tci2510d419324714","title":"TCI D4193 25316-40-9 Doxorubicin Hydrochloride","description":"\u003ch3\u003eDescription\u003c\/h3\u003e\n\u003cp\u003eTCI D4193 Doxorubicin Hydrochloride, bearing CAS number 25316-40-9, is an anthracycline compound supplied in its hydrochloride salt form and classified within chemical biology, specifically the field of glycoscience, because its structure contains an amino sugar moiety attached to a polyketide aglycone core. It is one of the most widely recognised reagents in cell biology research and experimental oncology, employed as a comparative treatment in cell viability assays, DNA damage studies, and drug resistance research. Its established role as a reference compound makes it an important part of the modern biomedical research laboratory toolkit.\u003c\/p\u003e\n\u003cp\u003eThe characteristics that make doxorubicin such a frequently chosen compound include its ability to intercalate between DNA base pairs and its influence on the activity of the topoisomerase II enzyme, two properties that together produce clear and readily observable cellular responses. The molecule is also intrinsically fluorescent, so its uptake into cells can be monitored directly by fluorescence microscopy or flow cytometry without the need for any additional labelling step. The daunosamine sugar portion improves solubility in water, and the hydrochloride salt form makes the preparation of aqueous stock solutions straightforward and practical for routine bench work.\u003c\/p\u003e\n\u003cp\u003eIn Indonesian laboratories, this reagent is typically found in university research groups, biomedical and pharmaceutical research institutes, and cell culture facilities working on oncology-related questions. It commonly serves as the positive control or benchmark treatment in cytotoxicity screening panels, where new candidate compounds are compared against a well-characterised standard. Because its behaviour in cell-based systems is thoroughly documented, it also supports method development, assay validation, and the training of researchers and postgraduate students in cell biology techniques.\u003c\/p\u003e\n\u003ch3\u003eLaboratory Applications\u003c\/h3\u003e\n\u003cul\u003e\n\u003cli\u003eCell viability and cytotoxicity assays, where it functions as a reliable comparative treatment against which the activity of newly synthesised or extracted candidate compounds can be measured.\u003c\/li\u003e\n\u003cli\u003eDNA damage studies, since its intercalation between DNA base pairs and its effect on topoisomerase II activity generate clear, reproducible cellular responses suitable for mechanistic investigation.\u003c\/li\u003e\n\u003cli\u003eDrug resistance research, in which it is used as a reference anthracycline to characterise resistant cell populations and to examine how treatment responses shift across experimental conditions.\u003c\/li\u003e\n\u003cli\u003eCellular uptake and localisation experiments, taking advantage of its intrinsic fluorescence so that entry into cells can be tracked by fluorescence microscopy without adding any external label.\u003c\/li\u003e\n\u003cli\u003eFlow cytometry workflows in experimental oncology, where the compound's own fluorescent signal allows quantitative assessment of accumulation across cell populations without an additional staining procedure.\u003c\/li\u003e\n\u003c\/ul\u003e\n\u003ch3\u003eSpecifications\u003c\/h3\u003e\n\u003cul\u003e\n\u003cli\u003eBrand: TCI\u003c\/li\u003e\n\u003cli\u003eCAS Number: 25316-40-9\u003c\/li\u003e\n\u003cli\u003eCategory: Chemistry \u0026gt; Chemical Biology \u0026gt; Glycoscience\u003c\/li\u003e\n\u003cli\u003eChemical class: anthracycline compound supplied as the hydrochloride salt\u003c\/li\u003e\n\u003cli\u003eSolubility note: the daunosamine sugar moiety supports water solubility, and the hydrochloride salt form facilitates preparation of aqueous stock solutions\u003c\/li\u003e\n\u003cli\u003ePack sizes: available in the pack sizes listed on the product page; please confirm the option required when ordering\u003c\/li\u003e\n\u003cli\u003eStorage: store according to the conditions stated on the manufacturer's label and product documentation\u003c\/li\u003e\n\u003c\/ul\u003e\n\u003ch3\u003eHandling and Storage\u003c\/h3\u003e\n\u003cp\u003eStore this product under the conditions specified on the manufacturer's label and accompanying documentation, keeping the container tightly closed and protected from light, moisture, and elevated temperature. Use clean, chemically compatible containers for aqueous stock solutions, label them clearly with concentration and preparation date, and aliquot where repeated freeze-thaw cycles would otherwise be required. Handle the material only in a designated laboratory area using appropriate personal protective equipment, including gloves, a laboratory coat, and eye protection, and carry out weighing and solution preparation with suitable engineering controls in place. Avoid the generation of dust or aerosols, keep the compound away from incompatible materials, and dispose of residues and contaminated consumables through the established chemical waste procedures of your institution. Always consult the Safety Data Sheet before first use.\u003c\/p\u003e","brand":"TCI","offers":[{"title":"25mg","offer_id":48086677881050,"sku":"TCI2510D419324714","price":6409000.0,"currency_code":"IDR","in_stock":true},{"title":"100mg","offer_id":48086677913818,"sku":"TCI2510D419324715","price":19169000.0,"currency_code":"IDR","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0756\/7156\/8602\/files\/TCI2510D4193.jpg?v=1767107201"},{"product_id":"tci2510d453225150","title":"TCI D4532 23541-50-6 Daunorubicin Hydrochloride","description":"\u003ch3\u003eDescription\u003c\/h3\u003e\n\u003cp\u003eDaunorubicin Hydrochloride is a chemical compound widely used in chemical biology and glycoscience research. As a key reagent in laboratory settings, it plays a crucial role in studying antitumor compounds and the mechanisms of cancer treatments. Its ability to interact with DNA and RNA makes it essential for investigating molecular interactions, biological activity, and toxic effects. This compound is frequently employed in experiments aimed at understanding the pharmacological and biochemical properties of therapeutic agents.\u003c\/p\u003e\n\u003cp\u003eThe compound’s unique chemical structure allows for specific interactions with nucleic acids, making it a preferred choice for researchers in pharmacology and biotechnology. Its stability under certain conditions ensures reliable results across various experimental setups. Additionally, its effectiveness in biological assays contributes to its popularity in both academic and industrial research environments. These properties make it an indispensable tool for scientists working on cancer therapy development and related fields.\u003c\/p\u003e\n\u003cp\u003eIn Indonesian laboratories, Daunorubicin Hydrochloride is commonly used in scientific studies focused on the efficacy of cancer treatments and the development of new therapeutic approaches. It is also integral to research projects involving molecular biology, drug discovery, and biochemical analysis. Its presence in these studies highlights its importance in advancing medical research and innovation within the region.\u003c\/p\u003e\n\u003ch3\u003eLaboratory Applications\u003c\/h3\u003e\n\u003cul\u003e\n\u003cli\u003eCancer drug development research utilizes Daunorubicin Hydrochloride to evaluate the efficacy and mechanism of action of chemotherapeutic agents in vitro and in vivo.\u003c\/li\u003e\n\u003cli\u003eMolecular biology studies benefit from its ability to interact with DNA and RNA, enabling investigations into gene expression and cellular processes.\u003c\/li\u003e\n\u003cli\u003eToxicology experiments rely on this compound to assess the biological effects and potential side effects of antitumor drugs on living systems.\u003c\/li\u003e\n\u003cli\u003ePharmacological research employs Daunorubicin Hydrochloride to study drug metabolism, absorption, and interaction with biological targets.\u003c\/li\u003e\n\u003cli\u003eBiochemical assays use the compound to analyze enzyme activity and protein binding, contributing to the understanding of cellular functions.\u003c\/li\u003e\n\u003c\/ul\u003e\n\u003ch3\u003eSpecifications\u003c\/h3\u003e\n\u003cul\u003e\n\u003cli\u003eBrand: TCI\u003c\/li\u003e\n\u003cli\u003eCAS number: 23541-50-6\u003c\/li\u003e\n\u003cli\u003eCategory: Chemistry \u0026gt; Chemical Biology \u0026gt; Glycoscience\u003c\/li\u003e\n\u003cli\u003ePack sizes: Available in various quantities as per supplier specifications\u003c\/li\u003e\n\u003cli\u003ePhysical form: Powder\u003c\/li\u003e\n\u003cli\u003eStorage note: Store in a cool, dry place away from light and moisture\u003c\/li\u003e\n\u003c\/ul\u003e\n\u003ch3\u003eHandling and Storage\u003c\/h3\u003e\n\u003cp\u003eDaunorubicin Hydrochloride should be stored in a cool, dry environment, away from direct light and moisture to maintain its stability and potency. It is recommended to use airtight containers to prevent exposure to humidity and contaminants. Due to its potential biological activity, it should be handled with appropriate personal protective equipment, such as gloves and safety goggles, to ensure laboratory safety. The compound should be kept in a secure location, away from incompatible substances to prevent chemical reactions. Regular monitoring of storage conditions is essential to ensure the integrity of the material during long-term use. Proper labeling and documentation are also important for safe handling and regulatory compliance in laboratory settings.\u003c\/p\u003e","brand":"TCI","offers":[{"title":"20mg","offer_id":48086696067290,"sku":"TCI2510D453225150","price":3458000.0,"currency_code":"IDR","in_stock":true},{"title":"100mg","offer_id":48086696100058,"sku":"TCI2510D453225151","price":12058000.0,"currency_code":"IDR","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0756\/7156\/8602\/files\/TCI2510D4532.jpg?v=1767107697"},{"product_id":"tci2510m232040556","title":"TCI M2320 50-07-7 Ametycin","description":"\u003cp\u003e\u003cstrong\u003eAmetycin\u003c\/strong\u003e (CAS 50-07-7) is a high-quality chemical from TCI, supplied as \u003cstrong\u003eHPLC Grade\u003c\/strong\u003e.\u003c\/p\u003e\u003cp\u003e\u003cstrong\u003eApplication:\u003c\/strong\u003e Synthesis reagent for a wide range of organic chemistry transformations in laboratory and industrial settings.\u003c\/p\u003e\u003cp\u003e\u003cstrong\u003eSpecifications:\u003c\/strong\u003e\u003c\/p\u003e\u003cul\u003e\n\u003cli\u003eMolecular formula: C15H18N4O5\u003c\/li\u003e\n\u003cli\u003eCAS number: 50-07-7\u003c\/li\u003e\n\u003cli\u003ePurity: \u0026gt;98.0%(HPLC)\u003c\/li\u003e\n\u003cli\u003eTCI product code: M2320\u003c\/li\u003e\n\u003c\/ul\u003e\u003cp\u003e\u003cstrong\u003eSynonyms:\u003c\/strong\u003e Mitomycin C\u003c\/p\u003e\u003cp\u003eAvailable from \u003cstrong\u003eAMI Scientific\u003c\/strong\u003e, the authorised TCI distributor in Indonesia. \u003cstrong\u003eContact us for pricing and stock availability\u003c\/strong\u003e — we ship throughout Indonesia.\u003c\/p\u003e","brand":"TCI","offers":[{"title":"10mg","offer_id":48087671996634,"sku":"TCI2510M232040556","price":3036000.0,"currency_code":"IDR","in_stock":true},{"title":"50mg","offer_id":48087672029402,"sku":"TCI2510M232040557","price":10344000.0,"currency_code":"IDR","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0756\/7156\/8602\/files\/TCI2510M2320.jpg?v=1767126448"},{"product_id":"tci2510p163247292","title":"TCI P1632 33069-62-4 Paclitaxel","description":"\u003cp\u003e\u003cstrong\u003ePaclitaxel\u003c\/strong\u003e (CAS 33069-62-4) is a high-quality chemical from TCI, supplied as \u003cstrong\u003eHPLC Grade\u003c\/strong\u003e.\u003c\/p\u003e\u003cp\u003e\u003cstrong\u003eApplication:\u003c\/strong\u003e Synthesis reagent for a wide range of organic chemistry transformations in laboratory and industrial settings.\u003c\/p\u003e\u003cp\u003e\u003cstrong\u003eSpecifications:\u003c\/strong\u003e\u003c\/p\u003e\u003cul\u003e\n\u003cli\u003eMolecular formula: C47H51NO14\u003c\/li\u003e\n\u003cli\u003eCAS number: 33069-62-4\u003c\/li\u003e\n\u003cli\u003ePurity: \u0026gt;98.0%(HPLC)\u003c\/li\u003e\n\u003cli\u003eTCI product code: P1632\u003c\/li\u003e\n\u003c\/ul\u003e\u003cp\u003eAvailable from \u003cstrong\u003eAMI Scientific\u003c\/strong\u003e, the authorised TCI distributor in Indonesia. \u003cstrong\u003eContact us for pricing and stock availability\u003c\/strong\u003e — we ship throughout Indonesia.\u003c\/p\u003e","brand":"TCI","offers":[{"title":"100mg","offer_id":48088063049946,"sku":"TCI2510P163247292","price":10849000.0,"currency_code":"IDR","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0756\/7156\/8602\/files\/TCI2510P1632.jpg?v=1767135010"},{"product_id":"tci2510r009749555","title":"TCI R0097 53123-88-9 Rapamycin","description":"\u003cp\u003e\u003cstrong\u003eRapamycin\u003c\/strong\u003e (CAS 53123-88-9) is a high-quality chemical from TCI, supplied as \u003cstrong\u003eHPLC Grade\u003c\/strong\u003e.\u003c\/p\u003e\u003cp\u003e\u003cstrong\u003eApplication:\u003c\/strong\u003e Synthesis reagent for a wide range of organic chemistry transformations in laboratory and industrial settings.\u003c\/p\u003e\u003cp\u003e\u003cstrong\u003eSpecifications:\u003c\/strong\u003e\u003c\/p\u003e\u003cul\u003e\n\u003cli\u003eMolecular formula: C51H79NO13\u003c\/li\u003e\n\u003cli\u003eCAS number: 53123-88-9\u003c\/li\u003e\n\u003cli\u003ePurity: \u0026gt;95.0%(HPLC)\u003c\/li\u003e\n\u003cli\u003eTCI product code: R0097\u003c\/li\u003e\n\u003c\/ul\u003e\u003cp\u003eAvailable from \u003cstrong\u003eAMI Scientific\u003c\/strong\u003e, the authorised TCI distributor in Indonesia. \u003cstrong\u003eContact us for pricing and stock availability\u003c\/strong\u003e — we ship throughout Indonesia.\u003c\/p\u003e","brand":"TCI","offers":[{"title":"25mg","offer_id":48088203264218,"sku":"TCI2510R009749555","price":7111000.0,"currency_code":"IDR","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0756\/7156\/8602\/files\/TCI2510R0097.jpg?v=1767137861"}],"url":"https:\/\/amiscientific.com\/en\/collections\/tci-l4-payload-drug-candidates-adc-preparation-research-reagents.oembed","provider":"AMI Scientific","version":"1.0","type":"link"}