{"title":"Phosphine Ligands [Cross-coupling Reaction using Transition Metal Catalysts]","description":"\u003cp\u003e\u003cstrong\u003ePhosphine Ligands [Cross-coupling Reaction using Transition Metal Catalysts]\u003c\/strong\u003e — berisi ligan fosfin, senyawa dengan atom fosfor trivalen yang mendonorkan pasangan elektron, dengan variasi struktur seperti fosfin tridentat, difosfin biaril, dan fosfin tersubstitusi aril elektron-tarik. Golongan ini berperan mengatur sifat elektronik dan sterik pusat logam transisi pada katalis reaksi pembentukan ikatan karbon-karbon.\u003c\/p\u003e\u003cp\u003ePhosphine Ligands dipakai berpasangan dengan logam transisi seperti paladium atau nikel dalam reaksi cross-coupling, misalnya Suzuki, Negishi, dan Buchwald-Hartwig, untuk membentuk ikatan karbon-karbon maupun karbon-nitrogen. Kimiawan sintesis organik dan pengembang proses farmasi memanfaatkan variasi kerangka biaril atau tridentat untuk menyesuaikan aktivitas serta selektivitas katalis pada substrat yang menantang.\u003c\/p\u003e\u003cp\u003eContoh produk dalam koleksi ini: \u003ca href=\"\/en\/products\/tci2510v013256551\"\u003eTCI V0132 384842-25-5 vBRIDP(regR)\u003c\/a\u003e, \u003ca href=\"\/en\/products\/tci2510b595712735\"\u003eTCI B5957 325773-62-4 2,2'-Bis[bis(3,5-dimethylphenyl)phosphino]-1,1'-biphenyl\u003c\/a\u003e, \u003ca href=\"\/en\/products\/tci2510t430456056\"\u003eTCI T4304 22031-12-5 1,1,1-Tris(diphenylphosphinomethyl)ethane\u003c\/a\u003e, \u003ca href=\"\/en\/products\/tci2510b678313701\"\u003eTCI B6783 23582-02-7 Bis(2-diphenylphosphinoethyl)phenylphosphine\u003c\/a\u003e, \u003ca href=\"\/en\/products\/tci2510t412155863\"\u003eTCI T4121 3411-48-1 Tri(naphthalen-1-yl)phosphane\u003c\/a\u003e, \u003ca href=\"\/en\/products\/tci2510b693013814\"\u003eTCI B6930 1055888-89-5 3-(Di-tert-butylphosphaneyl)propane-1-sulfonic Acid\u003c\/a\u003e, \u003ca href=\"\/en\/products\/tci2510t411555859\"\u003eTCI T4115 13406-29-6 Tris[4-(trifluoromethyl)phenyl]phosphine\u003c\/a\u003e, \u003ca href=\"\/en\/products\/tci2510c298117891\"\u003eTCI C2981 384842-24-4 Cy-vBRIDP(regR)\u003c\/a\u003e.\u003c\/p\u003e\u003cp\u003ePemilihan memperhatikan geometri koordinasi (bidentat atau tridentat), sifat elektronik substituen pada cincin aril, serta kepekaan terhadap oksidasi yang mungkin memerlukan penanganan dalam atmosfer inert. Seluruh produk merupakan produk asli Tokyo Chemical Industry (TCI) Jepang, dengan kemurnian, kemasan, dan kondisi penyimpanan tercantum pada halaman masing-masing item.\u003c\/p\u003e\u003cp\u003eKategori lain yang sejajar di bawah Cross-coupling Reaction using Transition Metal Catalysts [C-C Bond Formation], sering dipakai bersamaan dalam satu alur kerja laboratorium:\u003c\/p\u003e\u003cul\u003e\n\u003cli\u003e\u003ca href=\"\/en\/collections\/tci-l4-palladium-catalysts-cross-coupling-reaction-using-transition-metal-catalysts\"\u003ePalladium Catalysts [Cross-coupling Reaction using Transition Metal Catalysts]\u003c\/a\u003e\u003c\/li\u003e\n\u003cli\u003e\u003ca href=\"\/en\/collections\/tci-l4-n-heterocyclic-carbene-nhc-ligands-cross-coupling-reaction-using-transition-metal-catalysts\"\u003eN-Heterocyclic Carbene (NHC) Ligands [Cross-coupling Reaction using Transition Metal Catalysts]\u003c\/a\u003e\u003c\/li\u003e\n\u003cli\u003e\u003ca href=\"\/en\/collections\/tci-l4-nickel-catalysis-and-inorganic-chemistry\"\u003eNickel [Catalysis and Inorganic Chemistry]\u003c\/a\u003e\u003c\/li\u003e\n\u003cli\u003e\u003ca href=\"\/en\/collections\/tci-l4-nickel-catalysts-cross-coupling-reaction-using-transition-metal-catalysts\"\u003eNickel Catalysts [Cross-coupling Reaction using Transition Metal Catalysts]\u003c\/a\u003e\u003c\/li\u003e\n\u003cli\u003e\u003ca href=\"\/en\/collections\/tci-l4-copper-catalysts-cross-coupling-reaction-using-transition-metal-catalysts\"\u003eCopper Catalysts [Cross-coupling Reaction using Transition Metal Catalysts]\u003c\/a\u003e\u003c\/li\u003e\n\u003cli\u003e\u003ca href=\"\/en\/collections\/tci-l4-bases-and-additives-cross-coupling-reaction-using-transition-metal-catalysts\"\u003eBases and Additives [Cross-coupling Reaction using Transition Metal Catalysts]\u003c\/a\u003e\u003c\/li\u003e\n\u003c\/ul\u003e\u003cp\u003eKembali ke \u003ca href=\"\/en\/collections\/tci-l3-cross-coupling-reaction-using-transition-metal-catalysts-c-c-bond-form\"\u003eCross-coupling Reaction using Transition Metal Catalysts [C-C Bond Formation]\u003c\/a\u003e. Untuk pengadaan volume besar, kemasan khusus, atau grade tertentu, hubungi tim AMI Scientific — distributor resmi TCI Japan di Indonesia — untuk pengecekan ketersediaan dan lead time langsung ke Jepang.\u003c\/p\u003e","products":[{"product_id":"tci2510d383424226","title":"TCI D3834 628333-86-8 1-[2-(Di-tert-butylphosphino)phenyl]-3,5-diphenyl-1H-pyrazole","description":"\u003ch3\u003eDescription\u003c\/h3\u003e\n\u003cp\u003e1-[2-(Di-tert-butylphosphino)phenyl]-3,5-diphenyl-1H-pyrazole from TCI, listed under CAS number 628333-86-8, is a phosphine ligand built on a pyrazole framework and designed for the catalysis of cross-coupling reactions. The molecule combines an electron-rich phosphorus atom bearing di-tert-butyl groups with a diphenyl-substituted pyrazole ring, the two connected through a phenylene bridge. In the laboratory, this compound acts as a supporting ligand for transition metals, particularly palladium, where its task is to form the active catalytic complex and to direct the course of the catalytic cycle in reactions that build carbon–carbon and carbon–heteroatom bonds.\u003c\/p\u003e\n\u003cp\u003eThe properties that make this ligand a preferred choice are the combination of high basicity and substantial steric bulk contributed by the di-tert-butylphosphino group. High basicity accelerates the oxidative addition step on less reactive substrates, while the steric bulk promotes the reductive elimination step so that the catalytic cycle turns over more rapidly. The pyrazole ring supplies an additional donor nitrogen atom together with a rigid aromatic framework, giving a directed coordination environment around the metal centre. A structure of this kind generally allows low catalyst loadings and a broad substrate scope.\u003c\/p\u003e\n\u003cp\u003eIn Indonesian laboratories, a ligand of this type is typically used in synthetic and methodology work where a palladium-catalysed coupling has to be assembled from the metal precursor and the ligand in situ, or pre-formed as a defined complex before use. It suits organic synthesis groups in universities and research institutes, as well as process and formulation development laboratories that prepare intermediates on a small scale and need a coupling system that performs reliably on demanding substrates.\u003c\/p\u003e\n\u003ch3\u003eLaboratory Applications\u003c\/h3\u003e\n\u003cul\u003e\n\u003cli\u003eSuzuki–Miyaura coupling: the high basicity of the di-tert-butylphosphino group assists oxidative addition on less reactive aryl substrates, while the steric bulk speeds reductive elimination and turnover.\u003c\/li\u003e\n\u003cli\u003eBuchwald–Hartwig type carbon–nitrogen bond formation: the electron-rich phosphorus centre and rigid pyrazole framework give the directed coordination environment needed for reliable amination of aryl partners.\u003c\/li\u003e\n\u003cli\u003eGeneral carbon–carbon bond construction: the ligand forms active catalytic complexes with palladium and steers the catalytic cycle, supporting couplings that would otherwise stall on hindered substrates.\u003c\/li\u003e\n\u003cli\u003eCarbon–heteroatom coupling methodology studies: the additional donor nitrogen atom of the pyrazole ring offers a defined coordination geometry that researchers can exploit when screening reaction conditions.\u003c\/li\u003e\n\u003cli\u003eLow-loading catalysis work: because the structure generally permits reduced catalyst charges and broad substrate scope, it suits laboratories optimising ligand-to-metal ratios and catalyst economy.\u003c\/li\u003e\n\u003c\/ul\u003e\n\u003ch3\u003eSpecifications\u003c\/h3\u003e\n\u003cul\u003e\n\u003cli\u003eBrand: TCI\u003c\/li\u003e\n\u003cli\u003eCAS number: 628333-86-8\u003c\/li\u003e\n\u003cli\u003eCategory: Chemistry \u0026gt; Catalysis and Inorganic Chemistry \u0026gt; Cross-Coupling [Catalysis]\u003c\/li\u003e\n\u003cli\u003eChemical name: 1-[2-(Di-tert-butylphosphino)phenyl]-3,5-diphenyl-1H-pyrazole\u003c\/li\u003e\n\u003cli\u003ePack sizes: available in the standard research-scale pack sizes offered by the manufacturer; please confirm the packaging option required when ordering.\u003c\/li\u003e\n\u003cli\u003eStorage: keep in the closed original container under the conditions stated on the manufacturer's label and safety data sheet.\u003c\/li\u003e\n\u003c\/ul\u003e\n\u003ch3\u003eHandling and Storage\u003c\/h3\u003e\n\u003cp\u003eStore the product in its original tightly closed container, kept in a cool, dry and well-ventilated place away from heat, ignition sources and incompatible materials, and follow the specific storage conditions printed on the manufacturer's label and safety data sheet. As with other trialkylphosphine ligands, minimise exposure to air and moisture during handling; use tightly sealed glass or the supplied original containers rather than transferring to open vessels. Weigh and dispense in a fume hood using an inert atmosphere where the protocol calls for it, and wear a laboratory coat, safety glasses and suitable chemical-resistant gloves. Keep the container closed when not in use, label all secondary containers clearly, and dispose of residues and contaminated consumables through the laboratory's chemical waste procedure. Consult the manufacturer's safety data sheet before first use.\u003c\/p\u003e","brand":"TCI","offers":[{"title":"1g","offer_id":48086640558298,"sku":"TCI2510D383424226","price":1546000.0,"currency_code":"IDR","in_stock":true},{"title":"5g","offer_id":48086640591066,"sku":"TCI2510D383424227","price":4470000.0,"currency_code":"IDR","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0756\/7156\/8602\/files\/TCI2510D3834.jpg?v=1767106644"},{"product_id":"tci2510b27098335","title":"TCI B2709 161265-03-8 4,5-Bis(diphenylphosphino)-9,9-dimethylxanthene","description":"\u003cp\u003e\u003cstrong\u003e4,5-Bis(diphenylphosphino)-9,9-dimethylxanthene\u003c\/strong\u003e (CAS 161265-03-8) is a high-quality chemical from TCI, supplied as \u003cstrong\u003eGC Grade \/ for Synthesis\u003c\/strong\u003e.\u003c\/p\u003e\u003cp\u003e\u003cstrong\u003eApplication:\u003c\/strong\u003e Synthesis reagent for a wide range of organic chemistry transformations in laboratory and industrial settings.\u003c\/p\u003e\u003cp\u003e\u003cstrong\u003eSpecifications:\u003c\/strong\u003e\u003c\/p\u003e\u003cul\u003e\n\u003cli\u003eMolecular formula: C39H32OP2\u003c\/li\u003e\n\u003cli\u003eCAS number: 161265-03-8\u003c\/li\u003e\n\u003cli\u003ePurity: \u0026gt;98.0%(GC)\u003c\/li\u003e\n\u003cli\u003eTCI product code: B2709\u003c\/li\u003e\n\u003c\/ul\u003e\u003cp\u003e\u003cstrong\u003eSynonyms:\u003c\/strong\u003e Xantphos\u003c\/p\u003e\u003cp\u003eAvailable from \u003cstrong\u003eAMI Scientific\u003c\/strong\u003e, the authorised TCI distributor in Indonesia. \u003cstrong\u003eContact us for pricing and stock availability\u003c\/strong\u003e — we ship throughout Indonesia.\u003c\/p\u003e","brand":"TCI","offers":[{"title":"1g","offer_id":48085673771226,"sku":"TCI2510B27098335","price":1378000.0,"currency_code":"IDR","in_stock":true},{"title":"5g","offer_id":48085673803994,"sku":"TCI2510B27098336","price":4751000.0,"currency_code":"IDR","in_stock":true},{"title":"25g","offer_id":48085673836762,"sku":"TCI2510B27098337","price":16133000.0,"currency_code":"IDR","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0756\/7156\/8602\/files\/TCI2510B2709_a01ae08d-27fb-441f-84af-46c6c6b59945.jpg?v=1767338005"},{"product_id":"tci2510b523911837","title":"TCI B5239 940934-47-4 4,5-Bis(dicyclohexylphosphino)-9,9-dimethylxanthene","description":"\u003cp\u003e\u003cstrong\u003e4,5-Bis(dicyclohexylphosphino)-9,9-dimethylxanthene\u003c\/strong\u003e (CAS 940934-47-4) is a high-quality chemical from TCI, supplied as \u003cstrong\u003eGC Grade \/ for Synthesis\u003c\/strong\u003e.\u003c\/p\u003e\u003cp\u003e\u003cstrong\u003eApplication:\u003c\/strong\u003e Synthesis reagent for a wide range of organic chemistry transformations in laboratory and industrial settings.\u003c\/p\u003e\u003cp\u003e\u003cstrong\u003eSpecifications:\u003c\/strong\u003e\u003c\/p\u003e\u003cul\u003e\n\u003cli\u003eMolecular formula: C39H56OP2\u003c\/li\u003e\n\u003cli\u003eCAS number: 940934-47-4\u003c\/li\u003e\n\u003cli\u003ePurity: \u0026gt;97.0%(GC)\u003c\/li\u003e\n\u003cli\u003eTCI product code: B5239\u003c\/li\u003e\n\u003c\/ul\u003e\u003cp\u003eAvailable from \u003cstrong\u003eAMI Scientific\u003c\/strong\u003e, the authorised TCI distributor in Indonesia. \u003cstrong\u003eContact us for pricing and stock availability\u003c\/strong\u003e — we ship throughout Indonesia.\u003c\/p\u003e","brand":"TCI","offers":[{"title":"200mg","offer_id":48085860188378,"sku":"TCI2510B523911837","price":1462000.0,"currency_code":"IDR","in_stock":true},{"title":"1g","offer_id":48085860221146,"sku":"TCI2510B523911838","price":4807000.0,"currency_code":"IDR","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0756\/7156\/8602\/files\/TCI2510B5239_8968e7d3-81bf-4e16-9ce5-1780519639a0.jpg?v=1767856027"},{"product_id":"tci2510t166652920","title":"TCI T1666 24171-89-9 Tri(2-thienyl)phosphine","description":"\u003cp\u003e\u003cstrong\u003eTri(2-thienyl)phosphine\u003c\/strong\u003e (CAS 24171-89-9) is a high-quality chemical from TCI, supplied as \u003cstrong\u003eGC Grade \/ for Synthesis\u003c\/strong\u003e.\u003c\/p\u003e\u003cp\u003e\u003cstrong\u003eApplication:\u003c\/strong\u003e Used as a phosphine ligand in transition-metal catalysis.\u003c\/p\u003e\u003cp\u003e\u003cstrong\u003eSpecifications:\u003c\/strong\u003e\u003c\/p\u003e\u003cul\u003e\n\u003cli\u003eMolecular formula: C12H9PS3\u003c\/li\u003e\n\u003cli\u003eCAS number: 24171-89-9\u003c\/li\u003e\n\u003cli\u003ePurity: \u0026gt;96.0%(GC)\u003c\/li\u003e\n\u003cli\u003eTCI product code: T1666\u003c\/li\u003e\n\u003c\/ul\u003e\u003cp\u003eAvailable from \u003cstrong\u003eAMI Scientific\u003c\/strong\u003e, the authorised TCI distributor in Indonesia. \u003cstrong\u003eContact us for pricing and stock availability\u003c\/strong\u003e — we ship throughout Indonesia.\u003c\/p\u003e","brand":"TCI","offers":[{"title":"1g","offer_id":48088433524954,"sku":"TCI2510T166652920","price":2643000.0,"currency_code":"IDR","in_stock":true},{"title":"5g","offer_id":48088433557722,"sku":"TCI2510T166652921","price":8432000.0,"currency_code":"IDR","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0756\/7156\/8602\/files\/TCI2510T1666.jpg?v=1767141996"},{"product_id":"tci2510t404755774","title":"TCI T4047 97739-46-3 1,3,5,7-Tetramethyl-8-phenyl-2,4,6-trioxa-8-phosphaadamantane","description":"\u003cp\u003e\u003cstrong\u003e1,3,5,7-Tetramethyl-8-phenyl-2,4,6-trioxa-8-phosphaadamantane\u003c\/strong\u003e (CAS 97739-46-3) is a high-quality chemical from TCI, supplied as \u003cstrong\u003eHPLC Grade\u003c\/strong\u003e.\u003c\/p\u003e\u003cp\u003e\u003cstrong\u003eApplication:\u003c\/strong\u003e Aromatic carbocyclic compound serving as a core scaffold in organic and materials synthesis.\u003c\/p\u003e\u003cp\u003e\u003cstrong\u003eSpecifications:\u003c\/strong\u003e\u003c\/p\u003e\u003cul\u003e\n\u003cli\u003eMolecular formula: C16H21O3P\u003c\/li\u003e\n\u003cli\u003eCAS number: 97739-46-3\u003c\/li\u003e\n\u003cli\u003ePurity: \u0026gt;95.0%(HPLC)(qNMR)\u003c\/li\u003e\n\u003cli\u003eTCI product code: T4047\u003c\/li\u003e\n\u003c\/ul\u003e\u003cp\u003e\u003cstrong\u003eSynonyms:\u003c\/strong\u003e 1,3,5,7-Tetramethyl-8-phenyl-2,4,6-trioxa-8-phosphatricyclo[3.3.1.1~3,7~]decane; MeCgPPh\u003c\/p\u003e\u003cp\u003eAvailable from \u003cstrong\u003eAMI Scientific\u003c\/strong\u003e, the authorised TCI distributor in Indonesia. \u003cstrong\u003eContact us for pricing and stock availability\u003c\/strong\u003e — we ship throughout Indonesia.\u003c\/p\u003e","brand":"TCI","offers":[{"title":"200mg","offer_id":48088586289370,"sku":"TCI2510T404755774","price":2306000.0,"currency_code":"IDR","in_stock":true},{"title":"1g","offer_id":48088586322138,"sku":"TCI2510T404755775","price":7167000.0,"currency_code":"IDR","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0756\/7156\/8602\/files\/TCI2510T4047.jpg?v=1767144654"}],"url":"https:\/\/amiscientific.com\/en\/collections\/tci-l4-phosphine-ligands-cross-coupling-reaction-using-transition-metal-catalysts.oembed","provider":"AMI Scientific","version":"1.0","type":"link"}