{"title":"Reagents for Life-style related Disease Models","description":"\u003cp\u003e\u003cstrong\u003eReagents for Life-style related Disease Models\u003c\/strong\u003e — menghimpun bahan kimia seperti alloxan, asam arakidonat, dan adenosin difosfat yang dipakai peneliti untuk menyusun model penelitian terkait pola metabolik dan kardiovaskular pada hewan percobaan. Senyawa dalam kelompok ini mencakup induktor metabolik, mediator lipid, hingga pewarna dan senyawa referensi pada riset farmakologi.\u003c\/p\u003e\u003cp\u003eReagents for Life-style related Disease Models digunakan peneliti farmakologi dan fisiologi untuk menyusun model penelitian pada hewan uji, misalnya melalui pemberian alloxan pada studi metabolisme glukosa atau asam arakidonat pada studi jalur lipid. Senyawa seperti Potassium Oxonate dan Propranolol Hydrochloride juga dipakai sebagai agen pendukung dalam protokol penelitian praklinis di laboratorium.\u003c\/p\u003e\u003cp\u003eContoh produk dalam koleksi ini: \u003ca href=\"\/en\/products\/tci2510a0216307\"\u003eTCI A0216 2244-11-3 Alloxan Monohydrate\u003c\/a\u003e, \u003ca href=\"\/en\/products\/tci2510d004719346\"\u003eTCI D0047 56-47-3 Deoxycorticosterone Acetate\u003c\/a\u003e, \u003ca href=\"\/en\/products\/tci2510a07811027\"\u003eTCI A0781 506-32-1 Arachidonic Acid\u003c\/a\u003e, \u003ca href=\"\/en\/products\/tci2510d182821755\"\u003eTCI D1828 20830-75-5 Digoxin\u003c\/a\u003e, \u003ca href=\"\/en\/products\/tci2510a0626831\"\u003eTCI A0626 16178-48-6 Adenosine 5'-Diphosphate Disodium Salt\u003c\/a\u003e, \u003ca href=\"\/en\/products\/tci2510d419324714\"\u003eTCI D4193 25316-40-9 Doxorubicin Hydrochloride\u003c\/a\u003e, \u003ca href=\"\/en\/products\/tci2510r004149491\"\u003eTCI R0041 632-69-9 Acid Red 94\u003c\/a\u003e, \u003ca href=\"\/en\/products\/tci2510e084028635\"\u003eTCI E0840 56390-09-1 Epirubicin Hydrochloride\u003c\/a\u003e.\u003c\/p\u003e\u003cp\u003ePemilihan reagen model penelitian ini perlu memperhatikan kemurnian, bentuk garam atau hidrat, serta kelarutan dalam pelarut yang sesuai dengan protokol pemberian pada studi hewan yang direncanakan. Seluruh produk merupakan produk asli Tokyo Chemical Industry (TCI) Jepang, dengan kemurnian, kemasan, dan kondisi penyimpanan tercantum pada halaman masing-masing item.\u003c\/p\u003e\u003cp\u003eKategori lain yang sejajar di bawah Animal Disease Models Preparation, sering dipakai bersamaan dalam satu alur kerja laboratorium:\u003c\/p\u003e\u003cul\u003e\n\u003cli\u003e\u003ca href=\"\/en\/collections\/tci-l4-reagents-for-inflammation-and-immunity-disorder-models\"\u003eReagents for Inflammation and Immunity Disorder Models\u003c\/a\u003e\u003c\/li\u003e\n\u003cli\u003e\u003ca href=\"\/en\/collections\/tci-l4-reagents-for-pain-and-itch-models\"\u003eReagents for Pain and Itch Models\u003c\/a\u003e\u003c\/li\u003e\n\u003cli\u003e\u003ca href=\"\/en\/collections\/tci-l4-reagents-for-central-nervous-system-disease-models\"\u003eReagents for Central Nervous System Disease Models\u003c\/a\u003e\u003c\/li\u003e\n\u003cli\u003e\u003ca href=\"\/en\/collections\/tci-l4-reagents-for-carcinogenic-models\"\u003eReagents for Carcinogenic Models\u003c\/a\u003e\u003c\/li\u003e\n\u003cli\u003e\u003ca href=\"\/en\/collections\/tci-l4-reagents-for-disease-models-other\"\u003eReagents for Disease Models (Other)\u003c\/a\u003e\u003c\/li\u003e\n\u003c\/ul\u003e\u003cp\u003eKembali ke \u003ca href=\"\/en\/collections\/tci-l3-animal-disease-models-preparation\"\u003eAnimal Disease Models Preparation\u003c\/a\u003e. Untuk pengadaan volume besar, kemasan khusus, atau grade tertentu, hubungi tim AMI Scientific — distributor resmi TCI Japan di Indonesia — untuk pengecekan ketersediaan dan lead time langsung ke Jepang.\u003c\/p\u003e","products":[{"product_id":"tci2510d004719346","title":"TCI D0047 56-47-3 Deoxycorticosterone Acetate","description":"\u003ch3\u003eDescription\u003c\/h3\u003e\n\u003cp\u003eDeoxycorticosterone Acetate (D0047), with CAS number 56-47-3, is a chemical compound widely used in life science research, particularly in the development of animal disease models. This compound serves as an experimental agent to investigate the mechanisms of diseases linked to hormonal imbalances and hypertension. In laboratory settings, it is employed to induce specific physiological responses in test animals, enabling researchers to study the effects of hormonal disturbances on the body's systems. Its role is crucial in understanding the physiological and pathological processes associated with various diseases.\u003c\/p\u003e\n\u003cp\u003eThe compound is chemically stable and can be stored under specific conditions, making it convenient for use in a variety of experimental setups. Its stability ensures consistent performance across different experiments, which is essential for reliable scientific results. Additionally, it is considered relatively safe for use in animal research when administered in appropriate doses, reducing potential risks to both the animals and the researchers. This safety profile contributes to its popularity among laboratories conducting experimental studies.\u003c\/p\u003e\n\u003cp\u003eIn Indonesian laboratories, D0047 is commonly used in research related to hypertension and hormonal disorders. Many research institutions and universities utilize this compound to study the physiological responses of animals to hormonal changes. These studies support the development of therapeutic approaches and contribute to the broader understanding of endocrine-related diseases.\u003c\/p\u003e\n\u003ch3\u003eLaboratory Applications\u003c\/h3\u003e\n\u003cul\u003e\n\u003cli\u003eHypertension Research: This compound is used to induce hypertension in animal models, allowing researchers to study the physiological and pathological changes associated with high blood pressure.\u003c\/li\u003e\n\u003cli\u003eHormonal Disorder Studies: It helps in investigating the effects of hormonal imbalances on various organ systems, aiding in the development of treatment strategies.\u003c\/li\u003e\n\u003cli\u003ePharmacological Testing: D0047 is employed in drug testing to evaluate the efficacy and safety of new compounds in managing hormonal and cardiovascular conditions.\u003c\/li\u003e\n\u003cli\u003eEndocrinology Research: It supports studies on the endocrine system by mimicking natural hormone activity, providing insights into hormone-related diseases.\u003c\/li\u003e\n\u003cli\u003eComparative Physiology Studies: Researchers use it to compare physiological responses across different species, contributing to a broader understanding of biological mechanisms.\u003c\/li\u003e\n\u003c\/ul\u003e\n\u003ch3\u003eSpecifications\u003c\/h3\u003e\n\u003cul\u003e\n\u003cli\u003eBrand: TCI\u003c\/li\u003e\n\u003cli\u003eCAS Number: 56-47-3\u003c\/li\u003e\n\u003cli\u003eCategory: Life Science \u0026gt; Biochemicals and Reagents \u0026gt; Animal Disease Models Preparation\u003c\/li\u003e\n\u003cli\u003ePack Sizes: Available in various quantities as per supplier specifications\u003c\/li\u003e\n\u003cli\u003ePhysical Form: Solid\u003c\/li\u003e\n\u003cli\u003eStorage Note: Store in a cool, dry place away from direct sunlight\u003c\/li\u003e\n\u003c\/ul\u003e\n\u003ch3\u003eHandling and Storage\u003c\/h3\u003e\n\u003cp\u003eDeoxycorticosterone Acetate should be stored in a cool, dry environment to maintain its chemical stability and prevent degradation. It is recommended to keep the compound in airtight containers to minimize exposure to moisture and air, which can affect its integrity. Proper labeling of containers is essential to ensure safe handling and prevent accidental misuse. In laboratory settings, it should be handled with standard safety precautions, including the use of gloves and appropriate personal protective equipment. Regular monitoring of storage conditions is advised to ensure the compound remains suitable for experimental use. Laboratories should also maintain proper documentation and follow established safety protocols to ensure compliance with regulatory standards.\u003c\/p\u003e","brand":"TCI","offers":[{"title":"1g","offer_id":48086336143578,"sku":"TCI2510D004719346","price":3064000.0,"currency_code":"IDR","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0756\/7156\/8602\/files\/TCI2510D0047.jpg?v=1767100718"},{"product_id":"tci2510d182821755","title":"TCI D1828 20830-75-5 Digoxin","description":"\u003ch3\u003eDescription\u003c\/h3\u003e\n\u003cp\u003eDigoxin is a chemical compound classified under the category of digitalis glycosides, commonly used in biochemical and pharmacological research. As a key component in the study of cardiac physiology, it plays a vital role in understanding the mechanisms of action of cardiac medications. Its strong pharmacological activity makes it an essential tool for investigating the effects of drugs on the cardiovascular system. In the laboratory, Digoxin is widely utilized for its ability to modulate heart rate and contractility, making it a valuable asset in pharmacological studies and drug development.\u003c\/p\u003e\n\u003cp\u003eDigoxin is known for its chemical stability under controlled conditions, which ensures consistent results in experimental settings. However, it is highly sensitive to moisture and light, requiring careful handling and storage to maintain its integrity. These properties make it a preferred choice for researchers who require reliable and reproducible data. Its availability in solid form simplifies its use in both qualitative and quantitative analyses, enhancing its versatility in various laboratory applications.\u003c\/p\u003e\n\u003cp\u003eIn Indonesian laboratories, Digoxin is frequently used in public health and pharmaceutical research. It serves as a critical reagent for studying the pharmacological effects and mechanisms of action of drugs in human physiology. Its application supports the development of more effective and safe therapeutic options for the Indonesian population. Researchers rely on Digoxin to advance their understanding of cardiovascular diseases and improve treatment strategies.\u003c\/p\u003e\n\u003ch3\u003eLaboratory Applications\u003c\/h3\u003e\n\u003cul\u003e\n\u003cli\u003ePharmacological research for studying cardiac drug mechanisms and effects on heart function.\u003c\/li\u003e\n\u003cli\u003eDevelopment of new pharmaceuticals by analyzing the pharmacological properties of Digoxin.\u003c\/li\u003e\n\u003cli\u003eToxicological studies to evaluate the safety and potential side effects of the compound.\u003c\/li\u003e\n\u003cli\u003eBiochemical experiments to investigate the interaction of Digoxin with cellular and molecular targets.\u003c\/li\u003e\n\u003cli\u003ePublic health research to understand the impact of cardiac medications on human health and disease management.\u003c\/li\u003e\n\u003c\/ul\u003e\n\u003ch3\u003eSpecifications\u003c\/h3\u003e\n\u003cul\u003e\n\u003cli\u003eBrand: TCI\u003c\/li\u003e\n\u003cli\u003eCAS number: 20830-75-5\u003c\/li\u003e\n\u003cli\u003eCategory: Chemistry \u0026gt; Chemical Biology \u0026gt; Glycoscience\u003c\/li\u003e\n\u003cli\u003ePack sizes: Available in various quantities as per standard laboratory requirements\u003c\/li\u003e\n\u003cli\u003ePhysical form: Solid\u003c\/li\u003e\n\u003cli\u003eStorage note: Must be stored in a cool, dry place away from light and moisture\u003c\/li\u003e\n\u003c\/ul\u003e\n\u003ch3\u003eHandling and Storage\u003c\/h3\u003e\n\u003cp\u003eDigoxin should be stored in a cool, dry environment, away from direct light and moisture to maintain its chemical stability. It is recommended to use airtight containers made of glass or high-density polyethylene to prevent exposure to humidity. Due to its sensitivity, it is important to handle Digoxin with clean, dry gloves and avoid contact with moisture during preparation. In laboratory settings, it should be kept in a designated storage area with controlled environmental conditions to ensure its integrity. Always follow standard safety protocols when handling this compound to prevent degradation and ensure accurate experimental results.\u003c\/p\u003e","brand":"TCI","offers":[{"title":"100mg","offer_id":48086477865178,"sku":"TCI2510D182821755","price":1125000.0,"currency_code":"IDR","in_stock":true},{"title":"1g","offer_id":48086477897946,"sku":"TCI2510D182821756","price":4667000.0,"currency_code":"IDR","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0756\/7156\/8602\/files\/TCI2510D1828.jpg?v=1767103763"},{"product_id":"tci2510d419324714","title":"TCI D4193 25316-40-9 Doxorubicin Hydrochloride","description":"\u003ch3\u003eDescription\u003c\/h3\u003e\n\u003cp\u003eTCI D4193 Doxorubicin Hydrochloride, bearing CAS number 25316-40-9, is an anthracycline compound supplied in its hydrochloride salt form and classified within chemical biology, specifically the field of glycoscience, because its structure contains an amino sugar moiety attached to a polyketide aglycone core. It is one of the most widely recognised reagents in cell biology research and experimental oncology, employed as a comparative treatment in cell viability assays, DNA damage studies, and drug resistance research. Its established role as a reference compound makes it an important part of the modern biomedical research laboratory toolkit.\u003c\/p\u003e\n\u003cp\u003eThe characteristics that make doxorubicin such a frequently chosen compound include its ability to intercalate between DNA base pairs and its influence on the activity of the topoisomerase II enzyme, two properties that together produce clear and readily observable cellular responses. The molecule is also intrinsically fluorescent, so its uptake into cells can be monitored directly by fluorescence microscopy or flow cytometry without the need for any additional labelling step. The daunosamine sugar portion improves solubility in water, and the hydrochloride salt form makes the preparation of aqueous stock solutions straightforward and practical for routine bench work.\u003c\/p\u003e\n\u003cp\u003eIn Indonesian laboratories, this reagent is typically found in university research groups, biomedical and pharmaceutical research institutes, and cell culture facilities working on oncology-related questions. It commonly serves as the positive control or benchmark treatment in cytotoxicity screening panels, where new candidate compounds are compared against a well-characterised standard. Because its behaviour in cell-based systems is thoroughly documented, it also supports method development, assay validation, and the training of researchers and postgraduate students in cell biology techniques.\u003c\/p\u003e\n\u003ch3\u003eLaboratory Applications\u003c\/h3\u003e\n\u003cul\u003e\n\u003cli\u003eCell viability and cytotoxicity assays, where it functions as a reliable comparative treatment against which the activity of newly synthesised or extracted candidate compounds can be measured.\u003c\/li\u003e\n\u003cli\u003eDNA damage studies, since its intercalation between DNA base pairs and its effect on topoisomerase II activity generate clear, reproducible cellular responses suitable for mechanistic investigation.\u003c\/li\u003e\n\u003cli\u003eDrug resistance research, in which it is used as a reference anthracycline to characterise resistant cell populations and to examine how treatment responses shift across experimental conditions.\u003c\/li\u003e\n\u003cli\u003eCellular uptake and localisation experiments, taking advantage of its intrinsic fluorescence so that entry into cells can be tracked by fluorescence microscopy without adding any external label.\u003c\/li\u003e\n\u003cli\u003eFlow cytometry workflows in experimental oncology, where the compound's own fluorescent signal allows quantitative assessment of accumulation across cell populations without an additional staining procedure.\u003c\/li\u003e\n\u003c\/ul\u003e\n\u003ch3\u003eSpecifications\u003c\/h3\u003e\n\u003cul\u003e\n\u003cli\u003eBrand: TCI\u003c\/li\u003e\n\u003cli\u003eCAS Number: 25316-40-9\u003c\/li\u003e\n\u003cli\u003eCategory: Chemistry \u0026gt; Chemical Biology \u0026gt; Glycoscience\u003c\/li\u003e\n\u003cli\u003eChemical class: anthracycline compound supplied as the hydrochloride salt\u003c\/li\u003e\n\u003cli\u003eSolubility note: the daunosamine sugar moiety supports water solubility, and the hydrochloride salt form facilitates preparation of aqueous stock solutions\u003c\/li\u003e\n\u003cli\u003ePack sizes: available in the pack sizes listed on the product page; please confirm the option required when ordering\u003c\/li\u003e\n\u003cli\u003eStorage: store according to the conditions stated on the manufacturer's label and product documentation\u003c\/li\u003e\n\u003c\/ul\u003e\n\u003ch3\u003eHandling and Storage\u003c\/h3\u003e\n\u003cp\u003eStore this product under the conditions specified on the manufacturer's label and accompanying documentation, keeping the container tightly closed and protected from light, moisture, and elevated temperature. Use clean, chemically compatible containers for aqueous stock solutions, label them clearly with concentration and preparation date, and aliquot where repeated freeze-thaw cycles would otherwise be required. Handle the material only in a designated laboratory area using appropriate personal protective equipment, including gloves, a laboratory coat, and eye protection, and carry out weighing and solution preparation with suitable engineering controls in place. Avoid the generation of dust or aerosols, keep the compound away from incompatible materials, and dispose of residues and contaminated consumables through the established chemical waste procedures of your institution. Always consult the Safety Data Sheet before first use.\u003c\/p\u003e","brand":"TCI","offers":[{"title":"25mg","offer_id":48086677881050,"sku":"TCI2510D419324714","price":6409000.0,"currency_code":"IDR","in_stock":true},{"title":"100mg","offer_id":48086677913818,"sku":"TCI2510D419324715","price":19169000.0,"currency_code":"IDR","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0756\/7156\/8602\/files\/TCI2510D4193.jpg?v=1767107201"},{"product_id":"tci2510e084028635","title":"TCI E0840 56390-09-1 Epirubicin Hydrochloride","description":"\u003ch3\u003eDescription\u003c\/h3\u003e\n\u003cp\u003eTCI E0840 Epirubicin Hydrochloride is the hydrochloride salt form of epirubicin, an anthracycline antibiotic that is the 4'-position epimer of doxorubicin. The molecule consists of a conjugated anthracyclinone aglycone core linked to an amino sugar through a glycosidic bond, which makes the compound relevant to the field of glycoscience as well as to oncology-related research. In the laboratory, this material serves as a research reagent and reference compound rather than a therapeutic agent. Researchers use it in studies of anticancer drug mechanisms, cytotoxicity testing on cell cultures, drug delivery system development, and as a standard in analytical method development.\u003c\/p\u003e\n\u003cp\u003eThe property that makes this compound important for research is its extensively documented mode of action. Epirubicin intercalates between DNA base pairs and interferes with the activity of topoisomerase II enzymes, thereby inhibiting replication and transcription in rapidly dividing cells. The anthracycline core is also chromophoric and fluorescent, which is a practical advantage because the distribution of the compound inside cells can be observed by fluorescence microscopy without the need for additional labelling. The hydrochloride salt form improves handling characteristics relative to the free base, making the material more convenient to weigh out and prepare for laboratory work.\u003c\/p\u003e\n\u003cp\u003eIn Indonesian laboratories, this material is typically encountered in university pharmacology and pharmaceutical chemistry departments, biomedical research institutes, and analytical laboratories that develop and validate methods for anthracycline compounds. It is generally used at small scale in cell culture facilities and instrument rooms, handled under the supervision of trained personnel who follow institutional protocols for cytotoxic research chemicals. Its role in such settings is as a well-characterised reference material against which experimental results can be compared.\u003c\/p\u003e\n\u003ch3\u003eLaboratory Applications\u003c\/h3\u003e\n\u003cul\u003e\n\u003cli\u003eAnticancer drug mechanism studies: the documented DNA intercalation and topoisomerase II interference of epirubicin make it a dependable model compound for probing how anthracyclines disrupt replication and transcription.\u003c\/li\u003e\n\u003cli\u003eCytotoxicity testing on cell cultures: because its cytotoxic behaviour toward rapidly dividing cells is extensively characterised, it serves as a reliable positive control and comparator in cell viability assays.\u003c\/li\u003e\n\u003cli\u003eDrug delivery system development: the hydrochloride salt form eases preparation and loading work, while the fluorescent anthracycline core lets researchers track carrier uptake and release inside cells.\u003c\/li\u003e\n\u003cli\u003eAnalytical method development: as a reference compound it supports the establishment, calibration, and comparison of chromatographic and spectroscopic methods intended for anthracycline determination.\u003c\/li\u003e\n\u003cli\u003eGlycoscience research: the amino sugar joined to the aglycone core through a glycosidic bond makes the molecule a useful subject for studying glycosidic linkages in bioactive natural product frameworks.\u003c\/li\u003e\n\u003c\/ul\u003e\n\u003ch3\u003eSpecifications\u003c\/h3\u003e\n\u003cul\u003e\n\u003cli\u003eBrand: TCI (Tokyo Chemical Industry)\u003c\/li\u003e\n\u003cli\u003eCAS number: 56390-09-1\u003c\/li\u003e\n\u003cli\u003eCategory: Chemistry \u0026gt; Chemical Biology \u0026gt; Glycoscience\u003c\/li\u003e\n\u003cli\u003eProduct code: E0840\u003c\/li\u003e\n\u003cli\u003ePack sizes: available in laboratory-scale research quantities; please refer to the pack size options listed for this item\u003c\/li\u003e\n\u003cli\u003eStorage note: store according to the manufacturer's stated conditions on the product label and certificate of analysis\u003c\/li\u003e\n\u003c\/ul\u003e\n\u003ch3\u003eHandling and Storage\u003c\/h3\u003e\n\u003cp\u003eStore this material in its original tightly closed container, protected from light and moisture, under the storage conditions stated by the manufacturer on the product label. Amber glass or otherwise light-protected containers are appropriate given the chromophoric nature of the anthracycline core. Because this is a cytotoxic research chemical, handle it only in a designated area with appropriate engineering controls, such as a fume hood or biological safety cabinet, and wear gloves, a laboratory coat, and eye protection. Avoid generating dust when weighing the solid, keep the container closed when not in use, and dispose of residues and contaminated consumables through your institution's chemical waste procedures. This product is intended for research use only and not for therapeutic application. 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