{"title":"Reagents for the Generation of Arynes","description":"\u003cp\u003e\u003cstrong\u003eReagents for the Generation of Arynes\u003c\/strong\u003e — berisi reagen pemicu eliminasi seperti garam fluorida (tetrabutilammonium fluorida, sesium fluorida), nitrit organik, dan timbal tetraasetat yang digunakan untuk membangkitkan spesies aryne dan heteroaryne reaktif secara in situ. Reagen-reagen ini bekerja melalui mekanisme eliminasi pada prekursor silil triflat atau dekomposisi diazonium.\u003c\/p\u003e\u003cp\u003eReagents for the Generation of Arynes dipakai dalam reaksi sikloadisi, insersi, dan fungsionalisasi cincin aromatik untuk membangun senyawa polisiklik kompleks dalam sintesis total dan kimia material. Kimiawan sintesis organik memanfaatkannya untuk menghasilkan aryne secara terkendali sebagai langkah kunci pembentukan ikatan karbon-karbon baru.\u003c\/p\u003e\u003cp\u003eContoh produk dalam koleksi ini: \u003ca href=\"\/en\/products\/tci2510t133852469\"\u003eTCI T1338 429-41-4 Tetrabutylammonium Fluoride (ca 1mol\/L in Tetrahydrofuran)\u003c\/a\u003e, \u003ca href=\"\/en\/products\/tci2510c220416885\"\u003eTCI C2204 13400-13-0 Cesium Fluoride\u003c\/a\u003e, \u003ca href=\"\/en\/products\/tci2510n035743076\"\u003eTCI N0357 540-80-7 tert-Butyl Nitrite\u003c\/a\u003e, \u003ca href=\"\/en\/products\/tci2510i008935063\"\u003eTCI I0089 110-46-3 Isoamyl Nitrite\u003c\/a\u003e, \u003ca href=\"\/en\/products\/tci2510l002136888\"\u003eTCI L0021 546-67-8 Lead Tetraacetate (contains Acetic Acid)\u003c\/a\u003e.\u003c\/p\u003e\u003cp\u003ePilih reagen sesuai jalur pembentukan aryne yang dituju (fluorida untuk eliminasi silil triflat, nitrit organik untuk dekomposisi diazonium), dan perhatikan bentuk sediaan, misalnya larutan dalam tetrahidrofuran, untuk memudahkan penanganan. Seluruh produk merupakan produk asli Tokyo Chemical Industry (TCI) Jepang, dengan kemurnian, kemasan, dan kondisi penyimpanan tercantum pada halaman masing-masing item.\u003c\/p\u003e\u003cp\u003eKategori lain yang sejajar di bawah Aryne Precursors, Heteroaryne Precursors, sering dipakai bersamaan dalam satu alur kerja laboratorium:\u003c\/p\u003e\u003cul\u003e\n\u003cli\u003e\u003ca href=\"\/en\/collections\/tci-l4-benzyne-precursors\"\u003eBenzyne Precursors\u003c\/a\u003e\u003c\/li\u003e\n\u003cli\u003e\u003ca href=\"\/en\/collections\/tci-l4-naphthalyne-precursors\"\u003eNaphthalyne Precursors\u003c\/a\u003e\u003c\/li\u003e\n\u003cli\u003e\u003ca href=\"\/en\/collections\/tci-l4-pyridyne-precursors\"\u003ePyridyne Precursors\u003c\/a\u003e\u003c\/li\u003e\n\u003cli\u003e\u003ca href=\"\/en\/collections\/tci-l4-quinolyne-precursors\"\u003eQuinolyne Precursors\u003c\/a\u003e\u003c\/li\u003e\n\u003cli\u003e\u003ca href=\"\/en\/collections\/tci-l4-aryne-precursors-other-related-compounds\"\u003eAryne Precursors (Other), Related Compounds\u003c\/a\u003e\u003c\/li\u003e\n\u003c\/ul\u003e\u003cp\u003eKembali ke \u003ca href=\"\/en\/collections\/tci-l3-aryne-precursors-heteroaryne-precursors\"\u003eAryne Precursors, Heteroaryne Precursors\u003c\/a\u003e. Untuk pengadaan volume besar, kemasan khusus, atau grade tertentu, hubungi tim AMI Scientific — distributor resmi TCI Japan di Indonesia — untuk pengecekan ketersediaan dan lead time langsung ke Jepang.\u003c\/p\u003e","products":[{"product_id":"tci2510c220416885","title":"TCI C2204 13400-13-0 Cesium Fluoride","description":"\u003ch3\u003eDescription\u003c\/h3\u003e\n\u003cp\u003eCesium Fluoride is an inorganic salt that pairs the large cesium cation with the fluoride anion, producing one of the most reactive sources of fluoride available for organic synthesis. In the laboratory it serves as a nucleophilic fluorination reagent, as a mild yet effective base in a range of coupling reactions, and as a reagent for cleaving silyl protecting groups. Its role is significant in medicinal chemistry and materials chemistry, because introducing fluorine atoms into a molecule can alter the electronic properties, solubility, and metabolic stability of the target compound.\u003c\/p\u003e\n\u003cp\u003eThe property that sets this material apart is the combination of relatively good solubility in aprotic organic solvents with \"naked fluoride\" behaviour arising from loose ion pairing. Because the cesium cation is large and soft, the ionic bond to fluoride is weakened, so the fluoride anion is freer to attack the substrate and delivers higher reaction rates than the lighter alkali metal fluorides. Cesium fluoride also acts as a base strong enough to activate boron and silicon reagents, yet soft enough to leave sensitive functional groups intact. It is strongly hygroscopic, which must be taken into account in every handling step.\u003c\/p\u003e\n\u003cp\u003eIn Indonesian laboratories this reagent is typically used in university and institutional organic synthesis groups, in medicinal chemistry work where fluorinated analogues are prepared, and in materials chemistry research. Because the local climate carries high ambient humidity throughout the year, working practice usually centres on keeping the container tightly closed, minimising exposure to open air, and weighing quickly so the reagent retains its reactivity between uses.\u003c\/p\u003e\n\u003ch3\u003eLaboratory Applications\u003c\/h3\u003e\n\u003cul\u003e\n\u003cli\u003eNucleophilic fluorination — the loose ion pairing releases a comparatively free fluoride anion, giving faster substitution of leaving groups than lighter alkali metal fluorides can achieve.\u003c\/li\u003e\n\u003cli\u003eRemoval of silyl protecting groups — the strong affinity of fluoride for silicon cleaves silyl ethers cleanly, making it a standard deprotection reagent in multi-step synthetic sequences.\u003c\/li\u003e\n\u003cli\u003eBase for coupling reactions — it is basic enough to activate boron reagents in cross-coupling chemistry while remaining soft enough not to destroy sensitive functional groups.\u003c\/li\u003e\n\u003cli\u003eMedicinal chemistry synthesis — introducing fluorine into candidate molecules modifies electronic properties, solubility, and metabolic stability, all of which matter when preparing and comparing drug analogues.\u003c\/li\u003e\n\u003cli\u003eMaterials chemistry research — fluorine incorporation changes the electronic character and stability of target compounds, supporting the preparation of fluorinated materials in research laboratories.\u003c\/li\u003e\n\u003c\/ul\u003e\n\u003ch3\u003eSpecifications\u003c\/h3\u003e\n\u003cul\u003e\n\u003cli\u003eBrand: TCI\u003c\/li\u003e\n\u003cli\u003eProduct code: C2204\u003c\/li\u003e\n\u003cli\u003eCAS number: 13400-13-0\u003c\/li\u003e\n\u003cli\u003eCategory: Chemistry \u0026gt; Catalysis and Inorganic Chemistry \u0026gt; Main-group Elements [Catalysis and Inorganic Chemistry]\u003c\/li\u003e\n\u003cli\u003ePack sizes: available in the catalogue pack sizes offered by TCI for this product code\u003c\/li\u003e\n\u003cli\u003eStorage note: strongly hygroscopic; keep the container tightly closed and protected from moisture\u003c\/li\u003e\n\u003c\/ul\u003e\n\u003ch3\u003eHandling and Storage\u003c\/h3\u003e\n\u003cp\u003eStore cesium fluoride in a tightly closed original container in a dry place, away from moisture, since the material is strongly hygroscopic and readily takes up water from the surrounding air. Containers that seal well, and ideally storage inside a desiccator, help preserve reactivity between uses. Weigh and transfer quickly to limit exposure to open air, preferably in a fume hood, and use appropriate gloves, eye protection, and a laboratory coat. Keep the container clearly labelled, avoid contamination of the bulk material, and follow the safety data sheet supplied with the product for detailed handling and disposal guidance.\u003c\/p\u003e","brand":"TCI","offers":[{"title":"25g","offer_id":48086111092954,"sku":"TCI2510C220416885","price":1913000.0,"currency_code":"IDR","in_stock":true},{"title":"100g","offer_id":48086111125722,"sku":"TCI2510C220416886","price":4807000.0,"currency_code":"IDR","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0756\/7156\/8602\/files\/TCI2510C2204.jpg?v=1767097915"},{"product_id":"tci2510t133852469","title":"TCI T1338 429-41-4 Tetrabutylammonium Fluoride (ca 1mol\/L in Tetrahydrofuran)","description":"\u003cp\u003e\u003cstrong\u003eTetrabutylammonium Fluoride (ca. 1mol\/L in Tetrahydrofuran)\u003c\/strong\u003e (CAS 429-41-4) is a high-quality chemical from TCI, supplied as \u003cstrong\u003eReagent Grade\u003c\/strong\u003e.\u003c\/p\u003e\u003cp\u003e\u003cstrong\u003eApplication:\u003c\/strong\u003e Five-membered heterocyclic compound used as a building block in pharmaceutical, agrochemical, and functional-material synthesis.\u003c\/p\u003e\u003cp\u003e\u003cstrong\u003eSpecifications:\u003c\/strong\u003e\u003c\/p\u003e\u003cul\u003e\n\u003cli\u003eMolecular formula: C16H36FN\u003c\/li\u003e\n\u003cli\u003eCAS number: 429-41-4\u003c\/li\u003e\n\u003cli\u003eTCI product code: T1338\u003c\/li\u003e\n\u003c\/ul\u003e\u003cp\u003e\u003cstrong\u003eSynonyms:\u003c\/strong\u003e TBAF (ca. 1mol\/L in Tetrahydrofuran)\u003c\/p\u003e\u003cp\u003eAvailable from \u003cstrong\u003eAMI Scientific\u003c\/strong\u003e, the authorised TCI distributor in Indonesia. \u003cstrong\u003eContact us for pricing and stock availability\u003c\/strong\u003e — we ship throughout Indonesia.\u003c\/p\u003e","brand":"TCI","offers":[{"title":"25mL","offer_id":48088398889178,"sku":"TCI2510T133852469","price":704000.0,"currency_code":"IDR","in_stock":true},{"title":"100mL","offer_id":48088398921946,"sku":"TCI2510T133852470","price":1659000.0,"currency_code":"IDR","in_stock":true},{"title":"500mL","offer_id":48088398954714,"sku":"TCI2510T133852471","price":4863000.0,"currency_code":"IDR","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0756\/7156\/8602\/files\/TCI2510T1338.jpg?v=1767141450"}],"url":"https:\/\/amiscientific.com\/en\/collections\/tci-l4-reagents-for-the-generation-of-arynes.oembed","provider":"AMI Scientific","version":"1.0","type":"link"}