{"title":"Stable Carbenes [Carbon-Donor Ligands]","description":"\u003cp\u003e\u003cstrong\u003eStable Carbenes [Carbon-Donor Ligands]\u003c\/strong\u003e — berisi karbena N-heterosiklik (NHC) bebas seperti turunan imidazolilidena dan imidazolidinilidena dengan berbagai substituen aril dan alkil. Kelompok ligan donor-karbon ini menyumbangkan pasangan elektron kuat ke pusat logam transisi sehingga membentuk kompleks katalitik yang stabil.\u003c\/p\u003e\u003cp\u003eStable carbenes ini digunakan peneliti katalisis untuk menyusun kompleks NHC-logam yang berperan dalam reaksi cross-coupling seperti Suzuki, Negishi, dan Buchwald-Hartwig, serta metatesis olefin. Variasi gugus aril seperti 2,6-diisopropilfenil atau mesitil memengaruhi sifat sterik dan elektronik ligan sehingga menentukan selektivitas dan aktivitas katalis yang dihasilkan.\u003c\/p\u003e\u003cp\u003eContoh produk dalam koleksi ini: \u003ca href=\"\/en\/products\/tci2510b35069440\"\u003eTCI B3506 258278-28-3 1,3-Bis(2,6-diisopropylphenyl)imidazolidin-2-ylidene\u003c\/a\u003e, \u003ca href=\"\/en\/products\/tci2510d347223754\"\u003eTCI D3472 157197-53-0 1,3-Di-tert-butylimidazol-2-ylidene\u003c\/a\u003e, \u003ca href=\"\/en\/products\/tci2510b34659384\"\u003eTCI B3465 244187-81-3 1,3-Bis(2,6-diisopropylphenyl)imidazol-2-ylidene\u003c\/a\u003e, \u003ca href=\"\/en\/products\/tci2510d387024277\"\u003eTCI D3870 141556-42-5 1,3-Dimesitylimidazol-2-ylidene\u003c\/a\u003e.\u003c\/p\u003e\u003cp\u003eKarena bersifat sensitif terhadap udara dan kelembapan, penanganan dan penyimpanan dalam kondisi inert perlu diperhatikan, selain kesesuaian gugus substituen sterik dengan sistem logam target. Seluruh produk merupakan produk asli Tokyo Chemical Industry (TCI) Jepang, dengan kemurnian, kemasan, dan kondisi penyimpanan tercantum pada halaman masing-masing item.\u003c\/p\u003e\u003cp\u003eKategori lain yang sejajar di bawah N-Heterocyclic Carbene (NHC) Ligands [Cross-coupling Reaction using Transition Metal Catalysts], sering dipakai bersamaan dalam satu alur kerja laboratorium:\u003c\/p\u003e\u003cul\u003e\n\u003cli\u003e\u003ca href=\"\/en\/collections\/tci-l4-imidazolinium-salts-cyclic-alkyl-amino-carbene-caac-pecursors-carbon-donor-ligands\"\u003eImidazolinium Salts, Cyclic Alkyl Amino Carbene (CAAC) Pecursors [Carbon-Donor Ligands]\u003c\/a\u003e\u003c\/li\u003e\n\u003cli\u003e\u003ca href=\"\/en\/collections\/tci-l4-n-heterocyclic-carbene-nhc-co2-adducts-and-nhc-hco3-salts-carbon-donor-ligands\"\u003eN-Heterocyclic Carbene (NHC)-CO2 Adducts and NHC-HCO3 Salts [Carbon-Donor Ligands]\u003c\/a\u003e\u003c\/li\u003e\n\u003c\/ul\u003e\u003cp\u003eKembali ke \u003ca href=\"\/en\/collections\/tci-l4-n-heterocyclic-carbene-nhc-ligands-cross-coupling-reaction-using-transition-metal-catalysts\"\u003eN-Heterocyclic Carbene (NHC) Ligands [Cross-coupling Reaction using Transition Metal Catalysts]\u003c\/a\u003e. Untuk pengadaan volume besar, kemasan khusus, atau grade tertentu, hubungi tim AMI Scientific — distributor resmi TCI Japan di Indonesia — untuk pengecekan ketersediaan dan lead time langsung ke Jepang.\u003c\/p\u003e","products":[{"product_id":"tci2510d347223754","title":"TCI D3472 157197-53-0 1,3-Di-tert-butylimidazol-2-ylidene","description":"\u003ch3\u003eDescription\u003c\/h3\u003e\n\u003cp\u003eTCI D3472 1,3-Di-tert-butylimidazol-2-ylidene is a free N-heterocyclic carbene, a carbon-donor ligand widely used in organometallic catalysis and organocatalysis research. The compound is supplied as the isolated carbene rather than as an imidazolium precursor salt, which means researchers can use it directly without a separate deprotonation step involving a strong base. The two tert-butyl groups on the nitrogen atoms provide substantial steric protection around the carbene centre, making the carbene stable enough to be handled with air-free techniques while remaining highly reactive toward transition metals and a variety of electrophiles.\u003c\/p\u003e\n\u003cp\u003eThe property that makes this ligand a preferred choice is its strength as a sigma donor, which far exceeds that of conventional phosphines. The bond formed between the carbene and the metal centre is very strong, giving catalyst complexes that are more resistant to heat and longer-lived through the catalytic cycle. The steric bulk of the tert-butyl groups also shapes the environment around the metal, influencing both the oxidative addition and reductive elimination steps, and often improving activity on difficult or hindered substrates. As a free carbene, however, the compound is correspondingly demanding in its handling requirements.\u003c\/p\u003e\n\u003cp\u003eIn Indonesian laboratories, this ligand is typically found in university and institutional research groups working on homogeneous catalysis, ligand design, and methodology development for organic synthesis. Because it arrives as the pre-formed carbene, it fits well into workflows where a Schlenk line or glovebox is already in routine use and where researchers want to avoid the variability introduced by generating the carbene in situ from an imidazolium salt before each experiment.\u003c\/p\u003e\n\u003ch3\u003eLaboratory Applications\u003c\/h3\u003e\n\u003cul\u003e\n\u003cli\u003ePreparation of transition metal NHC complexes — the isolated carbene coordinates directly to metal precursors, removing the in-situ deprotonation step and giving more reproducible complex formation.\u003c\/li\u003e\n\u003cli\u003eCross-coupling catalyst development — its strong sigma donation and steric bulk influence oxidative addition and reductive elimination, frequently improving turnover on hindered or otherwise difficult substrates.\u003c\/li\u003e\n\u003cli\u003eOrganocatalysis studies — as a free N-heterocyclic carbene it can act as a nucleophilic catalyst in its own right, without any metal centre or activating base present.\u003c\/li\u003e\n\u003cli\u003eThermally demanding catalytic reactions — the very strong carbene-metal bond makes the resulting complexes more heat resistant and longer-lived over extended catalytic cycles.\u003c\/li\u003e\n\u003cli\u003eLigand structure–activity comparison work — the well-defined tert-butyl substitution pattern makes it a useful benchmark ligand when evaluating steric and electronic effects against phosphines.\u003c\/li\u003e\n\u003c\/ul\u003e\n\u003ch3\u003eSpecifications\u003c\/h3\u003e\n\u003cul\u003e\n\u003cli\u003eBrand: TCI\u003c\/li\u003e\n\u003cli\u003eCAS Number: 157197-53-0\u003c\/li\u003e\n\u003cli\u003eCategory: Chemistry \u0026gt; Catalysis and Inorganic Chemistry \u0026gt; Carbon-Donor Ligands [Catalysis]\u003c\/li\u003e\n\u003cli\u003eChemical class: free N-heterocyclic carbene (isolated carbene, not an imidazolium precursor salt)\u003c\/li\u003e\n\u003cli\u003ePack sizes: available in standard TCI research-scale packaging; please confirm the required size when ordering\u003c\/li\u003e\n\u003cli\u003eStorage: keep under inert atmosphere and handle using air-free techniques\u003c\/li\u003e\n\u003c\/ul\u003e\n\u003ch3\u003eHandling and Storage\u003c\/h3\u003e\n\u003cp\u003eAs a free N-heterocyclic carbene, this material must be kept under an inert atmosphere and handled using air-free technique — a glovebox or Schlenk line is strongly recommended. Store the container tightly sealed in its original packaging, ideally within a secondary sealed container or desiccator, and keep it away from moisture, air, protic solvents, and electrophilic contaminants. Transfer only with dry, inert-gas-purged glassware and dry solvents. Work in a fume hood, wear appropriate gloves, safety glasses, and a laboratory coat, and consult the manufacturer's safety data sheet before first use.\u003c\/p\u003e","brand":"TCI","offers":[{"title":"1g","offer_id":48086617587930,"sku":"TCI2510D347223754","price":5623000.0,"currency_code":"IDR","in_stock":true},{"title":"5g","offer_id":48086617620698,"sku":"TCI2510D347223755","price":17173000.0,"currency_code":"IDR","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0756\/7156\/8602\/files\/TCI2510D3472.jpg?v=1767106136"},{"product_id":"tci2510d387024277","title":"TCI D3870 141556-42-5 1,3-Dimesitylimidazol-2-ylidene","description":"\u003ch3\u003eDescription\u003c\/h3\u003e\n\u003cp\u003eTCI D3870 1,3-Dimesitylimidazol-2-ylidene, widely known by the abbreviation IMes, is an isolated free N-heterocyclic carbene supplied ready to use as a carbon-donor ligand. Unlike imidazolium salts, which still require a deprotonation step before they can be used, this compound is already in its active carbene form and can therefore be coordinated directly to a transition metal centre. Its role in the laboratory is to provide a strongly donating ligand for the preparation of catalytic complexes based on palladium, nickel, copper, ruthenium, gold, and other metals employed in modern organic synthesis.\u003c\/p\u003e\n\u003cp\u003eThe characteristics that make IMes so highly valued are its sigma-donor strength, which far exceeds that of conventional phosphines, combined with the steric bulk of the two mesityl groups flanking the carbene centre. This combination produces a strong, thermally robust metal–ligand bond, accelerates the oxidative addition step, and promotes reductive elimination, so that many coupling reactions can proceed at low catalyst loadings. NHC-ligated complexes also tend to be more resistant to decomposition than their phosphine analogues, which translates into longer-lived catalytic systems and more reproducible results across repeated runs.\u003c\/p\u003e\n\u003cp\u003eIn Indonesian laboratories, this reagent is typically used in university and institutional research groups as well as in industrial R\u0026amp;D units working on catalyst development and methodology studies in organic synthesis. It is normally handled on a small scale under inert conditions, using a glovebox or Schlenk line, for the in-house preparation of metal–NHC complexes that are then applied in cross-coupling and related transformations. Because the free carbene is highly sensitive as a direct consequence of its reactivity, it is generally reserved for work where dry, air-free technique is already routine.\u003c\/p\u003e\n\u003ch3\u003eLaboratory Applications\u003c\/h3\u003e\n\u003cul\u003e\n\u003cli\u003ePreparation of palladium–NHC catalysts: the isolated free carbene coordinates directly to palladium precursors without a separate deprotonation step, giving well-defined complexes for cross-coupling chemistry.\u003c\/li\u003e\n\u003cli\u003eNickel and copper complex synthesis: the strong sigma-donation of IMes stabilises these first-row metal centres, supporting catalyst systems intended to replace more costly precious-metal alternatives.\u003c\/li\u003e\n\u003cli\u003eRuthenium catalyst development: the thermally robust metal–ligand bond formed by this carbene suits ruthenium complexes used in demanding transformations that require prolonged heating.\u003c\/li\u003e\n\u003cli\u003eGold complex preparation: the bulky mesityl substituents provide the steric protection around the metal centre that gold–NHC species require for defined coordination and handling.\u003c\/li\u003e\n\u003cli\u003eLow-loading coupling reaction studies: because IMes accelerates oxidative addition and promotes reductive elimination, it enables catalytic screening work at reduced catalyst loadings.\u003c\/li\u003e\n\u003c\/ul\u003e\n\u003ch3\u003eSpecifications\u003c\/h3\u003e\n\u003cul\u003e\n\u003cli\u003eBrand: TCI\u003c\/li\u003e\n\u003cli\u003eProduct code: D3870\u003c\/li\u003e\n\u003cli\u003eCAS number: 141556-42-5\u003c\/li\u003e\n\u003cli\u003eChemical name: 1,3-Dimesitylimidazol-2-ylidene (IMes)\u003c\/li\u003e\n\u003cli\u003eCategory: Chemistry \u0026gt; Catalysis and Inorganic Chemistry \u0026gt; Carbon-Donor Ligands [Catalysis]\u003c\/li\u003e\n\u003cli\u003eStorage note: air- and moisture-sensitive free carbene; store under inert gas — please refer to the TCI catalogue and product label for available pack sizes and the manufacturer's stated storage temperature\u003c\/li\u003e\n\u003c\/ul\u003e\n\u003ch3\u003eHandling and Storage\u003c\/h3\u003e\n\u003cp\u003eAs a free N-heterocyclic carbene, this material is highly sensitive to air and moisture and must be stored under an inert atmosphere such as dry nitrogen or argon. Keep the container tightly closed in its original packaging, or transfer the contents to a Schlenk flask or a sealed vial held inside a glovebox. Weighing and transfer operations should be carried out under inert conditions using dry solvents and oven-dried or flame-dried glassware. Work in a well-ventilated fume hood, wear gloves, safety glasses, and a laboratory coat, and avoid contact with water or ambient air. Always consult the manufacturer's safety data sheet before use, and follow your institution's procedures for the disposal of reactive organometallic waste.\u003c\/p\u003e","brand":"TCI","offers":[{"title":"1g","offer_id":48086642524378,"sku":"TCI2510D387024277","price":4414000.0,"currency_code":"IDR","in_stock":true},{"title":"5g","offer_id":48086642557146,"sku":"TCI2510D387024278","price":13492000.0,"currency_code":"IDR","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0756\/7156\/8602\/files\/TCI2510D3870.jpg?v=1767106709"},{"product_id":"tci2510b34659384","title":"TCI B3465 244187-81-3 1,3-Bis(2,6-diisopropylphenyl)imidazol-2-ylidene","description":"\u003cp\u003e\u003cstrong\u003e1,3-Bis(2,6-diisopropylphenyl)imidazol-2-ylidene\u003c\/strong\u003e (CAS 244187-81-3) is a high-quality chemical from TCI, supplied as \u003cstrong\u003eHPLC Grade\u003c\/strong\u003e.\u003c\/p\u003e\u003cp\u003e\u003cstrong\u003eApplication:\u003c\/strong\u003e Five-membered heterocyclic compound used as a building block in pharmaceutical, agrochemical, and functional-material synthesis.\u003c\/p\u003e\u003cp\u003e\u003cstrong\u003eSpecifications:\u003c\/strong\u003e\u003c\/p\u003e\u003cul\u003e\n\u003cli\u003eMolecular formula: C27H36N2\u003c\/li\u003e\n\u003cli\u003eCAS number: 244187-81-3\u003c\/li\u003e\n\u003cli\u003ePurity: \u0026gt;98.0%(HPLC)(T)\u003c\/li\u003e\n\u003cli\u003eTCI product code: B3465\u003c\/li\u003e\n\u003c\/ul\u003e\u003cp\u003e\u003cstrong\u003eSynonyms:\u003c\/strong\u003e IPr\u003c\/p\u003e\u003cp\u003eAvailable from \u003cstrong\u003eAMI Scientific\u003c\/strong\u003e, the authorised TCI distributor in Indonesia. \u003cstrong\u003eContact us for pricing and stock availability\u003c\/strong\u003e — we ship throughout Indonesia.\u003c\/p\u003e","brand":"TCI","offers":[{"title":"1g","offer_id":48085726953690,"sku":"TCI2510B34659384","price":3796000.0,"currency_code":"IDR","in_stock":true},{"title":"5g","offer_id":48085726986458,"sku":"TCI2510B34659385","price":11018000.0,"currency_code":"IDR","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0756\/7156\/8602\/files\/TCI2510B3465_eba57cc9-d3e6-4fe0-b95f-f12cb79b86fa.jpg?v=1767432807"},{"product_id":"tci2510b35069440","title":"TCI B3506 258278-28-3 1,3-Bis(2,6-diisopropylphenyl)imidazolidin-2-ylidene","description":"\u003cp\u003e\u003cstrong\u003e1,3-Bis(2,6-diisopropylphenyl)imidazolidin-2-ylidene\u003c\/strong\u003e (CAS 258278-28-3) is a high-quality chemical from TCI, supplied as \u003cstrong\u003eHPLC Grade\u003c\/strong\u003e.\u003c\/p\u003e\u003cp\u003e\u003cstrong\u003eApplication:\u003c\/strong\u003e Five-membered heterocyclic compound used as a building block in pharmaceutical, agrochemical, and functional-material synthesis.\u003c\/p\u003e\u003cp\u003e\u003cstrong\u003eSpecifications:\u003c\/strong\u003e\u003c\/p\u003e\u003cul\u003e\n\u003cli\u003eMolecular formula: C27H38N2\u003c\/li\u003e\n\u003cli\u003eCAS number: 258278-28-3\u003c\/li\u003e\n\u003cli\u003ePurity: \u0026gt;95.0%(HPLC)(T)\u003c\/li\u003e\n\u003cli\u003eTCI product code: B3506\u003c\/li\u003e\n\u003c\/ul\u003e\u003cp\u003e\u003cstrong\u003eSynonyms:\u003c\/strong\u003e SIPr\u003c\/p\u003e\u003cp\u003eAvailable from \u003cstrong\u003eAMI Scientific\u003c\/strong\u003e, the authorised TCI distributor in Indonesia. \u003cstrong\u003eContact us for pricing and stock availability\u003c\/strong\u003e — we ship throughout Indonesia.\u003c\/p\u003e","brand":"TCI","offers":[{"title":"1g","offer_id":48085729149146,"sku":"TCI2510B35069440","price":8264000.0,"currency_code":"IDR","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0756\/7156\/8602\/files\/TCI2510B3506.jpg?v=1767089973"}],"url":"https:\/\/amiscientific.com\/en\/collections\/tci-l4-stable-carbenes-carbon-donor-ligands.oembed","provider":"AMI Scientific","version":"1.0","type":"link"}