{"title":"Sulfur Transfer Reagents [Nucleic Acid Synthesis]","description":"\u003cp\u003e\u003cstrong\u003eSulfur Transfer Reagents [Nucleic Acid Synthesis]\u003c\/strong\u003e — menghimpun reagen sulfurisasi seperti xanthane hydride, disulfida aril, dan turunan ditiazol yang berfungsi mentransfer atom belerang ke gugus fosfit. Kelompok ini berperan mengubah ikatan fosfit triester menjadi fosforotioat pada sintesis oligonukleotida.\u003c\/p\u003e\u003cp\u003eReagen ini dipakai dalam sintesis oligonukleotida fase padat oleh peneliti biologi molekuler dan pengembang asam nukleat untuk menghasilkan ikatan fosforotioat yang menggantikan fosfat alami, meningkatkan ketahanan oligonukleotida terhadap degradasi enzimatik selama proses sintesis otomatis pada synthesizer DNA\/RNA.\u003c\/p\u003e\u003cp\u003eContoh produk dalam koleksi ini: \u003ca href=\"\/en\/products\/tci2510x000156686\"\u003eTCI X0001 6846-35-1 Xanthane Hydride\u003c\/a\u003e, \u003ca href=\"\/en\/products\/tci2510d592026910\"\u003eTCI D5920 1192027-04-5 N,N-Dimethyl-N'-(3-thioxo-3H-1,2,4-dithiazol-5-yl)formimidamide\u003c\/a\u003e, \u003ca href=\"\/en\/products\/tci2510b36239592\"\u003eTCI B3623 15088-78-5 Bis(phenylacetyl) Disulfide\u003c\/a\u003e, \u003ca href=\"\/en\/products\/tci2510b31258896\"\u003eTCI B3125 66304-01-6 3H-1,2-Benzodithiol-3-one 1,1-Dioxide\u003c\/a\u003e.\u003c\/p\u003e\u003cp\u003ePemilihan reagen sulfurisasi mempertimbangkan kecepatan reaksi, kelarutan dalam pelarut sintesis oligonukleotida seperti asetonitril atau piridina, dan kompatibilitasnya dengan siklus sintesis otomatis yang digunakan. Seluruh produk merupakan produk asli Tokyo Chemical Industry (TCI) Jepang, dengan kemurnian, kemasan, dan kondisi penyimpanan tercantum pada halaman masing-masing item.\u003c\/p\u003e\u003cp\u003eKategori lain yang sejajar di bawah Nucleic Acid Chemistry, sering dipakai bersamaan dalam satu alur kerja laboratorium:\u003c\/p\u003e\u003cul\u003e\n\u003cli\u003e\u003ca href=\"\/en\/collections\/tci-l4-phosphorylating-agents-and-phosphorothioating-agents-nucleic-acid-synthesis\"\u003ePhosphorylating Agents and Phosphorothioating Agents [Nucleic Acid Synthesis]\u003c\/a\u003e\u003c\/li\u003e\n\u003cli\u003e\u003ca href=\"\/en\/collections\/tci-l4-coupling-activators-and-condensing-agents-nucleic-acid-synthesis\"\u003eCoupling Activators and Condensing Agents [Nucleic Acid Synthesis]\u003c\/a\u003e\u003c\/li\u003e\n\u003cli\u003e\u003ca href=\"\/en\/collections\/tci-l4-protecting-agents-for-hydroxy-and-amino-groups-nucleic-acid-synthesis\"\u003eProtecting Agents for Hydroxy and Amino Groups [Nucleic Acid Synthesis]\u003c\/a\u003e\u003c\/li\u003e\n\u003cli\u003e\u003ca href=\"\/en\/collections\/tci-l4-nucleoside-phosphoramidites-nucleic-acid-synthesis\"\u003eNucleoside Phosphoramidites [Nucleic Acid Synthesis]\u003c\/a\u003e\u003c\/li\u003e\n\u003cli\u003e\u003ca href=\"\/en\/collections\/tci-l4-peptide-nucleic-acid-pna-monomers\"\u003ePeptide Nucleic Acid (PNA) Monomers\u003c\/a\u003e\u003c\/li\u003e\n\u003c\/ul\u003e\u003cp\u003eKembali ke \u003ca href=\"\/en\/collections\/tci-l3-nucleic-acid-chemistry\"\u003eNucleic Acid Chemistry\u003c\/a\u003e. Untuk pengadaan volume besar, kemasan khusus, atau grade tertentu, hubungi tim AMI Scientific — distributor resmi TCI Japan di Indonesia — untuk pengecekan ketersediaan dan lead time langsung ke Jepang.\u003c\/p\u003e","products":[{"product_id":"tci2510d592026910","title":"TCI D5920 1192027-04-5 N,N-Dimethyl-N'-(3-thioxo-3H-1,2,4-dithiazol-5-yl)formimidamide","description":"\u003ch3\u003eDescription\u003c\/h3\u003e\n\u003cp\u003eTCI D5920, CAS number 1192027-04-5, is N,N-Dimethyl-N'-(3-thioxo-3H-1,2,4-dithiazol-5-yl)formimidamide, a heterocyclic reagent known among oligonucleotide researchers as the DDTT sulfurizing reagent. The molecule carries a 1,2,4-dithiazole ring bearing a thioxo group, which serves as the source of the reactive sulfur atom. In the laboratory, this material acts as a sulfur transfer reagent in solid-phase oligonucleotide synthesis, converting phosphite linkages into phosphorothioates after the coupling step. That role makes it an important component in the preparation of antisense oligonucleotides, aptamers, and a wide range of modified nucleic acid constructs used in biomolecular research.\u003c\/p\u003e\n\u003cp\u003eThe property that makes this reagent so widely chosen is its high sulfurization efficiency combined with short reaction times, so synthesis cycles on automated synthesizers remain compact without sacrificing completeness of conversion. The reagent also shows good solution stability in the solvents commonly used in phosphoramidite workflows, which means a prepared solution can be installed on the instrument and drawn upon repeatedly over a normal working period. In addition, its tendency not to generate excessive side reactions helps keep the crude product profile clean, simplifying downstream purification and analysis of the assembled sequence.\u003c\/p\u003e\n\u003cp\u003eIn Indonesian laboratories, this reagent is typically found wherever nucleic acid chemistry is practised: university research groups working on molecular biology and medicinal chemistry, institutional biotechnology laboratories, and service units that assemble custom oligonucleotides for internal projects. It is generally ordered as part of a phosphoramidite reagent set alongside coupling and deblocking solutions, and used on automated synthesizers as well as in smaller manual solid-phase preparations where modified backbones are required.\u003c\/p\u003e\n\u003ch3\u003eLaboratory Applications\u003c\/h3\u003e\n\u003cul\u003e\n\u003cli\u003eSolid-phase oligonucleotide synthesis — the reagent transfers sulfur to the phosphite linkage immediately after coupling, converting it cleanly to a phosphorothioate within a short cycle step.\u003c\/li\u003e\n\u003cli\u003eAntisense oligonucleotide preparation — phosphorothioate backbones are central to antisense constructs, and this reagent installs them with the high conversion efficiency such sequences require throughout every linkage.\u003c\/li\u003e\n\u003cli\u003eAptamer synthesis — selected backbone positions can be sulfurized during assembly, allowing researchers to build modified aptamer sequences on the same automated synthesizer platform without additional handling steps.\u003c\/li\u003e\n\u003cli\u003eModified nucleic acid construct research — the reagent supports preparation of nucleic acid analogues where phosphorothioate linkages are introduced at defined positions for biomolecular and structural investigations.\u003c\/li\u003e\n\u003cli\u003eAutomated synthesizer workflows — its good solution stability in common phosphoramidite solvents lets a single prepared bottle stay mounted on the instrument and serve repeated synthesis runs.\u003c\/li\u003e\n\u003c\/ul\u003e\n\u003ch3\u003eSpecifications\u003c\/h3\u003e\n\u003cul\u003e\n\u003cli\u003eBrand: TCI\u003c\/li\u003e\n\u003cli\u003eCAS number: 1192027-04-5\u003c\/li\u003e\n\u003cli\u003eChemical name: N,N-Dimethyl-N'-(3-thioxo-3H-1,2,4-dithiazol-5-yl)formimidamide\u003c\/li\u003e\n\u003cli\u003eCategory: Chemistry \u0026gt; Building Blocks \u0026gt; Heterocyclic Building Blocks\u003c\/li\u003e\n\u003cli\u003eCommon designation: DDTT sulfurizing reagent\u003c\/li\u003e\n\u003cli\u003ePack sizes: available in standard TCI research-scale packaging; please confirm the size required when ordering\u003c\/li\u003e\n\u003cli\u003eStorage: keep in the closed original container under the conditions stated on the manufacturer label\u003c\/li\u003e\n\u003c\/ul\u003e\n\u003ch3\u003eHandling and Storage\u003c\/h3\u003e\n\u003cp\u003eStore the reagent in its original tightly closed container, kept dry and away from moisture, heat, and direct sunlight, and follow the storage conditions printed on the manufacturer label. Keep containers well sealed between uses, as sulfur transfer reagents of this type are best protected from atmospheric humidity. Prepared solutions should be held in clean, dry, chemically compatible amber glass bottles fitted with septum caps when installed on a synthesizer. Handle the material in a well-ventilated fume hood while wearing safety glasses, nitrile gloves, and a laboratory coat. Weigh and dissolve using dry glassware and anhydrous solvents to preserve reactivity. Label all prepared solutions with contents and preparation date, keep the reagent separated from strong oxidizing agents, and dispose of residues and rinse solvents as chemical waste according to your institution's procedures. Consult the manufacturer's safety data sheet before first use.\u003c\/p\u003e","brand":"TCI","offers":[{"title":"5g","offer_id":48086783754458,"sku":"TCI2510D592026910","price":1913000.0,"currency_code":"IDR","in_stock":true},{"title":"25g","offer_id":48086783787226,"sku":"TCI2510D592026911","price":5060000.0,"currency_code":"IDR","in_stock":true},{"title":"100g","offer_id":48086783819994,"sku":"TCI2510D592026912","price":15150000.0,"currency_code":"IDR","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0756\/7156\/8602\/files\/TCI2510D5920.jpg?v=1767109438"},{"product_id":"tci2510b31258896","title":"TCI B3125 66304-01-6 3H-1,2-Benzodithiol-3-one 1,1-Dioxide","description":"\u003cp\u003e\u003cstrong\u003e3H-1,2-Benzodithiol-3-one 1,1-Dioxide\u003c\/strong\u003e (CAS 66304-01-6) is a high-quality chemical from TCI, supplied as \u003cstrong\u003eHPLC Grade\u003c\/strong\u003e.\u003c\/p\u003e\u003cp\u003e\u003cstrong\u003eApplication:\u003c\/strong\u003e Synthesis reagent for a wide range of organic chemistry transformations in laboratory and industrial settings.\u003c\/p\u003e\u003cp\u003e\u003cstrong\u003eSpecifications:\u003c\/strong\u003e\u003c\/p\u003e\u003cul\u003e\n\u003cli\u003eMolecular formula: C7H4O3S2\u003c\/li\u003e\n\u003cli\u003eCAS number: 66304-01-6\u003c\/li\u003e\n\u003cli\u003ePurity: \u0026gt;98.0%(HPLC)\u003c\/li\u003e\n\u003cli\u003eTCI product code: B3125\u003c\/li\u003e\n\u003c\/ul\u003e\u003cp\u003e\u003cstrong\u003eSynonyms:\u003c\/strong\u003e Beaucage Reagent\u003c\/p\u003e\u003cp\u003eAvailable from \u003cstrong\u003eAMI Scientific\u003c\/strong\u003e, the authorised TCI distributor in Indonesia. \u003cstrong\u003eContact us for pricing and stock availability\u003c\/strong\u003e — we ship throughout Indonesia.\u003c\/p\u003e","brand":"TCI","offers":[{"title":"1g","offer_id":48085704147162,"sku":"TCI2510B31258896","price":2110000.0,"currency_code":"IDR","in_stock":true},{"title":"5g","offer_id":48085704179930,"sku":"TCI2510B31258897","price":7280000.0,"currency_code":"IDR","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0756\/7156\/8602\/files\/TCI2510B3125_04bdaf0b-d7c6-4cb8-91ca-9d6476c3a2db.jpg?v=1767431437"},{"product_id":"tci2510x000156686","title":"TCI X0001 6846-35-1 Xanthane Hydride","description":"\u003cp\u003e\u003cstrong\u003eXanthane Hydride\u003c\/strong\u003e (CAS 6846-35-1) is a high-quality chemical from TCI, supplied as \u003cstrong\u003eHPLC Grade\u003c\/strong\u003e.\u003c\/p\u003e\u003cp\u003e\u003cstrong\u003eApplication:\u003c\/strong\u003e Synthesis reagent for a wide range of organic chemistry transformations in laboratory and industrial settings.\u003c\/p\u003e\u003cp\u003e\u003cstrong\u003eSpecifications:\u003c\/strong\u003e\u003c\/p\u003e\u003cul\u003e\n\u003cli\u003eMolecular formula: C2H2N2S3\u003c\/li\u003e\n\u003cli\u003eCAS number: 6846-35-1\u003c\/li\u003e\n\u003cli\u003ePurity: \u0026gt;96.0%(HPLC)\u003c\/li\u003e\n\u003cli\u003eTCI product code: X0001\u003c\/li\u003e\n\u003c\/ul\u003e\u003cp\u003e\u003cstrong\u003eSynonyms:\u003c\/strong\u003e ADTT; 5-Amino-3H-1,2,4-dithiazole-3-thione; 3-Amino-1,2,4-dithiazole-5-thione; 5-Imino-5H-[1,2,4]dithiazole-3-thiol\u003c\/p\u003e\u003cp\u003eAvailable from \u003cstrong\u003eAMI Scientific\u003c\/strong\u003e, the authorised TCI distributor in Indonesia. \u003cstrong\u003eContact us for pricing and stock availability\u003c\/strong\u003e — we ship throughout Indonesia.\u003c\/p\u003e","brand":"TCI","offers":[{"title":"25g","offer_id":48088632393946,"sku":"TCI2510X000156686","price":3064000.0,"currency_code":"IDR","in_stock":true},{"title":"100g","offer_id":48088632426714,"sku":"TCI2510X000156687","price":8938000.0,"currency_code":"IDR","in_stock":true},{"title":"500g","offer_id":48088632459482,"sku":"TCI2510X000156688","price":21754000.0,"currency_code":"IDR","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0756\/7156\/8602\/files\/TCI2510X0001.jpg?v=1767145794"}],"url":"https:\/\/amiscientific.com\/en\/collections\/tci-l4-sulfur-transfer-reagents-nucleic-acid-synthesis.oembed","provider":"AMI Scientific","version":"1.0","type":"link"}