{"product_id":"tci2510b627313108","title":"TCI B6273 2378619-75-9 b-Tz","description":"\u003ch3\u003eDescription\u003c\/h3\u003e\n\u003cp\u003eTCI catalogue number B6273, corresponding to CAS number 2378619-75-9, is marketed under the short name b-Tz and is classified as a heterocyclic building block. The abbreviation \"Tz\" in modern reagent nomenclature generally refers to the tetrazine framework, a six-membered aromatic ring containing four nitrogen atoms that has become the backbone of contemporary bioorthogonal chemistry. In the laboratory, reagents of this type act as high-speed reaction partners, allowing two molecules to find one another and join selectively even within complex biological environments, without disturbing the natural functional groups present in the surroundings.\u003c\/p\u003e\n\u003cp\u003eThe characteristic that makes this class of reagent distinctive is its exceptionally rapid rate in inverse electron demand Diels-Alder reactions with strained dienophile partners, accompanied by high selectivity and minimal side products. That speed matters a great deal when researchers work at low concentrations, for example when labelling biomolecules inside living cells or when experimental time is limited. Another hallmark of the tetrazine framework is its distinctive colour absorption, so the disappearance of colour can often serve as a rough visual indication that the reaction is proceeding.\u003c\/p\u003e\n\u003cp\u003eIn Indonesian laboratories, a heterocyclic building block of this kind is typically used in synthetic chemistry and chemical biology research groups at universities and research institutes, as well as in laboratories developing conjugation methods for biomolecules. It is generally ordered in small research quantities for method development work, where selectivity and reaction speed are more important than bulk volume, and is handled as part of a broader collection of building blocks held for exploratory synthesis.\u003c\/p\u003e\n\u003ch3\u003eLaboratory Applications\u003c\/h3\u003e\n\u003cul\u003e\n\u003cli\u003eBioorthogonal ligation studies, where the reagent pairs with a strained dienophile to form a covalent linkage rapidly and selectively without interfering with native biological functional groups.\u003c\/li\u003e\n\u003cli\u003eBiomolecule labelling at low concentration, taking advantage of the very fast inverse electron demand Diels-Alder rate that allows conjugation to complete within limited experimental time windows.\u003c\/li\u003e\n\u003cli\u003eHeterocyclic building block applications in synthetic organic chemistry, where the nitrogen-rich aromatic ring serves as a starting scaffold for constructing more elaborate target molecules.\u003c\/li\u003e\n\u003cli\u003eConjugation method development, where the high selectivity and minimal side product formation of this reagent class simplify purification and make reaction outcomes easier to interpret.\u003c\/li\u003e\n\u003cli\u003eReaction progress monitoring work, since the characteristic colour absorption of the tetrazine framework means loss of colour gives a rough visual indication that coupling has occurred.\u003c\/li\u003e\n\u003c\/ul\u003e\n\u003ch3\u003eSpecifications\u003c\/h3\u003e\n\u003cul\u003e\n\u003cli\u003eBrand: TCI\u003c\/li\u003e\n\u003cli\u003eCatalogue number: B6273\u003c\/li\u003e\n\u003cli\u003eCAS number: 2378619-75-9\u003c\/li\u003e\n\u003cli\u003eShort name: b-Tz\u003c\/li\u003e\n\u003cli\u003eCategory: Chemistry \u0026gt; Building Blocks \u0026gt; Heterocyclic Building Blocks\u003c\/li\u003e\n\u003cli\u003ePack sizes and storage conditions: as stated on the manufacturer's label and accompanying documentation\u003c\/li\u003e\n\u003c\/ul\u003e\n\u003ch3\u003eHandling and Storage\u003c\/h3\u003e\n\u003cp\u003eStore the material according to the conditions specified by the manufacturer on the product label, keeping the container tightly closed in its original packaging and protected from light, heat, and moisture. Reagents of this class are generally kept in a cool, dry, well-ventilated chemical store away from incompatible substances. Handle in a fume hood using appropriate personal protective equipment, including safety glasses, gloves, and a laboratory coat. Allow refrigerated containers to reach room temperature before opening to avoid moisture condensation, and always consult the accompanying safety data sheet before use.\u003c\/p\u003e","brand":"TCI","offers":[{"title":"250mg","offer_id":48085927461082,"sku":"TCI2510B627313108","price":1590750.0,"currency_code":"IDR","in_stock":true},{"title":"1g","offer_id":48085927493850,"sku":"TCI2510B627313109","price":4664100.0,"currency_code":"IDR","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0756\/7156\/8602\/files\/TCI2510B6273_c76055dc-e1b0-41cd-9624-97677e7ad889.jpg?v=1767865100","url":"https:\/\/amiscientific.com\/en\/products\/tci2510b627313108","provider":"AMI Scientific","version":"1.0","type":"link"}