{"product_id":"tci2510c176116426","title":"TCI C1761 1075-35-0 5-Chloro-2-methylindole","description":"\u003ch3\u003eDescription\u003c\/h3\u003e\n\u003cp\u003eTCI C1761 5-Chloro-2-methylindole is a heterocyclic compound built on the indole core, the bicyclic ring system formed by the fusion of a benzene ring with a pyrrole ring. This particular derivative carries a methyl group at the two position and a chlorine atom at the five position. In synthetic organic laboratories, the material serves as a heterocyclic building block that supplies a ready-made, pre-substituted indole framework. Working from such an intermediate removes several steps from a synthetic route, because researchers no longer need to construct the indole ring themselves through classical approaches such as the Fischer indole synthesis, along with the purification work that each of those steps demands.\u003c\/p\u003e\n\u003cp\u003eThe property that makes this compound a frequent choice lies in its locked-in substitution pattern. The methyl group at the two position blocks one of the reactive sites on the pyrrole ring while simultaneously raising electron density, so electrophilic substitution reactions tend to be directed toward the three position, which is in fact the most common point of functionalisation in indole chemistry. The chlorine atom on the benzene ring plays a dual role: it acts as an electron-withdrawing group that tunes the electronic character of the molecule, and it also serves as a handle for transition-metal-catalysed cross-coupling reactions. The indole N–H group likewise remains available for alkylation, acylation, or sulfonylation whenever a route calls for it.\u003c\/p\u003e\n\u003cp\u003eIn Indonesian laboratories, a building block of this type is typically used in university and institutional research groups working on organic synthesis, medicinal chemistry, and the preparation of heterocyclic intermediates. It is normally handled at bench scale within a fume hood as part of multi-step route development, where a substituted indole core is required as a starting point rather than a target. Researchers select it when the aim is to reach a functionalised indole product without first assembling the ring system from simpler precursors.\u003c\/p\u003e\n\u003ch3\u003eLaboratory Applications\u003c\/h3\u003e\n\u003cul\u003e\n\u003cli\u003eHeterocyclic building block supply: provides a pre-formed indole skeleton that shortens multi-step routes by eliminating the need to construct the ring system in-house.\u003c\/li\u003e\n\u003cli\u003eElectrophilic substitution at the three position: the two-methyl group blocks a competing reactive site and raises electron density, directing incoming electrophiles to the preferred position.\u003c\/li\u003e\n\u003cli\u003eTransition-metal-catalysed cross-coupling: the chlorine atom on the benzene ring serves as a reactive handle through which new carbon–carbon or carbon–heteroatom bonds can be installed.\u003c\/li\u003e\n\u003cli\u003eNitrogen functionalisation chemistry: the free indole N–H group remains open for alkylation, acylation, or sulfonylation when a synthetic route requires modification at nitrogen.\u003c\/li\u003e\n\u003cli\u003eMedicinal chemistry intermediate preparation: the substituted indole core is a recurring motif in research-scale synthesis, making this material useful for building more elaborate target molecules.\u003c\/li\u003e\n\u003c\/ul\u003e\n\u003ch3\u003eSpecifications\u003c\/h3\u003e\n\u003cul\u003e\n\u003cli\u003eBrand: TCI (Tokyo Chemical Industry)\u003c\/li\u003e\n\u003cli\u003eCAS number: 1075-35-0\u003c\/li\u003e\n\u003cli\u003eCatalogue code: C1761\u003c\/li\u003e\n\u003cli\u003eCategory: Chemistry \u0026gt; Building Blocks \u0026gt; Heterocyclic Building Blocks\u003c\/li\u003e\n\u003cli\u003ePack sizes: available in standard research-scale catalogue pack sizes; please confirm the currently listed options when ordering\u003c\/li\u003e\n\u003cli\u003eStorage: keep in a cool, dry place in the tightly closed original container\u003c\/li\u003e\n\u003c\/ul\u003e\n\u003ch3\u003eHandling and Storage\u003c\/h3\u003e\n\u003cp\u003eStore the container tightly closed in a cool, dry, and well-ventilated area, away from direct sunlight, heat sources, and incompatible materials such as strong oxidising agents. The original supplier packaging is the most suitable container; if the material must be transferred, use a clean, chemically compatible vessel that is clearly labelled with the compound name and CAS number. Handle the solid inside a fume hood to limit inhalation of dust, and wear appropriate personal protective equipment including safety goggles, chemical-resistant gloves, and a laboratory coat. Avoid contact with skin and eyes, keep the container closed when not in use to prevent moisture uptake, and follow the manufacturer's safety data sheet together with local institutional procedures for handling and waste disposal.\u003c\/p\u003e","brand":"TCI","offers":[{"title":"1g","offer_id":48086087303386,"sku":"TCI2510C176116426","price":1618050.0,"currency_code":"IDR","in_stock":true},{"title":"5g","offer_id":48086087336154,"sku":"TCI2510C176116427","price":4929750.0,"currency_code":"IDR","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0756\/7156\/8602\/files\/TCI2510C1761.jpg?v=1768816697","url":"https:\/\/amiscientific.com\/en\/products\/tci2510c176116426","provider":"AMI Scientific","version":"1.0","type":"link"}