{"product_id":"tci2510c227416993","title":"TCI C2274 1121-79-5 3-Chloro-6-methylpyridazine","description":"\u003ch3\u003eDescription\u003c\/h3\u003e\n\u003cp\u003e3-Chloro-6-methylpyridazine from TCI, supplied under catalogue code C2274, is a heterocyclic building block based on the pyridazine ring — a six-membered ring containing two adjacent nitrogen atoms. The compound carries a chlorine atom at position three and a methyl group at position six, providing one reactive site ready for substitution together with one group that can be elaborated further. Pyridazine rings are increasingly used in medicinal chemistry because of their large dipole moment and their capacity for hydrogen bonding, properties that help improve solubility and shape how a molecule interacts with its biological target.\u003c\/p\u003e\n\u003cp\u003eThe reason chemists select this compound lies in the reactivity of the chlorine on an electron-deficient ring. Because the two neighbouring nitrogen atoms withdraw electron density from the ring, the chlorine atom becomes readily displaced by nucleophiles such as amines, alkoxides, and thiols through nucleophilic aromatic substitution, even without requiring a metal catalyst. The methyl group at position six, meanwhile, can be oxidised to an aldehyde or a carboxylic acid, or functionalised through benzylic halogenation, opening a second synthetic branch. These two orthogonal handles on a small scaffold allow a single starting material to be developed in several directions.\u003c\/p\u003e\n\u003cp\u003eIn Indonesian laboratories, this building block is typically used in university and institutional research groups working on synthetic organic chemistry and medicinal chemistry, as well as in pharmaceutical and agrochemical development work. It commonly appears in bench-scale route scouting, in the preparation of analogue series where a substituted pyridazine core is needed, and in postgraduate research projects. Sourcing a defined heterocyclic intermediate from an established supplier saves considerable synthesis time compared with preparing the ring system in-house.\u003c\/p\u003e\n\u003ch3\u003eLaboratory Applications\u003c\/h3\u003e\n\u003cul\u003e\n\u003cli\u003eNucleophilic aromatic substitution chemistry — the electron-deficient pyridazine ring activates the chlorine at position three, letting amines, alkoxides, and thiols be installed directly without needing a metal catalyst system.\u003c\/li\u003e\n\u003cli\u003eMedicinal chemistry scaffold development — the pyridazine core contributes a large dipole moment and hydrogen-bonding capability, properties useful for tuning solubility and target interaction in candidate molecules.\u003c\/li\u003e\n\u003cli\u003eAnalogue library preparation — the single reactive chlorine site allows one common intermediate to be diversified into many related structures by varying the incoming nucleophile.\u003c\/li\u003e\n\u003cli\u003eSide-chain functionalisation studies — the methyl group at position six can be oxidised to an aldehyde or carboxylic acid, or halogenated benzylically, creating a second independent point for structural elaboration.\u003c\/li\u003e\n\u003cli\u003eHeterocyclic route scouting — having two orthogonal reactive handles on one compact ring lets researchers test several synthetic directions from a single defined starting material.\u003c\/li\u003e\n\u003c\/ul\u003e\n\u003ch3\u003eSpecifications\u003c\/h3\u003e\n\u003cul\u003e\n\u003cli\u003eBrand: TCI (Tokyo Chemical Industry)\u003c\/li\u003e\n\u003cli\u003eCatalogue code: C2274\u003c\/li\u003e\n\u003cli\u003eCAS number: 1121-79-5\u003c\/li\u003e\n\u003cli\u003eCategory: Chemistry \u0026gt; Building Blocks \u0026gt; Heterocyclic Building Blocks\u003c\/li\u003e\n\u003cli\u003ePack sizes: available in standard TCI research-scale pack sizes; please refer to the product listing for the sizes currently offered\u003c\/li\u003e\n\u003cli\u003eStorage: keep the container tightly closed in a cool, dry, well-ventilated place\u003c\/li\u003e\n\u003c\/ul\u003e\n\u003ch3\u003eHandling and Storage\u003c\/h3\u003e\n\u003cp\u003eStore the material in its original tightly closed container in a cool, dry, well-ventilated area, away from direct sunlight, heat sources, and incompatible materials such as strong oxidising agents. Keep the container sealed when not in use to limit exposure to atmospheric moisture. Handle the compound in a fume hood using appropriate personal protective equipment, including safety goggles, chemical-resistant gloves, and a laboratory coat. Avoid inhalation of dust or vapour and avoid contact with skin and eyes. Transfer with clean, dry glassware or spatulas to prevent contamination of the bulk material. Dispose of residues and contaminated packaging in accordance with applicable laboratory waste procedures, and consult the manufacturer's safety data sheet before first use.\u003c\/p\u003e","brand":"TCI","offers":[{"title":"5g","offer_id":48086116696282,"sku":"TCI2510C227416993","price":2254350.0,"currency_code":"IDR","in_stock":true},{"title":"25g","offer_id":48086116729050,"sku":"TCI2510C227416994","price":8082900.0,"currency_code":"IDR","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0756\/7156\/8602\/files\/TCI2510C2274.jpg?v=1767098053","url":"https:\/\/amiscientific.com\/en\/products\/tci2510c227416993","provider":"AMI Scientific","version":"1.0","type":"link"}