{"product_id":"tci2510c237617133","title":"TCI C2376 1722-10-7 3-Chloro-6-methoxypyridazine","description":"\u003ch3\u003eDescription\u003c\/h3\u003e\n\u003cp\u003eTCI C2376 3-Chloro-6-methoxypyridazine is a heterocyclic building block from the pyridazine family, a six-membered aromatic ring containing two adjacent nitrogen atoms. The compound carries two substituents positioned opposite one another on the ring: a chlorine atom and a methoxy group. The presence of two neighbouring nitrogen atoms renders the ring electron-deficient, making it highly susceptible to nucleophilic attack at the carbon bearing the chlorine. For this reason the material is frequently selected as a practical starting point for constructing nitrogen-containing molecules in organic synthesis and medicinal chemistry laboratories.\u003c\/p\u003e\n\u003cp\u003eThe most notable characteristic of this material is its directed and predictable reactivity. The chlorine atom acts as a leaving group ready to be displaced by amines, alcohols, thiols, and other nucleophiles through nucleophilic aromatic substitution, often without the need for a metal catalyst. The methoxy group, meanwhile, confers stability on the ring while also serving as a masked protecting group that can be unmasked to the corresponding pyridazinone when required. That same chlorine can also be exploited in cross-coupling reactions to form carbon-carbon bonds, giving synthetic chemists two complementary routes from a single scaffold.\u003c\/p\u003e\n\u003cp\u003eIn Indonesian laboratories, this building block is typically used in university and institutional research settings where nitrogen-heterocyclic scaffolds are assembled step by step. It suits synthetic organic chemistry groups, medicinal chemistry programmes exploring new molecular frameworks, and method-development work in which a reliable, well-behaved starting material shortens the route to a target. Because its reactivity is predictable, it is also convenient for teaching advanced synthesis practicals and for small-scale exploratory reactions.\u003c\/p\u003e\n\u003ch3\u003eLaboratory Applications\u003c\/h3\u003e\n\u003cul\u003e\n\u003cli\u003eNucleophilic aromatic substitution studies — the electron-deficient pyridazine ring and activated chlorine allow clean displacement by amines, alcohols, or thiols, frequently without any metal catalyst.\u003c\/li\u003e\n\u003cli\u003eMedicinal chemistry scaffold construction — provides a compact nitrogen-rich core that can be elaborated at two distinct positions, supporting systematic exploration of structure-activity relationships in discovery work.\u003c\/li\u003e\n\u003cli\u003eCross-coupling chemistry — the chlorine substituent serves as a handle for forming carbon-carbon bonds, enabling aryl and alkyl fragments to be joined onto the pyridazine ring.\u003c\/li\u003e\n\u003cli\u003ePyridazinone synthesis — the methoxy group functions as a masked protecting group that can be converted to the corresponding pyridazinone when the synthetic route calls for that motif.\u003c\/li\u003e\n\u003cli\u003eGeneral heterocyclic building block work — its predictable, directed reactivity makes it a dependable starting material for assembling nitrogen-containing molecules in multi-step organic synthesis.\u003c\/li\u003e\n\u003c\/ul\u003e\n\u003ch3\u003eSpecifications\u003c\/h3\u003e\n\u003cul\u003e\n\u003cli\u003eBrand: TCI\u003c\/li\u003e\n\u003cli\u003eCAS number: 1722-10-7\u003c\/li\u003e\n\u003cli\u003eCategory: Chemistry \u0026gt; Building Blocks \u0026gt; Heterocyclic Building Blocks\u003c\/li\u003e\n\u003cli\u003eProduct code: C2376\u003c\/li\u003e\n\u003cli\u003ePack sizes: available in the standard research-scale pack sizes offered by TCI for this catalogue item\u003c\/li\u003e\n\u003cli\u003eStorage: store in a cool, dry place in a tightly closed container\u003c\/li\u003e\n\u003c\/ul\u003e\n\u003ch3\u003eHandling and Storage\u003c\/h3\u003e\n\u003cp\u003eStore the container tightly closed in a cool, dry, well-ventilated area, away from direct sunlight, heat sources, and incompatible materials. Keep the compound in its original supplier packaging or in a chemically compatible sealed container, and reseal promptly after each use to limit exposure to atmospheric moisture. Handle in a fume hood using standard personal protective equipment, including safety glasses, gloves, and a laboratory coat. Avoid inhalation of dust and contact with skin and eyes. Label all secondary containers clearly and follow institutional procedures for chemical waste disposal.\u003c\/p\u003e","brand":"TCI","offers":[{"title":"5g","offer_id":48086123479258,"sku":"TCI2510C237617133","price":1696800.0,"currency_code":"IDR","in_stock":true},{"title":"25g","offer_id":48086123512026,"sku":"TCI2510C237617134","price":5910450.0,"currency_code":"IDR","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0756\/7156\/8602\/files\/TCI2510C2376.jpg?v=1767098231","url":"https:\/\/amiscientific.com\/en\/products\/tci2510c237617133","provider":"AMI Scientific","version":"1.0","type":"link"}