Amonium Format - Agen Pereduksi dan Penyangga

Ammonium format (Ammonium formate) is a chemical compound in the form of an ammonium salt of formic acid with the structural formula NH4HCO2. It has a white crystalline solid form that is readily soluble in water and alcohol.

This compound is used as a reducing agent in chemical reactions such as reductive amination, which converts ketones or aldehydes into amines. In addition to being a reducing agent, ammonium formate is used as a mobile phase additive or buffer to increase ionization and component separation efficiency.

Ammonium Formate Specifications

Based on TCI Chemical, here are the specifications for Ammonium Formate.

• Purity: Minimum 98.0% (based on volumetric/titration analysis).

• Molecular Formula: CH5NO2

• Molecular Weight: 63.06 g/mol.

• Physical Appearance: White to almost white powder or crystals.

• Identity (NMR): Confirms to structure.

• Melting Point: Ranges from 117.0 to 121.0 °C.

• Solubility: Soluble in water and ether.

• Physical State (at 20°C): Solid

• Storage Temperature: below 15°C

Ammonium Formate Handling Procedures

Ammonium formate is a chemical that can potentially harm health, causing serious skin and eye irritation. To prevent this, handling this compound must be done using adequate Personal Protective Equipment.

Before interacting with ammonium formate, it is mandatory to wear gloves and eye protection. Then, make sure to thoroughly wash the skin after contact with this chemical.

In case of direct exposure, immediately take emergency response actions according to the affected area. If it gets on the skin, immediately wash with running water, remove contaminated clothing, and seek medical attention immediately. But if it gets in the eyes, rinse with running water for several minutes. Remove contact lenses if the victim is wearing them.

After emergency measures, seek medical help if there is further irritation. Contact a local doctor for treatment.

Advantages of Ammonium Formate

1. High Volatility

The advantage of this compound is that it is highly volatile, especially in analytical instruments such as Liquid Chromatography-Mass Spectrometry (LC-MS). Its volatile nature means it does not leave solid salt deposits that can clog the sensitivity of the mass detector.

2. Effective Buffer System

In HPLC (High-Performance Liquid Chromatography) and LC-MC, ammonium formate serves as an excellent mobile phase buffer. This material can maintain the pH stability of the solution for optimal compound separation without compromising instrument performance.

The effectiveness of the buffer system is used to increase the ionization efficiency of molecules, so that the analyte signal is read more accurately.

3. Ease of Post-Reaction Purification

Residual ammonium formate in the reaction mixture is very easy to remove due to its volatile nature. Post-synthesis cleanup can be done through low-temperature evaporation or lyophilization, which significantly simplifies the final product surfacing stage.

4. Versatile Reagent in Synthesis

Ammonium formate is important in the Leuckart Reaction. In this reaction, ammonium formate serves dual functions as both a reducing agent and a nitrogen source to convert ketones into amines.

Ammonium formate is ideal for the Leuckart Reaction because it functions as both a nitrogen source and a reducing agent for drug discovery research needs.

Applications of Ammonium Formate in Research

1. Catalytic Transfer Hydrogenation

Organic synthesis researchers carry out reduction reactions to convert nitro groups into amines. Typically, this process requires high-pressure hydrogen gas which risks explosions.

Ammonium formate is used as an alternative liquid hydrogen donor that is much safer. When heated with a Palladium on Carbon (Pd/C) catalyst, ammonium formate slowly decomposes and releases hydrogen directly into the reaction mixture.

2. Nanomaterial Synthesis

Material research requires ammonium formate as a mild reducing agent. This research uses it to reduce metal ions into pure metal nanoparticles with more controlled size and morphology.

Ammonium Formate Available at AMI Scientific

Ammonium Formate is a reducing agent in chemical reactions such as reductive amination, which converts ketones or aldehydes into amines. Together with TCI Japan, we offer a distribution system for goods delivery within 2 weeks. This speed makes your research process more efficient, quickly completed, and publication targets achieved.

Accelerate your research cycle now. Contact AMI Scientific for consultation and ordering TCI A3378 Ammonium Formate via this link.