Clofazimine - Obat dan Produk Riset Farmasi

Clofazimine - Obat dan Produk Riset Farmasi

Clofazimine is an aminophenazone antimycobacterial drug used for leprosy treatment. This drug is usually combined with Rifampicin and Dapsone for Multi-Drug Therapy for bacterial resistance.

The anti-inflammatory effects of Clofazimine are used to treat inflammatory reactions in leprosy patients. Therefore, clofazimine acts as an anti-inflammatory.

Clofazimine works by binding to the DNA of Mycobacterium leprae bacteria, which inhibits bacterial growth. Gradually, this process kills the bacteria causing the infection.

Specifications of Clofazimine TCI C2866

Clofazimine has the code C2866 from TCI (Tokyo Chemical Industry). This information is used for laboratory research purposes according to TCI Reagent Grade standards.

Clofazimine is soluble in chloroform, Dimethylformamide (DMF), Ether, Acetone. But it is insoluble in water.

  • Product Name: Clofazimine

  • Brand: TCI (Tokyo Chemical Industry)

  • Product Number (Catalog No.): C2866

  • CAS RN: 2030-63-9

  • Chemical Formula: C27H22Cl2N4

  • Molecular Weight (MW): 473.40

  • Purity - HPLC: Min. 98.0% (area%)

  • Purity - Titration: Min. 98.0% (Nonaqueous Titration)

  • Melting Point: 219 °C

  • Appearance: Powder or crystal.

  • Color: Yellow to Amber to Dark Red (varies due to its photosensitive chemical properties).


Applications of Clofazimine in Research

Clofazimine is often the subject of drug repurposing. This research demonstrates the potential of old drugs to treat new diseases.

Its cell-penetrating or lipophilic ability is one of the considerations for using this drug. The following are applications of Clofazimine for research.

1. Cancer drug research

Clofazimine is often used in cancer research because of its ability to inhibit beta-catenin signaling pathways. This pathway is overactive in various types of cancer, leading to uncontrolled cell growth.

The study "Clofazimine targets tumor-initiating cells by blocking Wnt signaling" showed that Clofazimine could inhibit cell growth in triple-negative breast cancer, liver cancer, and ovarian cancer.

2. Research on Drug-Resistant Tuberculosis (MDR-TB)

A study from The New England Journal of Medicine titled "A Trial of a Shorter Regimen for Rifampin-Resistant Tuberculosis" tested the effectiveness of Clofazimine in shortening the duration of treatment for resistant tuberculosis.

The focus of this research was to incorporate Clofazimine into a 9-12 month TB treatment regimen as a substitute for more toxic injectable drugs.

3. Research on autoimmune diseases

Clofazimine can block potassium ion channels in T cells, as published by PLoS ONE. A study titled "Clofazimine Inhibits Human Kv1.3 Potassium Channel by Perturbing Calcium Oscillation in T Lymphocytes" shows the potential of Clofazimine to treat Psoriasis, Multiple Sclerosis (MS), and Rheumatoid Arthritis.

Safety Mechanisms for Clofazimine TCI C2866

Because Clofazimine is a crystalline laboratory chemical according to the Safety Data Sheet standard, the following are the mandatory work safety protocols you must use in the laboratory.

  • Use an N95 dust mask, safety goggles, face shield, gloves, and a closed laboratory coat when preparing Clofazimine packaging.

  • Store Clofazimine in dark glass containers or wrapped in aluminum foil. Exposure to direct light can degrade the chemical structure.

  • Store at room temperature (20-25°C). Avoid extreme temperatures >30°C.

  • Store in a dry place with good ventilation.

GHS (Globally Harmonized System) classifies Clofazimine as potentially hazardous because it can cause skin irritation and respiratory tract irritation (if inhaled). Long-term exposure can alter pigmentation and cause gastrointestinal disorders.

If you are contaminated with Clofazimine, there are steps you can take.

  • Rinse with running water for 15 minutes if it gets into the eyes.

  • Wash with soap and running water until clean.

  • Move to an open-air area to help breathing if inhaled.

  • If swallowed, seek medical help immediately. Avoid inducing vomiting.

Get Research Products at AMI Scientific!

AMI Scientific is a chemical distributor for academic and industrial research needs that provides Clofazimine TCI C2866. Together with TCI Japan, we offer a distribution system with a delivery time of 2 weeks. This speed makes your research process more efficient, completed quickly, and publication targets achieved. The faster it arrives, the faster you get promoted.

Accelerate your research cycle now. Contact AMI Scientific for consultation and ordering Clofazimine TCI C2866 via this link.

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