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Description
4-(Boc-amino)-1-methyl-1H-imidazole-2-carboxylic Acid (CAS 128293-64-1) is a Boc-protected heterocyclic amino acid designed for stepwise, peptide-like assembly. Its free carboxylic acid and protected amine allow iterative coupling and deprotection cycles, making it a standard imidazole unit in the synthesis of pyrrole-imidazole polyamides that bind the DNA minor groove in a sequence-specific manner. It therefore supports chemical biology research on gene regulation, molecular probes and heterocyclic medicinal chemistry. TCI product B6350 is offered in 250 mg and 1 g packs; keep it cool, dry, tightly closed and away from strong acids, and consult the manufacturer's Safety Data Sheet.
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Scientific References
KIM et al. (1997). ChemInform Abstract: Short Synthesis of (3S,6S,9S)‐2‐Oxo‐3‐(N‐boc‐amino)‐1‐azabicyclo(4.3.0) nonane‐9‐carboxylic Acid Methyl Ester: Tandem Cyclization Protocol.. ChemInformdoi:10.1002/chin.199749168
Kim et al. (1997). Short synthesis of (3S,6S,9S)-2-oxo-3-(N-Boc-amino)-1-azabicyclo[4.3.0]nonane-9-carboxylic acid methyl ester: Tandem cyclization protocol. Tetrahedron Lettersdoi:10.1016/s0040-4039(97)01492-5
References were compiled automatically from Crossref and every DOI was verified to exist. AMI Scientific is not affiliated with the authors or the publishers.
