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Description
TCI B6415 4-[(tert-Butoxycarbonyl)amino]-1-cubanecarboxylic Acid (CAS 1000931-72-5) is a non-heterocyclic building block built on the rigid cubane framework, carrying a free carboxylic acid and a Boc-protected amine on opposite positions. This bifunctional design lets researchers introduce the cubane motif into peptides and small molecules through familiar amide coupling chemistry without an extra protection step. Cubane derivatives are widely studied as benzene bioisosteres, offering a rigid three-dimensional alternative that preserves substituent vectors. AMI Scientific offers this TCI product in a 100 mg pack suited to exploratory synthesis, with full quality details available in the manufacturer's Certificate of Analysis and Safety Data Sheet.
Scientific References
Kadyrov et al. (2021). Convenient Synthesis of (R)-3-[(tert-Butoxycarbonyl)amino]piperidine and (R)-3-[(tert-Butoxycarbonyl)amino]azepane. Synthesisdoi:10.1055/a-1526-7657
(2012). Discussion Addendum For: Efficient Asymmetric Synthesis of N-tert-Butoxycarbonyl a-Amino Acids using 4-tert-Butoxycarbonyl-5,6-Diphenylmorpholin-2-one:. Organic Synthesesdoi:10.15227/orgsyn.089.0394
IHLE et al. (1996). ChemInform Abstract: Preparation of 4‐Alkyl‐2‐(N‐(tert‐butoxycarbonyl)amino)pyridines by Alkylation, Nucleophilic Addition, and Acylation of 2‐(N‐(tert‐ Butoxycarbonyl)amino)‐4‐picoline.. ChemInformdoi:10.1002/chin.199646162
References were compiled automatically from Crossref and every DOI was verified to exist. AMI Scientific is not affiliated with the authors or the publishers.
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