TCI B6605 Boc-Phe(4-I)-OH is a Boc-protected 4-iodophenylalanine derivative widely used as a building block in peptide chemistry. The acid-labile Boc group allows controlled deprotection during chain assembly, while the para-iodo substituent serves as a versatile handle for palladium-catalysed cross-coupling. Researchers commonly employ it to incorporate unnatural amino acid residues and to enable late-stage diversification of peptide scaffolds. AMI Scientific supplies this TCI reagent in 1 g and 5 g pack sizes for peptide synthesis, medicinal chemistry, and chemical biology laboratories.
TCI brochures (PDF)
- Amino Acids and Peptide Synthesis Reagents 2025-08-14 · p. 16
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- Rodriguez et al. (1990). A general route to “carba” peptide bond replacements: Unequivocal synthesis of Boc--Phe-ψ(CH2-CH2)--Ala-OH and Boc--Phe-ψ(CH2-CH2)--Ala-OH.. Tetrahedron Letters doi:10.1016/s0040-4039(00)97829-8
- Hayashi et al. (2014). Development of potent antagonists for formyl peptide receptor 1 based on Boc-Phe-d-Leu-Phe-d-Leu-Phe-OH. Bioorganic & Medicinal Chemistry doi:10.1016/j.bmc.2014.06.048
- Karle et al. (2002). Infinite pleated β-sheet formed by the β-hairpin Boc-β-Phe-β-Phe- d -Pro-Gly-β-Phe-β-Phe-OMe. Proceedings of the National Academy of Sciences doi:10.1073/pnas.022616499
References were compiled automatically from Crossref and every DOI was verified to exist. AMI Scientific is not affiliated with the authors or the publishers.
Product Categories
- Chemical BiologyPeptide ChemistryAmino Acid Derivatives [Peptide Chemistry]
- Chemical BiologyPeptide ChemistryUnnatural Amino Acid Derivatives
- Pharmaceutical Development and Drug Discovery Research ReagentsPeptide ChemistryAmino Acid Derivatives [Peptide Chemistry]
- Pharmaceutical Development and Drug Discovery Research ReagentsPeptide ChemistryUnnatural Amino Acid Derivatives
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