TCI C0238 2-Chlorophenetole (CAS 614-72-2) is an ortho-substituted aromatic ether bearing both an aryl chloride and an ethoxy group. The aryl chloride can be engaged in palladium- or nickel-catalyzed cross-coupling, while the ethoxy substituent modulates the electronic character of the ring. Its ortho substitution pattern makes it useful for probing steric effects and for building selectively functionalized aromatic scaffolds. AMI Scientific offers this TCI building block in 10 mL and 25 mL packs for research-scale synthetic work.
—
| Brand | — |
|---|---|
| CAS number | — |
| Molecular formula | — |
| Purity | — |
| Category | — |
| Pack sizes | — |
| Physical form | — |
| Storage | — |
—
- Sano et al. (2006). Short-step synthesis of droloxifene via the three-component coupling reaction among aromatic aldehyde, cinnamyltrimethylsilane, and β-chlorophenetole. Tetrahedron Letters doi:10.1016/j.tetlet.2005.12.117
- Shiina et al. (2007). An expeditious synthesis of tamoxifen, a representative SERM (selective estrogen receptor modulator), via the three-component coupling reaction among aromatic aldehyde, cinnamyltrimethylsilane, and β-chlorophenetole. Bioorganic & Medicinal Chemistry doi:10.1016/j.bmc.2007.09.008
References were compiled automatically from Crossref and every DOI was verified to exist. AMI Scientific is not affiliated with the authors or the publishers.
