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Description
TCI C0239 4-Chlorophenetole (CAS 622-61-7) is the para isomer of chlorophenetole, combining an ethoxy group with an aromatic chlorine on the same ring. The electron-donating ethoxy group influences ring reactivity, while the aryl chloride offers a handle for transition-metal-catalyzed cross-coupling. Its symmetric substitution pattern often simplifies purification of downstream derivatives. AMI Scientific supplies this TCI building block in a 25 g pack suited to research-scale synthesis.
Scientific References
Sano et al. (2006). Short-step synthesis of droloxifene via the three-component coupling reaction among aromatic aldehyde, cinnamyltrimethylsilane, and β-chlorophenetole. Tetrahedron Lettersdoi:10.1016/j.tetlet.2005.12.117
Shiina et al. (2007). An expeditious synthesis of tamoxifen, a representative SERM (selective estrogen receptor modulator), via the three-component coupling reaction among aromatic aldehyde, cinnamyltrimethylsilane, and β-chlorophenetole. Bioorganic & Medicinal Chemistrydoi:10.1016/j.bmc.2007.09.008
References were compiled automatically from Crossref and every DOI was verified to exist. AMI Scientific is not affiliated with the authors or the publishers.
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