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Description
TCI D4178 is 4-(4,5-Diphenyl-1H-imidazol-2-yl)phenol, supplied with the designation [for Biochemical Research]. Structurally, it is a derivative of lophine (2,4,5-triphenylimidazole) in which the phenyl group at the 2-position has been replaced by a 4-hydroxyphenyl group. The compound belongs to the family of luminescent compounds and detection reagents used in life science research. In the laboratory, it serves as a luminescence-active compound and as a substrate or enhancer in detection systems based on oxidative reactions, particularly those involving hydrogen peroxide and peroxidase enzymes, making it relevant to the development of sensitive biochemical analytical methods.
The property that makes this material attractive is its triphenyl-substituted imidazole core, which is highly conjugated and widely recognized as a classical chemiluminescent scaffold. The lophine framework is able to emit light when it undergoes oxidation under appropriate conditions, and the addition of a phenolic hydroxyl group at the para position provides two advantages at once: it increases the ease with which the molecule is oxidized, while also supplying a functional group that can be further derivatized or can interact through hydrogen bonding. The extended aromatic system likewise renders the compound fluorescent, broadening the range of optical measurements in which it can participate.
In Indonesian laboratories, a reagent of this type is typically found in university research groups, biochemistry and analytical chemistry laboratories, and institutional research centres working on luminescence-based detection. It is generally handled at small scale on the laboratory bench, where researchers prepare solutions for oxidative detection experiments and optical measurements. Because it is designated for biochemical research, it is intended for research use and method development rather than routine production or clinical diagnostic work.
Laboratory Applications
- Chemiluminescence detection studies: the lophine-derived imidazole core emits light upon oxidation, making the compound a well-established scaffold for developing and evaluating light-emitting analytical reactions.
- Hydrogen peroxide detection systems: the compound acts as a substrate or enhancer in oxidative detection schemes where hydrogen peroxide is the analyte or the driving oxidant of the reaction.
- Peroxidase-based assay development: it participates in detection systems involving peroxidase enzymes, supporting the construction of sensitive enzymatic assays for biochemical research applications.
- Fluorescence measurement work: the extended aromatic conjugation of the triphenyl-substituted imidazole makes the molecule fluorescent, allowing its use in optical characterization and fluorescence-based experiments.
- Synthetic derivatization and probe design: the para-positioned phenolic hydroxyl group provides a reactive handle for further chemical modification or for hydrogen-bonding interactions in designed probe molecules.
Specifications
- Brand: TCI
- CAS number: 1752-94-9
- Chemical name: 4-(4,5-Diphenyl-1H-imidazol-2-yl)phenol, designated [for Biochemical Research]
- Category: Life Science > Biochemicals and Reagents > Luminescent Compounds/Detection
- Pack sizes: available in the standard research-scale pack sizes offered by the manufacturer; please confirm the required packaging when ordering
- Storage note: store in a tightly closed container, protected from light, in a cool and dry place
Handling and Storage
Store the reagent in its original tightly closed container, kept in a cool, dry and well-ventilated area away from direct sunlight and from strong oxidizing agents, since the compound is designed to be readily oxidized. Amber glass or otherwise light-protected containers are appropriate, and the container should be resealed promptly after each use to limit exposure to moisture and air. Handle the material inside a fume hood using standard personal protective equipment, including a laboratory coat, chemical-resistant gloves and safety glasses. Avoid generating dust, avoid inhalation and skin or eye contact, and wash hands thoroughly after handling. Always consult the manufacturer's safety data sheet before use, and dispose of residues and contaminated materials in accordance with applicable chemical waste procedures.
![4-(4,5-Diphenyl-1H-imidazol-2-yl)phenol [for Biochemical Research] (CAS 1752-94-9) - TCI D4178 - AMI Scientific](http://amiscientific.com/cdn/shop/files/TCI2510D4178.jpg?v=1767107168&width=1946)
![4-(4,5-Diphenyl-1H-imidazol-2-yl)phenol [for Biochemical Research] (CAS 1752-94-9) - TCI D4178 - AMI Scientific](http://amiscientific.com/cdn/shop/files/TCI2510D4178.jpg?v=1767107168&width=1445)
