(S)-(+)-Ibuprofen TCI I0549

(S)-(+)-Ibuprofen is the single-enantiomer form of ibuprofen, a 2-arylpropionic acid belonging to the non-steroidal anti-inflammatory drug class. Unlike racemic ibuprofen, which contains a mixture of both enantiomers, this material carries only the S configuration — the pharmacologically active form responsible for cyclooxygenase enzyme inhibition. In the laboratory it serves as a biochemical reagent, a reference enzyme inhibitor, and a comparison substance for stereochemical studies. The availability of a pure enantiomeric form allows researchers to separate the contribution of each configuration to biological activity, something that cannot be done when only racemic material is on hand.

The principal characteristic that drives its selection is stereochemical purity, since many enzymology experiments and chiral chromatography methods require a single-enantiomer standard as a point of reference. Its carboxylic acid group is readily derivatised into esters or amides, which is why the compound has also become a classic substrate in biocatalysis research, particularly in kinetic resolution work using lipases. Being a solid that is stable at room temperature, it is straightforward to weigh out and to prepare as a stock solution, which simplifies routine handling in day-to-day bench work.

In Indonesian laboratories, this material is typically used in university pharmacy and pharmaceutical chemistry departments, biochemistry research groups, and analytical laboratories that develop or validate chiral separation methods. It commonly appears in enzyme inhibition assays, in method development for chiral HPLC, and in biocatalysis projects investigating enantioselective transformations. Because it is supplied as a stable solid, it fits well into teaching and research settings where a reliable, well-defined reference compound is needed for repeated experiments over an extended period.

• Enzyme inhibition studies — the single S configuration acts as the pharmacologically active cyclooxygenase inhibitor, giving a defined reference point for measuring inhibitory response without interference from the opposite enantiomer.
• Chiral chromatography method development — a pure enantiomer standard is required to establish retention behaviour, confirm peak identity, and verify enantiomeric resolution during chiral HPLC method validation work.
• Biocatalysis and kinetic resolution research — the carboxylic acid group makes this compound a classic substrate for lipase-catalysed ester and amide transformations studied in enantioselective biotransformation experiments.
• Stereochemistry comparison studies — having the isolated S form allows researchers to distinguish the biological contribution of each configuration, a comparison that is impossible using racemic ibuprofen alone.
• Derivatisation and synthetic reference work — the readily derivatised carboxylic acid function supports preparation of ester and amide analogues used as intermediates or as analytical reference materials.

• Product code: I0549

Store the container tightly closed in a cool, dry, well-ventilated area, protected from direct sunlight and away from sources of heat or ignition. Original supplier packaging or a clean, chemically compatible glass or high-density polyethylene container with a secure closure is suitable for storage and for any aliquots taken. Handle in a fume hood or a well-ventilated workspace, and wear standard personal protective equipment including a laboratory coat, safety goggles, and appropriate gloves. Avoid generating dust when weighing the solid, close the container promptly after use to limit moisture uptake, label all secondary containers clearly, and consult the supplier safety data sheet before first use and for waste disposal guidance.

—