1alpha-Methylandrostan-17beta-ol-3-one TCI M1800

TCI M1800 1alpha-Methylandrostan-17beta-ol-3-one is a synthetic steroid compound belonging to the androstane class, distributed by AMI Scientific under the TCI brand. The molecule carries a methyl group at the 1alpha position, a hydroxyl group at the 17beta position, and a ketone group at position 3. It is classified within the biochemicals and reagents category for steroids, and in the laboratory it serves both as a reference material and as an object of study in steroid chemistry research. The rigid, well-defined androstane core makes this compound useful for examining the relationship between substitution patterns and the physicochemical properties of steroid molecules.

The characteristic that leads researchers to select this compound is its highly specific substitution pattern, including the defined spatial orientation of the alpha and beta configurations at particular positions. This clear stereochemistry matters because the behaviour of a steroid molecule is governed by its three-dimensional arrangement rather than by its molecular formula alone. The steroid framework is lipophilic, so the material dissolves more readily in organic solvents such as methanol, ethanol, and chloroform than it does in water. The presence of a conjugated ketone group and a secondary hydroxyl group also provides reactive sites for researchers who wish to prepare derivatives or perform derivatisation for instrumental analysis.

In Indonesian laboratories, this compound is typically encountered in university research groups, pharmaceutical and natural-product chemistry laboratories, and analytical facilities that work on steroid characterisation. It is normally handled in small quantities on an analytical balance, dissolved in a suitable organic solvent, and used as a comparison standard or a starting material for structural studies. Method development work and postgraduate research projects in steroid chemistry represent the most common contexts in which it is requested.

• Reference material in steroid analysis, where the defined substitution pattern and known stereochemistry allow analysts to confirm the identity of peaks obtained from chromatographic or spectroscopic runs.
• Structure-property relationship studies, since the rigid androstane skeleton lets researchers isolate the effect of a single substitution pattern on the physicochemical behaviour of the molecule.
• Derivatisation chemistry, because the secondary hydroxyl group at the 17beta position offers a convenient reactive handle for preparing esters, ethers, or other analytical derivatives.
• Carbonyl-directed synthetic work, as the ketone group at position 3 provides a defined reaction site for condensation, reduction, or other transformations in steroid synthesis studies.
• Teaching and method development in stereochemistry, where the explicit alpha and beta orientations make the compound a clear illustration of how three-dimensional arrangement governs steroid molecular properties.

• Chemical class: synthetic androstane-type steroid with 1alpha-methyl, 17beta-hydroxyl, and 3-keto substitution
• Solubility behaviour: lipophilic steroid framework, more soluble in organic solvents such as methanol, ethanol, and chloroform than in water

Store this compound in its original tightly closed container in a cool, dry place, protected from direct light and from moisture, in line with the manufacturer's instructions on the product label. Amber glass vials or the supplied container are appropriate for keeping the material, and any solutions prepared in organic solvents should be kept in sealed, solvent-compatible containers and clearly labelled. Handle the compound in a well-ventilated area or a fume hood, wearing a laboratory coat, gloves, and safety glasses, and avoid generating dust or inhaling the powder. Weigh out only the amount required, close the container immediately after use, and consult the manufacturer's safety data sheet before first handling. As a biologically active steroid, it should be treated with care, kept away from unauthorised access, and disposed of as chemical waste through the laboratory's established procedures rather than through ordinary drains or general refuse.

—