6-Methyleneandrost-4-ene-3,17-dione TCI M3121

TCI M3121 6-Methyleneandrost-4-ene-3,17-dione is a synthetic steroid compound bearing CAS number 19457-55-7, built on the classical androstane skeleton with ketone groups at positions 3 and 17 and an exocyclic methylene group at position 6. In the laboratory, this material serves as a building block for pharmaceutical ingredient development, particularly in research on steroid compounds that interact with enzymes in hormone biosynthesis pathways. Its rigid polycyclic structure, rich in stereogenic centres, makes it a valuable starting point for synthetic chemists who wish to construct new steroid derivatives without having to assemble the core framework from scratch.

The characteristics that make this compound a frequent choice are the combination of a conjugated enone group on the A ring and an exocyclic methylene on the B ring — two reactive sites that can be addressed selectively through addition, oxidation, reduction, or dehydrogenation reactions. The ketone at C-17 provides an additional handle for side-chain modification. Because the steroid framework is already fully formed, the stereochemical configuration is preserved throughout the synthetic sequence, allowing researchers to obtain more consistent results from batch to batch. Small pack sizes suit exploratory work where only milligram quantities are consumed per reaction.

In Indonesian laboratories, this reagent is typically used in university medicinal chemistry groups, pharmaceutical research and development divisions, and institutional laboratories working on steroid derivatives. It is generally ordered in small quantities for method development, reference standard preparation, and multi-step synthesis trials. Researchers value the availability of a well-defined steroid building block locally, since it shortens the lead time for exploratory synthesis programmes and reduces dependence on lengthy import procedures for small research quantities.

• Steroid derivative synthesis — the fully formed androstane core lets chemists focus on functional group modification rather than lengthy construction of the polycyclic framework itself.
• Pharmaceutical building block research — the compound serves as an intermediate for developing active pharmaceutical ingredients in the steroid class under research and experimental use conditions.
• Enzyme interaction studies — its structure is relevant to investigations of steroid compounds that interact with enzymes along hormone biosynthesis pathways in mechanistic research work.
• Selective functionalisation studies — the conjugated enone on the A ring and the exocyclic methylene on the B ring allow chemists to explore site-selective addition, oxidation, and reduction chemistry.
• Reference material preparation — the defined steroid structure and preserved stereochemistry support its use in preparing comparison materials for analytical method development in laboratories.

Store the compound in its original tightly closed container in a cool, dry place, protected from light, moisture, and sources of heat or ignition. Amber glass vials or the manufacturer's supplied packaging are suitable containers; transfer only the quantity required for each experiment and reseal promptly to limit exposure to atmospheric moisture. Handle in a well-ventilated area or fume hood using standard personal protective equipment, including safety glasses, a laboratory coat, and chemically resistant gloves. Avoid generating dust when weighing the solid. As with all steroid research reagents, restrict handling to trained personnel, consult the manufacturer's safety data sheet before use, and dispose of residues and contaminated materials through the laboratory's chemical waste stream.

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