5-(4-Methylpiperazin-1-yl)pyridin-2-amine TCI M3176

5-(4-Methylpiperazin-1-yl)pyridin-2-amine, identified by CAS number 571189-49-6, is a heterocyclic compound that combines an amino-substituted pyridine ring at the 2-position with a methylated piperazine ring attached at the 5-position. As a heterocyclic building block, this molecule brings together two structural motifs that appear very frequently in modern drug compounds within a single, neatly pre-assembled framework. Having it on hand in the laboratory allows researchers to enter the target-molecule construction stage far more quickly, because the attachment of the piperazine to the pyridine ring — a step that ordinarily requires a coupling reaction — has already been carried out at the outset.

The property that makes this material a frequent choice is the reactivity of the 2-aminopyridine group, which is highly valuable in medicinal chemistry. That amine group can be acylated, sulfonylated, or coupled with aryl halides through palladium catalysis to form amide bonds as well as amine linkages, which serve as the principal connectors in many kinase inhibitor compounds. The N-methylpiperazine ring, meanwhile, contributes basicity and polarity that help improve the solubility of the resulting compound in aqueous media — a factor that often determines whether biological testing succeeds or fails.

In Indonesian laboratories, a building block of this kind is typically used in synthetic and medicinal chemistry research groups at universities and research institutes, as well as in pharmaceutical development work where candidate molecules are assembled step by step. Because the piperazine–pyridine connection is already in place, working groups can devote their reagent budget and bench time to the later, more exploratory stages of a synthetic route rather than to preparing the core scaffold themselves.

• Kinase inhibitor scaffold assembly — the 2-aminopyridine group couples readily with aryl halides under palladium catalysis to form the amine linkages that connect fragments in many inhibitor structures.
• Amide bond formation studies — the free aromatic amine can be acylated directly, giving researchers a reliable handle for building amide-linked analogues around a fixed heterocyclic core.
• Sulfonamide derivative synthesis — sulfonylation of the 2-aminopyridine nitrogen allows preparation of sulfonamide series while the N-methylpiperazine portion of the molecule remains untouched.
• Solubility optimisation of lead compounds — the basic, polar N-methylpiperazine ring is introduced together with the core, improving aqueous solubility of candidates destined for biological assays.
• Medicinal chemistry analogue libraries — the pre-formed piperazine–pyridine connection shortens each synthetic route, letting a group prepare many related target molecules from one common starting material.

• Product code: M3176
• Chemical name: 5-(4-Methylpiperazin-1-yl)pyridin-2-amine

Store the container in a cool, dry place, tightly closed and protected from light and moisture, following the storage conditions stated on the manufacturer's label and safety data sheet. Keep the material in its original supplier container or in a suitably compatible, well-sealed vessel, and reseal promptly after each use to limit exposure to atmospheric moisture. Handle in a well-ventilated area or fume hood, wearing gloves, safety glasses, and a laboratory coat, and avoid contact with skin and eyes as well as inhalation of dust. Consult the safety data sheet before use and dispose of residues in accordance with applicable laboratory waste procedures.

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