Nortropinone Hydrochloride TCI N0844

Nortropinone Hydrochloride from TCI (catalog number N0844) is the hydrochloride salt of nortropinone, a bicyclic ketone built on the 8-azabicyclo[3.2.1]octan-3-one framework. Structurally, nortropinone is tropinone without the methyl group on the nitrogen atom. Tropinone itself is well known in the history of chemistry through Robinson's classic synthesis. The compound is classified among the alkaloids in biochemical reagents. In the laboratory it serves as a key intermediate for building a wide range of tropane derivatives and alkaloid analogues in medicinal chemistry research.

Researchers choose Nortropinone Hydrochloride because it has two reactive sites: a secondary amine that can be functionalized and a ketone carbonyl group at the 3-position. The ketone can be reduced stereoselectively to either the endo or exo alcohol, treated with Grignard reagents, or converted through reductive amination. The hydrochloride salt form is generally more stable and easier to handle as a solid than the free base. The free amine can be released with a base shortly before a reaction, for example to prepare N-Boc-nortropinone, a protected intermediate widely used in synthesis.

In Indonesia, this compound is useful for medicinal chemistry laboratories, university organic synthesis research groups, and pharmaceutical research and development teams working with tropane-based scaffolds. It suits projects that design and prepare alkaloid analogues, build compound libraries around the bicyclic tropane core, or study structure–activity relationships. Because it comes from a recognized reagent brand with a clear catalog identity, laboratories can document it reliably in research records, synthetic procedures, and theses.

• Synthesis of tropane derivatives: the 8-azabicyclo[3.2.1]octan-3-one framework gives a ready-made bicyclic core, so researchers can build tropane analogues without constructing the ring system from scratch.
• N-functionalization of the secondary amine: because the nitrogen has no methyl group, it can be alkylated, acylated, or protected, which lets chemists attach many different substituents to the tropane scaffold.
• Stereoselective ketone reduction: the carbonyl at the 3-position can be reduced to either the endo or exo alcohol, which is useful for studying how stereochemistry affects the properties of tropane compounds.
• Carbon–carbon bond formation and reductive amination: the ketone reacts with Grignard reagents and can be converted through reductive amination, extending the scaffold with new carbon or nitrogen substituents.
• Preparation of N-Boc-nortropinone: releasing the free amine with a base just before the reaction allows convenient Boc protection, giving an intermediate that is widely used in multistep synthesis.

Store Nortropinone Hydrochloride in its original, tightly sealed container in a cool, dry, well-ventilated area, away from moisture, strong bases, and oxidizing agents. Always follow the specific storage conditions on the TCI product label and Safety Data Sheet. Reseal the container promptly after use so the solid does not take up moisture from the air. When handling, wear suitable personal protective equipment such as a lab coat, safety glasses, and chemical-resistant gloves. Weigh and transfer the material in a fume hood or ventilated enclosure to avoid inhaling dust. Keep the container clearly labeled, and dispose of residues and contaminated materials according to your institution's chemical waste procedures and local regulations.

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