Oxalyl Chloride TCI O0082

Oxalyl Chloride from TCI is the diacyl chloride of oxalic acid. It is a highly reactive liquid reagent and one of the core tools of the synthetic chemist. In the laboratory it has two main roles. First, it activates dimethyl sulfoxide in the Swern oxidation, which converts primary and secondary alcohols into aldehydes and ketones. Second, it converts carboxylic acids into acyl chlorides. In glycoscience, the reagent is important for the selective oxidation and modification of hydroxyl groups on carbohydrates.

Chemists choose oxalyl chloride because its reactions run under relatively mild conditions and its by-products are all gases: carbon monoxide, carbon dioxide and hydrogen chloride. These gases leave the reaction mixture easily, which makes the workup simpler. With a small amount of DMF as catalyst, acyl chloride formation can proceed at room temperature or below, so the method suits sensitive substrates. In the Swern oxidation, the reagent lets chemists oxidize alcohols without heavy metals and without over-oxidation to carboxylic acids. This gives cleaner product profiles for delicate carbohydrate and natural product intermediates.

In Indonesia, oxalyl chloride is widely needed by synthetic organic chemistry laboratories at universities, research institutes and pharmaceutical development facilities. Research groups working on carbohydrate chemistry, glycoconjugate synthesis and medicinal chemistry use it routinely to prepare aldehyde intermediates and activated acid derivatives. As a TCI product supplied through AMI Scientific, it gives Indonesian researchers access to a trusted reagent brand for multistep synthesis, method development and teaching laboratories that demonstrate classical oxidation and acylation chemistry.

• Swern oxidation: oxalyl chloride activates dimethyl sulfoxide, so primary and secondary alcohols can be oxidized to aldehydes and ketones under mild conditions without heavy metal oxidants.
• Acyl chloride preparation: with catalytic DMF it converts carboxylic acids into acyl chlorides at room temperature or below, and its gaseous by-products make workup and isolation simple.
• Carbohydrate modification in glycoscience: it enables selective oxidation and functionalization of sugar hydroxyl groups, which supports the synthesis of modified monosaccharides, oligosaccharide building blocks and glycoconjugates.
• Synthesis of sensitive intermediates: because the reactions run under mild conditions and do not over-oxidize to carboxylic acids, it suits delicate substrates in natural product and medicinal chemistry.
• Amide and ester formation workflows: the acyl chlorides it generates react readily with amines and alcohols, making it a practical first step for building amide and ester linkages.

Oxalyl chloride reacts vigorously with water and moisture, releasing hydrogen chloride and other toxic gases. Keep it in its original tightly closed container, ideally under an inert atmosphere such as nitrogen or argon, in a cool, dry, well-ventilated area away from water, alcohols, bases and oxidizers. Handle it only inside a properly working fume hood and wear chemical-resistant gloves, safety goggles or a face shield, and a lab coat. Transfer it with dry syringes or cannulas and add it slowly, because reactions give off gas. Always consult the supplier's Safety Data Sheet before use and dispose of waste according to local regulations.

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