4'-Phenoxyacetophenone TCI P1355

4'-Phenoxyacetophenone from TCI is an aromatic ketone: an acetophenone that carries a phenoxy group at the para position. Its structure combines two useful units in one molecule, a reactive acetyl group and a diphenyl ether framework. The compound is classed as a non-heterocyclic building block for organic synthesis. In the laboratory, researchers use it as a starting point for preparing chalcones, heterocycles, and a range of synthetic intermediates. The diphenyl ether motif itself appears widely in pharmaceutical compounds, agrochemicals, and high-performance polymers, which makes this molecule a practical entry point into those structural families.

Chemists choose this compound mainly because its acetyl group is easy to modify. The hydrogen atoms on the methyl group are acidic enough to form an enolate, so the compound works well in aldol condensations, alpha-halogenation, and Mannich reactions. The carbonyl group can also be reduced, converted into an oxime, or used to build heterocyclic rings. The phenoxy group, for its part, extends the aromatic system and makes the molecule more lipophilic. Lipophilicity is often a goal in bioactive compound design, so derivatives of this building block are of interest for structure-activity relationship studies.

In Indonesia, this material is relevant to organic chemistry and pharmaceutical chemistry laboratories at universities, where students and researchers synthesize and characterize new compounds. It suits undergraduate and postgraduate research projects that study carbonyl reactivity, as well as medicinal chemistry work that explores diphenyl ether derivatives. Research institutes and industrial R&D groups working on pharmaceutical, agrochemical, or polymer intermediates may also find it a useful starting material. Because it comes from TCI, laboratories can expect a consistent supply for repeated synthetic work.

• Chalcone synthesis: the acidic methyl hydrogens of the acetyl group form an enolate that condenses with aromatic aldehydes, giving chalcones that carry a diphenyl ether unit.
• Heterocycle construction: the carbonyl group and the adjacent methyl group can serve as reactive sites for ring-forming reactions, so the compound is a convenient precursor for a range of heterocyclic scaffolds.
• Alpha-halogenation and Mannich reactions: enolate formation at the methyl position allows controlled functionalization, producing alpha-halo ketones or Mannich bases that can be carried into further synthetic steps.
• Carbonyl transformations: the ketone can be reduced to the corresponding alcohol or converted into an oxime, which gives easy access to several different functional groups from a single starting material.
• Structure-activity relationship studies: the phenoxy group adds aromatic extent and lipophilicity, so derivatives built from this compound help medicinal chemists see how those features affect biological activity.

• Chemical class: aromatic ketone (para-phenoxy-substituted acetophenone with a diphenyl ether framework)

Store 4'-Phenoxyacetophenone in its original, tightly sealed container in a cool, dry, well-ventilated area, away from direct sunlight, heat sources, and strong oxidizing agents. Glass or other chemically compatible containers with secure caps are suitable if the material has to be transferred. Label every container clearly. Handle the compound in a fume hood or a well-ventilated area, and wear standard personal protective equipment, including a lab coat, safety glasses, and chemical-resistant gloves. Avoid creating dust or inhaling vapors, and prevent contact with skin and eyes. Read the TCI Safety Data Sheet before use for specific hazard information, recommended storage temperature, and first-aid measures. Dispose of waste according to institutional and local chemical waste regulations.

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