Phenyl Bromoacetate TCI P1936

Phenyl Bromoacetate from TCI (product code P1936, CAS 620-72-4) is the phenyl ester of bromoacetic acid. One molecule holds two reactive groups: a bromine atom alpha to the carbonyl and a phenyl ester group. As a non-heterocyclic building block, Phenyl Bromoacetate is used in the laboratory as an alkylating reagent that adds a phenoxycarbonylmethyl unit to other molecules. It is also a versatile intermediate for synthesising esters, amides and substituted carbonyl compounds, which makes it a useful reagent to keep on the shelf in organic synthesis work.

Chemists choose this compound mainly because its alpha carbon is electrophilic. Nucleophiles such as amines, thiols, phenolates and carbanions attack this carbon readily through nucleophilic substitution. The phenyl ester group is an activated ester and reacts more readily than ordinary alkyl esters, so it can be converted into amides or other esters under relatively mild conditions. The compound can also be used in Reformatsky-type reactions. With two separate reactive sites, chemists can build molecules step by step, using one site first and the other later in a planned synthetic sequence.

In Indonesia, organic synthesis laboratories at universities and research institutions use Phenyl Bromoacetate. Typical projects include modifying bioactive compounds, preparing linkers and developing new synthetic routes for target molecules. Research groups in medicinal chemistry, natural product derivatisation and synthetic methodology may use it as a key alkylating agent or ester intermediate. Graduate students and researchers who need a dependable, well-defined building block from an established brand can source it as the TCI-branded product listed here.

• Alkylation of nucleophiles: the electrophilic alpha carbon reacts readily with amines, thiols, phenolates and carbanions, so it is a practical way to attach a phenoxycarbonylmethyl unit to a target molecule.
• Amide synthesis from an activated ester: the phenyl ester is more reactive than ordinary alkyl esters, so it can be converted into amides under relatively mild conditions that protect sensitive functional groups.
• Transesterification to other esters: because of its activated phenyl ester group, the compound can be turned into other esters under gentle conditions, which helps when building ester-containing intermediates.
• Reformatsky-type reactions: as an alpha-bromo ester, it can take part in Reformatsky-type chemistry to build substituted carbonyl compounds and form new carbon-carbon bonds.
• Linker preparation and bioactive compound modification: with two reactive sites in one molecule, it suits stepwise assembly, where one site joins a substrate and the other is used later for further functionalisation.

• Chemical identity: phenyl ester of bromoacetic acid (Phenyl Bromoacetate)

Store Phenyl Bromoacetate in its original, tightly closed container in a cool, dry, well-ventilated area, away from moisture, heat sources and incompatible materials such as strong bases, strong oxidisers and nucleophilic reagents. Always check the storage temperature recommended on the TCI label and Safety Data Sheet. The compound is a reactive alkylating agent, so handle it only in a fume hood and wear suitable chemical-resistant gloves, safety goggles and a laboratory coat. Avoid breathing vapours or dust, and avoid any contact with skin and eyes. Label secondary containers clearly, reseal containers promptly after use, and dispose of waste according to institutional and local chemical waste regulations.

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