2-Chloropyrimidine (TCI C1050, CAS 1722-12-9) is an electron-deficient heterocyclic building block in which the C-2 chlorine is readily displaced by nucleophiles. It provides fast access to 2-substituted pyrimidines through reaction with amines, alcohols, and thiols under mild conditions. The chlorine also serves as a handle for transition-metal-catalyzed cross-coupling, making the compound valuable for library synthesis and medicinal chemistry. AMI Scientific supplies this reagent in a 25 g pack; keep it tightly closed, dry, and away from strong bases and moisture.
Related TCI products
- TCI T2550 1780-27-4 4,5,6-Trichloropyrimidine
- TCI T2512 5750-76-5 2,4,5-Trichloropyrimidine
- TCI T1810 32980-71-5 2,4,6,8-Tetrachloropyrimido[5,4-d]pyrimidine
- TCI T1217 1780-40-1 2,4,5,6-Tetrachloropyrimidine
- TCI B4950 146533-41-7 5-(4-Bromophenyl)-4,6-dichloropyrimidine
- TCI B2847 32779-36-5 5-Bromo-2-chloropyrimidine
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- Maltese (1995). Relative Reactivity in Piperidino-Dechlorination of 2,4-Diamino-6-chloropyrimidine and 2,4-Diamino-6-chloropyrimidine N(3)-Oxide and Their Acetylamino Analogs. The Journal of Organic Chemistry doi:10.1021/jo00113a025
- Żywicka et al. (2024). Cross-Section Calculations for Electron-Impact Ionization of Pyrimidine Molecule and Its Halogenated Derivatives: 2-Chloropyrimidine, 5-Chloropyrimidine, 2-Bromopyrimidine and 5-Bromopyrimidine. Molecules doi:10.3390/molecules30010006
- Dong et al. (2019). Durable Antipilling Modification of Cotton Fabric with Chloropyrimidine Compounds. Polymers doi:10.3390/polym11101697
References were compiled automatically from Crossref and every DOI was verified to exist. AMI Scientific is not affiliated with the authors or the publishers.
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