TCI C1541, (R)-(-)-1-Cyclohexylethylamine (CAS 5913-13-3), is a chiral amine widely applied in asymmetric synthesis and in the classical resolution of racemic carboxylic acids. The bulky cyclohexyl ring adjacent to the stereogenic centre creates an effective chiral environment for diastereomeric salt formation and selective crystallisation. It also serves as a chiral auxiliary, a precursor to chiral ligands, and a derivatising agent for enantiomeric purity determination. Supplied by AMI Scientific in a 5 g pack, this basic liquid should be handled in a fume hood and stored tightly closed in a cool, dry place.
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- Sakai et al. (2006). Molecular mechanism of DCR phenomenon observed in (RS)-1-cyclohexylethylamine–mandelic acid resolution system. Tetrahedron: Asymmetry doi:10.1016/j.tetasy.2006.06.037
- Patel et al. (2012). Functionalization of Keggin type manganese substituted phosphotungstate by R-(−)-1-cyclohexylethylamine: Synthesis and characterization. Inorganica Chimica Acta doi:10.1016/j.ica.2011.10.017
- Turani‐I‐Belloto et al. (2023). Synthesis and Characterization of (R)‐N‐1‐Cyclohexylethylamine Borane. ChemistrySelect doi:10.1002/slct.202301646
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