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Description
3-Chloro-4-fluoroanisole (TCI C2217) is an anisole-based fluorinated building block in which chlorine and fluorine atoms occupy adjacent positions on the benzene ring. This particular substitution pattern is what distinguishes it from other isomers and makes it a valuable starting material for synthetic chemists. In the laboratory, the compound serves as a scaffold for constructing densely substituted aromatic molecules, especially in medicinal chemistry projects where every substituent must be placed precisely so that interactions with a biological target can be mapped carefully.
The property that makes this compound a preferred choice is the ease with which its regiochemistry can be controlled. The combination of an electron-donating methoxy group and two electron-withdrawing halogens produces a distinctive electron-density distribution, so directed metalation reactions and subsequent substitutions can be predicted with greater confidence. The fluorine atom bonded directly to the aromatic ring provides high bond stability while also influencing lipophilicity and the acidity of neighbouring groups. The chlorine atom, meanwhile, can either be retained as a final substituent or used as a cross-coupling point.
Its liquid form makes handling straightforward for routine bench work, which suits the way Indonesian laboratories typically operate. University research groups, contract synthesis laboratories and pharmaceutical development units use materials of this type when a defined halogenated aromatic core is required as the entry point to a longer synthetic sequence. Supplied by AMI Scientific, it fits into the workflow of teams that need reliable building blocks for exploratory and scale-up chemistry alike.
Laboratory Applications
Medicinal chemistry scaffold construction: the fixed chlorine and fluorine positions let researchers build densely substituted aromatic candidates while keeping every substituent placement deliberate and traceable.
Directed metalation chemistry: the interplay between the methoxy donor and the two halogen acceptors gives a predictable electron-density profile that guides deprotonation to the intended ring position.
Cross-coupling reaction sequences: the chlorine atom acts as a defined handle for coupling steps, allowing further aromatic fragments to be attached at a known location on the ring.
Structure-activity relationship studies: the fluorine substituent modulates lipophilicity and neighbouring-group acidity, letting chemists probe how those parameters shift biological interaction with a target.
Multi-step synthetic route development: as an entry-point intermediate, it provides a stable halogenated aromatic core from which longer laboratory-scale synthetic sequences can be planned.
Specifications
Brand: TCI
CAS Number: 202925-07-3
Category: Chemistry > Building Blocks > Fluorinated Building Blocks
Pack sizes: available in the standard TCI catalogue pack sizes
Physical form: liquid
Storage: store in a cool, well-ventilated area in a tightly closed container
Handling and Storage
Store the container tightly closed in a cool, dry and well-ventilated area, away from heat sources, direct sunlight and incompatible materials such as strong oxidising agents. Original manufacturer containers or chemically compatible glass bottles with secure closures are appropriate; keep them clearly labelled. Handle the material inside a fume hood and wear standard laboratory personal protective equipment, including safety goggles, a laboratory coat and chemically resistant gloves. Avoid inhaling vapours and prevent contact with skin and eyes. Reseal containers immediately after dispensing, and consult the manufacturer's safety data sheet before use and for disposal guidance.
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