Dihydroartemisinin TCI D3793

Name: TCI D3793 71939-50-9 Dihydroartemisinin
Brand: TCI
SKU: TCI2510D379324171
Price: 2804550.0 IDR
Availability: InStock

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Berat 1g 5g

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Description

TCI D3793 Dihydroartemisinin is a sesquiterpene lactone compound and the reduced derivative of artemisinin, the natural compound isolated from the plant *Artemisia annua*. Its most important structural feature is the endoperoxide bridge within the cyclic framework, a group believed to be the key to its antimalarial activity. In the laboratory, this compound serves as a raw material for biochemical and pharmacological research, as a comparative reference standard in analytical testing, and as an important intermediate in the synthesis of other artemisinin derivatives developed as therapeutic candidates.

The property that makes this compound so widely used is the characteristic reactivity of the peroxide bridge, which can generate radical species when it interacts with heme iron in malaria parasites — a mechanism that has become the focus of a great deal of research. In addition, the hemiacetal hydroxyl group at the lactol position provides an easily accessible point of chemical modification, so the compound can be converted into esters, ethers, or conjugates with carrier molecules in order to study structure–activity relationships. On the other hand, the presence of the peroxide makes this compound relatively sensitive to heat, light, and strongly acidic conditions.

In Indonesian laboratories, this material is typically used in university pharmacy and chemistry departments, government and institutional research centres, and pharmaceutical research and development units working on antimalarial chemistry. It is commonly handled in synthetic organic chemistry work, in analytical method development where a reference compound is required, and in biochemical assays exploring the mechanism of action of artemisinin-type compounds. Because it is used in small research quantities, it is generally kept in a controlled, well-organised chemical store.

Laboratory Applications

Antimalarial mechanism research — the endoperoxide bridge generates radical species on interaction with heme iron, making the compound central to studies of how artemisinin-type agents act on malaria parasites.
Reference standard in analytical testing — the material is used as a comparative standard when developing and running analytical methods that must identify or confirm dihydroartemisinin in a sample.
Synthetic intermediate for artemisinin derivatives — the compound is an important starting point in the preparation of other artemisinin derivatives being developed as therapeutic candidates in medicinal chemistry programmes.
Structure–activity relationship studies — the accessible hemiacetal hydroxyl group at the lactol position allows conversion into esters and ethers, so researchers can compare activity across systematically modified analogues.
Bioconjugate preparation — the same lactol position permits coupling to carrier molecules, supporting research that examines how a carrier changes the behaviour of the parent compound.

Specifications

Brand: TCI
CAS number: 71939-50-9
Category: Life Science > Biochemicals and Reagents > Antibiotics
Chemical class: sesquiterpene lactone; reduced derivative of artemisinin
Pack sizes: available in standard research-scale packaging as supplied by the manufacturer
Storage note: sensitive to heat, light, and strongly acidic conditions; store accordingly

Handling and Storage

Store the compound in a cool, dry place, protected from direct light and away from heat sources, since the peroxide bridge makes it relatively sensitive to these conditions. Keep it in its original tightly closed container, or in an amber glass vial where the original packaging is not used, and avoid contact with strong acids and strong oxidising or reducing agents. Handle it in a well-ventilated area or fume hood, using gloves, safety glasses, and a laboratory coat. Weigh out only the quantity required, close the container promptly afterwards, and label all working solutions clearly. Follow the manufacturer's safety data sheet and your institution's chemical waste procedures for disposal.