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Description
TCI D4293 is 2,3-Dimethylbenzonitrile, an aromatic compound that carries a nitrile group on a benzene ring together with two methyl groups at the 2 and 3 positions. As a non-heterocyclic building block, this material supplies a neatly pre-substituted aryl framework, so researchers do not have to construct that substitution pattern from scratch. The nitrile group is one of the most flexible functional groups in organic synthesis because it can be converted into a wide range of other groups, which is why this compound frequently serves as the starting point for multi-step synthetic routes in research laboratories.
The main reason chemists select this material is the transformational versatility of the nitrile group. Nitriles can be hydrolysed to carboxylic acids or amides, reduced to benzylic amines, added to by organometallic reagents to give ketones, and converted into tetrazoles, which are widely used as bioisosteric replacements for acid groups in medicinal chemistry. The two adjacent methyl groups impart a characteristic steric environment around the nitrile while also providing benzylic positions that can be functionalised through halogenation or oxidation. This combination allows the assembly of molecules with ortho substitution patterns that are difficult to reach by direct substitution reactions.
In Indonesian laboratories, this type of building block is typically used in university and institutional research groups, in synthetic and medicinal chemistry programmes, and in method development work where a defined aryl scaffold is needed as the entry point to a longer route. It is normally handled at bench scale for exploratory reactions and route scouting, then reused as a reliable intermediate once a synthetic sequence has been established and needs to be repeated consistently.
Laboratory Applications
- Multi-step synthetic route development — the nitrile group offers a single handle that can be redirected into acids, amides, amines, or ketones, allowing one starting material to serve several planned routes.
- Medicinal chemistry scaffold preparation — conversion of the nitrile into tetrazole gives a well-established bioisosteric replacement for carboxylic acid groups, supporting structure–activity exploration around an ortho-substituted aryl core.
- Benzylic functionalisation studies — the two adjacent methyl groups provide reactive benzylic positions that can be modified by halogenation or oxidation, giving access to further substituted derivatives from a single scaffold.
- Preparation of ortho-substituted aromatic targets — the fixed 2,3-dimethyl arrangement supplies a substitution pattern that is difficult to install selectively through direct aromatic substitution on simpler rings.
- Organometallic addition chemistry — the nitrile reacts with organometallic reagents to give ketones, making this compound useful for teaching and research work on carbon–carbon bond formation at a sterically defined aryl position.
Specifications
- Brand: TCI
- CAS number: 5724-56-1
- Category: Chemistry > Building Blocks > Non-Heterocyclic Building Blocks
- Chemical name: 2,3-Dimethylbenzonitrile
- Pack sizes: available in standard research and laboratory pack sizes; please confirm the required quantity when ordering
- Storage: store in a closed original container under the conditions stated on the product label and safety data sheet
Handling and Storage
Store the container tightly closed in a cool, dry, well-ventilated area away from heat, ignition sources, and incompatible chemicals such as strong oxidising agents, strong acids, and strong bases. Keep the material in its original supplier container, or in a clean, chemically compatible and clearly labelled alternative, and keep it separate from food and other laboratory consumables. Handle in a fume hood using safety glasses, chemical-resistant gloves, and a laboratory coat, and avoid inhalation of vapours as well as contact with skin and eyes. Transfer with clean, dry equipment to prevent contamination, close the container immediately after use, and collect residues and contaminated materials as chemical waste. Always review the manufacturer safety data sheet before first use and follow your institution's own laboratory safety procedures.
