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TCI

CAS 6571-51-3

1,11-Dioxa[11]paracyclophane TCI D4298

1,11-Dioxa[11]paracyclophane TCI D4298
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Description

TCI D4298 is 1,11-Dioxa[11]paracyclophane, a macrocyclic compound belonging to the cyclophane family. Its structure consists of a para-substituted benzene core connected by a carbon-chain bridge that incorporates two ether oxygen atoms. This large ring architecture creates a defined molecular cavity and forces the aromatic ring into a slightly twisted or bent conformation. As a synthetic reagent within the chelation and complexation group of compounds, it serves research in supramolecular chemistry, where the interactions between host molecules and guest molecules are the central subject of study.

The property that makes this compound valuable is the combination of a macrocyclic cavity with two electron-donating oxygen atoms positioned along the bridging framework. The ether oxygen atoms are able to interact with cations and other positively charged species through ion–dipole interactions, while the aromatic ring contributes an electron-rich pi surface capable of stabilising a guest through cation–pi interactions or aromatic stacking. The paracyclophane geometry, with its eleven-atom bridge, also makes the molecule an interesting example for examining ring strain, conformational dynamics, and the influence of geometry on the spectroscopic behaviour of the benzene ring.

In Indonesian laboratories, this reagent belongs in the setting of university and institutional research groups working on synthetic and supramolecular chemistry rather than in routine analytical or quality-control testing. It is typically requested in small research quantities for host–guest binding studies, model-compound work, and structural investigations. Because it is a specialised synthetic reagent, it is normally handled by trained researchers in a fume hood as part of a defined experimental programme.

Laboratory Applications

  • Host–guest complexation studies: the macrocyclic cavity together with two ether oxygen donors allows the compound to bind cationic and positively charged guest species for supramolecular investigation.
  • Cation recognition research: the ether oxygen atoms interact with cations through ion–dipole interactions, making the molecule a useful framework for studying selective binding behaviour.
  • Cation–pi interaction studies: the electron-rich pi surface of the para-substituted benzene ring can stabilise guest species, providing a defined system for probing this interaction mode.
  • Ring strain and conformational analysis: the eleven-atom bridge across a paracyclophane core gives a well-defined model for examining strain and conformational dynamics in macrocycles.
  • Spectroscopic structure–property investigation: the twisted or bent aromatic ring makes this compound a suitable model for correlating molecular geometry with the spectroscopic properties of benzene.

Specifications

  • Brand: TCI (Tokyo Chemical Industry)
  • CAS number: 6571-51-3
  • Chemical name: 1,11-Dioxa[11]paracyclophane
  • Category: Chemistry > Synthetic Reagents > Chelation/Complexation Compounds
  • Pack sizes: available in research-scale packaging as supplied by the manufacturer; please confirm the currently offered size when ordering
  • Storage: keep in the tightly closed original container, protected from light and moisture, in accordance with the manufacturer's label and safety data sheet

Handling and Storage

Store the material in its original tightly closed container in a cool, dry, well-ventilated place away from direct sunlight, heat sources, and moisture, following the storage conditions stated on the manufacturer's label and safety data sheet. Amber glass or the supplied original packaging is suitable for keeping the compound protected from light. Handle the reagent in a fume hood using safety glasses, chemical-resistant gloves, and a laboratory coat, and avoid inhaling dust or vapour and any contact with skin and eyes. Use clean, dry spatulas and glassware when transferring the material to avoid contamination, close the container immediately after use, and consult the safety data sheet before handling, spill cleanup, or disposal.

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