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Description
TCI D4810 5,6-Diamino-1,3-dipropyluracil Hydrochloride is a heterocyclic building block supplied as the hydrochloride salt of a uracil derivative that carries two propyl groups on the nitrogen atoms at positions 1 and 3, together with two adjacent amino groups at positions 5 and 6. This vicinal diamino arrangement on the pyrimidinedione core is exactly what makes the compound a key intermediate in xanthine synthesis. In medicinal chemistry laboratories, the material is used routinely as a starting point for constructing purine frameworks: the amino groups are acylated first, and the product is then cyclized to form an imidazole ring fused to the uracil core.
The property that makes this compound a widely preferred choice is the practicality of its hydrochloride salt form. Free-base diaminouracils tend to oxidize readily on exposure to air, whereas the salt form is considerably more stable for storage and weighing, and it offers good solubility in water as well as in water-alcohol mixtures, so acylation reactions can be run in aqueous media. The two propyl groups are already installed from the outset, which spares researchers the selective alkylation of the uracil nitrogens — a step that is normally difficult to control. The differing reactivity of the two amino groups also permits directed acylation at the 5-position.
In Indonesian laboratories, this building block fits naturally into medicinal chemistry and synthetic organic chemistry programmes at university research groups, pharmaceutical R&D units, and institutional laboratories working on purine and xanthine chemistry. Because the salt form tolerates weighing and handling under ordinary bench conditions and dissolves in aqueous media, it suits laboratories that prefer to avoid strictly inert-atmosphere technique for routine multi-step synthesis work.
Laboratory Applications
Xanthine synthesis — the vicinal 5,6-diamino arrangement on the pyrimidinedione core provides the direct precursor needed to close the fused imidazole ring of the xanthine system.
Purine framework construction — acylation of the amino groups followed by cyclization builds the purine skeleton in a short, well-established two-stage sequence from a single starting material.
Medicinal chemistry research — the pre-installed 1,3-dipropyl substitution pattern lets researchers focus synthetic effort on the imidazole ring rather than on controlling selective N-alkylation.
Aqueous-phase acylation chemistry — good solubility in water and in water-alcohol mixtures means acylation steps can be carried out in aqueous media without switching to specialized solvent systems.
Selective amino-group derivatization — the different reactivity of the 5- and 6-amino groups allows directed acylation at the 5-position, giving controlled access to unsymmetrically substituted intermediates.
Specifications
Brand: TCI
CAS Number: 324002-49-5
Category: Chemistry > Building Blocks > Heterocyclic Building Blocks
Chemical form: hydrochloride salt of a 1,3-dipropyluracil derivative bearing vicinal 5,6-diamino groups
Pack sizes: available in standard laboratory research quantities; please contact us for currently offered sizes
Storage: store in a tightly closed container, protected from air and moisture
Handling and Storage
Store the material in a tightly closed original container, kept dry and protected from prolonged exposure to air, since diaminouracils are prone to oxidation; the hydrochloride salt form is markedly more stable than the free base but still benefits from careful closure after each use. Keep the container in a cool, dry, well-ventilated chemical store away from incompatible reagents. Handle the solid in a fume hood, using gloves, safety glasses, and a laboratory coat, and avoid generating dust during weighing. Return the container promptly to storage and consult the manufacturer's safety data sheet before first use.
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