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Description
TCI D4820 is 7-Deazapurine, a heterocyclic compound that acts as a purine analogue in which the nitrogen atom at position seven is replaced by a carbon atom, producing a pyrrolo[2,3-d]pyrimidine framework. This compound serves as one of the important starting materials in nucleoside chemistry and medicinal chemistry, because it is able to mimic the shape of natural purine bases without carrying all of their binding properties. In the laboratory, this material is used to build nucleoside analogues, modified nucleotides, and a wide range of small molecules that target purine-binding enzymes, which makes its role highly central in biochemical research and the discovery of active compounds.
The properties that make 7-deazapurine a frequent choice are its altered hydrogen bonding pattern and electronic character compared with ordinary purine. The loss of the nitrogen atom at position seven removes one hydrogen bond acceptor point while simultaneously opening that position for further substitution, so researchers can add new functional groups in a direction that is not possible with natural purine. This flat, electron-rich bicyclic framework also provides good stability toward common reaction conditions and facilitates both substitution and coupling reactions, making it a dependable platform for stepwise molecular construction.
In Indonesian laboratories, this building block is typically used in university and institutional research groups working on nucleoside chemistry, medicinal chemistry, and biochemistry. It is handled in synthetic organic chemistry workflows where a purine-like scaffold must be elaborated into more complex targets, and in screening-oriented projects where analogues of natural bases are prepared for evaluation against purine-binding enzymes. Because it is a starting material rather than a finished product, it is normally requested in research quantities suited to bench-scale synthesis.
Laboratory Applications
- Nucleoside analogue synthesis — the pyrrolo[2,3-d]pyrimidine core mimics the shape of natural purine bases, allowing researchers to assemble analogues that engage biological targets while carrying deliberately modified recognition properties.
- Modified nucleotide preparation — because position seven is available for substitution, this scaffold lets chemists install new functional groups and build nucleotides that natural purine chemistry cannot readily provide.
- Medicinal chemistry scaffold development — the electron-rich bicyclic framework is stable under common reaction conditions, making it a reliable platform for stepwise elaboration into small molecule candidates during discovery work.
- Purine-binding enzyme inhibitor studies — the altered hydrogen bonding pattern, with one acceptor point removed, gives researchers a controlled way to probe how target enzymes recognise and bind purine-like ligands.
- Substitution and coupling reaction chemistry — the flat heterocyclic core tolerates standard synthetic transformations well, so it suits multi-step routes that rely on successive substitution or coupling steps to extend the molecule.
Specifications
- Brand: TCI
- CAS number: 271-70-5
- Chemical name: 7-Deazapurine
- Category: Chemistry > Building Blocks > Heterocyclic Building Blocks
- Pack sizes: research quantities as offered by the manufacturer; please confirm the available pack size when ordering
- Storage: store according to the manufacturer's label and the accompanying safety data sheet
Handling and Storage
Store this material in its original tightly closed container in a cool, dry, well-ventilated area, away from heat, direct sunlight, and incompatible chemicals. Keep the container sealed when not in use to limit exposure to moisture and air, and follow the storage conditions stated on the manufacturer's label and safety data sheet. Handle the compound in a fume hood using appropriate personal protective equipment, including safety glasses, gloves, and a laboratory coat. Avoid the generation of dust, avoid inhalation and skin contact, and wash hands after handling. Use clean, dry spatulas and glassware when transferring the material to prevent contamination of the stock, and label all secondary containers clearly. Dispose of residues and contaminated materials in accordance with applicable laboratory waste procedures.
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