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Description
5-Ethyluracil is a pyrimidine base analogue derived from uracil, carrying an ethyl group substituted at the fifth position of the ring. Uracil itself is one of the constituent bases of RNA, so modification at position five yields a compound that remains recognizable to biological systems while carrying distinctly different steric and electronic character. In the laboratory, this compound serves as a starting material for the synthesis of modified nucleosides, as a comparison compound in studies of pyrimidine metabolism, and as a test substrate in research on enzymes that act on pyrimidine bases.
The property that makes this material important is the strategic position of its substituent. Position five of the pyrimidine ring is the most widely explored point of modification in nucleoside chemistry, because substituents placed there are relatively well tolerated by many enzymes while still being able to alter base-pairing behaviour, solubility, and metabolic stability. The ethyl group contributes a moderate increase in hydrophobicity — greater than the methyl group of thymine, yet still compact. The pyrimidine ring also presents NH and carbonyl groups that are readily available for glycosylation, directed alkylation, and the formation of characteristic hydrogen bonds.
In Indonesian laboratories, 5-Ethyluracil is typically used in university and institutional research settings working on nucleoside chemistry, biochemistry, and pyrimidine metabolism. It is normally handled at small scale on the synthetic bench or in enzyme assay work, where it functions either as a building block toward modified nucleoside targets or as a reference compound alongside natural bases such as uracil and thymine. Its role suits organic synthesis groups and life science research units rather than routine analytical service work.
Laboratory Applications
Modified nucleoside synthesis — the free NH and carbonyl positions on the pyrimidine ring make this base a direct substrate for glycosylation reactions that build nucleoside analogues with a five-position ethyl group.
Pyrimidine metabolism studies — serves as a comparison compound against uracil and thymine, allowing researchers to trace how an enlarged five-position substituent affects metabolic recognition and processing.
Enzyme substrate specificity research — used as a test compound for enzymes acting on pyrimidine bases, since position-five substituents are often tolerated while still probing the limits of the active site.
Directed alkylation chemistry — the ring nitrogen and carbonyl functionalities provide defined reactive handles for selective alkylation work aimed at building more elaborate pyrimidine derivatives.
Base-pairing and hydrogen bonding investigations — the retained NH and carbonyl groups permit characteristic hydrogen bond formation, making the compound useful for studying how five-position bulk influences pairing behaviour.
Specifications
Brand: TCI
Catalogue number: E0807
CAS number: 4212-49-1
Category: Life Science > Biochemicals and Reagents > Nucleosides, Nucleotides, Oligonucleotides
Pack sizes: available in standard research-scale packaging as supplied by TCI; please confirm the required size when ordering
Storage note: store in a cool, dry place in the tightly closed original container
Handling and Storage
Store 5-Ethyluracil in its original tightly closed container in a cool, dry, and well-ventilated place, protected from moisture and away from strong oxidising agents and incompatible chemicals. Amber glass or the manufacturer's supplied container is suitable for keeping the material sealed and dry; transfer any working portions into clean, clearly labelled vessels. Handle the compound in a fume hood or well-ventilated area, wearing safety glasses, gloves, and a laboratory coat, and avoid generating or inhaling dust when weighing out solid material. Wash hands thoroughly after handling, keep the container closed when not in use, and consult the manufacturer's safety data sheet before first use for full hazard and disposal guidance.
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