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Description
Etravirine is a diarylpyrimidine-class compound known as a non-nucleoside inhibitor of the HIV-1 reverse transcriptase enzyme. Supplied as a material for research purposes, this compound is used in life science laboratories as a pharmacological tool for studying the working mechanism of the reverse transcriptase enzyme, the resistance patterns of viruses against drugs, and the behaviour of antiviral compounds within biological systems. Its role is important because it provides a well-characterised reference point for researchers developing new antiviral compounds or establishing analytical methods for pharmaceutical preparations.
The characteristic that makes etravirine scientifically interesting is its conformational flexibility. Its diarylpyrimidine structure can adjust its shape within the binding pocket of the enzyme, so that it remains effective against a number of viral variants that have mutated and become resistant to earlier generations of inhibitors. This property makes it a classic example in the study of structure-based drug design. From a physicochemical standpoint, the compound is a solid that is very slightly soluble in water but soluble in certain organic solvents, so preparation of stock solutions generally uses dimethyl sulfoxide.
In Indonesian laboratories, this material is typically handled in university life science departments, pharmaceutical research groups, and quality control laboratories that develop analytical methods for pharmaceutical preparations. It is normally weighed out in small quantities, dissolved in dimethyl sulfoxide to make a stock solution, and then diluted into working concentrations for enzyme or cell-based experiments. Because it is intended for research use, it is kept within the controlled chemical inventory of the laboratory rather than in general open storage.
Laboratory Applications
Reverse transcriptase enzyme mechanism studies, where this compound serves as a well-characterised non-nucleoside inhibitor allowing researchers to probe how the enzyme functions under controlled laboratory conditions.
Viral drug resistance research, because its diarylpyrimidine scaffold remains effective against mutated viral variants, making it suitable for examining resistance patterns that defeat earlier inhibitor generations.
Antiviral compound development programmes, where it acts as a reference comparator against which newly synthesised candidate antiviral compounds can be evaluated within the same experimental system.
Analytical method development for pharmaceutical preparations, since a characterised reference compound is required when establishing and validating methods intended for pharmaceutical formulation work.
Structure-based drug design teaching and investigation, as its conformational flexibility within the enzyme binding pocket makes it a classic worked example of this design approach.
Specifications
Brand: TCI
CAS number: 269055-15-4
Category: Life Science > Biochemicals and Reagents > Antibiotics
Pack size: 1 unit pack
Physical form: solid, very slightly soluble in water and soluble in certain organic solvents
Storage note: keep in the laboratory chemical inventory under controlled conditions; for research use only
Handling and Storage
Store the container tightly closed in a cool, dry place away from direct sunlight and out of the general open-shelf area, keeping it within the controlled chemical inventory of the laboratory. Use the original supplier container for the bulk material, and transfer stock solutions into clean, tightly sealed vials that are compatible with dimethyl sulfoxide and clearly labelled with the compound identity and preparation date. Handle the solid inside a fume hood or with appropriate local exhaust to avoid dust generation, and wear a laboratory coat, safety glasses, and suitable gloves. Weigh out only the quantity required, avoid contact with skin and eyes, and follow institutional procedures for the disposal of residues. This material is intended for research purposes and should not be used in human or veterinary applications.
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