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Description
TCI F0791 4-Fluoro-3-methylbenzaldehyde is a fluorinated aromatic aldehyde that carries a methyl group on the benzene ring. The aldehyde group is one of the most versatile functional groups in organic chemistry, since it can be converted into alcohols, carboxylic acids, imines, alkenes, and a wide range of heterocyclic rings. For this reason, the compound serves in synthesis laboratories as an intermediate that connects the earliest reaction steps with far more elaborate final molecular frameworks, particularly when the target structure requires an aromatic ring that already contains both fluorine and a methyl substituent.
The main attraction of this compound lies in its pre-arranged substitution pattern, which spares researchers from carrying out the selective fluorination or methylation steps that are so often troublesome. The fluorine atom, positioned para to the formyl group, exerts a distinctive electronic influence and becomes a site that can be exploited in nucleophilic aromatic substitution reactions under the right conditions, while the adjacent methyl group introduces mild steric hindrance and alters the lipophilicity profile of the resulting product. Together these features give the building block a predictable and well-defined reactivity.
In Indonesian laboratories this compound is generally handled as a clear liquid that dissolves readily in common organic solvents such as dichloromethane, which makes it straightforward to incorporate into standard bench-scale procedures. Research groups in universities, government institutes, and industrial R&D units typically call on building blocks of this type when they are assembling fluorine-containing scaffolds and prefer to begin from a ready-made aromatic core rather than construct the substitution pattern themselves.
Laboratory Applications
- Fluorinated scaffold construction: the ring already carries fluorine and methyl in fixed positions, so researchers can build target frameworks without performing selective fluorination or methylation steps.
- Aldehyde-based functional group interconversion: the formyl group can be transformed into alcohols, carboxylic acids, imines, or alkenes, giving a single starting material several divergent synthetic routes.
- Heterocyclic ring synthesis: the aldehyde functionality participates in condensation chemistry that closes various heterocyclic rings, carrying the fluorine and methyl substituents into the final product.
- Nucleophilic aromatic substitution studies: the fluorine atom para to the formyl group serves as a reactive site that can be displaced under appropriately chosen reaction conditions.
- Lipophilicity and structure modification work: the adjacent methyl group provides mild steric hindrance and shifts the lipophilicity profile, which is useful when tuning the properties of downstream molecules.
Specifications
- Brand: TCI (Tokyo Chemical Industry)
- CAS number: 135427-08-6
- Category: Chemistry > Building Blocks > Fluorinated Building Blocks
- Product code: F0791
- Physical form: clear liquid, soluble in common organic solvents such as dichloromethane
- Pack sizes: available in the standard research-scale packaging offered by the manufacturer; storage in a cool, dry place away from light is recommended
Handling and Storage
Store the compound in a cool, dry place, protected from light and away from heat sources, ignition sources, and strong oxidising agents. Keep it in its original tightly closed container, or in a chemically compatible glass bottle with a well-sealed cap, to limit exposure to air and moisture. As an aromatic aldehyde, the material should be handled inside a fume hood with adequate ventilation. Laboratory personnel should wear safety glasses, chemical-resistant gloves, and a laboratory coat, avoid direct contact with skin and eyes, and consult the manufacturer's safety data sheet before use. Transfer with clean, dry glassware and close the container promptly after dispensing.
