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Description
TCI H0198 4-Hydroxybenzaldehyde is the para isomer of hydroxybenzaldehyde, bearing a phenolic hydroxyl group and an aldehyde group positioned directly opposite one another on the benzene ring. The compound ranks among the most widely used aromatic building blocks in organic synthesis laboratories because it serves as a starting point toward a broad family of valuable phenolic derivatives, including aroma compounds and pharmaceutical intermediates. At the researcher's bench, this material becomes the reference choice whenever a molecular design calls for a para-hydroxybenzene core that can be elaborated further through established, well-documented routes.
The property that makes it a frequent selection is its balance between reactivity and stability. The para arrangement places the hydroxyl group in direct conjugation with the aldehyde group, giving the ring a distinctive electronic character so that both substitution and condensation reactions proceed along patterns that are easy to predict. Its crystalline solid form makes accurate weighing straightforward and allows repurification by recrystallization whenever that is required. The compound also dissolves in many common organic solvents available in the laboratory, which simplifies the preparation of reaction systems.
In Indonesian laboratories, 4-Hydroxybenzaldehyde is typically kept as a standing bench reagent in organic synthesis groups at universities and research institutes, as well as in industrial R&D units developing flavour, fragrance, and fine-chemical routes. Its predictable handling behaviour and wide documentation make it suitable for teaching-scale preparations and method development alike, where reproducible starting material is more important than exotic reactivity.
Laboratory Applications
Synthesis of phenolic derivatives — the free phenolic hydroxyl can be alkylated, acylated, or otherwise protected, giving a direct and well-documented entry into substituted phenol families.
Preparation of pharmaceutical intermediates — its role as a recognised starting point toward valuable derivatives makes it suitable for building intermediate scaffolds in medicinal chemistry programmes.
Aroma compound synthesis — the para-hydroxybenzene core is a known precursor to aroma-active phenolic compounds, so the material supports flavour and fragrance route development work.
Condensation reactions — the aldehyde group participates in condensation chemistry with predictable outcomes, which helps researchers plan multi-step sequences with confidence in each stage.
Aromatic substitution studies — conjugation between the hydroxyl and aldehyde groups gives the ring a distinctive electronic profile useful for investigating and teaching substitution behaviour.
Specifications
Brand: TCI (Tokyo Chemical Industry)
CAS Number: 123-08-0
Catalogue Number: H0198
Category: Chemistry > Building Blocks > Non-Heterocyclic Building Blocks
Physical form: crystalline solid
Pack sizes: available in standard TCI research pack sizes; please confirm the size required when ordering
Storage: keep in a closed container in a cool, dry place away from light
Handling and Storage
Store the container tightly closed in a cool, dry, well-ventilated area, away from direct sunlight and sources of heat or ignition. Amber glass bottles or the original manufacturer packaging are suitable, since they limit exposure to light and moisture that can degrade phenolic aldehydes over time. Handle the solid inside a fume hood and wear standard laboratory protection — safety glasses, gloves, and a laboratory coat — to avoid contact with skin, eyes, and inhalation of dust. Weigh out only the quantity needed, close the container promptly after use to reduce moisture uptake, and keep the material separated from strong oxidising agents and strong bases. Consult the manufacturer's Safety Data Sheet before first use and follow institutional waste disposal procedures for residues.
